Genular: Defining Cellular Identity and Function

Details for: Prdx3

Gene ID: 11757

Symbol: Prdx3

Ensembl ID: ENSMUSG00000024997

Description: peroxiredoxin 3

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Detoxification of reactive oxygen species
(R-MMU-3299685)
Antioxidant activity
(GO:0016209)
Cell redox homeostasis
(GO:0045454)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to reactive oxygen species
(GO:0034614)
Cellular response to stress
(GO:0033554)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Endosome
(GO:0005768)
Hydrogen peroxide catabolic process
(GO:0042744)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
Maternal placenta development
(GO:0001893)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Myelin sheath
(GO:0043209)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of kinase activity
(GO:0033673)
Negative regulation of neuron apoptotic process
(GO:0043524)
Nucleoplasm
(GO:0005654)
Oxidoreductase activity
(GO:0016491)
Peptidyl-cysteine oxidation
(GO:0018171)
Peroxidase activity
(GO:0004601)
Peroxiredoxin activity
(GO:0051920)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Protein-containing complex
(GO:0032991)
Protein kinase binding
(GO:0019901)
Regulation of mitochondrial membrane potential
(GO:0051881)
Response to hydrogen peroxide
(GO:0042542)
Response to lipopolysaccharide
(GO:0032496)
Response to oxidative stress
(GO:0006979)
Thioredoxin-dependent peroxiredoxin activity
(GO:0140824)
Thioredoxin peroxidase activity
(GO:0008379)

Other Information

Proteins

Thioredoxin-dependent peroxide reductase, mitochondrial

Genular Protein ID: 3805866502

Symbol: PRDX3_MOUSE

Name: Thioredoxin-dependent peroxide reductase, mitochondrial

UniProtKB Accession Codes:

P20108

Database IDs:

Citations:

PubMed ID: 2583515

Title: Cloning of a housekeeping-type gene (MER5) preferentially expressed in murine erythroleukemia cells.

PubMed ID: 2583515

DOI: 10.1016/0378-1119(89)90297-7

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9497357

Title: Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha.

PubMed ID: 9497357

DOI: 10.1074/jbc.273.11.6297

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

PubMed ID: 27037278

Title: Accelerated decline of physical strength in peroxiredoxin-3 knockout mice.

PubMed ID: 27037278

DOI: 10.1177/1535370216642039

PubMed ID: 31740833

Title: ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5.

PubMed ID: 31740833

DOI: 10.1038/s41589-019-0399-y

Sequence Information:

Length: 257
Mass: 28127
Checksum: 66513F2C5F1D56C0
Sequence:

MAAAAGRLLW SSVARHASAI SRSISASTVL RPVASRRTCL TDILWSASAQ GKSAFSTSSS 
FHTPAVTQHA PYFKGTAVVN GEFKELSLDD FKGKYLVLFF YPLDFTFVCP TEIVAFSDKA 
NEFHDVNCEV VAVSVDSHFS HLAWINTPRK NGGLGHMNIT LLSDITKQIS RDYGVLLESA 
GIALRGLFII DPNGVVKHLS VNDLPVGRSV EETLRLVKAF QFVETHGEVC PANWTPESPT 
IKPSPTASKE YFEKVHQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prdx3

Associated with

Other Information

Cloning of a housekeeping-type gene (MER5) preferentially expressed in murine erythroleukemia cells. PubMed ID: 2583515

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. PubMed ID: 9497357

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753

Accelerated decline of physical strength in peroxiredoxin-3 knockout mice. PubMed ID: 27037278

ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5. PubMed ID: 31740833