Genular: Defining Cellular Identity and Function

Details for: Alox12

Gene ID: 11684

Symbol: Alox12

Ensembl ID: ENSMUSG00000000320

Description: arachidonate 12-lipoxygenase

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Biosynthesis of dha-derived spms
(R-MMU-9018677)
Biosynthesis of dpa-derived spms
(R-MMU-9018683)
Biosynthesis of dpan-3 spms
(R-MMU-9025094)
Biosynthesis of dpan-3-derived maresins
(R-MMU-9026290)
Biosynthesis of dpan-6 spms
(R-MMU-9025106)
Biosynthesis of specialized proresolving mediators (spms)
(R-MMU-9018678)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Synthesis of 12-eicosatetraenoic acid derivatives
(R-MMU-2142712)
Synthesis of hepoxilins (hx) and trioxilins (trx)
(R-MMU-2142696)
Synthesis of lipoxins (lx)
(R-MMU-2142700)
Arachidonate 12(s)-lipoxygenase activity
(GO:0004052)
Arachidonate 15-lipoxygenase activity
(GO:0050473)
Arachidonic acid metabolic process
(GO:0019369)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dioxygenase activity
(GO:0051213)
Establishment of skin barrier
(GO:0061436)
Fatty acid metabolic process
(GO:0006631)
Fatty acid oxidation
(GO:0019395)
Hepoxilin biosynthetic process
(GO:0051122)
Hydrolase activity
(GO:0016787)
Iron ion binding
(GO:0005506)
Linoleate 13s-lipoxygenase activity
(GO:0016165)
Linoleic acid metabolic process
(GO:0043651)
Lipid metabolic process
(GO:0006629)
Lipid oxidation
(GO:0034440)
Lipoxin a4 biosynthetic process
(GO:2001303)
Lipoxin b4 biosynthetic process
(GO:2001306)
Lipoxygenase pathway
(GO:0019372)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of muscle cell apoptotic process
(GO:0010656)
Negative regulation of platelet aggregation
(GO:0090331)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
(GO:0016702)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of endothelial tube morphogenesis
(GO:1905956)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mitochondrial depolarization
(GO:0051901)
Positive regulation of reactive oxygen species biosynthetic process
(GO:1903428)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Sarcolemma
(GO:0042383)
Unsaturated fatty acid metabolic process
(GO:0033559)

Other Information

Proteins

Lipoxin synthase 12-LO

Genular Protein ID: 1544679544

Symbol: LOX12_MOUSE

Name: Lipoxin synthase 12-LO

UniProtKB Accession Codes:

P39655 Q8BHG4

Database IDs:

Citations:

PubMed ID: 8188678

Title: cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases.

PubMed ID: 8188678

DOI: 10.1016/s0021-9258(17)36743-1

PubMed ID: 7576099

Title: 12-lipoxygenase isoenzymes in mouse skin tumor development.

PubMed ID: 7576099

DOI: 10.1002/mc.2940140208

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 7792391

Title: 12-lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes.

PubMed ID: 7792391

DOI: 10.1016/0090-6980(94)00005-h

PubMed ID: 7868854

Title: Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells.

PubMed ID: 7868854

DOI: 10.1177/43.3.7868854

PubMed ID: 9501222

Title: Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase.

PubMed ID: 9501222

DOI: 10.1073/pnas.95.6.3100

PubMed ID: 10383730

Title: Basal transepidermal water loss is increased in platelet-type 12-lipoxygenase deficient mice.

PubMed ID: 10383730

DOI: 10.1046/j.1523-1747.1999.00595.x

PubMed ID: 11256953

Title: Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes.

PubMed ID: 11256953

DOI: 10.1042/0264-6021:3550097

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 25293588

Title: Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.

PubMed ID: 25293588

DOI: 10.1194/jlr.m054072

Sequence Information:

Length: 663
Mass: 75390
Checksum: 205BE32BE2CF3E87
Sequence:

MGRYRVRVVT GAWLFSGSLN LVRLWLVGEH REAKLELQLR PARGKEEEFD FDVPEDLGPL 
QFVKLHKQHT VVDDAWFCNL ITVQGPGTSA EAVFPCYRWV QGEGILSLPE GTARLAGDNA 
LDVFQKYREK ELKERQQTYC WATWKEGLPQ TIAADCKDDL PPNMRFHEEK RLDFEWTLKA 
GVLEMGLKRV YTLLRSWNHL EDFDQIFWGQ KSALAEKVHQ CWQEDELFGY QFLNGANPML 
LRRSTSLPSR LVLPSGMEEL QAQLEKELKN GSLFEADFIL LDGIPANVIR GEPQYLAAPL 
VMLRMDPGGK LLPMAIQIQP PNPSSPAPTL FLPSDPPLAW LLAKIWVRNS DFQLQELQFH 
LLNTHLVAEV IAVATMRCLP GLHPIFKLLV PHIRYTMEIN TRSRTQLISD GGIFDQVVST 
GGGGHVQLLT RAVAQLTYHS LCPPDDLANR GLLRIPSALY ARDALQLWEV TARYVKGMVH 
LFYQSDDIVR GDPELQAWCR EITEVGLCHA QDRGFPVSFQ SRAQLCHFLT MCVFTCTAQH 
AAINQGQLDW YGWVPNAPCT MRMPPPTSKD DVTMETVMGS LPDVQKACLQ MTITWHLGRL 
QPDMVPLGHH TEKYFSDPRT KAVLSQFQAD LDNLEKEITA RNEQLDLPYE YLKPSRIENS 
ITI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Alox12

Associated with

Other Information

cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. PubMed ID: 8188678

12-lipoxygenase isoenzymes in mouse skin tumor development. PubMed ID: 7576099

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

12-lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes. PubMed ID: 7792391

Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells. PubMed ID: 7868854

Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase. PubMed ID: 9501222

Basal transepidermal water loss is increased in platelet-type 12-lipoxygenase deficient mice. PubMed ID: 10383730

Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes. PubMed ID: 11256953

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction. PubMed ID: 25293588