Details for: ADCYAP1R1

Gene ID: 117

Symbol: ADCYAP1R1

Ensembl ID: ENSG00000078549

Description: ADCYAP receptor type I

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.01
    Marker Score: 74269
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.01
    Marker Score: 8314.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.97
    Marker Score: 39215
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.96
    Marker Score: 1140
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.9
    Marker Score: 72310
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.9
    Marker Score: 14585
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.89
    Marker Score: 2107
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.87
    Marker Score: 27943
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.78
    Marker Score: 6882
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.64
    Marker Score: 34997.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.51
    Marker Score: 2869
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.48
    Marker Score: 12753
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167296
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.43
    Marker Score: 19275
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.16
    Marker Score: 11029
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.11
    Marker Score: 966
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.11
    Marker Score: 11465
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.05
    Marker Score: 2141
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.03
    Marker Score: 1588
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71803.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1
    Marker Score: 61221
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.98
    Marker Score: 642
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13438
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 489
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.82
    Marker Score: 1689.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.8
    Marker Score: 762
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.78
    Marker Score: 832
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.76
    Marker Score: 454
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.74
    Marker Score: 3002
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.67
    Marker Score: 4039
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.65
    Marker Score: 1857
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.63
    Marker Score: 2919
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 494
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 271
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.56
    Marker Score: 312
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.56
    Marker Score: 214
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.54
    Marker Score: 314
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.53
    Marker Score: 502
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.51
    Marker Score: 127
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.5
    Marker Score: 763
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.48
    Marker Score: 160
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.46
    Marker Score: 554
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.45
    Marker Score: 562.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.44
    Marker Score: 758
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.44
    Marker Score: 2350
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.43
    Marker Score: 1794
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.42
    Marker Score: 3980
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.41
    Marker Score: 660
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.41
    Marker Score: 215
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.39
    Marker Score: 225
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.39
    Marker Score: 433
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.39
    Marker Score: 623.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.38
    Marker Score: 467.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.37
    Marker Score: 996.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.36
    Marker Score: 127
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.34
    Marker Score: 378
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.33
    Marker Score: 199
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.33
    Marker Score: 762
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.32
    Marker Score: 112
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 141
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.31
    Marker Score: 1217
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.31
    Marker Score: 128
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.3
    Marker Score: 547
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.3
    Marker Score: 1007
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.28
    Marker Score: 2111
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.28
    Marker Score: 133
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.27
    Marker Score: 1437
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.27
    Marker Score: 493
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.27
    Marker Score: 9016
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.26
    Marker Score: 370
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.26
    Marker Score: 622
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.25
    Marker Score: 190
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.25
    Marker Score: 250
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.23
    Marker Score: 235
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.23
    Marker Score: 83
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.23
    Marker Score: 266
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.22
    Marker Score: 99
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.21
    Marker Score: 103
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.21
    Marker Score: 348
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 196
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 475
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2
    Marker Score: 6679.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.19
    Marker Score: 43
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.18
    Marker Score: 59
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.18
    Marker Score: 209
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.18
    Marker Score: 365

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Other Information

**Key characteristics:** * Type: GPCR * Ensembl ID: ENSG00000078549 * Protein length: 111 amino acids * Tissue expression: pvalb GABAergic cortical interneuron, chandelier pvalb GABAergic cortical interneuron, sst GABAergic cortical interneuron, corneal endothelial cell, vip GABAergic cortical interneuron, sncg GABAergic cortical interneuron, plasma cell, lamp5 GABAergic cortical interneuron, caudal ganglionic eminence derived GABAergic cortical interneuron, astrocyte of the cerebral cortex **Pathways and functions:** ADCYAP1R1 is a GPCR that belongs to the Class b/2 (secretin family receptors) of GPCRs. It is known to be a receptor for vasoactive intestinal polypeptide (VIP), a hormone that is involved in regulating blood pressure and fluid balance in the body. Through its interaction with VIP, ADCYAP1R1 is involved in regulating the activity of endothelial cells in the brain. It is expressed in blood-brain barrier (BBB) endothelial cells, which are responsible for maintaining the blood-brain barrier and regulating the passage of substances between the blood and the brain. ADCYAP1R1 signaling has been shown to be important for the regulation of BBB permeability, inflammation, and angiogenesis in the brain. **Clinical significance:** Mutations in the ADCYAP1R1 gene have been linked to several neurological disorders, including autism spectrum disorder (ASD), schizophrenia, and epilepsy. In mouse models, mutations in ADCYAP1R1 have been shown to cause neurodevelopmental abnormalities, including cognitive impairments and seizures. These findings suggest that ADCYAP1R1 is a potential therapeutic target for neurodevelopmental disorders.

Genular Protein ID: 2390252204

Symbol: PACR_HUMAN

Name: Pituitary adenylate cyclase-activating polypeptide type I receptor

UniProtKB Accession Codes:

P41586 A8K1Y1 B7ZLA7 B8ZZK3 Q17S10

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 6 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 8 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 3 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7902709

Title: Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor.

PubMed ID: 7902709

DOI: 10.1006/bbrc.1993.2423

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7851900

Title: Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7.

PubMed ID: 7851900

DOI: 10.1006/geno.1994.1560

PubMed ID: 10583729

Title: N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants.

PubMed ID: 10583729

DOI: 10.1046/j.1365-2826.1999.00411.x

PubMed ID: 17470806

Title: Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.

PubMed ID: 17470806

DOI: 10.1073/pnas.0611397104

PubMed ID: 21625560

Title: Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors.

PubMed ID: 21625560

DOI: 10.1371/journal.pone.0019682

Sequence Information:

  • Length: 468
  • Mass: 53314
  • Checksum: BB515B84E9F28977
  • Sequence:
    • MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS SPGCPGMWDN 
ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF GDSNSLDLSD MGVVSRNCTE 
DGWSEPFPHY FDACGFDEYE SETGDQDYYY LSVKALYTVG YSTSLVTLTT AMVILCRFRK 
LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN 
YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN 
DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLR LARSTLLLIP 
LFGIHYTVFA FSPENVSKRE RLVFELGLGS FQGFVVAVLY CFLNGEVQAE IKRKWRSWKV 
NRYFAVDFKH RHPSLASSGV NGGTQLSILS KSSSQIRMSG LPADNLAT

Genular Protein ID: 4033488491

Symbol: A0A994J7E9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A994J7E9

Database IDs:

ARBA 11 CDD 1 CTD 1 EMBL 4 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 6 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

Sequence Information:

  • Length: 495
  • Mass: 56444
  • Checksum: AE54BAD52C894FA0
  • Sequence:
    • MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS SPGCPGMWDN 
ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF GDSNSLDLSD MGVVSRNCTE 
DGWSEPFPHY FDACGFDEYE SETGDQDYYY LSVKALYTVG YSTSLVTLTT AMVILCRFRK 
LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN 
YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN 
DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYFC VQKCYCKPQR 
AQQHSCKMSE LSTITLRLAR STLLLIPLFG IHYTVFAFSP ENVSKRERLV FELGLGSFQG 
FVVAVLYCFL NGEVQAEIKR KWRSWKVNRY FAVDFKHRHP SLASSGVNGG TQLSILSKSS 
SQIRMSGLPA DNLAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.