Genular: Defining Cellular Identity and Function

Details for: Alox8

Gene ID: 11688

Symbol: Alox8

Ensembl ID: ENSMUSG00000020891

Description: arachidonate 8-lipoxygenase

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Synthesis of 15-eicosatetraenoic acid derivatives
(R-MMU-2142770)
Adherens junction
(GO:0005912)
Arachidonate 8(r)-lipoxygenase activity
(GO:0047677)
Arachidonate 8(s)-lipoxygenase activity
(GO:0036403)
Arachidonate 15-lipoxygenase activity
(GO:0050473)
Arachidonic acid metabolic process
(GO:0019369)
Calcium ion binding
(GO:0005509)
Cannabinoid biosynthetic process
(GO:1901696)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dioxygenase activity
(GO:0051213)
Endocannabinoid signaling pathway
(GO:0071926)
Focal adhesion
(GO:0005925)
Hepoxilin biosynthetic process
(GO:0051122)
Iron ion binding
(GO:0005506)
Linoleate 9s-lipoxygenase activity
(GO:1990136)
Linoleate 13s-lipoxygenase activity
(GO:0016165)
Linoleic acid metabolic process
(GO:0043651)
Lipid binding
(GO:0008289)
Lipid metabolic process
(GO:0006629)
Lipid oxidation
(GO:0034440)
Lipoxin a4 biosynthetic process
(GO:2001303)
Lipoxygenase pathway
(GO:0019372)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of growth
(GO:0045926)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
(GO:0016702)
Phospholipid metabolic process
(GO:0006644)
Plasma membrane
(GO:0005886)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of keratinocyte differentiation
(GO:0045618)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)

Other Information

Proteins

Arachidonate 15-lipoxygenase B

Genular Protein ID: 1703246082

Symbol: ALOX8_MOUSE

Name: Arachidonate 15-lipoxygenase B

UniProtKB Accession Codes:

O35936 B1ASX5

Database IDs:

Citations:

PubMed ID: 9305900

Title: Molecular cloning and functional expression of a phorbol ester-inducible 8S-lipoxygenase from mouse skin.

PubMed ID: 9305900

DOI: 10.1074/jbc.272.39.24410

PubMed ID: 9518531

Title: cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin.

PubMed ID: 9518531

DOI: 10.1016/s0005-2760(97)00214-2

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10965849

Title: 8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytes.

PubMed ID: 10965849

PubMed ID: 10625675

Title: Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2.

PubMed ID: 10625675

DOI: 10.1074/jbc.275.2.1287

PubMed ID: 11368335

Title: Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine.

PubMed ID: 11368335

DOI: 10.1006/abbi.2000.2175

PubMed ID: 16143298

Title: Synthesis of 8,9-leukotriene A4 by murine 8-lipoxygenase.

PubMed ID: 16143298

DOI: 10.1016/j.bbrc.2005.08.099

PubMed ID: 16112079

Title: Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist.

PubMed ID: 16112079

DOI: 10.1016/j.bbrc.2005.08.029

PubMed ID: 15558016

Title: An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis.

PubMed ID: 15558016

DOI: 10.1038/sj.onc.1208269

PubMed ID: 27435673

Title: Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS.

PubMed ID: 27435673

DOI: 10.1074/jbc.m116.741454

Sequence Information:

Length: 677
Mass: 76230
Checksum: 78DB1AC9C2F68399
Sequence:

MAKCRVRVST GEACGAGTWD KVSVSIVGTH GESPLVPLDH LGKEFSAGAE EDFEVTLPQD 
VGTVLMLRVH KAPPEVSLPL MSFRSDAWFC RWFELEWLPG AALHFPCYQW LEGAGELVLR 
EGAAKVSWQD HHPTLQDQRQ KELESRQKMY SWKTYIEGWP RCLDHETVKD LDLNIKYSAM 
KNAKLFFKAH SAYTELKVKG LLDRTGLWRS LREMRRLFNF RKTPAAEYVF AHWQEDAFFA 
SQFLNGINPV LIRRCHSLPN NFPVTDEMVA PVLGPGTSLQ AELEKGSLFL VDHGILSGVH 
TNILNGKPQF SAAPMTLLHQ SSGSGPLLPI AIQLKQTPGP DNPIFLPSDD TWDWLLAKTW 
VRNSEFYIHE AVTHLLHAHL IPEVFALATL RQLPRCHPLF KLLIPHIRYT LHINTLAREL 
LVAPGKLIDK STGLGTGGFS DLIKRNMEQL NYSVLCLPED IRARGVEDIP GYYYRDDGMQ 
IWGAIKSFVS EIVSIYYPSD TSVQDDQELQ AWVREIFSEG FLGRESSGMP SLLDTREALV 
QYITMVIFTC SAKHAAVSSG QFDSCVWMPN LPPTMQLPPP TSKGQARPES FIATLPAVNS 
SSYHIIALWL LSAEPGDQRP LGHYPDEHFT EDAPRRSVAA FQRKLIQISK GIRERNRGLA 
LPYTYLDPPL IENSVSI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Alox8

Associated with

Other Information

Molecular cloning and functional expression of a phorbol ester-inducible 8S-lipoxygenase from mouse skin. PubMed ID: 9305900

cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin. PubMed ID: 9518531

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytes. PubMed ID: 10965849

Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2. PubMed ID: 10625675

Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine. PubMed ID: 11368335

Synthesis of 8,9-leukotriene A4 by murine 8-lipoxygenase. PubMed ID: 16143298

Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist. PubMed ID: 16112079

An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis. PubMed ID: 15558016

Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS. PubMed ID: 27435673