Details for: CLC

Gene ID: 1178

Symbol: CLC

Ensembl ID: ENSG00000105205

Description: Charcot-Leyden crystal galectin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 6.1075
    Cell Significance Index: -0.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 2.0107
    Cell Significance Index: -0.5100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2255
    Cell Significance Index: 29.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 0.6367
    Cell Significance Index: -0.7900
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.5818
    Cell Significance Index: 4.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.3066
    Cell Significance Index: -1.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1492
    Cell Significance Index: 3.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1306
    Cell Significance Index: 3.5000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0913
    Cell Significance Index: 1.3000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0848
    Cell Significance Index: 1.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0608
    Cell Significance Index: 0.8300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0368
    Cell Significance Index: 0.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0157
    Cell Significance Index: 0.2300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0155
    Cell Significance Index: 0.1600
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.0056
    Cell Significance Index: 0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0034
    Cell Significance Index: 4.6000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0031
    Cell Significance Index: 0.0500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.0031
    Cell Significance Index: 0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0006
    Cell Significance Index: 1.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0005
    Cell Significance Index: 0.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0015
    Cell Significance Index: -0.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0018
    Cell Significance Index: -1.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0019
    Cell Significance Index: -1.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0019
    Cell Significance Index: -1.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0022
    Cell Significance Index: -0.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0025
    Cell Significance Index: -0.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0029
    Cell Significance Index: -0.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0030
    Cell Significance Index: -0.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0031
    Cell Significance Index: -1.1100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0054
    Cell Significance Index: -0.7900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0059
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0073
    Cell Significance Index: -1.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0078
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0094
    Cell Significance Index: -1.0800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0098
    Cell Significance Index: -0.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0102
    Cell Significance Index: -1.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0102
    Cell Significance Index: -0.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0102
    Cell Significance Index: -1.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0106
    Cell Significance Index: -0.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0109
    Cell Significance Index: -0.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0128
    Cell Significance Index: -0.9900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0151
    Cell Significance Index: -0.2200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0151
    Cell Significance Index: -0.2600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0156
    Cell Significance Index: -0.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0157
    Cell Significance Index: -0.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0161
    Cell Significance Index: -0.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0169
    Cell Significance Index: -1.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0173
    Cell Significance Index: -0.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0174
    Cell Significance Index: -1.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0184
    Cell Significance Index: -0.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0185
    Cell Significance Index: -0.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0215
    Cell Significance Index: -0.7900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0221
    Cell Significance Index: -0.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0224
    Cell Significance Index: -0.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0236
    Cell Significance Index: -0.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0238
    Cell Significance Index: -0.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0248
    Cell Significance Index: -0.7300
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: -0.0249
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0255
    Cell Significance Index: -0.7500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0278
    Cell Significance Index: -0.3200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0281
    Cell Significance Index: -0.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0295
    Cell Significance Index: -0.8500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0296
    Cell Significance Index: -0.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0306
    Cell Significance Index: -0.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0311
    Cell Significance Index: -0.6800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0313
    Cell Significance Index: -0.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0314
    Cell Significance Index: -1.0900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0317
    Cell Significance Index: -0.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0319
    Cell Significance Index: -1.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0342
    Cell Significance Index: -1.1200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0349
    Cell Significance Index: -0.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0358
    Cell Significance Index: -1.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0361
    Cell Significance Index: -0.8700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0361
    Cell Significance Index: -0.8800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0372
    Cell Significance Index: -0.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0376
    Cell Significance Index: -0.6300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0377
    Cell Significance Index: -0.4600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0392
    Cell Significance Index: -0.9800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0398
    Cell Significance Index: -0.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0405
    Cell Significance Index: -1.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0411
    Cell Significance Index: -0.8600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0413
    Cell Significance Index: -0.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0416
    Cell Significance Index: -0.7000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0418
    Cell Significance Index: -0.6000
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0429
    Cell Significance Index: -0.5500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0430
    Cell Significance Index: -0.8400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0431
    Cell Significance Index: -0.3900
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.0432
    Cell Significance Index: -0.4800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0435
    Cell Significance Index: -0.4500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0441
    Cell Significance Index: -1.1000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0453
    Cell Significance Index: -0.5400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0468
    Cell Significance Index: -0.5000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0469
    Cell Significance Index: -0.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0483
    Cell Significance Index: -1.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Multifunctional protein**: The CLC protein exhibits a range of biological activities, including carbohydrate binding, cysteine-type endopeptidase activity, lysophospholipase activity, and protein binding. 2. **Immune regulation**: The CLC protein is involved in regulating activated T cell proliferation, T cell anergy, and T cell cytokine production, highlighting its role in modulating immune responses. 3. **Cellular localization**: The CLC protein is expressed in various cell types, including Mueller cells, retina horizontal cells, and goblet cells, indicating its widespread presence in the body. 4. **Signaling pathways**: The CLC protein is involved in multiple signaling pathways, including those related to carbohydrate binding, collagen-containing extracellular matrix, and apoptosis. **Pathways and Functions:** 1. **Carbohydrate binding**: The CLC protein binds to carbohydrates, which is essential for its biological activities, including immune regulation and cellular homeostasis. 2. **Cysteine-type endopeptidase activity**: The CLC protein exhibits cysteine-type endopeptidase activity, which is involved in the processing of peptides and proteins, regulating immune responses and cellular homeostasis. 3. **Lysophospholipase activity**: The CLC protein possesses lysophospholipase activity, which is involved in the metabolism of lipids and phospholipids, regulating cellular homeostasis and immune responses. 4. **Protein binding**: The CLC protein binds to various proteins, including collagen, which is essential for maintaining the integrity of the extracellular matrix and regulating immune responses. 5. **Regulation of activated T cell proliferation**: The CLC protein modulates the proliferation of activated T cells, which is crucial for maintaining immune homeostasis and preventing autoimmune diseases. 6. **Regulation of T cell anergy**: The CLC protein regulates T cell anergy, which is essential for preventing excessive immune responses and maintaining immune homeostasis. 7. **Regulation of T cell cytokine production**: The CLC protein modulates the production of cytokines, which is crucial for regulating immune responses and maintaining immune homeostasis. 8. **Apoptotic process**: The CLC protein is involved in the apoptotic process, regulating the death of cells and preventing autoimmunity. **Clinical Significance:** The CLC gene and its protein product have significant implications for understanding and treating various diseases, including: 1. **Autoimmune disorders**: The CLC protein's role in regulating immune responses and preventing autoimmunity makes it a potential target for therapies in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Inflammatory diseases**: The CLC protein's involvement in regulating inflammatory responses and maintaining immune homeostasis makes it a potential target for therapies in inflammatory diseases, such as asthma and inflammatory bowel disease. 3. **Cancer**: The CLC protein's role in regulating apoptosis and cellular homeostasis makes it a potential target for therapies in cancer, including cancer immunotherapy and targeted therapies. 4. **Neurological disorders**: The CLC protein's involvement in regulating immune responses and maintaining neural homeostasis makes it a potential target for therapies in neurological disorders, such as Alzheimer's disease and multiple sclerosis. In conclusion, the Charcot-Leyden crystal galectin (CLC) gene and its protein product are multifunctional molecules involved in various biological processes, including immune regulation, apoptosis, and cellular homeostasis. Further research on the CLC gene and its protein product will provide valuable insights into the mechanisms of immune regulation and cellular homeostasis, ultimately leading to the development of novel therapies for various diseases.

