Genular: Defining Cellular Identity and Function

Details for: Alk

Gene ID: 11682

Symbol: Alk

Ensembl ID: ENSMUSG00000055471

Description: anaplastic lymphoma kinase

Associated with

Mdk and ptn in alk signaling
(R-MMU-9851151)
Signaling by alk
(R-MMU-201556)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Adult behavior
(GO:0030534)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Brain development
(GO:0007420)
Cell body
(GO:0044297)
Energy homeostasis
(GO:0097009)
Heparin binding
(GO:0008201)
Hippocampus development
(GO:0021766)
Identical protein binding
(GO:0042802)
Kinase activity
(GO:0016301)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of lipid catabolic process
(GO:0050995)
Nervous system development
(GO:0007399)
Nucleotide binding
(GO:0000166)
Peptidyl-tyrosine autophosphorylation
(GO:0038083)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of dendrite development
(GO:1900006)
Positive regulation of kinase activity
(GO:0033674)
Protein-containing complex
(GO:0032991)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Receptor complex
(GO:0043235)
Receptor signaling protein tyrosine kinase activator activity
(GO:0030298)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dopamine receptor signaling pathway
(GO:0060159)
Regulation of neuron differentiation
(GO:0045664)
Response to environmental enrichment
(GO:0090648)
Response to stress
(GO:0006950)
Swimming behavior
(GO:0036269)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

ALK_MOUSE

Genular Protein ID: 2898417670

Symbol: ALK_MOUSE

Name: N/A

UniProtKB Accession Codes:

P97793 E9QKV3

Database IDs:

Citations:

PubMed ID: 9053841

Title: Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.

PubMed ID: 9053841

DOI: 10.1038/sj.onc.1200849

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15226403

Title: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.

PubMed ID: 15226403

DOI: 10.1242/jcs.01183

PubMed ID: 16458083

Title: Characterization of the expression of the ALK receptor tyrosine kinase in mice.

PubMed ID: 16458083

DOI: 10.1016/j.modgep.2005.11.006

PubMed ID: 16878150

Title: Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase.

PubMed ID: 16878150

DOI: 10.1038/sj.onc.1209840

PubMed ID: 17487225

Title: Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications.

PubMed ID: 17487225

DOI: 10.1038/sj.npp.1301446

PubMed ID: 19200234

Title: ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction.

PubMed ID: 19200234

DOI: 10.1111/j.1460-9568.2008.06593.x

PubMed ID: 22079349

Title: Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.

PubMed ID: 22079349

DOI: 10.1016/j.pbb.2011.10.024

PubMed ID: 19459784

Title: Anaplastic lymphoma kinase: signalling in development and disease.

PubMed ID: 19459784

DOI: 10.1042/bj20090387

PubMed ID: 30497772

Title: Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN.

PubMed ID: 30497772

DOI: 10.1016/j.neuron.2018.10.051

PubMed ID: 32442405

Title: Identification of ALK in Thinness.

PubMed ID: 32442405

DOI: 10.1016/j.cell.2020.04.034

Sequence Information:

Length: 1621
Mass: 174948
Checksum: 72D1022E117F303E
Sequence:

