Details for: AP2S1

Gene ID: 1175

Symbol: AP2S1

Ensembl ID: ENSG00000042753

Description: adaptor related protein complex 2 subunit sigma 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.87
    Marker Score: 8161.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.47
    Marker Score: 194096
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.25
    Marker Score: 3717.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.22
    Marker Score: 25114
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.13
    Marker Score: 3779
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.99
    Marker Score: 34802.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.87
    Marker Score: 5601
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.81
    Marker Score: 2808
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.74
    Marker Score: 94803.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.65
    Marker Score: 22838
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.61
    Marker Score: 66898
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.56
    Marker Score: 2674
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.4
    Marker Score: 11539
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.4
    Marker Score: 24154.5
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.4
    Marker Score: 999
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.37
    Marker Score: 31289
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.37
    Marker Score: 6140
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.3
    Marker Score: 13967
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.26
    Marker Score: 9750
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.25
    Marker Score: 4565.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.24
    Marker Score: 1236
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.24
    Marker Score: 3074
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.23
    Marker Score: 5557
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.22
    Marker Score: 14199
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.22
    Marker Score: 9070
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.18
    Marker Score: 1944
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.17
    Marker Score: 8524
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.16
    Marker Score: 4508
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.13
    Marker Score: 4851
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.11
    Marker Score: 5096
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.09
    Marker Score: 875
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.09
    Marker Score: 2343
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.08
    Marker Score: 7390
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.07
    Marker Score: 5643
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.07
    Marker Score: 3183
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.06
    Marker Score: 13165
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.05
    Marker Score: 3268
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.05
    Marker Score: 1497
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.05
    Marker Score: 15277
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.05
    Marker Score: 2077
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.05
    Marker Score: 836
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.04
    Marker Score: 22968
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.04
    Marker Score: 1287
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.02
    Marker Score: 6351
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.02
    Marker Score: 4757
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.02
    Marker Score: 1352
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.02
    Marker Score: 1901
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.02
    Marker Score: 1039
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.01
    Marker Score: 3329
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2
    Marker Score: 3221
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2
    Marker Score: 485
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2
    Marker Score: 449
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.99
    Marker Score: 12950
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.99
    Marker Score: 1327
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.98
    Marker Score: 3957
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.98
    Marker Score: 1868
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.98
    Marker Score: 977
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.97
    Marker Score: 1853
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.97
    Marker Score: 3346
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.97
    Marker Score: 2082
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.97
    Marker Score: 4668.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.96
    Marker Score: 11635
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.96
    Marker Score: 5412
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.96
    Marker Score: 7248
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.95
    Marker Score: 1632
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.95
    Marker Score: 2354
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.95
    Marker Score: 2515
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.94
    Marker Score: 5212
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.94
    Marker Score: 1288
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.93
    Marker Score: 2843
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.93
    Marker Score: 4377
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.92
    Marker Score: 2057
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.92
    Marker Score: 2074
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.92
    Marker Score: 3352
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.91
    Marker Score: 18929
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.91
    Marker Score: 1004
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.91
    Marker Score: 612
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.9
    Marker Score: 1931
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.9
    Marker Score: 415
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.88
    Marker Score: 5586
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.88
    Marker Score: 750
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.86
    Marker Score: 7189
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.86
    Marker Score: 63407
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.86
    Marker Score: 928
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.86
    Marker Score: 445
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.86
    Marker Score: 1781
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.86
    Marker Score: 2858
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.84
    Marker Score: 2450
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.84
    Marker Score: 1155
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.84
    Marker Score: 1259
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.84
    Marker Score: 4628
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.83
    Marker Score: 1043
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.83
    Marker Score: 633
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.83
    Marker Score: 3333
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.82
    Marker Score: 18491
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.82
    Marker Score: 647
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.82
    Marker Score: 685
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.81
    Marker Score: 7534
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.81
    Marker Score: 1250
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.81
    Marker Score: 2963

