Details for: CLCA1

Gene ID: 1179

Symbol: CLCA1

Ensembl ID: ENSG00000016490

Description: chloride channel accessory 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 6.9009
    Cell Significance Index: 74.7900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 6.1549
    Cell Significance Index: 62.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.1008
    Cell Significance Index: -4.8700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 3.8608
    Cell Significance Index: 58.1800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 3.6959
    Cell Significance Index: -2.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 3.1625
    Cell Significance Index: 111.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.8362
    Cell Significance Index: 196.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0450
    Cell Significance Index: 1846.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.9522
    Cell Significance Index: 48.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5705
    Cell Significance Index: 170.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3916
    Cell Significance Index: 226.3300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.1928
    Cell Significance Index: 9.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.1916
    Cell Significance Index: 12.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.1348
    Cell Significance Index: -3.0400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0100
    Cell Significance Index: 24.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9638
    Cell Significance Index: 27.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7596
    Cell Significance Index: 34.4300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3951
    Cell Significance Index: 5.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3429
    Cell Significance Index: 65.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3421
    Cell Significance Index: 33.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1315
    Cell Significance Index: 2.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1139
    Cell Significance Index: 13.0500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0938
    Cell Significance Index: 1.1900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0767
    Cell Significance Index: 0.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0528
    Cell Significance Index: 1.6900
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.0337
    Cell Significance Index: 0.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0070
    Cell Significance Index: 1.4000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0065
    Cell Significance Index: 0.1600
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0041
    Cell Significance Index: 0.0300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0032
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0007
    Cell Significance Index: 1.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0024
    Cell Significance Index: -0.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0029
    Cell Significance Index: -1.0500
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0033
    Cell Significance Index: -0.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0062
    Cell Significance Index: -3.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0062
    Cell Significance Index: -2.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0091
    Cell Significance Index: -0.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0098
    Cell Significance Index: -1.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0116
    Cell Significance Index: -3.3500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0130
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0154
    Cell Significance Index: -2.6300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0156
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0161
    Cell Significance Index: -3.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0169
    Cell Significance Index: -0.7900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0174
    Cell Significance Index: -0.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0194
    Cell Significance Index: -0.5400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0217
    Cell Significance Index: -0.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0220
    Cell Significance Index: -3.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0233
    Cell Significance Index: -3.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0234
    Cell Significance Index: -2.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0280
    Cell Significance Index: -0.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0313
    Cell Significance Index: -3.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0313
    Cell Significance Index: -1.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0313
    Cell Significance Index: -0.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0323
    Cell Significance Index: -2.4800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0338
    Cell Significance Index: -0.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0376
    Cell Significance Index: -0.7800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0420
    Cell Significance Index: -0.4600
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0435
    Cell Significance Index: -0.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0464
    Cell Significance Index: -3.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0466
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0483
    Cell Significance Index: -0.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0495
    Cell Significance Index: -1.4200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0509
    Cell Significance Index: -0.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0543
    Cell Significance Index: -2.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0565
    Cell Significance Index: -1.8500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0565
    Cell Significance Index: -0.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0584
    Cell Significance Index: -1.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0591
    Cell Significance Index: -3.6300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0592
    Cell Significance Index: -0.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0605
    Cell Significance Index: -2.1200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0611
    Cell Significance Index: -1.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0623
    Cell Significance Index: -0.8500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0643
    Cell Significance Index: -0.7600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0645
    Cell Significance Index: -0.8300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0653
    Cell Significance Index: -0.5700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0655
    Cell Significance Index: -0.6600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0668
    Cell Significance Index: -0.9500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0673
    Cell Significance Index: -0.4600
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0694
    Cell Significance Index: -0.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0695
    Cell Significance Index: -2.6300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0736
    Cell Significance Index: -0.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0757
    Cell Significance Index: -4.2500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0763
    Cell Significance Index: -0.7300
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0788
    Cell Significance Index: -0.7000
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0797
    Cell Significance Index: -1.0200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0820
    Cell Significance Index: -0.9900
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0831
    Cell Significance Index: -0.9300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0832
    Cell Significance Index: -0.7900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0838
    Cell Significance Index: -0.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0870
    Cell Significance Index: -2.1700
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0899
    Cell Significance Index: -0.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0902
    Cell Significance Index: -4.7000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0915
    Cell Significance Index: -1.2200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0916
    Cell Significance Index: -0.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium-activated chloride channel regulator:** CLCA1 acts as a regulator of chloride channels, modulating their activity in response to calcium signaling. 2. **Ion transport:** CLCA1 is involved in chloride transport across cellular membranes, influencing the balance of ions and maintaining cellular homeostasis. 3. **Cellular localization:** CLCA1 is expressed in various cell types, including blood vessel endothelial cells, intestinal goblet cells, and GABAergic interneurons. 4. **Diversity of functions:** CLCA1's role extends beyond chloride transport, influencing cellular signaling, gene expression, and metal ion binding. **Pathways and Functions:** 1. **Calcium ion transport:** CLCA1 modulates calcium-activated chloride channel activity, influencing calcium signaling and cellular homeostasis. 2. **Chloride channel activity:** CLCA1 regulates the activity of chloride channels, controlling the transport of chloride ions across cellular membranes. 3. **Cellular response to hypoxia:** CLCA1 has been implicated in the cellular response to hypoxia, influencing gene expression and cellular adaptation. 4. **Extracellular region and plasma membrane:** CLCA1 is localized to the extracellular region and plasma membrane, where it regulates chloride transport and ion balance. 5. **Microvillus and zymogen granule membrane:** CLCA1 is also expressed in microvillus and zymogen granule membranes, where it influences cellular signaling and ion transport. **Clinical Significance:** 1. **Respiratory diseases:** CLCA1 dysregulation has been linked to respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. 2. **Gastrointestinal disorders:** CLCA1's role in chloride transport and ion balance makes it a potential target for gastrointestinal disorders, such as inflammatory bowel disease (IBD) and gastroesophageal reflux disease (GERD). 3. **Neurological disorders:** CLCA1's expression in GABAergic interneurons and its role in regulating chloride transport make it a potential target for neurological disorders, such as epilepsy and anxiety disorders. 4. **Cancer:** CLCA1's involvement in metal ion binding and proteolysis may also make it a potential target for cancer research, particularly in the context of metastasis and tumor growth. In conclusion, CLCA1 is a multifunctional protein with diverse roles in cellular regulation, ion transport, and signaling. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 880919068

