Genular: Defining Cellular Identity and Function

Details for: Alox5

Gene ID: 11689

Symbol: Alox5

Ensembl ID: ENSMUSG00000025701

Description: arachidonate 5-lipoxygenase

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Biosynthesis of aspirin-triggered d-series resolvins
(R-MMU-9020265)
Biosynthesis of d-series resolvins
(R-MMU-9018676)
Biosynthesis of dha-derived spms
(R-MMU-9018677)
Biosynthesis of dpa-derived spms
(R-MMU-9018683)
Biosynthesis of dpan-3 spms
(R-MMU-9025094)
Biosynthesis of dpan-3-derived 13-series resolvins
(R-MMU-9026403)
Biosynthesis of dpan-3-derived maresins
(R-MMU-9026290)
Biosynthesis of dpan-3-derived protectins and resolvins
(R-MMU-9026286)
Biosynthesis of e-series 18(r)-resolvins
(R-MMU-9023661)
Biosynthesis of e-series 18(s)-resolvins
(R-MMU-9018896)
Biosynthesis of electrophilic ω-3 pufa oxo-derivatives
(R-MMU-9027604)
Biosynthesis of epa-derived spms
(R-MMU-9018679)
Biosynthesis of maresins
(R-MMU-9018682)
Biosynthesis of specialized proresolving mediators (spms)
(R-MMU-9018678)
Fatty acid metabolism
(R-MMU-8978868)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Neutrophil degranulation
(R-MMU-6798695)
Synthesis of 5-eicosatetraenoic acids
(R-MMU-2142688)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-MMU-2142691)
Synthesis of lipoxins (lx)
(R-MMU-2142700)
Arachidonate 5-lipoxygenase activity
(GO:0004051)
Arachidonic acid metabolic process
(GO:0019369)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Dendritic cell migration
(GO:0036336)
Dioxygenase activity
(GO:0051213)
Glucose homeostasis
(GO:0042593)
Hepoxilin biosynthetic process
(GO:0051122)
Humoral immune response
(GO:0006959)
Hydrolase activity
(GO:0016787)
Inflammatory response
(GO:0006954)
Iron ion binding
(GO:0005506)
Leukocyte chemotaxis involved in inflammatory response
(GO:0002232)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Leukotriene a4 biosynthetic process
(GO:1901753)
Leukotriene biosynthetic process
(GO:0019370)
Leukotriene metabolic process
(GO:0006691)
Leukotriene production involved in inflammatory response
(GO:0002540)
Linoleic acid metabolic process
(GO:0043651)
Lipid metabolic process
(GO:0006629)
Lipid oxidation
(GO:0034440)
Lipoxin biosynthetic process
(GO:2001301)
Lipoxygenase pathway
(GO:0019372)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of response to endoplasmic reticulum stress
(GO:1903573)
Negative regulation of sprouting angiogenesis
(GO:1903671)
Negative regulation of vascular wound healing
(GO:0061044)
Negative regulation of wound healing
(GO:0061045)
Nuclear envelope
(GO:0005635)
Nuclear envelope lumen
(GO:0005641)
Nuclear matrix
(GO:0016363)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
(GO:0016702)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of leukocyte adhesion to arterial endothelial cell
(GO:1904999)
Positive regulation of vasoconstriction
(GO:0045907)
Protein binding
(GO:0005515)
Regulation of cellular response to oxidative stress
(GO:1900407)
Regulation of cytokine production involved in inflammatory response
(GO:1900015)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of inflammatory response
(GO:0050727)
Regulation of inflammatory response to wounding
(GO:0106014)
Regulation of insulin secretion
(GO:0050796)
Regulation of reactive oxygen species biosynthetic process
(GO:1903426)
Sarcolemma
(GO:0042383)

Other Information

Proteins

Arachidonate 5-lipoxygenase

Genular Protein ID: 2797612411

Symbol: LOX5_MOUSE

Name: Arachidonate 5-lipoxygenase

UniProtKB Accession Codes:

P48999 Q3TB75

Database IDs:

Citations:

PubMed ID: 7629107

Title: cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase.

PubMed ID: 7629107

DOI: 10.1074/jbc.270.30.17993

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7809134

Title: Altered inflammatory responses in leukotriene-deficient mice.

PubMed ID: 7809134

DOI: 10.1073/pnas.91.26.12852

PubMed ID: 7969451

Title: Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene.

PubMed ID: 7969451

DOI: 10.1038/372179a0

PubMed ID: 17392829

Title: Selective 5-lipoxygenase expression in Langerhans cells and impaired dendritic cell migration in 5-LO-deficient mice reveal leukotriene action in skin.