MGAAGFLWLL PPLLLAAASY SGAATDQRAG SPASGPPLQP REPLSYSRLQ RKSLAVDFVV 
PSLFRVYARD LLLPQPRSPS EPEAGGLEAR GSLALDCEPL LRLLGPLPGI SWADGASSPS 
PEAGPTLSRV LKGGSVRKLR RAKQLVLELG EETILEGCIG PPEEVAAVGI LQFNLSELFS 
WWILHGEGRL RIRLMPEKKA SEVGREGRLS SAIRASQPRL LFQIFGTGHS SMESPSETPS 
PPGTFMWNLT WTMKDSFPFL SHRSRYGLEC SFDFPCELEY SPPLHNHGNQ SWSWRHVPSE 
EASRMNLLDG PEAEHSQEMP RGSFLLLNTS ADSKHTILSP WMRSSSDHCT LAVSVHRHLQ 
PSGRYVAQLL PHNEAGREIL LVPTPGKHGW TVLQGRVGRP ANPFRVALEY ISSGNRSLSA 
VDFFALKNCS EGTSPGSKMA LQSSFTCWNG TVLQLGQACD FHQDCAQGED EGQLCSKLPA 
GFYCNFENGF CGWTQSPLSP HMPRWQVRTL RDAHSQGHQG RALLLSTTDI LASEGATVTS 
ATFPAPMKNS PCELRMSWLI RGVLRGNVSL VLVENKTGKE QSRTVWHVAT DEGLSLWQHT 
VLSLLDVTDR FWLQIVTWWG PGSRATVGFD NISISLDCYL TISGEEKMSL NSVPKSRNLF 
EKNPNKESKS WANISGPTPI FDPTVHWLFT TCGASGPHGP TQAQCNNAYQ NSNLSVVVGS 
EGPLKGVQIW KVPATDTYSI SGYGAAGGKG GKNTMMRSHG VSVLGIFNLE KGDTLYILVG 
QQGEDACPRA NQLIQKVCVG ENNVIEEEIR VNRSVHEWAG GGGGGGGATY VFKMKDGVPV 
PLIIAAGGGG RAYGAKTETF HPERLESNSS VLGLNGNSGA AGGGGGWNDN TSLLWAGKSL 
LEGAAGGHSC PQAMKKWGWE TRGGFGGGGG GCSSGGGGGG YIGGNAASNN DPEMDGEDGV 
SFISPLGILY TPALKVMEGH GEVNIKHYLN CSHCEVDECH MDPESHKVIC FCDHGTVLAD 
DGVSCIVSPT PEPHLPLSLI LSVVTSALVA ALVLAFSGIM IVYRRKHQEL QAMQMELQSP 
EYKLSKLRTS TIMTDYNPNY CFAGKTSSIS DLKEVPRKNI TLIRGLGHGA FGEVYEGQVS 
GMPNDPSPLQ VAVKTLPEVC SEQDELDFLM EALIISKFNH QNIVRCIGVS LQALPRFILL 
ELMAGGDLKS FLRETRPRPN QPTSLAMLDL LHVARDIACG CQYLEENHFI HRDIAARNCL 
LTCPGAGRIA KIGDFGMARD IYRASYYRKG GCAMLPVKWM PPEAFMEGIF TSKTDTWSFG 
VLLWEIFSLG YMPYPSKSNQ EVLEFVTSGG RMDPPKNCPG PVYRIMTQCW QHQPEDRPNF 
AIILERIEYC TQDPDVINTA LPIEYGPVVE EEEKVPMRPK DPEGMPPLLV SPQPAKHEEA 
SAAPQPAALT APGPSVKKPP GAGAGAGAGA GAGPVPRGAA DRGHVNMAFS QPNPPPELHK 
GPGSRNKPTS LWNPTYGSWF TEKPAKKTHP PPGAEPQARA GAAEGGWTGP GAGPRRAEAA 
LLLEPSALSA TMKEVPLFRL RHFPCGNVNY GYQQQGLPLE ATAAPGDTML KSKNKVTQPG 
P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Alk

Associated with

Other Information

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. PubMed ID: 9053841

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth. PubMed ID: 15226403

Characterization of the expression of the ALK receptor tyrosine kinase in mice. PubMed ID: 16458083

Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase. PubMed ID: 16878150

Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications. PubMed ID: 17487225

ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction. PubMed ID: 19200234

Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis. PubMed ID: 22079349

Anaplastic lymphoma kinase: signalling in development and disease. PubMed ID: 19459784

Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. PubMed ID: 30497772

Identification of ALK in Thinness. PubMed ID: 32442405