Genular: Defining Cellular Identity and Function

Details for: Ambp

Gene ID: 11699

Symbol: Ambp

Ensembl ID: ENSMUSG00000028356

Description: alpha 1 microglobulin/bikunin precursor

Associated with

Binding and uptake of ligands by scavenger receptors
(R-MMU-2173782)
Scavenging of heme from plasma
(R-MMU-2168880)
Vesicle-mediated transport
(R-MMU-5653656)
Antioxidant activity
(GO:0016209)
Carbohydrate binding
(GO:0030246)
Cell surface
(GO:0009986)
Cellular oxidant detoxification
(GO:0098869)
Cellular response to reactive oxygen species
(GO:0034614)
Chondroitin sulfate binding
(GO:0035374)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen fibril binding
(GO:0098633)
Cytochrome c metabolic process
(GO:1903606)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum
(GO:0005783)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Heme binding
(GO:0020037)
Hemoglobin metabolic process
(GO:0020027)
Iga binding
(GO:0019862)
Matrix side of mitochondrial inner membrane
(GO:0099617)
Membrane
(GO:0016020)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrion
(GO:0005739)
Negative regulation of peptidase activity
(GO:0010466)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on nad(p)h, heme protein as acceptor
(GO:0016653)
Peptidase inhibitor activity
(GO:0030414)
Plasma membrane
(GO:0005886)
Protein catabolic process
(GO:0030163)
Protein homodimerization activity
(GO:0042803)
Protein maturation
(GO:0051604)
Serine-type endopeptidase inhibitor activity
(GO:0004867)

Other Information

Proteins

Protein AMBP

Genular Protein ID: 3763846894

Symbol: AMBP_MOUSE

Name: Protein AMBP

UniProtKB Accession Codes:

Q07456 Q61294 Q925W1 Q9DBJ9

Database IDs:

Citations:

PubMed ID: 7689339

Title: Mouse alpha-1-microglobulin/bikunin precursor: cDNA analysis, gene evolution and physical assignment of the gene next to the orosomucoid locus.

PubMed ID: 7689339

DOI: 10.1016/0167-4781(93)90115-t

PubMed ID: 7533761

Title: cDNA sequencing of mouse alpha 1-microglobulin/inter-alpha-trypsin inhibitor light chain and its expression in acute inflammation.

PubMed ID: 7533761

DOI: 10.1093/oxfordjournals.jbchem.a124594

PubMed ID: 10395906

Title: The alpha1-microglobulin/bikunin gene: characterization in mouse and evolution.

PubMed ID: 10395906

DOI: 10.1016/s0378-1119(99)00191-2

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11243855

Title: Impaired fertility in female mice lacking urinary trypsin inhibitor.

PubMed ID: 11243855

DOI: 10.1006/bbrc.2001.4475

PubMed ID: 11145954

Title: Defect in SHAP-hyaluronan complex causes severe female infertility. A study by inactivation of the bikunin gene in mice.

PubMed ID: 11145954

DOI: 10.1074/jbc.c000899200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 32092412

Title: Human radical scavenger alpha1-microglobulin protects against hemolysis in vitro and alpha1-microglobulin knockout mice exhibit a macrocytic anemia phenotype.

PubMed ID: 32092412

DOI: 10.1016/j.freeradbiomed.2020.02.018

PubMed ID: 32092411

Title: Knockout of the radical scavenger alpha1-microglobulin in mice results in defective bikunin synthesis, endoplasmic reticulum stress and increased body weight.

PubMed ID: 32092411

DOI: 10.1016/j.freeradbiomed.2020.02.019

Sequence Information:

Length: 349
Mass: 39029
Checksum: CFB9208D37DF0021
Sequence:

MQGLRTLFLL LTACLASRAD PASTLPDIQV QENFSESRIY GKWYNLAVGS TCPWLSRIKD 
KMSVSTLVLQ EGATETEISM TSTRWRRGVC EEITGAYQKT DIDGKFLYHK SKWNITLESY 
VVHTNYDEYA IFLTKKSSHH HGLTITAKLY GREPQLRDSL LQEFKDVALN VGISENSIIF 
MPDRGECVPG DREVEPTSIA RARRAVLPQE SEGSGTEPLI TGTLKKEDSC QLNYSEGPCL 
GMQERYYYNG ASMACETFQY GGCLGNGNNF ISEKDCLQTC RTIAACNLPI VQGPCRAFIK 
LWAFDAAQGK CIQFHYGGCK GNGNKFYSEK ECKEYCGVPG DGYEELIRS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ambp

Associated with

Other Information

Mouse alpha-1-microglobulin/bikunin precursor: cDNA analysis, gene evolution and physical assignment of the gene next to the orosomucoid locus. PubMed ID: 7689339

cDNA sequencing of mouse alpha 1-microglobulin/inter-alpha-trypsin inhibitor light chain and its expression in acute inflammation. PubMed ID: 7533761

The alpha1-microglobulin/bikunin gene: characterization in mouse and evolution. PubMed ID: 10395906

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Impaired fertility in female mice lacking urinary trypsin inhibitor. PubMed ID: 11243855

Defect in SHAP-hyaluronan complex causes severe female infertility. A study by inactivation of the bikunin gene in mice. PubMed ID: 11145954

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Human radical scavenger alpha1-microglobulin protects against hemolysis in vitro and alpha1-microglobulin knockout mice exhibit a macrocytic anemia phenotype. PubMed ID: 32092412

Knockout of the radical scavenger alpha1-microglobulin in mice results in defective bikunin synthesis, endoplasmic reticulum stress and increased body weight. PubMed ID: 32092411