Gene AP1S1 - ENSG00000106367 | NCBI Gene ID: 1174

Details for: AP1S1

Gene ID: 1174

Symbol: AP1S1

Ensembl ID: ENSG00000106367

Description: adaptor related protein complex 1 subunit sigma 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Disease
(R-HSA-1643685)
Golgi associated vesicle biogenesis
(R-HSA-432722)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Lysosome vesicle biogenesis
(R-HSA-432720)
Membrane trafficking
(R-HSA-199991)
Mhc class ii antigen presentation
(R-HSA-2132295)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(R-HSA-164938)
Nef mediated downregulation of mhc class i complex cell surface expression
(R-HSA-164940)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Trans-golgi network vesicle budding
(R-HSA-199992)
Viral infection pathways
(R-HSA-9824446)
Ap-1 adaptor complex
(GO:0030121)
Basolateral protein secretion
(GO:0110010)
Clathrin-coated pit
(GO:0005905)
Clathrin adaptor activity
(GO:0035615)
Cytoplasmic vesicle membrane
(GO:0030659)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular protein transport
(GO:0006886)
Lysosomal membrane
(GO:0005765)
Melanosome assembly
(GO:1903232)
Membrane
(GO:0016020)
Platelet dense granule organization
(GO:0060155)
Receptor-mediated endocytosis
(GO:0006898)
Response to virus
(GO:0009615)
Trans-golgi network membrane
(GO:0032588)
Vesicle-mediated transport
(GO:0016192)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: enterocyte (CL0000584)
Fold Change: 2.02
Marker Score: 9680
Cell Name: cell in vitro (CL0001034)
Fold Change: 2
Marker Score: 69346.5
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.93
Marker Score: 7581
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.82
Marker Score: 3689
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.8
Marker Score: 2015
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.71
Marker Score: 2524
Cell Name: stem cell (CL0000034)
Fold Change: 1.69
Marker Score: 4018
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.55
Marker Score: 3240
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.53
Marker Score: 1650
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.53
Marker Score: 1617
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.53
Marker Score: 841
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.5
Marker Score: 503
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.47
Marker Score: 3106
Cell Name: kidney cell (CL1000497)
Fold Change: 1.47
Marker Score: 980
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.47
Marker Score: 2262
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.45
Marker Score: 3880
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.43
Marker Score: 9146
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.43
Marker Score: 2430
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.43
Marker Score: 12294
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.41
Marker Score: 330
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.4
Marker Score: 1167
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.39
Marker Score: 4365
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.38
Marker Score: 1671
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.37
Marker Score: 1463
Cell Name: decidual cell (CL2000002)
Fold Change: 1.36
Marker Score: 5866
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.35
Marker Score: 4803
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.33
Marker Score: 1253
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.32
Marker Score: 1266
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.31
Marker Score: 2977
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.31
Marker Score: 722
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.29
Marker Score: 8266
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.29
Marker Score: 1218
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.25
Marker Score: 591
Cell Name: B-2 B cell (CL0000822)
Fold Change: 1.25
Marker Score: 1537
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.25
Marker Score: 470
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.24
Marker Score: 463
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.24
Marker Score: 428
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.24
Marker Score: 778
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.24
Marker Score: 3364
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.23
Marker Score: 2187
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.23
Marker Score: 1768
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.21
Marker Score: 1284
Cell Name: osteoclast (CL0000092)
Fold Change: 1.21
Marker Score: 603
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.21
Marker Score: 1138
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.21
Marker Score: 4466
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.2
Marker Score: 339
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.19
Marker Score: 1439
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.19
Marker Score: 15700
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.19
Marker Score: 1950
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.18
Marker Score: 609
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.18
Marker Score: 9230
Cell Name: male germ cell (CL0000015)
Fold Change: 1.17
Marker Score: 336
Cell Name: motor neuron (CL0000100)
Fold Change: 1.16
Marker Score: 691
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.14
Marker Score: 1185
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.13
Marker Score: 12748
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.11
Marker Score: 7244
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.11
Marker Score: 1124
Cell Name: lung secretory cell (CL1000272)
Fold Change: 1.09
Marker Score: 974.5
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.09
Marker Score: 387
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.09
Marker Score: 314
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.09
Marker Score: 2477
Cell Name: Unknown (CL0002371)
Fold Change: 1.09
Marker Score: 1154
Cell Name: secretory cell (CL0000151)
Fold Change: 1.08
Marker Score: 1976
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.07
Marker Score: 1341
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.06
Marker Score: 7916
Cell Name: club cell (CL0000158)
Fold Change: 1.06
Marker Score: 1239
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 1.06
Marker Score: 461
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.04
Marker Score: 10513.5
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.04
Marker Score: 2456
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.04
Marker Score: 540
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.04
Marker Score: 204
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.03
Marker Score: 1660
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.02
Marker Score: 5385
Cell Name: PP cell (CL0000696)
Fold Change: 1
Marker Score: 225
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1
Marker Score: 474
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71665
Cell Name: enteric neuron (CL0007011)
Fold Change: 1
Marker Score: 530
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47890
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.99
Marker Score: 1581
Cell Name: peptic cell (CL0000155)
Fold Change: 0.99
Marker Score: 414
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30386
Cell Name: basal cell (CL0000646)
Fold Change: 0.98
Marker Score: 1263
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.98
Marker Score: 617.5
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.96
Marker Score: 332
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.96
Marker Score: 1585
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2392
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.94
Marker Score: 3627
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.94
Marker Score: 3827
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.93
Marker Score: 634
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 480
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.93
Marker Score: 297
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 437
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.92
Marker Score: 341
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.92
Marker Score: 921
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.92
Marker Score: 650
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.92
Marker Score: 966
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5201
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2721
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.91
Marker Score: 5383
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.91
Marker Score: 2286

