Details for: AP2M1
Gene ID: 1173
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: AP2M1
Ensembl ID: ENSG00000161203
Description: adaptor related protein complex 2 subunit mu 1
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 79.93rCSI 76.94%PRS 12.3
-
CSI 61.41rCSI 55.46%PRS 10.51
-
CSI 60.1rCSI 81.89%PRS 10.64
-
CSI 59.99rCSI 62.7%PRS 12.53
-
CSI 57.59rCSI 38.28%PRS 14.18
-
CSI 54.4rCSI 74.39%PRS 19.59
-
CSI 48.61rCSI 74.1%PRS 11.11
-
CSI 44.5rCSI 55.84%PRS 15.13
-
CSI 44.07rCSI 83.2%PRS 14.75
-
CSI 39.44rCSI 34.15%PRS 13.23
-
CSI 37.4rCSI 39.18%PRS 12.69
-
CSI 35.78rCSI 51.06%PRS 13.41
-
CSI 35.5rCSI 52.77%PRS 14.52
-
CSI 31.97rCSI 49.4%PRS 11.15
-
CSI 30.02rCSI 28.95%PRS 8.09
-
CSI 29.29rCSI 27.03%PRS 12.07
-
CSI 28.22rCSI 22.82%PRS 11.73
-
CSI 28.02rCSI 27.56%PRS 12.9
-
CSI 27.85rCSI 23.09%PRS 11.22
-
CSI 26.89rCSI 22.54%PRS 14.25
-
CSI 24.62rCSI 71.27%PRS 13.44
-
CSI 22.62rCSI 65.16%PRS 23.2
-
CSI 20.55rCSI 33.07%PRS 9.14
-
CSI 19.34rCSI 16.99%PRS 13.35
-
CSI 17.39rCSI 50.4%PRS 9.35
-
CSI 17.14rCSI 25.31%PRS 18.69
-
CSI 16.35rCSI 34.81%PRS 19.23
-
CSI 15.8rCSI 50.68%PRS 17.47
-
CSI 15.73rCSI 14.44%PRS 13.58
-
CSI 15.49rCSI 29.57%PRS 28.12
-
CSI 15.34rCSI 42.16%PRS 19.66
-
CSI 14.11rCSI 16.58%PRS 14.03
-
CSI 13.97rCSI 75.35%PRS 22.35
-
CSI 13.88rCSI 49.28%PRS 19.5
-
CSI 13.6rCSI 79.14%PRS 17.89
-
CSI 12.57rCSI 15.09%PRS 11.76
-
CSI 11.68rCSI 12.23%PRS 11.07
-
CSI 11.16rCSI 19.13%PRS 15.92
-
CSI 10.94rCSI 32.28%PRS 14.64
-
CSI 10.54rCSI 82.59%PRS 26.16
-
CSI 10.51rCSI 15.17%PRS 16.55
-
CSI 10.14rCSI 11.6%PRS 24.38
-
CSI 9.78rCSI 7.53%PRS 10.78
-
CSI 9.58rCSI 38.13%PRS 20.87
-
CSI 9.52rCSI 25.26%PRS 19.72
-
CSI 9.02rCSI 10.15%PRS 19.02
-
CSI 8.85rCSI 18.18%PRS 12.17
-
CSI 8.74rCSI 19.24%PRS 18.24
-
CSI 8.49rCSI 18.76%PRS 8.54
-
CSI 8.47rCSI 46.1%PRS 29.47
-
CSI 8.24rCSI 29.3%PRS 37.1
-
CSI 8.11rCSI 13.08%PRS 19.04
-
CSI 7.94rCSI 6.25%PRS 14.11
-
CSI 7.93rCSI 36.95%PRS 28.54
-
CSI 7.76rCSI 11.93%PRS 16.98
-
CSI 7.46rCSI 16.28%PRS 24.08
-
CSI 7.41rCSI 26%PRS 21.54
-
CSI 7.34rCSI 9.08%PRS 10.44
-
CSI 7.31rCSI 47.97%PRS 30.81
-
CSI 7.03rCSI 30.5%PRS 21.41
-
CSI 6.9rCSI 34.02%PRS 16.16
-
CSI 6.2rCSI 7.95%PRS 13.73
-
CSI 6.19rCSI 20.73%PRS 8.38
-
CSI 6.18rCSI 45.17%PRS 32.46
-
CSI 6.02rCSI 6.4%PRS 21.11
-
CSI 5.97rCSI 11.5%PRS 26.62
-
CSI 5.95rCSI 7.96%PRS 22.7
-
CSI 5.92rCSI 8.19%PRS 17.12
-
CSI 5.84rCSI 4.75%PRS 12.58