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Other Information

**Key characteristics:** * AP2S1 is a protein of the immunoglobulin superfamily. * It is a transmembrane protein with a molecular weight of approximately 130 kDa. * AP2S1 is highly expressed in lymphoid tissues, including lymph nodes, spleen, and bone marrow. * It is also expressed in epithelial cells, where it is involved in the regulation of cell migration and differentiation. **Pathways and functions:** * AP2S1 is a key regulator of adaptive immune responses. It is involved in the activation of the adaptive immune system by binding to the CD28 molecule on the surface of T cells and B cells. This interaction allows AP2S1 to facilitate the transfer of a signal from the CD28 complex to the intracellular signaling pathway. * AP2S1 is also involved in the regulation of B-cell development and differentiation. It is expressed in hematopoietic stem cells and is essential for the survival and differentiation of B cells. * In addition to its role in adaptive immune responses, AP2S1 is also involved in the regulation of epithelial cell migration and differentiation. It is expressed in epithelial cells in the skin, lung, and gut, where it is involved in the formation of epithelial tissues. **Clinical significance:** AP2S1 is a promising target for the treatment of cancer and autoimmune diseases. Mutations in the AP2S1 gene have been linked to the development of several types of cancer, including lung cancer, breast cancer, and melanoma. AP2S1 is also a key target for autoimmune diseases, such as rheumatoid arthritis and Crohn's disease. **Additional information:** * AP2S1 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a member of the AP2 family of adaptor proteins, which are involved in the regulation of cell-cell and cell-extracellular matrix interactions. * AP2S1 is a promising target for the development of new cancer and autoimmune drugs.

Genular Protein ID: 2507034195

Symbol: AP2S1_HUMAN

Name: AP-2 complex subunit sigma

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9040778

Title: Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2-->q13.3.

PubMed ID: 9040778

DOI: 10.1159/000134463

PubMed ID: 9767099

Title: A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17.

PubMed ID: 9767099

DOI: 10.1016/s0378-1119(98)00406-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14745134

Title: Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network.

PubMed ID: 14745134

DOI: 10.1247/csf.28.419

PubMed ID: 15473838

Title: Adaptors for clathrin coats: structure and function.

PubMed ID: 15473838

DOI: 10.1146/annurev.cellbio.20.010403.104543

PubMed ID: 19033387

Title: The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.

PubMed ID: 19033387

DOI: 10.1242/jcs.033522

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23222959

Title: Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3.

PubMed ID: 23222959

DOI: 10.1038/ng.2492

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33859415

Title: A genome-wide atlas of co-essential modules assigns function to uncharacterized genes.

PubMed ID: 33859415

DOI: 10.1038/s41588-021-00840-z

PubMed ID: 24081735

Title: Identification of AP2S1 mutation and effects of low calcium formula in an infant with hypercalcemia and hypercalciuria.

PubMed ID: 24081735

DOI: 10.1210/jc.2013-2571

Sequence Information:

  • Length: 142
  • Mass: 17018
  • Checksum: CA3FD868C65AEDF6
  • Sequence:
  • MIRFILIQNR AGKTRLAKWY MQFDDDEKQK LIEEVHAVVT VRDAKHTNFV EFRNFKIIYR 
    RYAGLYFCIC VDVNDNNLAY LEAIHNFVEV LNEYFHNVCE LDLVFNFYKV YTVVDEMFLA 
    GEIRETSQTK VLKQLLMLQS LE

Genular Protein ID: 2145304583

Symbol: M0QYZ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 158
  • Mass: 18929
  • Checksum: 685BDAF358F5893D
  • Sequence:
  • MKLKGLGKRC KRREDLEIRF ILIQNRAGKT RLAKWYMQFD DDEKQKLIEE VHAVVTVRDA 
    KHTNFVEFRN FKIIYRRYAG LYFCICVDVN DNNLAYLEAI HNFVEVLNEY FHNVCELDLV 
    FNFYKVYTVV DEMFLAGEIR ETSQTKVLKQ LLMLQSLE

Genular Protein ID: 1402327176

Symbol: X6R390_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 156
  • Mass: 18414
  • Checksum: 068FA6AE5AC56109
  • Sequence:
  • MIRFILIQNR AGKTRLAKWY MQFDDDEKQK LIEEVHAVVT VRDAKHTNFV EVLAISVADS 
    LSVLQFRNFK IIYRRYAGLY FCICVDVNDN NLAYLEAIHN FVEVLNEYFH NVCELDLVFN 
    FYKVYTVVDE MFLAGEIRET SQTKVLKQLL MLQSLE

Genular Protein ID: 3944296357

Symbol: M0R0N4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 144
  • Mass: 17303
  • Checksum: DC3C494873F879A5
  • Sequence:
  • MVWIRFILIQ NRAGKTRLAK WYMQFDDDEK QKLIEEVHAV VTVRDAKHTN FVEFRNFKII 
    YRRYAGLYFC ICVDVNDNNL AYLEAIHNFV EVLNEYFHNV CELDLVFNFY KVYTVVDEMF 
    LAGEIRETSQ TKVLKQLLML QSLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.