Details for: AP1S1

Gene ID: 1174

Symbol: AP1S1

Ensembl ID: ENSG00000106367

Description: adaptor related protein complex 1 subunit sigma 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 206.4994
    Cell Significance Index: -32.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.0935
    Cell Significance Index: -29.7000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 80.9205
    Cell Significance Index: -33.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.5749
    Cell Significance Index: -33.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.1158
    Cell Significance Index: -26.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.4046
    Cell Significance Index: -32.1000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 49.5811
    Cell Significance Index: -33.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.6884
    Cell Significance Index: -27.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.1705
    Cell Significance Index: -33.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6359
    Cell Significance Index: -34.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.6063
    Cell Significance Index: -23.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2034
    Cell Significance Index: -22.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.7966
    Cell Significance Index: 675.5300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1893
    Cell Significance Index: -6.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.8511
    Cell Significance Index: 26.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3969
    Cell Significance Index: 124.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6748
    Cell Significance Index: 22.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5535
    Cell Significance Index: 848.3800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5111
    Cell Significance Index: 12.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.3683
    Cell Significance Index: 71.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3485
    Cell Significance Index: 165.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3436
    Cell Significance Index: 92.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3315
    Cell Significance Index: 27.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2755
    Cell Significance Index: 33.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2112
    Cell Significance Index: 218.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1601
    Cell Significance Index: 1047.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9879
    Cell Significance Index: 160.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9877
    Cell Significance Index: 46.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9520
    Cell Significance Index: 27.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8110
    Cell Significance Index: 17.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7261
    Cell Significance Index: 32.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7188
    Cell Significance Index: 10.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6761
    Cell Significance Index: 135.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6689
    Cell Significance Index: 47.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6303
    Cell Significance Index: 119.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6287
    Cell Significance Index: 277.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6190
    Cell Significance Index: 85.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5574
    Cell Significance Index: 16.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5508
    Cell Significance Index: 25.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5105
    Cell Significance Index: 5.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4707
    Cell Significance Index: 46.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4550
    Cell Significance Index: 58.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4165
    Cell Significance Index: 11.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4158
    Cell Significance Index: 30.9900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.4062
    Cell Significance Index: 6.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3796
    Cell Significance Index: 13.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3450
    Cell Significance Index: 44.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3409
    Cell Significance Index: 22.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3210
    Cell Significance Index: 16.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2877
    Cell Significance Index: 33.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2292
    Cell Significance Index: 7.3400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1812
    Cell Significance Index: 1.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1674
    Cell Significance Index: 10.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1625
    Cell Significance Index: 10.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1290
    Cell Significance Index: 25.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1141
    Cell Significance Index: 2.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0928
    Cell Significance Index: 33.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0802
    Cell Significance Index: 58.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0801
    Cell Significance Index: 2.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0191
    Cell Significance Index: 0.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0175
    Cell Significance Index: 0.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0145
    Cell Significance Index: 11.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0142
    Cell Significance Index: -26.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0216
    Cell Significance Index: -0.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0227
    Cell Significance Index: -41.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0258
    Cell Significance Index: -2.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0269
    Cell Significance Index: -2.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0275
    Cell Significance Index: -42.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0297
