Genular: Defining Cellular Identity and Function

Details for: Akr1b1

Gene ID: 11677

Symbol: Akr1b1

Ensembl ID: ENSMUSG00000001642

Description: aldo-keto reductase family 1 member B

Associated with

Fructose biosynthesis
(R-MMU-5652227)
Fructose metabolism
(R-MMU-5652084)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Metabolism of lipids
(R-MMU-556833)
Metabolism of steroid hormones
(R-MMU-196071)
Metabolism of steroids
(R-MMU-8957322)
Pregnenolone biosynthesis
(R-MMU-196108)
Alditol:nadp+ 1-oxidoreductase activity
(GO:0004032)
Allyl-alcohol dehydrogenase activity
(GO:0047655)
Cellular hyperosmotic salinity response
(GO:0071475)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to methylglyoxal
(GO:0097238)
Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity
(GO:0018505)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Daunorubicin metabolic process
(GO:0044597)
Doxorubicin metabolic process
(GO:0044598)
Epithelial cell maturation
(GO:0002070)
Extracellular space
(GO:0005615)
Fructose biosynthetic process
(GO:0046370)
Glyceraldehyde oxidoreductase activity
(GO:0043795)
Inner medullary collecting duct development
(GO:0072061)
L-ascorbic acid biosynthetic process
(GO:0019853)
L-glucuronate reductase activity
(GO:0047939)
Lipid metabolic process
(GO:0006629)
Mast cell granule
(GO:0042629)
Metanephric collecting duct development
(GO:0072205)
Monosaccharide metabolic process
(GO:0005996)
Nadp-retinol dehydrogenase activity
(GO:0052650)
Negative regulation of apoptotic process
(GO:0043066)
Norepinephrine metabolic process
(GO:0042415)
Nucleoplasm
(GO:0005654)
Oxidoreductase activity
(GO:0016491)
Paranodal junction
(GO:0033010)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane bounded cell projection cytoplasm
(GO:0032838)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Regulation of urine volume
(GO:0035809)
Renal water homeostasis
(GO:0003091)
Response to organic substance
(GO:0010033)
Retinal dehydrogenase activity
(GO:0001758)
Retinoid metabolic process
(GO:0001523)
Schmidt-lanterman incisure
(GO:0043220)
Schwann cell microvillus
(GO:0097454)
Sorbitol biosynthetic process
(GO:0006061)
Stress-activated protein kinase signaling cascade
(GO:0031098)
Tissue homeostasis
(GO:0001894)

Other Information

Proteins

Aldo-keto reductase family 1 member B1

Genular Protein ID: 3198863223

Symbol: ALDR_MOUSE

Name: Aldo-keto reductase family 1 member B1

UniProtKB Accession Codes:

P45376 O70130 Q99KC9

Database IDs:

Citations:

PubMed ID: 7851421

Title: Presence of a closely related subgroup in the aldo-ketoreductase family of the mouse.

PubMed ID: 7851421

DOI: 10.1111/j.1432-1033.1995.tb20408.x

PubMed ID: 9485485

Title: Characterization of the mouse aldose reductase gene and promoter in a lens epithelial cell line.

PubMed ID: 9485485

PubMed ID: 10092857

Title: Comparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes.

PubMed ID: 10092857

DOI: 10.1046/j.1432-1327.1999.00110.x

PubMed ID: 10049784

Title: Characterization of genomic regions directing the cell-specific expression of the mouse aldose reductase gene.

PubMed ID: 10049784

DOI: 10.1006/bbrc.1999.0164

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 10913167

Title: Aldose reductase-deficient mice develop nephrogenic diabetes insipidus.

PubMed ID: 10913167

DOI: 10.1128/mcb.20.16.5840-5846.2000

PubMed ID: 17381426

Title: Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes.

PubMed ID: 17381426

DOI: 10.1042/bj20061743

PubMed ID: 19010934

Title: Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7.

PubMed ID: 19010934

DOI: 10.1093/jb/mvn152

Sequence Information:

Length: 316
Mass: 35732
Checksum: E18759AD160B4A0E
Sequence:

MASHLELNNG TKMPTLGLGT WKSPPGQVTE AVKVAIDLGY RHIDCAQVYQ NEKEVGVALQ 
EKLKEQVVKR QDLFIVSKLW CTFHDKSMVK GAFQKTLSDL QLDYLDLYLI HWPTGFKPGP 
DYFPLDASGN VIPSDTDFVD TWTAMEQLVD EGLVKTIGVS NFNPLQIERI LNKPGLKYKP 
AVNQIECHPY LTQEKLIEYC HSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK 
YNKTTAQVLI RFPIQRNLVV IPKSVTPVRI AENLKVFDFE VSSEDMATLL SYNRNWRVCA 
LMSCAKHKDY PFHAEV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Akr1b1

Associated with

Other Information

Presence of a closely related subgroup in the aldo-ketoreductase family of the mouse. PubMed ID: 7851421

Characterization of the mouse aldose reductase gene and promoter in a lens epithelial cell line. PubMed ID: 9485485

Comparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes. PubMed ID: 10092857

Characterization of genomic regions directing the cell-specific expression of the mouse aldose reductase gene. PubMed ID: 10049784

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. PubMed ID: 10913167

Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes. PubMed ID: 17381426

Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7. PubMed ID: 19010934