Details for: AP2S1
Gene ID: 1175
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: AP2S1
Ensembl ID: ENSG00000042753
Description: adaptor related protein complex 2 subunit sigma 1
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 83.71rCSI 76.86%PRS 14.42
-
CSI 82.85rCSI 71.73%PRS 14.05
-
CSI 72.31rCSI 66.71%PRS 12.79
-
CSI 69.69rCSI 53.69%PRS 11.43
-
CSI 58.16rCSI 68.3%PRS 14.84
-
CSI 55.78rCSI 53.78%PRS 8.67
-
CSI 53.98rCSI 45.25%PRS 15.08
-
CSI 51.18rCSI 41.38%PRS 12.45
-
CSI 50.38rCSI 52.66%PRS 13.28
-
CSI 48.56rCSI 60.94%PRS 16.05
-
CSI 47.59rCSI 73.53%PRS 11.8
-
CSI 47.12rCSI 56.92%PRS 14.81
-
CSI 44.38rCSI 83.78%PRS 15.64
-
CSI 43.95rCSI 36.69%PRS 36.68
-
CSI 43.8rCSI 45.88%PRS 11.75
-
CSI 42.14rCSI 72.19%PRS 16.87
-
CSI 41.06rCSI 37.08%PRS 11.15
-
CSI 39.95rCSI 57.63%PRS 17.54
-
CSI 38.64rCSI 40.47%PRS 13.46
-
CSI 38.32rCSI 50.22%PRS 17.64
-
CSI 38.3rCSI 36.87%PRS 13.06
-
CSI 37.69rCSI 37.06%PRS 13.69
-
CSI 37.44rCSI 61.66%PRS 14.68
-
CSI 35.63rCSI 44.79%PRS 19.29
-
CSI 33.95rCSI 46.26%PRS 11.24
-
CSI 33.69rCSI 27.93%PRS 11.9
-
CSI 30.75rCSI 46.4%PRS 12.43
-
CSI 30.27rCSI 48.82%PRS 20.17
-
CSI 27.79rCSI 41.19%PRS 72.8
-
CSI 25.42rCSI 31.44%PRS 11.07
-
CSI 24.62rCSI 30.33%PRS 39.66
-
CSI 22.73rCSI 36.43%PRS 38.36
-
CSI 21.28rCSI 14.15%PRS 15.03
-
CSI 21.16rCSI 30.65%PRS 18.56
-
CSI 20.7rCSI 27.51%PRS 13.78
-
CSI 20.03rCSI 42.63%PRS 20.31
-
CSI 19.89rCSI 57.58%PRS 14.29
-
CSI 19.49rCSI 37.19%PRS 29.6
-
CSI 19.27rCSI 20.48%PRS 22.41
-
CSI 19.14rCSI 42.76%PRS 14.3
-
CSI 18.43rCSI 26.56%PRS 20.32
-
CSI 18.24rCSI 14.35%PRS 14.97
-
CSI 17.01rCSI 26.13%PRS 14.71
-
CSI 17rCSI 14.93%PRS 14.17
-
CSI 16.74rCSI 23.89%PRS 14.21
-
CSI 16.42rCSI 20.45%PRS 17.76
-
CSI 15.28rCSI 23.47%PRS 17.95
-
CSI 15.02rCSI 22.97%PRS 20.52
-
CSI 15.01rCSI 27.13%PRS 33.62
-
CSI 15.01rCSI 73.98%PRS 17.17
-
CSI 14.96rCSI 13.28%PRS 12.63
-
CSI 14.9rCSI 52.27%PRS 22.88
-
CSI 14.57rCSI 32.27%PRS 11.71
-
CSI 14.43rCSI 19.73%PRS 14.33
-
CSI 13.97rCSI 75.38%PRS 23.56
-
CSI 13.85rCSI 63.97%PRS 26.08
-
CSI 13.49rCSI 10.66%PRS 8.65
-
CSI 13.32rCSI 80.59%PRS 28
-
CSI 12.8rCSI 18.35%PRS 17.3
-
CSI 12.21rCSI 13.97%PRS 25.86
-