    Cell Significance Index: -40.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0305
    Cell Significance Index: -22.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0417
    Cell Significance Index: -26.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0504
    Cell Significance Index: -1.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0515
    Cell Significance Index: -29.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0579
    Cell Significance Index: -9.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0603
    Cell Significance Index: -37.6700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0621
    Cell Significance Index: -0.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0692
    Cell Significance Index: -4.6500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0693
    Cell Significance Index: -0.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0728
    Cell Significance Index: -33.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0920
    Cell Significance Index: -26.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1194
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1372
    Cell Significance Index: -15.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1803
    Cell Significance Index: -37.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2023
    Cell Significance Index: -29.4100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2085
    Cell Significance Index: -1.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2191
    Cell Significance Index: -5.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2252
    Cell Significance Index: -3.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2421
    Cell Significance Index: -6.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2476
    Cell Significance Index: -10.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2664
    Cell Significance Index: -6.1600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3066
    Cell Significance Index: -2.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3308
    Cell Significance Index: -34.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3325
    Cell Significance Index: -12.5900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4404
    Cell Significance Index: -2.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4498
    Cell Significance Index: -34.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4573
    Cell Significance Index: -25.6600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4744
    Cell Significance Index: -6.6500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5103
    Cell Significance Index: -3.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5235
    Cell Significance Index: -15.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5332
    Cell Significance Index: -32.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** AP1S1 is a member of the AP-1 complex, which is a heterotetrameric protein complex consisting of two alpha, two beta, and one gamma subunits. The AP1S1 protein is a gamma subunit of the AP-1 complex, which is responsible for binding to the cytoskeleton and regulating the movement of coated vesicles. AP1S1 is also involved in the regulation of receptor-mediated endocytosis, a process by which cells internalize receptors and ligands through the formation of clathrin-coated pits. Additionally, AP1S1 has been shown to interact with various signaling molecules, including Nef, a protein from HIV-1 that downregulates cell surface receptors. **Pathways and Functions** The AP1S1 protein is involved in several cellular processes, including: 1. **Receptor-mediated endocytosis**: AP1S1 regulates the internalization of receptors and ligands through the formation of clathrin-coated pits. 2. **Vesicle-mediated transport**: AP1S1 is involved in the movement of coated vesicles along the cytoskeleton. 3. **Antigen presentation**: AP1S1 is required for the proper presentation of antigens on the surface of antigen-presenting cells. 4. **Immune system function**: AP1S1 plays a role in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 5. **Viral infection pathways**: AP1S1 has been shown to interact with Nef, a protein from HIV-1 that downregulates cell surface receptors. **Clinical Significance** Dysregulation of the AP1S1 gene has been implicated in various diseases, including: 1. **HIV-1 infection**: AP1S1 has been shown to interact with Nef, a protein that downregulates cell surface receptors, leading to impaired immune function and increased susceptibility to HIV-1 infection. 2. **Cancer**: AP1S1 has been implicated in the regulation of cell surface receptor trafficking and immune system function, making it a potential target for cancer therapy. 3. **Neurological disorders**: AP1S1 has been shown to interact with various signaling molecules, including NMDA receptors, which are implicated in neurological disorders such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: AP1S1 has been implicated in the regulation of immune responses, making it a potential target for the treatment of infectious diseases such as tuberculosis and malaria. In conclusion, AP1S1 is a critical component of the AP-1 complex, involved in various cellular processes, including receptor-mediated endocytosis, vesicle-mediated transport, and antigen presentation. Dysregulation of the AP1S1 gene has been implicated in various diseases, making it a potential target for therapy. Further research is needed to fully understand the role of AP1S1 in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 166606752

Symbol: AP1S1_HUMAN

Name: AP-1 complex subunit sigma-1A

UniProtKB Accession Codes:

P61966 B2R5D8 P82267 Q00382 Q53YA7 Q9BTN4 Q9UDW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9733768

Title: Identification and characterization of novel clathrin adaptor-related proteins.

PubMed ID: 9733768

DOI: 10.1074/jbc.273.38.24693

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19057675

Title: Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord.

PubMed ID: 19057675

DOI: 10.1371/journal.pgen.1000296

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 158
  • Mass: 18733
  • Checksum: E461937790406D8B
  • Sequence:
    • MMRFMLLFSR QGKLRLQKWY LATSDKERKK MVRELMQVVL ARKPKMCSFL EWRDLKVVYK 
RYASLYFCCA IEGQDNELIT LELIHRYVEL LDKYFGSVCE LDIIFNFEKA YFILDEFLMG 
GDVQDTSKKS VLKAIEQADL LQEEDESPRS VLEEMGLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.