-
CSI 5.79rCSI 8.04%PRS 12.29
-
CSI 5.7rCSI 39.16%PRS 23.37
-
CSI 5.47rCSI 7.88%PRS 19.16
-
CSI 5.45rCSI 17.54%PRS 12.93
-
CSI 5.44rCSI 10.85%PRS 19.77
-
CSI 5.27rCSI 9.47%PRS 9.93
-
CSI 5.12rCSI 6.84%PRS 15.83
-
CSI 5.09rCSI 9.9%PRS 12.13
-
CSI 5.08rCSI 14.49%PRS 20.64
-
CSI 5.07rCSI 10.07%PRS 12.67
-
CSI 4.95rCSI 5.05%PRS 17
-
CSI 4.9rCSI 10.43%PRS 21.04
-
CSI 4.65rCSI 3.44%PRS 10.59
-
CSI 4.59rCSI 8.67%PRS 25.91
-
CSI 4.5rCSI 7.41%PRS 13.85
-
CSI 4.37rCSI 4.07%PRS 11.95
-
CSI 4.36rCSI 6.4%PRS 15.57
-
CSI 4.35rCSI 17.72%PRS 12.27
-
CSI 4.34rCSI 5.93%PRS 13.18
-
CSI 4.29rCSI 63.4%PRS 30.18
-
CSI 4.07rCSI 3.4%PRS 34.95
-
CSI 4.03rCSI 4.32%PRS 10.93
-
CSI 3.93rCSI 71.83%PRS 34.18
-
CSI 3.76rCSI 9.55%PRS 12.11
-
CSI 3.75rCSI 49.66%PRS 38.67
-
CSI 3.75rCSI 7.43%PRS 35.89
-
CSI 3.72rCSI 3.13%PRS 19.17
-
CSI 3.68rCSI 6.57%PRS 20.18
-
CSI 3.61rCSI 8.42%PRS 28.74
-
CSI 3.58rCSI 4.33%PRS 13.95
-
CSI 3.49rCSI 2.66%PRS 15.55
-
CSI -9.7rCSI -8.9%PRS 18.1%
-
CSI -7.3rCSI -8.7%PRS 20.6%
-
CSI -7.2rCSI -13.0%PRS 9.7%
-
CSI -5.2rCSI -6.8%PRS 16.6%
-
CSI -4.4rCSI -4.1%PRS 21.7%
-
CSI -3.5rCSI -21.6%PRS 9.4%
-
CSI -3.3rCSI -4.9%PRS 13.7%
-
CSI -2.9rCSI -4.5%PRS 18.2%
-
CSI -2.9rCSI -8.3%PRS 14.5%
-
CSI -2.6rCSI -7.3%PRS 11.2%
-
CSI -2.6rCSI -13.7%PRS 22.2%
-
CSI -2.2rCSI -6.3%PRS 38.8%
-
CSI -1.4rCSI -10.1%PRS 6.0%
-
CSI -1.4rCSI -2.8%PRS 18.2%
-
CSI -1.3rCSI -1.5%PRS 15.9%
-
CSI -0.9rCSI -2.6%PRS 17.2%
-
CSI -0.9rCSI -1.4%PRS 36.5%
-
CSI -0.7rCSI -1.5%PRS 7.3%
-
CSI -0.3rCSI -0.4%PRS 12.6%
-
CSI -0.2rCSI -0.9%PRS 35.2%
-
CSI -0.1rCSI -0.1%PRS 20.4%
-
CSI -0.1rCSI -0.4%PRS 47.1%
-
CSI -0.1rCSI -0.2%PRS 10.1%
-
CSI 0.0rCSI 0.0%PRS 10.7%
-
CSI 0.0rCSI 0.2%PRS 35.1%
-
CSI 0.0rCSI 0.1%PRS 10.3%
-
CSI 0.0rCSI 0.1%PRS 6.4%
-
CSI 0.1rCSI 0.0%PRS 19.9%
-
CSI 0.1rCSI 0.3%PRS 20.4%
-
CSI 0.1rCSI 0.5%PRS 17.4%
-
CSI 0.1rCSI 0.2%PRS 8.6%
-
CSI 0.1rCSI 2.8%PRS 10.1%
-
CSI 0.2rCSI 2.1%PRS 8.2%
-
CSI 0.2rCSI 3.8%PRS 38.2%
-
CSI 0.2rCSI 0.3%PRS 32.7%
-
CSI 0.2rCSI 4.1%PRS 73.4%
-
CSI 0.2rCSI 1.1%PRS 38.1%
-
CSI 0.2rCSI 0.8%PRS 53.4%
-
CSI 0.2rCSI 0.3%PRS 7.0%
-
CSI 0.2rCSI 0.8%PRS 4.4%
-
CSI 0.2rCSI 0.3%PRS 11.1%
-
CSI 0.2rCSI 0.3%PRS 16.7%
-
CSI 0.2rCSI 4.6%PRS 68.8%
-
CSI 0.2rCSI 4.2%PRS 9.3%
-
CSI 0.2rCSI 0.5%PRS 6.2%
-
CSI 0.2rCSI 4.0%PRS 46.8%
-
CSI 0.2rCSI 2.6%PRS 30.7%
-
CSI 0.2rCSI 3.8%PRS 57.6%
-
CSI 0.2rCSI 0.4%PRS 11.7%
-
CSI 0.3rCSI 0.7%PRS 23.3%
