Details for: ADCYAP1R1

Gene ID: 117

Symbol: ADCYAP1R1

Ensembl ID: ENSG00000078549

Description: ADCYAP receptor type I

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.6638
    Cell Significance Index: -19.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3285
    Cell Significance Index: 476.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5260
    Cell Significance Index: 35.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4327
    Cell Significance Index: 299.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4220
    Cell Significance Index: 9.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3651
    Cell Significance Index: 73.2400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.3189
    Cell Significance Index: 4.4600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1534
    Cell Significance Index: 1.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1210
    Cell Significance Index: 7.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0605
    Cell Significance Index: 1.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0493
    Cell Significance Index: 26.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0066
    Cell Significance Index: 0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0154
    Cell Significance Index: -0.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0168
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0266
    Cell Significance Index: -19.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0289
    Cell Significance Index: -18.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0351
    Cell Significance Index: -19.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0484
    Cell Significance Index: -21.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0540
    Cell Significance Index: -15.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0633
    Cell Significance Index: -13.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0661
    Cell Significance Index: -3.4700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0789
    Cell Significance Index: -1.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1008
    Cell Significance Index: -18.1800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1058
    Cell Significance Index: -1.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1074
    Cell Significance Index: -21.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1151
    Cell Significance Index: -2.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1173
    Cell Significance Index: -2.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1290
    Cell Significance Index: -17.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1322
    Cell Significance Index: -22.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1398
    Cell Significance Index: -3.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1454
    Cell Significance Index: -18.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1463
    Cell Significance Index: -21.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1579
    Cell Significance Index: -19.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1816
    Cell Significance Index: -18.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1954
    Cell Significance Index: -22.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2018
    Cell Significance Index: -20.6100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2169
    Cell Significance Index: -3.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2172
    Cell Significance Index: -7.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2286
    Cell Significance Index: -7.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2288
    Cell Significance Index: -17.5600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2463
    Cell Significance Index: -5.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2528
    Cell Significance Index: -18.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2568
    Cell Significance Index: -11.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2674
    Cell Significance Index: -5.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3199
    Cell Significance Index: -17.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3335
    Cell Significance Index: -9.3200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3360
    Cell Significance Index: -3.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3440
    Cell Significance Index: -12.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3441
    Cell Significance Index: -13.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3700
    Cell Significance Index: -17.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3771
    Cell Significance Index: -19.6400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3882
    Cell Significance Index: -3.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3942
    Cell Significance Index: -11.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3998
    Cell Significance Index: -11.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4163
    Cell Significance Index: -19.4100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4279
    Cell Significance Index: -5.4000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4360
    Cell Significance Index: -4.9900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4532
    Cell Significance Index: -5.4200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4629
    Cell Significance Index: -9.1100
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.4743
    Cell Significance Index: -3.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4857
    Cell Significance Index: -17.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5131
    Cell Significance Index: -13.1900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.5326
    Cell Significance Index: -7.3900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.5612
    Cell Significance Index: -5.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5709
    Cell Significance Index: -14.2400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5832
    Cell Significance Index: -11.6300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6228
    Cell Significance Index: -9.8800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6471
    Cell Significance Index: -7.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6500
    Cell Significance Index: -32.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7037
    Cell Significance Index: -14.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7320
    Cell Significance Index: -19.5500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.7323
    Cell Significance Index: -14.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7358
    Cell Significance Index: -14.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7401
    Cell Significance Index: -21.8000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7430
    Cell Significance Index: -18.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7493
    Cell Significance Index: -30.7000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7607
    Cell Significance Index: -19.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7659
    Cell Significance Index: -20.1400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7754
    Cell Significance Index: -19.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8138
    Cell Significance Index: -22.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8162
    Cell Significance Index: -21.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8506
    Cell Significance Index: -14.2400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8744
    Cell Significance Index: -21.3400
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.8796
    Cell Significance Index: -8.8600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.8834
    Cell Significance Index: -38.4100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.9062
    Cell Significance Index: -6.1400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.9164
    Cell Significance Index: -13.1600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.9399
    Cell Significance Index: -13.3700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.9542
    Cell Significance Index: -12.7200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9605
    Cell Significance Index: -20.5300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.9757
    Cell Significance Index: -12.7600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.9873
    Cell Significance Index: -15.8400
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.9935
    Cell Significance Index: -11.0400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -1.0009
    Cell Significance Index: -6.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.0045
    Cell Significance Index: -16.9200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -1.0278
    Cell Significance Index: -13.3000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -1.0328
    Cell Significance Index: -14.2800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.0409
    Cell Significance Index: -12.9100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0526
    Cell Significance Index: -18.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G Protein-Coupled Receptor (GPCR) Structure:** ADCYAP1R1 belongs to the class B/2 secretin family of GPCRs, characterized by a seven-transmembrane domain structure. 2. **PACAP Ligand Binding:** ADCYAP1R1 is activated by its ligand, PACAP, which binds to the receptor and triggers a conformational change, activating the G protein-coupled signaling pathway. 3. **Adenylate Cyclase Activation:** The activation of adenylate cyclase by ADCYAP1R1 results in the production of cAMP, a secondary messenger molecule that regulates various cellular processes, including cell differentiation, development, and response to stress. 4. **Signaling Pathways:** ADCYAP1R1 is involved in multiple signaling pathways, including the activation of trka receptors, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, and camp-mediated signaling. **Pathways and Functions:** 1. **Cell Differentiation:** ADCYAP1R1 plays a crucial role in the differentiation of various cell types, including GABAergic cortical interneurons, plasma cells, and astrocytes. 2. **Neurodevelopment:** ADCYAP1R1 is involved in the development of primary female sexual characteristics and spermatogenesis, highlighting its role in reproductive development. 3. **Immune System Regulation:** ADCYAP1R1 is expressed in plasma cells, suggesting its involvement in immune system regulation and response to stress. 4. **Stress Response:** ADCYAP1R1 is activated in response to xenobiotic stimuli, highlighting its role in stress response and adaptation. **Clinical Significance:** 1. **Neurodevelopmental Disorders:** Alterations in ADCYAP1R1 expression have been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Immune System Disorders:** Dysregulation of ADCYAP1R1 has been implicated in immune system disorders, including multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** ADCYAP1R1 has been identified as a potential oncogene, with its expression correlated with tumor progression and metastasis. 4. **Endocrine Disorders:** ADCYAP1R1 is involved in the regulation of endocrine functions, including the development of primary female sexual characteristics. In conclusion, ADCYAP1R1 is a critical component of the human genome, playing a pivotal role in various cellular processes, including cell differentiation, development, and response to stress. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of ADCYAP1R1 signaling and its clinical significance.