Genular Protein ID: 2719585957

Symbol: LEG10_HUMAN

Name: Galectin-10

UniProtKB Accession Codes:

Q05315 C5HZ13 C5HZ14 Q0VDE3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 13 Ensembl 1 EvolutionaryTrace 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 36 PDBsum 36 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SASBDB 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8419478

Title: Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily.

PubMed ID: 8419478

PubMed ID: 1577491

Title: Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14.

PubMed ID: 1577491

DOI: 10.1016/0888-7543(92)90237-m

PubMed ID: 9119387

Title: The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes.

PubMed ID: 9119387

DOI: 10.1006/geno.1996.4590

PubMed ID: 19497882

Title: A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.

PubMed ID: 19497882

DOI: 10.1073/pnas.0903568106

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16457599

Title: Comparative proteomics of nasal fluid in seasonal allergic rhinitis.

PubMed ID: 16457599

DOI: 10.1021/pr050341h

PubMed ID: 17502455

Title: Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function.

PubMed ID: 17502455

DOI: 10.1182/blood-2007-01-069229

PubMed ID: 19758173

Title: Galectin-10, eosinophils, and celiac disease.

PubMed ID: 19758173

DOI: 10.1111/j.1749-6632.2009.04627.x

PubMed ID: 22880030

Title: Galectin-10, a potential biomarker of eosinophilic airway inflammation.

PubMed ID: 22880030

DOI: 10.1371/journal.pone.0042549

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8747464

Title: Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins.

PubMed ID: 8747464

DOI: 10.1016/s0969-2126(01)00275-1

PubMed ID: 10529229

Title: Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution.

PubMed ID: 10529229

DOI: 10.1021/bi990756e

PubMed ID: 11834744

Title: Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion.

PubMed ID: 11834744

DOI: 10.1074/jbc.m200221200

Sequence Information:

  • Length: 142
  • Mass: 16453
  • Checksum: 2744F0C082C6446E
  • Sequence:
    • MSLLPVPYTE AASLSTGSTV TIKGRPLACF LNEPYLQVDF HTEMKEESDI VFHFQVCFGR 
RVVMNSREYG AWKQQVESKN MPFQDGQEFE LSISVLPDKY QVMVNGQSSY TFDHRIKPEA 
VKMVQVWRDI SLTKFNVSYL KR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.