Genular: Defining Cellular Identity and Function

Details for: Alox12b

Gene ID: 11686

Symbol: Alox12b

Ensembl ID: ENSMUSG00000032807

Description: arachidonate 12-lipoxygenase, 12R type

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Synthesis of 12-eicosatetraenoic acid derivatives
(R-MMU-2142712)
Arachidonate 8(r)-lipoxygenase activity
(GO:0047677)
Arachidonate 12(s)-lipoxygenase activity
(GO:0004052)
Arachidonic acid metabolic process
(GO:0019369)
Bicellular tight junction assembly
(GO:0070830)
Ceramide biosynthetic process
(GO:0046513)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dioxygenase activity
(GO:0051213)
Establishment of skin barrier
(GO:0061436)
Fatty acid metabolic process
(GO:0006631)
Hepoxilin biosynthetic process
(GO:0051122)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Linoleate 9s-lipoxygenase activity
(GO:1990136)
Linoleic acid metabolic process
(GO:0043651)
Lipid metabolic process
(GO:0006629)
Lipid oxidation
(GO:0034440)
Lipoxygenase pathway
(GO:0019372)
Metal ion binding
(GO:0046872)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
(GO:0016702)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mucus secretion
(GO:0070257)
Protein lipidation
(GO:0006497)
Sphingolipid metabolic process
(GO:0006665)

Other Information

Proteins

Epidermis-type lipoxygenase 12

Genular Protein ID: 1821908050

Symbol: LX12B_MOUSE

Name: Epidermis-type lipoxygenase 12

UniProtKB Accession Codes:

O70582

Database IDs:

Citations:

PubMed ID: 9518531

Title: cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin.

PubMed ID: 9518531

DOI: 10.1016/s0005-2760(97)00214-2

PubMed ID: 9837935

Title: Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment.

PubMed ID: 9837935

DOI: 10.1074/jbc.273.50.33540

PubMed ID: 10100631

Title: Murine 12(R)-lipoxygenase: functional expression, genomic structure and chromosomal localization.

PubMed ID: 10100631

DOI: 10.1016/s0014-5793(99)00196-9

PubMed ID: 11256953

Title: Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes.

PubMed ID: 11256953

DOI: 10.1042/0264-6021:3550097

PubMed ID: 16129665

Title: Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis.

PubMed ID: 16129665

DOI: 10.1074/jbc.m508260200

PubMed ID: 17403930

Title: 12R-lipoxygenase deficiency disrupts epidermal barrier function.

PubMed ID: 17403930

DOI: 10.1083/jcb.200612116

PubMed ID: 17429434

Title: A mouse mutation in the 12R-lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier.

PubMed ID: 17429434

DOI: 10.1038/sj.jid.5700825

PubMed ID: 21558561

Title: Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope.

PubMed ID: 21558561

DOI: 10.1074/jbc.m111.251496

Sequence Information:

Length: 701
Mass: 80578
Checksum: FAE3A3B8D2AA142E
Sequence:

MATYKVKVAT GTDFFSGTLD SISLTIVGTQ GESHKQRLNH FGRDFATGAV DDYTVQCQQD 
LGELIIIRLH KEPHSFLAKD PWYCNYVQIC APDCRVYHFP AYQWMDGYET LALREATGKI 
TADDTLPILL EHRQEEIRAK KDFYHWRVFV PGLPNYVDIP SYHPPPRRCR NPNRPEWDGY 
IPGFPILINI KATRFLNSNL RFSFVKTASF FYRLGPMALA FKLRGLVDRK RSWKRLKDIK 
NIFPATKSVV SEYVAEHWTE DSFFGYQYLN GINPGLIRRC TQIPDKFPVT DEMVAPFLGE 
GTCLQAELER GNIYLADYRI LDGIPTVELN GQQQHHCAPM CLLHFGPDGN MMPIAIQLSQ 
TPGPDCPIFL PNDSEWDWLL AKTWVRYAEF YSHEAVAHLL ESHLIGEAFC LALLRNLPMC 
HPLYKLLIPH TRYNVQINSI GRALLLNKGG LSARAMSLGL EGFAQVMVRG LSELTYKSLC 
IPNDFVERGV QDLPGYYFRD DSLAVWYAME RYVTEIITYY YPNDAAVEGD PELQCWVQEI 
FKECLLGRES SGFPTCLRTI PELIEYVTMV MYTCSARHAA VNSGQLEYTS WMPNFPSSMR 
NPPMQTKGLT TLQTYMDTLP DVKTTCIVLL VLWTLCREPD DRRPLGHFPD IHFVEEGPRR 
SIEAFRQNLN QISHNIRQRN KCLTLPYYYL DPVLIENSIS I

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Alox12b

Associated with

Other Information

cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin. PubMed ID: 9518531

Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment. PubMed ID: 9837935

Murine 12(R)-lipoxygenase: functional expression, genomic structure and chromosomal localization. PubMed ID: 10100631

Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes. PubMed ID: 11256953

Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis. PubMed ID: 16129665

12R-lipoxygenase deficiency disrupts epidermal barrier function. PubMed ID: 17403930

A mouse mutation in the 12R-lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier. PubMed ID: 17429434

Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope. PubMed ID: 21558561