Genular Protein ID: 2390252204

Symbol: PACR_HUMAN

Name: Pituitary adenylate cyclase-activating polypeptide type I receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7902709

Title: Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor.

PubMed ID: 7902709

DOI: 10.1006/bbrc.1993.2423

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7851900

Title: Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7.

PubMed ID: 7851900

DOI: 10.1006/geno.1994.1560

PubMed ID: 10583729

Title: N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants.

PubMed ID: 10583729

DOI: 10.1046/j.1365-2826.1999.00411.x

PubMed ID: 17470806

Title: Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.

PubMed ID: 17470806

DOI: 10.1073/pnas.0611397104

PubMed ID: 21625560

Title: Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors.

PubMed ID: 21625560

DOI: 10.1371/journal.pone.0019682

Sequence Information:

  • Length: 468
  • Mass: 53314
  • Checksum: BB515B84E9F28977
  • Sequence:
  • MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS SPGCPGMWDN 
    ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF GDSNSLDLSD MGVVSRNCTE 
    DGWSEPFPHY FDACGFDEYE SETGDQDYYY LSVKALYTVG YSTSLVTLTT AMVILCRFRK 
    LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN 
    YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN 
    DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLR LARSTLLLIP 
    LFGIHYTVFA FSPENVSKRE RLVFELGLGS FQGFVVAVLY CFLNGEVQAE IKRKWRSWKV 
    NRYFAVDFKH RHPSLASSGV NGGTQLSILS KSSSQIRMSG LPADNLAT

Genular Protein ID: 4033488491

Symbol: A0A994J7E9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 495
  • Mass: 56444
  • Checksum: AE54BAD52C894FA0
  • Sequence:
  • MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS SPGCPGMWDN 
    ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF GDSNSLDLSD MGVVSRNCTE 
    DGWSEPFPHY FDACGFDEYE SETGDQDYYY LSVKALYTVG YSTSLVTLTT AMVILCRFRK 
    LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN 
    YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN 
    DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYFC VQKCYCKPQR 
    AQQHSCKMSE LSTITLRLAR STLLLIPLFG IHYTVFAFSP ENVSKRERLV FELGLGSFQG 
    FVVAVLYCFL NGEVQAEIKR KWRSWKVNRY FAVDFKHRHP SLASSGVNGG TQLSILSKSS 
    SQIRMSGLPA DNLAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.