Genular: Defining Cellular Identity and Function

Details for: Alox15

Gene ID: 11687

Symbol: Alox15

Ensembl ID: ENSMUSG00000018924

Description: arachidonate 15-lipoxygenase

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Biosynthesis of dha-derived spms
(R-MMU-9018677)
Biosynthesis of dpa-derived spms
(R-MMU-9018683)
Biosynthesis of dpan-3 spms
(R-MMU-9025094)
Biosynthesis of dpan-3-derived protectins and resolvins
(R-MMU-9026286)
Biosynthesis of dpan-6 spms
(R-MMU-9025106)
Biosynthesis of e-series 18(r)-resolvins
(R-MMU-9023661)
Biosynthesis of e-series 18(s)-resolvins
(R-MMU-9018896)
Biosynthesis of epa-derived spms
(R-MMU-9018679)
Biosynthesis of protectins
(R-MMU-9018681)
Biosynthesis of specialized proresolving mediators (spms)
(R-MMU-9018678)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Synthesis of 12-eicosatetraenoic acid derivatives
(R-MMU-2142712)
Synthesis of 15-eicosatetraenoic acid derivatives
(R-MMU-2142770)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-MMU-2142691)
Apoptotic cell clearance
(GO:0043277)
Arachidonate 12(s)-lipoxygenase activity
(GO:0004052)
Arachidonate 15-lipoxygenase activity
(GO:0050473)
Arachidonic acid metabolic process
(GO:0019369)
Bone mineralization
(GO:0030282)
Cellular response to calcium ion
(GO:0071277)
Cellular response to interleukin-13
(GO:0035963)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Dioxygenase activity
(GO:0051213)
Fatty acid metabolic process
(GO:0006631)
Hepoxilin-epoxide hydrolase activity
(GO:0047977)
Hepoxilin a3 synthase activity
(GO:0051120)
Hepoxilin biosynthetic process
(GO:0051122)
Iron ion binding
(GO:0005506)
Linoleate 13s-lipoxygenase activity
(GO:0016165)
Linoleic acid metabolic process
(GO:0043651)
Lipid binding
(GO:0008289)
Lipid droplet
(GO:0005811)
Lipid metabolic process
(GO:0006629)
Lipid oxidation
(GO:0034440)
Lipoxin a4 biosynthetic process
(GO:2001303)
Lipoxygenase pathway
(GO:0019372)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of adaptive immune response
(GO:0002820)
Ossification
(GO:0001503)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
(GO:0016702)
Phosphatidylethanolamine biosynthetic process
(GO:0006646)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Plasma membrane
(GO:0005886)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of cell-substrate adhesion
(GO:0010811)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of heterotypic cell-cell adhesion
(GO:0034116)
Regulation of engulfment of apoptotic cell
(GO:1901074)
Regulation of inflammatory response
(GO:0050727)
Regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035358)
Response to endoplasmic reticulum stress
(GO:0034976)
Wound healing
(GO:0042060)

Other Information

Proteins

Arachidonate 15-lipoxygenase

Genular Protein ID: 190315556

Symbol: LOX15_MOUSE

Name: Arachidonate 15-lipoxygenase

UniProtKB Accession Codes:

P39654 Q4FJY9 Q5F2E3 Q6PHB2

Database IDs:

Citations:

PubMed ID: 8188678

Title: cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases.

PubMed ID: 8188678

DOI: 10.1016/s0021-9258(17)36743-1

PubMed ID: 7811740

Title: Cloning and characterization of a murine macrophage lipoxygenase.

PubMed ID: 7811740

DOI: 10.1016/0005-2760(94)00199-9

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8798642

Title: Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein.

PubMed ID: 8798642

DOI: 10.1074/jbc.271.39.24278

PubMed ID: 10432118

Title: Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase.

PubMed ID: 10432118

DOI: 10.1038/22572

PubMed ID: 11278875

Title: 12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells.

PubMed ID: 11278875

DOI: 10.1074/jbc.m011276200

PubMed ID: 14716014

Title: Regulation of bone mass in mice by the lipoxygenase gene Alox15.

PubMed ID: 14716014

DOI: 10.1126/science.1090985

PubMed ID: 15708862

Title: A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense.

PubMed ID: 15708862

DOI: 10.1074/jbc.m410638200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22215650

Title: 12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.

PubMed ID: 22215650

DOI: 10.1152/ajpendo.00373.2011

PubMed ID: 22503541

Title: 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance.

PubMed ID: 22503541

DOI: 10.1016/j.immuni.2012.03.010

Sequence Information:

Length: 663
Mass: 75445
Checksum: 0D5412B4502B5799
Sequence:

MGVYRIRVST GDSVYAGSNN EVYLWLIGQH GEASLGKLFR PCRNSEAEFK VDVSEYLGPL 
LFVRVQKWHY LKEDAWFCNW ISVKGPGDQG SEYTFPCYRW VQGTSILNLP EGTGCTVVED 
SQGLFRNHRE EELEERRSLY RWGNWKDGTI LNVAATSISD LPVDQRFRED KRLEFEASQV 
LGTMDTVINF PKNTVTCWKS LDDFNYVFKS GHTKMAERVR NSWKEDAFFG YQFLNGANPM 
VLKRSTCLPA RLVFPPGMEK LQAQLDEELK KGTLFEADFF LLDGIKANVI LCSQQYLAAP 
LVMLKLQPDG QLLPIAIQLE LPKTGSTPPP IFTPLDPPMD WLLAKCWVRS SDLQLHELQA 
HLLRGHLVAE VFAVATMRCL PSVHPVFKLL VPHLLYTMEI NVRARSDLIS ERGFFDKVMS 
TGGGGHLDLL KQAGAFLTYS SLCPPDDLAE RGLLDIDTCF YAKDALQLWQ VMNRYVVGMF 
DLYYKTDQAV QDDYELQSWC QEITEIGLQG AQDRGFPTSL QSRAQACHFI TMCIFTCTAQ 
HSSIHLGQLD WFYWVPNAPC TMRLPPPKTK DATMEKLMAT LPNPNQSTLQ INVVWLLGRR 
QAVMVPLGQH SEEHFPNPEA KAVLKKFREE LAALDKEIEI RNKSLDIPYE YLRPSLVENS 
VAI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Alox15

Associated with

Other Information

cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. PubMed ID: 8188678

Cloning and characterization of a murine macrophage lipoxygenase. PubMed ID: 7811740

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. PubMed ID: 8798642

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. PubMed ID: 10432118

12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells. PubMed ID: 11278875

Regulation of bone mass in mice by the lipoxygenase gene Alox15. PubMed ID: 14716014

A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. PubMed ID: 15708862

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response. PubMed ID: 22215650

12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance. PubMed ID: 22503541