Details for: Slc25a4

Gene ID: 11739

Symbol: Slc25a4

Ensembl ID: ENSMUSG00000031633

Description: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4

Associated with

  • Slc-mediated transmembrane transport
    (R-MMU-425407)
  • Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
    (R-MMU-83936)
  • Transport of small molecules
    (R-MMU-382551)
  • Transport of vitamins, nucleosides, and related molecules
    (R-MMU-425397)
  • Adaptive thermogenesis
    (GO:1990845)
  • Adp transport
    (GO:0015866)
  • Antiporter activity
    (GO:0015297)
  • Apoptotic mitochondrial changes
    (GO:0008637)
  • Atp:adp antiporter activity
    (GO:0005471)
  • Enzyme binding
    (GO:0019899)
  • Membrane
    (GO:0016020)
  • Membrane raft
    (GO:0045121)
  • Mitochondrial adp transmembrane transport
    (GO:0140021)
  • Mitochondrial atp transmembrane transport
    (GO:1990544)
  • Mitochondrial inner membrane
    (GO:0005743)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrial permeability transition pore complex
    (GO:0005757)
  • Mitochondrion
    (GO:0005739)
  • Myelin sheath
    (GO:0043209)
  • Negative regulation of cardiac muscle cell apoptotic process
    (GO:0010667)
  • Negative regulation of mitochondrial membrane permeability involved in apoptotic process
    (GO:1902109)
  • Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
    (GO:1901029)
  • Negative regulation of necroptotic process
    (GO:0060546)
  • Oxidative phosphorylation uncoupler activity
    (GO:0017077)
  • Positive regulation of cell growth involved in cardiac muscle cell development
    (GO:0061051)
  • Positive regulation of mitophagy
    (GO:1901526)
  • Protein binding
    (GO:0005515)
  • Proton transmembrane transporter activity
    (GO:0015078)
  • Regulation of mitochondrial membrane permeability
    (GO:0046902)
  • Transmembrane transport
    (GO:0055085)

Other Information

Genular Protein ID: 2931694151

Symbol: ADT1_MOUSE

Name: N/A

UniProtKB Accession Codes:

P48962 Q62164

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 1 GO 24 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 2 MINT 1 MaxQB 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8903724

Title: Rapid evolution of human pseudoautosomal genes and their mouse homologs.

PubMed ID: 8903724

DOI: 10.1007/s003359900007

PubMed ID: 10974536

Title: Expression and sequence analysis of the mouse adenine nucleotide translocase 1 and 2 genes.

PubMed ID: 10974536

DOI: 10.1016/s0378-1119(00)00252-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9207786

Title: A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator.

PubMed ID: 9207786

DOI: 10.1038/ng0797-226

PubMed ID: 11809823

Title: ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter.

PubMed ID: 11809823

DOI: 10.1091/mbc.01-05-0245

PubMed ID: 14749836

Title: The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore.

PubMed ID: 14749836

DOI: 10.1038/nature02229

PubMed ID: 16303948

Title: Eliminating the Ant1 isoform produces a mouse with CPEO pathology but normal ocular motility.

PubMed ID: 16303948

DOI: 10.1167/iovs.05-0695

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 19644512

Title: The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis.

PubMed ID: 19644512

DOI: 10.1038/cdd.2009.100

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20671283

Title: Retinal function and structure in Ant1-deficient mice.

PubMed ID: 20671283

DOI: 10.1167/iovs.10-5421

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 31489369

Title: Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD.

PubMed ID: 31489369

DOI: 10.1126/sciadv.aaw4597

PubMed ID: 31618756

Title: The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.

PubMed ID: 31618756

DOI: 10.1038/s41586-019-1667-4

PubMed ID: 31341297

Title: H+ transport is an integral function of the mitochondrial ADP/ATP carrier.

PubMed ID: 31341297

DOI: 10.1038/s41586-019-1400-3

Sequence Information:

  • Length: 298
  • Mass: 32904
  • Checksum: 3A849FEAB0981462
  • Sequence:
    • MGDQALSFLK DFLAGGIAAA VSKTAVAPIE RVKLLLQVQH ASKQISAEKQ YKGIIDCVVR 
IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDRHKQFW RYFAGNLASG 
GAAGATSLCF VYPLDFARTR LAADVGKGSS QREFNGLGDC LTKIFKSDGL KGLYQGFSVS 
VQGIIIYRAA YFGVYDTAKG MLPDPKNVHI IVSWMIAQSV TAVAGLVSYP FDTVRRRMMM 
QSGRKGADIM YTGTLDCWRK IAKDEGANAF FKGAWSNVLR GMGGAFVLVL YDEIKKYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.