Details for: AP2M1

Gene ID: 1173

Symbol: AP2M1

Ensembl ID: ENSG00000161203

Description: adaptor related protein complex 2 subunit mu 1

Associated with

Other Information

Genular Protein ID: 4071974767

Symbol: AP2M1_HUMAN

Name: AP-2 mu chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10910768

Title: RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis.

PubMed ID: 10910768

DOI: 10.1242/jcs.113.16.2837

PubMed ID: 12032142

Title: Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery.

PubMed ID: 12032142

DOI: 10.1074/jbc.m200522200

PubMed ID: 11877457

Title: Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals.

PubMed ID: 11877457

DOI: 10.1083/jcb.200111068

PubMed ID: 14745134

Title: Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network.

PubMed ID: 14745134

DOI: 10.1247/csf.28.419

PubMed ID: 12952941

Title: Clathrin-mediated endocytosis in AP-2-depleted cells.

PubMed ID: 12952941

DOI: 10.1083/jcb.200305145

PubMed ID: 12694563

Title: Endocytosis of the viral chemokine receptor US28 does not require beta-arrestins but is dependent on the clathrin-mediated pathway.

PubMed ID: 12694563

DOI: 10.1034/j.1600-0854.2003.00079.x

PubMed ID: 15473838

Title: Adaptors for clathrin coats: structure and function.

PubMed ID: 15473838

DOI: 10.1146/annurev.cellbio.20.010403.104543

PubMed ID: 14985334

Title: Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference.

PubMed ID: 14985334

DOI: 10.1074/jbc.c400046200

PubMed ID: 16581796

Title: Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization.

PubMed ID: 16581796

DOI: 10.1128/mcb.26.8.3231-3242.2006

PubMed ID: 17643423

Title: MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation.

PubMed ID: 17643423

DOI: 10.1016/j.yexcr.2007.06.015

PubMed ID: 19033387

Title: The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.

PubMed ID: 19033387

DOI: 10.1242/jcs.033522

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19419997

Title: The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway.

PubMed ID: 19419997

DOI: 10.1152/ajpcell.00630.2008

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23676497

Title: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.

PubMed ID: 23676497

DOI: 10.1172/jci65401

PubMed ID: 23529131

Title: Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium.

PubMed ID: 23529131

DOI: 10.1113/jphysiol.2013.251678

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25066864

Title: Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B.

PubMed ID: 25066864

DOI: 10.1016/j.mcn.2014.07.006

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33436498

Title: Cytoplasmic short linear motifs in ACE2 and integrin beta3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy.

PubMed ID: 33436498

DOI: 10.1126/scisignal.abf1117

PubMed ID: 11583591

Title: Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28.

PubMed ID: 11583591

DOI: 10.1042/0264-6021:3590427

PubMed ID: 31104773

Title: A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy.

PubMed ID: 31104773

DOI: 10.1016/j.ajhg.2019.04.001

Sequence Information:

  • Length: 435
  • Mass: 49655
  • Checksum: 82803219BA279954
  • Sequence:
  • MIGGLFIYNH KGEVLISRVY RDDIGRNAVD AFRVNVIHAR QQVRSPVTNI ARTSFFHVKR 
    SNIWLAAVTK QNVNAAMVFE FLYKMCDVMA AYFGKISEEN IKNNFVLIYE LLDEILDFGY 
    PQNSETGALK TFITQQGIKS QHQTKEEQSQ ITSQVTGQIG WRREGIKYRR NELFLDVLES 
    VNLLMSPQGQ VLSAHVSGRV VMKSYLSGMP ECKFGMNDKI VIEKQGKGTA DETSKSGKQS 
    IAIDDCTFHQ CVRLSKFDSE RSISFIPPDG EFELMRYRTT KDIILPFRVI PLVREVGRTK 
    LEVKVVIKSN FKPSLLAQKI EVRIPTPLNT SGVQVICMKG KAKYKASENA IVWKIKRMAG 
    MKESQISAEI ELLPTNDKKK WARPPISMNF EVPFAPSGLK VRYLKVFEPK LNYSDHDVIK 
    WVRYIGRSGI YETRC

Genular Protein ID: 2330299134

Symbol: E9PFW3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 460
  • Mass: 52304
  • Checksum: B693E3B0195DAC5F
  • Sequence:
  • MIGGLFIYNH KGEVLISRVY RDDIGSRQAA DSAVFSSSGP FPGEWLEANR RNAVDAFRVN 
    VIHARQQVRS PVTNIARTSF FHVKRSNIWL AAVTKQNVNA AMVFEFLYKM CDVMAAYFGK 
    ISEENIKNNF VLIYELLDEI LDFGYPQNSE TGALKTFITQ QGIKSQHQTK EEQSQITSQV 
    TGQIGWRREG IKYRRNELFL DVLESVNLLM SPQGQVLSAH VSGRVVMKSY LSGMPECKFG 
    MNDKIVIEKQ GKGTADETSK SGKQSIAIDD CTFHQCVRLS KFDSERSISF IPPDGEFELM 
    RYRTTKDIIL PFRVIPLVRE VGRTKLEVKV VIKSNFKPSL LAQKIEVRIP TPLNTSGVQV 
    ICMKGKAKYK ASENAIVWKI KRMAGMKESQ ISAEIELLPT NDKKKWARPP ISMNFEVPFA 
    PSGLKVRYLK VFEPKLNYSD HDVIKWVRYI GRSGIYETRC

Genular Protein ID: 2003025599

Symbol: B4DNB9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 460
  • Mass: 52338
  • Checksum: 06D349B013FD0192
  • Sequence:
  • MIGGLFIYNH KGEVLISRVY RDDIGSRQAA DSAVFSSSGP FPGEWLEANR RNAVDAFRVN 
    VIHARQQVRS PVTNIARTSF FHVKRSNIWL AAVTKQNVNA AMVFEFLYKM CDVMAAYFGK 
    ISEENIKNNF VLIYELLDEI LDFGYPQNSE TGALKTFITQ QGIKSQHQTK EEQSQITSQV 
    TGQIGWRREG IKYRRNELFL DVLESVNLLM SPQGQVLSAH VSGRVVMKSY LSGMPECKFG 
    MNDKIVIEKQ GKGTADETSK SGKQSIAIDD CTFHQCVRLS KFDSERSISF IPPDGEFELM 
    RYRTTKDIIF PFRVIPLVRE VGRTKLEVKV VIKSNFKPSL LAQKIEVRIP TPLNTSGVQV 
    ICMKGKAKYK ASENAIVWKI KRMAGMKESQ ISAEIELLPT NDKKKWARPP ISMNFEVPFA 
    PSGLKVRYLK VFEPKLNYSD HDVIKWVRYI GRSGIYETRC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.