Details for: CLC

Gene ID: 1178

Symbol: CLC

Ensembl ID: ENSG00000105205

Description: Charcot-Leyden crystal galectin

Associated with

Other Information

Genular Protein ID: 2719585957

Symbol: LEG10_HUMAN

Name: Galectin-10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8419478

Title: Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily.

PubMed ID: 8419478

PubMed ID: 1577491

Title: Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14.

PubMed ID: 1577491

DOI: 10.1016/0888-7543(92)90237-m

PubMed ID: 9119387

Title: The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes.

PubMed ID: 9119387

DOI: 10.1006/geno.1996.4590

PubMed ID: 19497882

Title: A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.

PubMed ID: 19497882

DOI: 10.1073/pnas.0903568106

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16457599

Title: Comparative proteomics of nasal fluid in seasonal allergic rhinitis.

PubMed ID: 16457599

DOI: 10.1021/pr050341h

PubMed ID: 17502455

Title: Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function.

PubMed ID: 17502455

DOI: 10.1182/blood-2007-01-069229

PubMed ID: 19758173

Title: Galectin-10, eosinophils, and celiac disease.

PubMed ID: 19758173

DOI: 10.1111/j.1749-6632.2009.04627.x

PubMed ID: 22880030

Title: Galectin-10, a potential biomarker of eosinophilic airway inflammation.

PubMed ID: 22880030

DOI: 10.1371/journal.pone.0042549

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8747464

Title: Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins.

PubMed ID: 8747464

DOI: 10.1016/s0969-2126(01)00275-1

PubMed ID: 10529229

Title: Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution.

PubMed ID: 10529229

DOI: 10.1021/bi990756e

PubMed ID: 11834744

Title: Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion.

PubMed ID: 11834744

DOI: 10.1074/jbc.m200221200

Sequence Information:

  • Length: 142
  • Mass: 16453
  • Checksum: 2744F0C082C6446E
  • Sequence:
  • MSLLPVPYTE AASLSTGSTV TIKGRPLACF LNEPYLQVDF HTEMKEESDI VFHFQVCFGR 
    RVVMNSREYG AWKQQVESKN MPFQDGQEFE LSISVLPDKY QVMVNGQSSY TFDHRIKPEA 
    VKMVQVWRDI SLTKFNVSYL KR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.