CSI 12.11rCSI 21.6%PRS 21.36
-
CSI 12.02rCSI 21.86%PRS 48.23
-
CSI 12rCSI 67.5%PRS 39.42
-
CSI 11.94rCSI 17.63%PRS 19.85
-
CSI 11.88rCSI 33.93%PRS 21.76
-
CSI 11.81rCSI 8.25%PRS 13.21
-
CSI 11.8rCSI 22.95%PRS 12.88
-
CSI 11.77rCSI 68.49%PRS 18.95
-
CSI 11.49rCSI 25.8%PRS 26.07
-
CSI 11.05rCSI 44%PRS 22.15
-
CSI 10.96rCSI 16.73%PRS 21.95
-
CSI 10.79rCSI 13.84%PRS 14.57
-
CSI 10.68rCSI 37.91%PRS 20.7
-
CSI 10.61rCSI 12.73%PRS 12.46
-
CSI 10.6rCSI 46.52%PRS 23.49
-
CSI 10rCSI 15.88%PRS 16.27
-
CSI 9.8rCSI 28.22%PRS 24.5
-
CSI 9.58rCSI 9.56%PRS 10.78
-
CSI 9.54rCSI 21.09%PRS 9.07
-
CSI 9.39rCSI 7.78%PRS 12.6
-
CSI 9.19rCSI 27.12%PRS 15.39
-
CSI 8.93rCSI 46.13%PRS 24.77
-
CSI 8.84rCSI 12.28%PRS 12.96
-
CSI 8.78rCSI 7.13%PRS 13.32
-
CSI 8.77rCSI 12.86%PRS 16.54
-
CSI 8.63rCSI 11.95%PRS 18.15
-
CSI 8.57rCSI 27.51%PRS 18.47
-
CSI 8.49rCSI 6.29%PRS 11.19
-
CSI 8.49rCSI 20.17%PRS 19
-
CSI 8.28rCSI 6.64%PRS 22.86
-
CSI 8.21rCSI 14.03%PRS 25.33
-
CSI 8.18rCSI 27.67%PRS 21.22
-
CSI 7.97rCSI 12.16%PRS 11.78
-
CSI 7.83rCSI 9.05%PRS 11.06
-
CSI 7.81rCSI 36.41%PRS 30.02
-
CSI 7.8rCSI 16.19%PRS 12.58
-
CSI 7.72rCSI 7.87%PRS 18.01
-
CSI 7.72rCSI 6.79%PRS 9.15
-
CSI 7.71rCSI 9.89%PRS 12.26
-
CSI 7.62rCSI 22.09%PRS 9.79
-
CSI -14.0rCSI -10.5%PRS 13.1%
-
CSI -6.5rCSI -9.6%PRS 14.5%
-
CSI -6.0rCSI -15.3%PRS 9.6%
-
CSI -2.2rCSI -11.3%PRS 23.0%
-
CSI -2.0rCSI -5.8%PRS 18.3%
-
CSI -2.0rCSI -4.4%PRS 7.7%
-
CSI -1.3rCSI -6.4%PRS 49.6%
-
CSI -0.8rCSI -1.0%PRS 6.9%
-
CSI -0.7rCSI -0.6%PRS 19.0%
-
CSI -0.7rCSI -2.1%PRS 7.9%
-
CSI -0.6rCSI -1.6%PRS 20.2%
-
CSI -0.5rCSI -0.6%PRS 21.8%
-
CSI -0.4rCSI -2.3%PRS 7.7%
-
CSI -0.3rCSI -1.0%PRS 6.8%
-
CSI -0.3rCSI -0.6%PRS 7.2%
-
CSI -0.1rCSI -0.2%PRS 36.5%
-
CSI 0.1rCSI 3.5%PRS 74.6%
-
CSI 0.2rCSI 2.3%PRS 47.2%
-
CSI 0.2rCSI 1.8%PRS 49.5%
-
CSI 0.2rCSI 4.3%PRS 35.9%
-
CSI 0.3rCSI 6.6%PRS 55.1%
-
CSI 0.3rCSI 1.5%PRS 18.4%
-
CSI 0.3rCSI 2.4%PRS 60.4%
-
CSI 0.4rCSI 1.5%PRS 7.5%
-
CSI 0.4rCSI 1.2%PRS 15.2%
-
CSI 0.4rCSI 0.7%PRS 8.1%
-
CSI 0.5rCSI 2.0%PRS 55.4%
-
CSI 0.5rCSI 1.7%PRS 10.7%
-
CSI 0.5rCSI 12.1%PRS 39.9%
-
CSI 0.5rCSI 0.5%PRS 14.4%
-
CSI 0.5rCSI 0.8%PRS 7.4%
-
CSI 0.5rCSI 1.5%PRS 8.5%
-