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**Key characteristics:** - AP1S1 is a type I transmembrane protein. - It is a member of the AP1 complex. - It is expressed in a number of cell types, including enterocytes, cell in vitro, and placental villous trophoblast. - It interacts with a variety of cell surface receptors, including CD28, CD3, and CD4. **Pathways and functions:** - AP1S1 is involved in the regulation of the adaptive immune response. - It is a key regulator of the activation of CD28 and CD3 receptors, which are expressed on T cells. - AP1S1 is also involved in the regulation of the activation of other cell surface receptors, such as those expressed on B cells and macrophages. - It is involved in the regulation of the trafficking of proteins between the endoplasmic reticulum (ER) and the cell surface. - It is also involved in the regulation of the formation of clathrin-coated pits, which are invaginations of the cell surface that are used for the sorting and packaging of proteins. **Clinical significance:** AP1S1 is a promising target for the treatment of HIV-1 infection. It is expressed in high levels in the plasma of people with HIV-1 infection, and it is known to interact with CD28 and CD3 receptors, which are expressed on T cells. This interaction allows AP1S1 to regulate the activation of T cells, which is essential for the control of HIV-1 infection. Therefore, targeting AP1S1 could provide a novel therapeutic approach for HIV-1 infection.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

AP-1 complex subunit sigma-1A

Genular Protein ID: 166606752

Symbol: AP1S1_HUMAN

Name: AP-1 complex subunit sigma-1A

UniProtKB Accession Codes:

P61966 B2R5D8 P82267 Q00382 Q53YA7 Q9BTN4 Q9UDW9

Database IDs:

Citations:

PubMed ID: 9733768

Title: Identification and characterization of novel clathrin adaptor-related proteins.

PubMed ID: 9733768

DOI: 10.1074/jbc.273.38.24693

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19057675

Title: Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord.

PubMed ID: 19057675

DOI: 10.1371/journal.pgen.1000296

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 158
Mass: 18733
Checksum: E461937790406D8B
Sequence:

MMRFMLLFSR QGKLRLQKWY LATSDKERKK MVRELMQVVL ARKPKMCSFL EWRDLKVVYK 
RYASLYFCCA IEGQDNELIT LELIHRYVEL LDKYFGSVCE LDIIFNFEKA YFILDEFLMG 
GDVQDTSKKS VLKAIEQADL LQEEDESPRS VLEEMGLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: AP1S1

Associated with

Cells (max top 100)

Other Information

Identification and characterization of novel clathrin adaptor-related proteins. PubMed ID: 9733768

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. PubMed ID: 16548883

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord. PubMed ID: 19057675

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569