Details for: CLCA1

Gene ID: 1179

Symbol: CLCA1

Ensembl ID: ENSG00000016490

Description: chloride channel accessory 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3167
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.14
    Marker Score: 3008
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.1
    Marker Score: 1702
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.97
    Marker Score: 258
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5321
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.87
    Marker Score: 2782
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.86
    Marker Score: 1466
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.84
    Marker Score: 614
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.84
    Marker Score: 1591
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12727
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.81
    Marker Score: 5360
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1565
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 682
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 297
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.67
    Marker Score: 214
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2789
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.66
    Marker Score: 256
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.65
    Marker Score: 244
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.62
    Marker Score: 1282
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.61
    Marker Score: 684
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.54
    Marker Score: 375
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.53
    Marker Score: 308
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.46
    Marker Score: 2224
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.45
    Marker Score: 1063
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 268
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.44
    Marker Score: 182
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.31
    Marker Score: 85
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.27
    Marker Score: 125
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.27
    Marker Score: 331
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.25
    Marker Score: 134
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.25
    Marker Score: 402
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 115
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 119
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.22
    Marker Score: 263
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.2
    Marker Score: 73
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.2
    Marker Score: 220
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.19
    Marker Score: 604
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 81
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.16
    Marker Score: 35
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.16
    Marker Score: 101
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.15
    Marker Score: 88
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.15
    Marker Score: 65
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.14
    Marker Score: 330
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.13
    Marker Score: 126
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 132
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.11
    Marker Score: 56
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.11
    Marker Score: 1484
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.11
    Marker Score: 82
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.1
    Marker Score: 85
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.09
    Marker Score: 103
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 81
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.09
    Marker Score: 59.5
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.09
    Marker Score: 67
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 76
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 28.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: follicular dendritic cell (CL0000442)
    Fold Change: 0.07
    Marker Score: 26

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Other Information

**Key characteristics:** * CLCA1 is a transmembrane protein with a single transmembrane domain that spans the cell membrane. * It is a member of the chloride intracellular channel family. * CLCA1 is a calcium-dependent chloride channel, which means its activity is modulated by calcium levels. * It is also involved in cellular response to hypoxia, suggesting a potential role in maintaining cellular homeostasis under hypoxic conditions. **Pathways and functions:** * CLCA1 is involved in calcium ion transport, maintaining intracellular calcium levels. * It is crucial for chloride homeostasis in various tissues, including blood vessels, the gut, and the brain. * It is involved in cellular response to hypoxia, protecting cells from damage by regulating the influx of Cl- ions. * CLCA1 also participates in chloride transmembrane transport, influencing the movement of Cl- ions between cells. * It is involved in the regulation of epithelial cell function, including the formation of microvilli. * It is also involved in the regulation of small molecule transport and cell signaling. **Clinical significance:** * Mutations in CLCA1 have been linked to various diseases, including hypertension, heart failure, and kidney disease. * CLCA1 inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** * CLCA1 is a highly conserved protein, with similar sequences found in mammals, birds, and fish. * It is a promising target for therapeutic intervention in various diseases involving abnormal chloride transport or signaling pathways.

Genular Protein ID: 880919068

Symbol: CLCA1_HUMAN

Name: Calcium-activated chloride channel regulator 1

UniProtKB Accession Codes:

A8K7I4 B2RAV5 O95151 Q5TDF4 Q9UNF6 Q9UPC6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9828122

Title: Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins.

PubMed ID: 9828122

DOI: 10.1006/geno.1998.5562

PubMed ID: 10437792

Title: Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea.

PubMed ID: 10437792

DOI: 10.1016/s0014-5793(99)00891-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 23112050

Title: Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.

PubMed ID: 23112050

DOI: 10.1074/jbc.m112.410282

PubMed ID: 11445004

Title: Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer.

PubMed ID: 11445004

DOI: 10.1089/10445490152122442

PubMed ID: 11956057

Title: Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway.

PubMed ID: 11956057

DOI: 10.1164/ajrccm.165.8.2107068

PubMed ID: 11842292

Title: A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.

PubMed ID: 11842292

DOI: 10.1067/mai.2002.121555

PubMed ID: 16012037

Title: Expression and distribution of ion transport mRNAs in human nasal mucosa and nasal polyps.

PubMed ID: 16012037

DOI: 10.1080/00016480510028519

PubMed ID: 15696080

Title: Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa.

PubMed ID: 15696080

DOI: 10.1016/j.jaci.2004.09.039

PubMed ID: 15919655

Title: hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels.

PubMed ID: 15919655

DOI: 10.1074/jbc.m504654200

PubMed ID: 16151054

Title: Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium.

PubMed ID: 16151054

DOI: 10.1165/rcmb.2004-0220rc

PubMed ID: 17622767

Title: Histamine induces MUC5AC expression via a hCLCA1 pathway.

PubMed ID: 17622767

DOI: 10.1159/000104419

Sequence Information:

  • Length: 914
  • Mass: 100226
  • Checksum: 8D8999E855822711
  • Sequence:
    • MGPFKSSVFI LILHLLEGAL SNSLIQLNNN GYEGIVVAID PNVPEDETLI QQIKDMVTQA 
SLYLLEATGK RFYFKNVAIL IPETWKTKAD YVRPKLETYK NADVLVAEST PPGNDEPYTE 
QMGNCGEKGE RIHLTPDFIA GKKLAEYGPQ GRAFVHEWAH LRWGVFDEYN NDEKFYLSNG 
RIQAVRCSAG ITGTNVVKKC QGGSCYTKRC TFNKVTGLYE KGCEFVLQSR QTEKASIMFA 
QHVDSIVEFC TEQNHNKEAP NKQNQKCNLR STWEVIRDSE DFKKTTPMTT QPPNPTFSLL 
QIGQRIVCLV LDKSGSMATG NRLNRLNQAG QLFLLQTVEL GSWVGMVTFD SAAHVQNELI 
QINSGSDRDT LAKRLPAAAS GGTSICSGLR SAFTVIRKKY PTDGSEIVLL TDGEDNTISG 
CFNEVKQSGA IIHTVALGPS AAQELEELSK MTGGLQTYAS DQVQNNGLID AFGALSSGNG 
AVSQRSIQLE SKGLTLQNSQ WMNGTVIVDS TVGKDTLFLI TWTMQPPQIL LWDPSGQKQG 
GFVVDKNTKM AYLQIPGIAK VGTWKYSLQA SSQTLTLTVT SRASNATLPP ITVTSKTNKD 
TSKFPSPLVV YANIRQGASP ILRASVTALI ESVNGKTVTL ELLDNGAGAD ATKDDGVYSR 
YFTTYDTNGR YSVKVRALGG VNAARRRVIP QQSGALYIPG WIENDEIQWN PPRPEINKDD 
VQHKQVCFSR TSSGGSFVAS DVPNAPIPDL FPPGQITDLK AEIHGGSLIN LTWTAPGDDY 
DHGTAHKYII RISTSILDLR DKFNESLQVN TTALIPKEAN SEEVFLFKPE NITFENGTDL 
FIAIQAVDKV DLKSEISNIA RVSLFIPPQT PPETPSPDET SAPCPNIHIN STIPGIHILK 
IMWKWIGELQ LSIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.