CSI 0.5rCSI 0.7%PRS 17.7%
-
CSI 0.5rCSI 1.4%PRS 20.8%
-
CSI 0.5rCSI 0.7%PRS 11.5%
-
CSI 0.5rCSI 2.3%PRS 12.4%
-
CSI 0.6rCSI 0.6%PRS 26.0%
-
CSI 0.6rCSI 0.7%PRS 21.6%
-
CSI 0.6rCSI 2.3%PRS 21.7%
-
CSI 0.6rCSI 2.8%PRS 49.2%
-
CSI 0.7rCSI 1.8%PRS 11.8%
-
CSI 0.7rCSI 1.1%PRS 10.8%
-
CSI 0.7rCSI 1.1%PRS 9.7%
-
CSI 0.7rCSI 1.5%PRS 5.3%
-
CSI 0.7rCSI 0.7%PRS 19.9%
-
CSI 0.7rCSI 1.6%PRS 19.4%
-
CSI 0.8rCSI 18.3%PRS 70.9%
-
CSI 0.8rCSI 1.1%PRS 20.5%
-
CSI 0.9rCSI 4.6%PRS 22.7%
-
CSI 0.9rCSI 4.7%PRS 42.1%
-
CSI 0.9rCSI 1.6%PRS 16.7%
-
CSI 0.9rCSI 2.4%PRS 15.1%
-
CSI 0.9rCSI 0.8%PRS 15.6%
-
CSI 1.0rCSI 2.5%PRS 11.6%
-
CSI 1.0rCSI 0.8%PRS 21.1%
-
CSI 1.0rCSI 1.5%PRS 13.3%
-
CSI 1.1rCSI 2.3%PRS 16.8%
-
CSI 1.1rCSI 3.7%PRS 48.2%
-
CSI 1.1rCSI 8.8%PRS 13.0%
-
CSI 1.1rCSI 3.6%PRS 35.2%
-
CSI 1.1rCSI 1.6%PRS 11.7%
-
CSI 1.1rCSI 5.6%PRS 16.4%
-
CSI 1.1rCSI 1.5%PRS 26.0%
-
CSI 1.1rCSI 2.7%PRS 15.9%
-
CSI 1.1rCSI 7.4%PRS 32.5%
-
CSI 1.2rCSI 2.0%PRS 9.6%
-
CSI 1.2rCSI 1.9%PRS 13.8%
-
CSI 1.2rCSI 6.8%PRS 16.8%
-
CSI 1.2rCSI 1.6%PRS 7.7%
-
CSI 1.2rCSI 5.5%PRS 12.3%
-
CSI 1.3rCSI 2.4%PRS 24.9%
-
CSI 1.3rCSI 24.8%PRS 39.4%
-
CSI 1.3rCSI 3.8%PRS 18.0%
-
CSI 1.4rCSI 4.4%PRS 15.4%
-
CSI 1.4rCSI 37.3%PRS 57.0%
-
CSI 1.5rCSI 22.2%PRS 39.3%
-
CSI 1.5rCSI 1.0%PRS 15.1%
-
CSI 1.5rCSI 3.4%PRS 13.2%
-
CSI 1.5rCSI 2.0%PRS 24.0%
-
CSI 1.5rCSI 26.2%PRS 49.0%
-
CSI 1.5rCSI 5.8%PRS 12.9%
-
CSI 1.5rCSI 23.8%PRS 31.1%
-
CSI 1.6rCSI 8.6%PRS 21.7%
-
CSI 1.6rCSI 2.8%PRS 7.4%
-
CSI 1.6rCSI 6.3%PRS 20.7%
-
CSI 1.6rCSI 1.9%PRS 7.3%
-
CSI 1.7rCSI 1.3%PRS 22.3%
-
CSI 1.7rCSI 2.3%PRS 12.8%
-
CSI 1.7rCSI 1.8%PRS 23.4%
-
CSI 1.8rCSI 3.1%PRS 10.5%
-
CSI 1.8rCSI 3.6%PRS 29.4%
-
CSI 1.8rCSI 4.2%PRS 26.7%
-
CSI 1.8rCSI 3.4%PRS 9.1%
-
CSI 1.8rCSI 5.7%PRS 19.6%
-
CSI 1.9rCSI 2.0%PRS 14.8%
-
CSI 1.9rCSI 2.2%PRS 9.2%
-
CSI 2.0rCSI 8.9%PRS 43.4%
-
CSI 2.0rCSI 4.7%PRS 19.9%
-
CSI 2.0rCSI 3.0%PRS 12.6%
-
CSI 2.0rCSI 17.9%PRS 73.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2507034195
Symbol: AP2S1_HUMAN
Name: AP-2 complex subunit sigma
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9040778
Title: Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2-->q13.3.
