Genular: Defining Cellular Identity and Function

Details for: Ap2a1

Gene ID: 11771

Symbol: Ap2a1

Ensembl ID: ENSMUSG00000060279

Description: adaptor-related protein complex 2, alpha 1 subunit

Associated with

Adaptive immune system
(R-MMU-1280218)
Axon guidance
(R-MMU-422475)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Developmental biology
(R-MMU-1266738)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-MMU-399721)
Immune system
(R-MMU-168256)
L1cam interactions
(R-MMU-373760)
Ldl clearance
(R-MMU-8964038)
Membrane trafficking
(R-MMU-199991)
Mhc class ii antigen presentation
(R-MMU-2132295)
Nervous system development
(R-MMU-9675108)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Pcp/ce pathway
(R-MMU-4086400)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plasma lipoprotein clearance
(R-MMU-8964043)
Recycling pathway of l1
(R-MMU-437239)
Retrograde neurotrophin signalling
(R-MMU-177504)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Trafficking of ampa receptors
(R-MMU-399719)
Trafficking of glur2-containing ampa receptors
(R-MMU-416993)
Transmission across chemical synapses
(R-MMU-112315)
Transport of small molecules
(R-MMU-382551)
Vldlr internalisation and degradation
(R-MMU-8866427)
Wnt5a-dependent internalization of fzd2, fzd5 and ror2
(R-MMU-5140745)
Wnt5a-dependent internalization of fzd4
(R-MMU-5099900)
Ap-2 adaptor complex
(GO:0030122)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Clathrin-coated pit
(GO:0005905)
Clathrin-coated vesicle
(GO:0030136)
Clathrin-dependent endocytosis
(GO:0072583)
Clathrin adaptor activity
(GO:0035615)
Clathrin adaptor complex
(GO:0030131)
Cytoplasmic side of plasma membrane
(GO:0009898)
Endocytosis
(GO:0006897)
Filopodium tip
(GO:0032433)
Intracellular protein transport
(GO:0006886)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Membrane
(GO:0016020)
Membrane coat
(GO:0030117)
Negative regulation of hyaluronan biosynthetic process
(GO:1900126)
Plasma membrane
(GO:0005886)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Postsynaptic neurotransmitter receptor internalization
(GO:0098884)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein transport
(GO:0015031)
Secretory granule
(GO:0030141)
Vesicle-mediated transport
(GO:0016192)

Other Information

Proteins

AP-2 complex subunit alpha-1

Genular Protein ID: 947895985

Symbol: AP2A1_MOUSE

Name: AP-2 complex subunit alpha-1

UniProtKB Accession Codes:

P17426

Database IDs:

Citations:

PubMed ID: 2564002

Title: Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).

PubMed ID: 2564002

DOI: 10.1083/jcb.108.3.833

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7559550

Title: The alpha chain of the AP-2 adaptor is a clathrin binding subunit.

PubMed ID: 7559550

DOI: 10.1074/jbc.270.40.23768

PubMed ID: 7593326

Title: Expression and localization of alpha-adaptin isoforms.

PubMed ID: 7593326

DOI: 10.1242/jcs.108.8.2865

PubMed ID: 14745134

Title: Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network.

PubMed ID: 14745134

DOI: 10.1247/csf.28.419

PubMed ID: 15473838

Title: Adaptors for clathrin coats: structure and function.

PubMed ID: 15473838

DOI: 10.1146/annurev.cellbio.20.010403.104543

PubMed ID: 17626015

Title: SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15.

PubMed ID: 17626015

DOI: 10.1074/jbc.m703815200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18625303

Title: Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis.

PubMed ID: 18625303

DOI: 10.1016/j.cellsig.2008.06.011

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23676497

Title: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.

PubMed ID: 23676497

DOI: 10.1172/jci65401

PubMed ID: 29262337

Title: APache is an AP2-interacting protein involved in synaptic vesicle trafficking and neuronal development.

PubMed ID: 29262337

DOI: 10.1016/j.celrep.2017.11.073

Sequence Information:

Length: 977
Mass: 107664
Checksum: F4ED87D3F9EF230A
Sequence:

MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL DGYSKKKYVC 
KLLFIFLLGH DIDFGHMEAV NLLSSNKYTE KQIGYLFISV LVNSNSELIR LINNAIKNDL 
ASRNPTFMCL ALHCIANVGS REMGEAFAAD IPRILVAGDS MDSVKQSAAL CLLRLYKASP 
DLVPMGEWTA RVVHLLNDQH MGVVTAAVSL ITCLCKKNPD DFKTCISLAV SRLSRIVSSA 
STDLQDYTYY FVPAPWLSVK LLRLLQCYPP PEDAAVKGRL VECLETVLNK AQEPPKSKKV 
QHSNAKNAIL FETISLIIHY DSEPNLLVRA CNQLGQFLQH RETNLRYLAL ESMCTLASSE 
FSHEAVKTHI DTVINALKTE RDVSVRQRAA DLLYAMCDRS NAKQIVSEML RYLETADYAI 
REEIVLKVAI LAEKYAVDYS WYVDTILNLI RIAGDYVSEE VWYRVLQIVT NRDDVQGYAA 
KTVFEALQAP ACHENMVKVG GYILGEFGNL IAGDPRSSPP VQFSLLHSKF HLCSVATRAL 
LLSTYIKFIN LFPETKATIQ GVLRAGSQLR NADVELQQRA VEYLTLSSVA STDVLATVLE 
EMPPFPERES SILAKLKRKK GPGAASALDD SRRDTSSNDI NGGVEPTPST VSTPSPSADL 
LGLRAAPPPA APPAPVGGNL LVDVFSDGPT AQPSLGPTPE EAFLSELEPP APESPMALLA 
DPAPAADPGP EDIGPPIPEA DELLNKFVCK NSGVLFENQL LQIGVKSEFR QNLGRMYLFY 
GNKTSVQFQN FLPTVVHPGD LQTQLAVQTK RVAAQVDGGA QVQQVLNIEC LRDFLTPPLL 
SVRFRYGGTA QSLTLKLPVT INKFFQPTEM AAQDFFQRWK QLSLPLQEAQ KIFKANHPMD 
AEVTKAKLLG FGSALLDNVD PNPENFVGAG IIQTKALQVG CLLRLEPNAQ AQMYRLTLRT 
SKEPVSRHLC ELLAQQF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ap2a1

Associated with

Other Information

Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). PubMed ID: 2564002

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The alpha chain of the AP-2 adaptor is a clathrin binding subunit. PubMed ID: 7559550

Expression and localization of alpha-adaptin isoforms. PubMed ID: 7593326

Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network. PubMed ID: 14745134

Adaptors for clathrin coats: structure and function. PubMed ID: 15473838

SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15. PubMed ID: 17626015

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis. PubMed ID: 18625303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. PubMed ID: 23676497

APache is an AP2-interacting protein involved in synaptic vesicle trafficking and neuronal development. PubMed ID: 29262337