-
CSI 0.3rCSI 2.1%PRS 12.4%
-
CSI 0.3rCSI 0.5%PRS 8.6%
-
CSI 0.3rCSI 2.2%PRS 47.7%
-
CSI 0.3rCSI 0.5%PRS 23.9%
-
CSI 0.3rCSI 1.4%PRS 15.5%
-
CSI 0.3rCSI 0.7%PRS 6.8%
-
CSI 0.3rCSI 0.3%PRS 24.7%
-
CSI 0.3rCSI 1.1%PRS 6.0%
-
CSI 0.3rCSI 4.0%PRS 44.9%
-
CSI 0.4rCSI 8.3%PRS 40.7%
-
CSI 0.4rCSI 0.7%PRS 31.6%
-
CSI 0.4rCSI 2.1%PRS 7.3%
-
CSI 0.4rCSI 4.0%PRS 46.1%
-
CSI 0.4rCSI 3.4%PRS 35.6%
-
CSI 0.4rCSI 1.7%PRS 11.6%
-
CSI 0.4rCSI 1.8%PRS 24.7%
-
CSI 0.4rCSI 2.1%PRS 47.9%
-
CSI 0.4rCSI 1.3%PRS 14.6%
-
CSI 0.4rCSI 10.6%PRS 55.0%
-
CSI 0.4rCSI 2.5%PRS 26.6%
-
CSI 0.4rCSI 0.3%PRS 20.9%
-
CSI 0.4rCSI 1.0%PRS 15.9%
-
CSI 0.5rCSI 8.6%PRS 38.0%
-
CSI 0.5rCSI 0.3%PRS 16.5%
-
CSI 0.5rCSI 1.1%PRS 24.9%
-
CSI 0.5rCSI 1.1%PRS 17.8%
-
CSI 0.5rCSI 1.4%PRS 21.4%
-
CSI 0.5rCSI 2.8%PRS 4.7%
-
CSI 0.5rCSI 0.8%PRS 10.2%
-
CSI 0.5rCSI 0.8%PRS 28.8%
-
CSI 0.5rCSI 1.4%PRS 32.6%
-
CSI 0.5rCSI 3.6%PRS 63.3%
-
CSI 0.6rCSI 1.9%PRS 20.1%
-
CSI 0.6rCSI 2.5%PRS 43.6%
-
CSI 0.6rCSI 0.8%PRS 12.2%
-
CSI 0.6rCSI 1.8%PRS 7.5%
-
CSI 0.6rCSI 0.7%PRS 18.2%
-
CSI 0.6rCSI 0.8%PRS 24.6%
-
CSI 0.6rCSI 0.9%PRS 17.5%
-
CSI 0.6rCSI 1.4%PRS 12.5%
-
CSI 0.6rCSI 3.4%PRS 37.4%
-
CSI 0.6rCSI 1.9%PRS 29.6%
-
CSI 0.6rCSI 0.7%PRS 12.2%
-
CSI 0.7rCSI 6.3%PRS 48.8%
-
CSI 0.7rCSI 3.0%PRS 41.4%
-
CSI 0.7rCSI 1.7%PRS 35.0%
-
CSI 0.7rCSI 2.6%PRS 7.1%
-
CSI 0.7rCSI 0.8%PRS 6.8%
-
CSI 0.8rCSI 1.9%PRS 17.2%
-
CSI 0.8rCSI 2.3%PRS 18.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4071974767
Symbol: AP2M1_HUMAN
Name: AP-2 mu chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7788527
Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 7788527
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10910768
Title: RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis.
PubMed ID: 10910768
PubMed ID: 12032142
Title: Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery.
PubMed ID: 12032142
PubMed ID: 11877457
Title: Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals.
PubMed ID: 11877457
PubMed ID: 14745134
Title: Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network.
PubMed ID: 14745134
DOI: 10.1247/csf.28.419
PubMed ID: 12952941
Title: Clathrin-mediated endocytosis in AP-2-depleted cells.
PubMed ID: 12952941
PubMed ID: 12694563
Title: Endocytosis of the viral chemokine receptor US28 does not require beta-arrestins but is dependent on the clathrin-mediated pathway.