PubMed ID: 17392829

DOI: 10.1038/sj.jid.5700796

PubMed ID: 18421434

Title: Identification of ALOX5 as a gene regulating adiposity and pancreatic function.

PubMed ID: 18421434

DOI: 10.1007/s00125-008-1002-3

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21224059

Title: Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.

PubMed ID: 21224059

DOI: 10.1016/j.ajpath.2010.11.033

PubMed ID: 21307302

Title: 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of omega-3 polyunsaturated fatty acids.

PubMed ID: 21307302

DOI: 10.1126/scitranslmed.3001571

PubMed ID: 23246375

Title: Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.

PubMed ID: 23246375

DOI: 10.1016/j.abb.2012.11.015

PubMed ID: 23720274

Title: 5-Lipoxygenase plays a pivotal role in endothelial adhesion of monocytes via an increased expression of Mac-1.

PubMed ID: 23720274

DOI: 10.1093/cvr/cvt135

PubMed ID: 24906289

Title: Deletion of Alox5 gene decreases osteogenic differentiation but increases adipogenic differentiation of mouse induced pluripotent stem cells.

PubMed ID: 24906289

DOI: 10.1007/s00441-014-1920-y

PubMed ID: 24226420

Title: Critical role of 5-lipoxygenase and heme oxygenase-1 in wound healing.

PubMed ID: 24226420

DOI: 10.1038/jid.2013.493

PubMed ID: 28694473

Title: 5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes.

PubMed ID: 28694473

DOI: 10.1038/s41598-017-05346-5

PubMed ID: 28965882

Title: The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing.

PubMed ID: 28965882

DOI: 10.1016/j.clim.2017.08.022

PubMed ID: 31642348

Title: Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.

PubMed ID: 31642348

DOI: 10.1089/ars.2019.7751

Sequence Information:

Length: 674
Mass: 77967
Checksum: 130F27F9A77A3D88
Sequence:

MPSYTVTVAT GSQWFAGTDD YIYLSLIGSA GCSEKHLLDK AFYNDFERGA VDSYDVTVDE 
ELGEIYLVKI EKRKYWLHDD WYLKYITLKT PHGDYIEFPC YRWITGEGEI VLRDGRAKLA 
RDDQIHILKQ HRRKELEARQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL 
NYSKAMENLF INRFMHMFQS SWHDFADFEK IFVKISNTIS ERVKNHWQED LMFGYQFLNG 
CNPVLIKRCT ALPPKLPVTT EMVECSLERQ LSLEQEVQEG NIFIVDYELL DGIDANKTDP 
CTHQFLAAPI CLLYKNLANK IVPIAIQLNQ TPGESNPIFL PTDSKYDWLL AKIWVRSSDF 
HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPLFKLLVAH VRFTIAINTK AREQLICEYG 
LFDKANATGG GGHVQMVQRA VQDLTYSSLC FPEAIKARGM DSTEDIPFYF YRDDGLLVWE 
AIQSFTMEVV SIYYENDQVV EEDQELQDFV KDVYVYGMRG KKASGFPKSI KSREKLSEYL 
TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW 
HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMIRFRK NLEAIVSVIA ERNKNKKLPY 
YYLSPDRIPN SVAI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Alox5

Associated with

Other Information

cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase. PubMed ID: 7629107

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Altered inflammatory responses in leukotriene-deficient mice. PubMed ID: 7809134

Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. PubMed ID: 7969451

Selective 5-lipoxygenase expression in Langerhans cells and impaired dendritic cell migration in 5-LO-deficient mice reveal leukotriene action in skin. PubMed ID: 17392829

Identification of ALOX5 as a gene regulating adiposity and pancreatic function. PubMed ID: 18421434

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help. PubMed ID: 21224059

5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of omega-3 polyunsaturated fatty acids. PubMed ID: 21307302

Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants. PubMed ID: 23246375

5-Lipoxygenase plays a pivotal role in endothelial adhesion of monocytes via an increased expression of Mac-1. PubMed ID: 23720274

Deletion of Alox5 gene decreases osteogenic differentiation but increases adipogenic differentiation of mouse induced pluripotent stem cells. PubMed ID: 24906289

Critical role of 5-lipoxygenase and heme oxygenase-1 in wound healing. PubMed ID: 24226420

5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes. PubMed ID: 28694473

The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing. PubMed ID: 28965882

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme. PubMed ID: 31642348