Details for: AP3S1

Gene ID: 1176

Symbol: AP3S1

Ensembl ID: ENSG00000177879

Description: adaptor related protein complex 3 subunit sigma 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.76
    Marker Score: 7930
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.12
    Marker Score: 1631
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.42
    Marker Score: 10456
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.34
    Marker Score: 20144
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.19
    Marker Score: 1309
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.1
    Marker Score: 16405
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.94
    Marker Score: 3951
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.94
    Marker Score: 678
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.91
    Marker Score: 9145
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.89
    Marker Score: 691
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.89
    Marker Score: 425
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.88
    Marker Score: 3525.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.86
    Marker Score: 1333
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.84
    Marker Score: 5095
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.79
    Marker Score: 1092
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.79
    Marker Score: 852
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.78
    Marker Score: 1583.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.77
    Marker Score: 2730.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.75
    Marker Score: 593
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.74
    Marker Score: 1097
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.73
    Marker Score: 7062.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.73
    Marker Score: 2665
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.73
    Marker Score: 489
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.71
    Marker Score: 4478
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.71
    Marker Score: 2061
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.7
    Marker Score: 22457
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.69
    Marker Score: 403
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.66
    Marker Score: 664
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.65
    Marker Score: 910
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.65
    Marker Score: 3763
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.65
    Marker Score: 12648
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.65
    Marker Score: 672
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.65
    Marker Score: 2032
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.64
    Marker Score: 3434
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.64
    Marker Score: 6353.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.64
    Marker Score: 1736.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.64
    Marker Score: 707.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.64
    Marker Score: 41875
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.63
    Marker Score: 10635
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.63
    Marker Score: 14017
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.63
    Marker Score: 1831
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.63
    Marker Score: 1554
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.63
    Marker Score: 2102.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.62
    Marker Score: 4406
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.62
    Marker Score: 4799
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.6
    Marker Score: 15194
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6
    Marker Score: 98327
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.6
    Marker Score: 1609
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.6
    Marker Score: 21469
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.59
    Marker Score: 6499
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.58
    Marker Score: 5628
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.58
    Marker Score: 1846
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.56
    Marker Score: 1507
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.56
    Marker Score: 632
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.56
    Marker Score: 17535
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.55
    Marker Score: 15382
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.55
    Marker Score: 2639.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.55
    Marker Score: 3650
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.55
    Marker Score: 1485
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.54
    Marker Score: 23055
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.54
    Marker Score: 3760
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.52
    Marker Score: 307
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.52
    Marker Score: 481
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.5
    Marker Score: 50707
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.5
    Marker Score: 2611.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.5
    Marker Score: 2059
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.5
    Marker Score: 1064
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.49
    Marker Score: 1945
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.49
    Marker Score: 2723
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.49
    Marker Score: 2140
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.48
    Marker Score: 366
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.48
    Marker Score: 2094
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.48
    Marker Score: 619
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.47
    Marker Score: 1256
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.47
    Marker Score: 15169
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.47
    Marker Score: 543
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.46
    Marker Score: 1678
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.46
    Marker Score: 334
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.46
    Marker Score: 972
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.45
    Marker Score: 385
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.45
    Marker Score: 1550
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.44
    Marker Score: 2228.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.44
    Marker Score: 1547
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.43
    Marker Score: 412
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.43
    Marker Score: 975
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.43
    Marker Score: 403.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.42
    Marker Score: 28344
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.42
    Marker Score: 399
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.42
    Marker Score: 2091
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.42
    Marker Score: 3215
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.41
    Marker Score: 3356
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.41
    Marker Score: 2501
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.41
    Marker Score: 360
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.41
    Marker Score: 78828
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.41
    Marker Score: 372.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.41
    Marker Score: 1255
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.4
    Marker Score: 754
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.4
    Marker Score: 53299.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.4
    Marker Score: 1320
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.4
    Marker Score: 664

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Other Information

**Key characteristics:** * AP3S1 is a transmembrane protein with a molecular weight of approximately 160 kDa. * It is a member of the AP3 family of adaptor proteins, which are involved in the regulation of intracellular transport. * AP3S1 is a key regulator of anterograde axonal transport and synaptic vesicle transport. * It is also involved in the early endosome, Golgi apparatus, Golgi associated vesicle biogenesis, Golgi to vacuole transport, and the insulin receptor signaling pathway. **Pathways and functions:** * AP3S1 is involved in the anterograde transport of vesicles from the endoplasmic reticulum (ER) to the cell body. * It is also involved in the retrograde transport of vesicles from the cell body to the ER. * It is involved in the formation of clathrin-coated vesicles, which are responsible for the transport of proteins and organelles between the ER and the cell body. * It is also involved in the biogenesis of Golgi-associated vesicles, which are responsible for the packaging and sorting of proteins and organelles. * It is involved in the transport of vesicles from the ER to the Golgi apparatus. * It is involved in the transport of vesicles from the Golgi apparatus to the lysosome. * It is involved in the transport of vesicles from the lysosome to the vacuole. **Clinical significance:** AP3S1 is a potential therapeutic target for a variety of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and Parkinson's disease. Mutations in the AP3S1 gene have been linked to the development of these diseases.

Genular Protein ID: 581609420

Symbol: AP3S1_HUMAN

Name: AP-3 complex subunit sigma-1

UniProtKB Accession Codes:

Q92572 O00647 O00676 O00721 O00727 Q53XL4 Q6ICQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8697810

Title: Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain.

PubMed ID: 8697810

DOI: 10.1159/000134341

PubMed ID: 9151686

Title: Characterization of the adaptor-related protein complex, AP-3.

PubMed ID: 9151686

DOI: 10.1083/jcb.137.4.835

PubMed ID: 9118953

Title: AP-3: an adaptor-like protein complex with ubiquitous expression.

PubMed ID: 9118953

DOI: 10.1093/emboj/16.5.917

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 193
  • Mass: 21732
  • Checksum: 1EF17F375881288D
  • Sequence:
    • MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL EGGLLIGGSD 
NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHVDKVHNIL 
AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS EAGLAGAPAR AVSAVKNMNL PEIPRNINIG 
DISIKVPNLP SFK

Genular Protein ID: 2777174227

Symbol: F5H459_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H459

Database IDs:

ARBA 5 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 162
  • Mass: 18772
  • Checksum: 4D6F1BC6FBB38176
  • Sequence:
    • MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL EGGLLIGGSD 
NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHVDKVHNIL 
AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS ETFIFQSPRQ DR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.