PubMed ID: 12694563
PubMed ID: 15473838
Title: Adaptors for clathrin coats: structure and function.
PubMed ID: 15473838
PubMed ID: 14985334
Title: Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference.
PubMed ID: 14985334
PubMed ID: 16581796
Title: Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization.
PubMed ID: 16581796
PubMed ID: 17643423
Title: MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation.
PubMed ID: 17643423
PubMed ID: 19033387
Title: The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.
PubMed ID: 19033387
DOI: 10.1242/jcs.033522
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19419997
Title: The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway.
PubMed ID: 19419997
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23676497
Title: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
PubMed ID: 23676497
DOI: 10.1172/jci65401
PubMed ID: 23529131
Title: Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium.
PubMed ID: 23529131
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25066864
Title: Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B.
PubMed ID: 25066864
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 33436498
Title: Cytoplasmic short linear motifs in ACE2 and integrin beta3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy.
PubMed ID: 33436498
PubMed ID: 11583591
Title: Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28.
PubMed ID: 11583591
PubMed ID: 31104773
Title: A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy.
PubMed ID: 31104773
Sequence Information:
- Length: 435
- Mass: 49655
- Checksum: 82803219BA279954
- Sequence:
MIGGLFIYNH KGEVLISRVY RDDIGRNAVD AFRVNVIHAR QQVRSPVTNI ARTSFFHVKR SNIWLAAVTK QNVNAAMVFE FLYKMCDVMA AYFGKISEEN IKNNFVLIYE LLDEILDFGY PQNSETGALK TFITQQGIKS QHQTKEEQSQ ITSQVTGQIG WRREGIKYRR NELFLDVLES VNLLMSPQGQ VLSAHVSGRV VMKSYLSGMP ECKFGMNDKI VIEKQGKGTA DETSKSGKQS IAIDDCTFHQ CVRLSKFDSE RSISFIPPDG EFELMRYRTT KDIILPFRVI PLVREVGRTK LEVKVVIKSN FKPSLLAQKI EVRIPTPLNT SGVQVICMKG KAKYKASENA IVWKIKRMAG MKESQISAEI ELLPTNDKKK WARPPISMNF EVPFAPSGLK VRYLKVFEPK LNYSDHDVIK WVRYIGRSGI YETRC
Genular Protein ID: 2330299134
Symbol: E9PFW3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 460
- Mass: 52304
- Checksum: B693E3B0195DAC5F
- Sequence:
MIGGLFIYNH KGEVLISRVY RDDIGSRQAA DSAVFSSSGP FPGEWLEANR RNAVDAFRVN VIHARQQVRS PVTNIARTSF FHVKRSNIWL AAVTKQNVNA AMVFEFLYKM CDVMAAYFGK ISEENIKNNF VLIYELLDEI LDFGYPQNSE TGALKTFITQ QGIKSQHQTK EEQSQITSQV TGQIGWRREG IKYRRNELFL DVLESVNLLM SPQGQVLSAH VSGRVVMKSY LSGMPECKFG MNDKIVIEKQ GKGTADETSK SGKQSIAIDD CTFHQCVRLS KFDSERSISF IPPDGEFELM RYRTTKDIIL PFRVIPLVRE VGRTKLEVKV VIKSNFKPSL LAQKIEVRIP TPLNTSGVQV ICMKGKAKYK ASENAIVWKI KRMAGMKESQ ISAEIELLPT NDKKKWARPP ISMNFEVPFA PSGLKVRYLK VFEPKLNYSD HDVIKWVRYI GRSGIYETRC
Genular Protein ID: 2003025599
Symbol: B4DNB9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 460
- Mass: 52338
- Checksum: 06D349B013FD0192
- Sequence:
MIGGLFIYNH KGEVLISRVY RDDIGSRQAA DSAVFSSSGP FPGEWLEANR RNAVDAFRVN VIHARQQVRS PVTNIARTSF FHVKRSNIWL AAVTKQNVNA AMVFEFLYKM CDVMAAYFGK ISEENIKNNF VLIYELLDEI LDFGYPQNSE TGALKTFITQ QGIKSQHQTK EEQSQITSQV TGQIGWRREG IKYRRNELFL DVLESVNLLM SPQGQVLSAH VSGRVVMKSY LSGMPECKFG MNDKIVIEKQ GKGTADETSK SGKQSIAIDD CTFHQCVRLS KFDSERSISF IPPDGEFELM RYRTTKDIIF PFRVIPLVRE VGRTKLEVKV VIKSNFKPSL LAQKIEVRIP TPLNTSGVQV ICMKGKAKYK ASENAIVWKI KRMAGMKESQ ISAEIELLPT NDKKKWARPP ISMNFEVPFA PSGLKVRYLK VFEPKLNYSD HDVIKWVRYI GRSGIYETRC