PubMed ID: 9040778
DOI: 10.1159/000134463
PubMed ID: 9767099
Title: A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17.
PubMed ID: 9767099
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14745134
Title: Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network.
PubMed ID: 14745134
DOI: 10.1247/csf.28.419
PubMed ID: 15473838
Title: Adaptors for clathrin coats: structure and function.
PubMed ID: 15473838
PubMed ID: 19033387
Title: The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.
PubMed ID: 19033387
DOI: 10.1242/jcs.033522
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23222959
Title: Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3.
PubMed ID: 23222959
DOI: 10.1038/ng.2492
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 33859415
Title: A genome-wide atlas of co-essential modules assigns function to uncharacterized genes.
PubMed ID: 33859415
PubMed ID: 24081735
Title: Identification of AP2S1 mutation and effects of low calcium formula in an infant with hypercalcemia and hypercalciuria.
PubMed ID: 24081735
DOI: 10.1210/jc.2013-2571
Sequence Information:
- Length: 142
- Mass: 17018
- Checksum: CA3FD868C65AEDF6
- Sequence:
MIRFILIQNR AGKTRLAKWY MQFDDDEKQK LIEEVHAVVT VRDAKHTNFV EFRNFKIIYR RYAGLYFCIC VDVNDNNLAY LEAIHNFVEV LNEYFHNVCE LDLVFNFYKV YTVVDEMFLA GEIRETSQTK VLKQLLMLQS LE
Genular Protein ID: 3944296357
Symbol: M0R0N4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 144
- Mass: 17303
- Checksum: DC3C494873F879A5
- Sequence:
MVWIRFILIQ NRAGKTRLAK WYMQFDDDEK QKLIEEVHAV VTVRDAKHTN FVEFRNFKII YRRYAGLYFC ICVDVNDNNL AYLEAIHNFV EVLNEYFHNV CELDLVFNFY KVYTVVDEMF LAGEIRETSQ TKVLKQLLML QSLE
Genular Protein ID: 2145304583
Symbol: M0QYZ2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 158
- Mass: 18929
- Checksum: 685BDAF358F5893D
- Sequence:
MKLKGLGKRC KRREDLEIRF ILIQNRAGKT RLAKWYMQFD DDEKQKLIEE VHAVVTVRDA KHTNFVEFRN FKIIYRRYAG LYFCICVDVN DNNLAYLEAI HNFVEVLNEY FHNVCELDLV FNFYKVYTVV DEMFLAGEIR ETSQTKVLKQ LLMLQSLE
Genular Protein ID: 1402327176
Symbol: X6R390_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 156
- Mass: 18414
- Checksum: 068FA6AE5AC56109
- Sequence:
MIRFILIQNR AGKTRLAKWY MQFDDDEKQK LIEEVHAVVT VRDAKHTNFV EVLAISVADS LSVLQFRNFK IIYRRYAGLY FCICVDVNDN NLAYLEAIHN FVEVLNEYFH NVCELDLVFN FYKVYTVVDE MFLAGEIRET SQTKVLKQLL MLQSLE