Symbol: CLCA1_HUMAN

Name: Calcium-activated chloride channel regulator 1

UniProtKB Accession Codes:

A8K7I4 B2RAV5 O95151 Q5TDF4 Q9UNF6 Q9UPC6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9828122

Title: Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins.

PubMed ID: 9828122

DOI: 10.1006/geno.1998.5562

PubMed ID: 10437792

Title: Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea.

PubMed ID: 10437792

DOI: 10.1016/s0014-5793(99)00891-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 23112050

Title: Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.

PubMed ID: 23112050

DOI: 10.1074/jbc.m112.410282

PubMed ID: 11445004

Title: Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer.

PubMed ID: 11445004

DOI: 10.1089/10445490152122442

PubMed ID: 11956057

Title: Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway.

PubMed ID: 11956057

DOI: 10.1164/ajrccm.165.8.2107068

PubMed ID: 11842292

Title: A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.

PubMed ID: 11842292

DOI: 10.1067/mai.2002.121555

PubMed ID: 16012037

Title: Expression and distribution of ion transport mRNAs in human nasal mucosa and nasal polyps.

PubMed ID: 16012037

DOI: 10.1080/00016480510028519

PubMed ID: 15696080

Title: Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa.

PubMed ID: 15696080

DOI: 10.1016/j.jaci.2004.09.039

PubMed ID: 15919655

Title: hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels.

PubMed ID: 15919655

DOI: 10.1074/jbc.m504654200

PubMed ID: 16151054

Title: Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium.

PubMed ID: 16151054

DOI: 10.1165/rcmb.2004-0220rc

PubMed ID: 17622767

Title: Histamine induces MUC5AC expression via a hCLCA1 pathway.

PubMed ID: 17622767

DOI: 10.1159/000104419

Sequence Information:

  • Length: 914
  • Mass: 100226
  • Checksum: 8D8999E855822711
  • Sequence:
    • MGPFKSSVFI LILHLLEGAL SNSLIQLNNN GYEGIVVAID PNVPEDETLI QQIKDMVTQA 
SLYLLEATGK RFYFKNVAIL IPETWKTKAD YVRPKLETYK NADVLVAEST PPGNDEPYTE 
QMGNCGEKGE RIHLTPDFIA GKKLAEYGPQ GRAFVHEWAH LRWGVFDEYN NDEKFYLSNG 
RIQAVRCSAG ITGTNVVKKC QGGSCYTKRC TFNKVTGLYE KGCEFVLQSR QTEKASIMFA 
QHVDSIVEFC TEQNHNKEAP NKQNQKCNLR STWEVIRDSE DFKKTTPMTT QPPNPTFSLL 
QIGQRIVCLV LDKSGSMATG NRLNRLNQAG QLFLLQTVEL GSWVGMVTFD SAAHVQNELI 
QINSGSDRDT LAKRLPAAAS GGTSICSGLR SAFTVIRKKY PTDGSEIVLL TDGEDNTISG 
CFNEVKQSGA IIHTVALGPS AAQELEELSK MTGGLQTYAS DQVQNNGLID AFGALSSGNG 
AVSQRSIQLE SKGLTLQNSQ WMNGTVIVDS TVGKDTLFLI TWTMQPPQIL LWDPSGQKQG 
GFVVDKNTKM AYLQIPGIAK VGTWKYSLQA SSQTLTLTVT SRASNATLPP ITVTSKTNKD 
TSKFPSPLVV YANIRQGASP ILRASVTALI ESVNGKTVTL ELLDNGAGAD ATKDDGVYSR 
YFTTYDTNGR YSVKVRALGG VNAARRRVIP QQSGALYIPG WIENDEIQWN PPRPEINKDD 
VQHKQVCFSR TSSGGSFVAS DVPNAPIPDL FPPGQITDLK AEIHGGSLIN LTWTAPGDDY 
DHGTAHKYII RISTSILDLR DKFNESLQVN TTALIPKEAN SEEVFLFKPE NITFENGTDL 
FIAIQAVDKV DLKSEISNIA RVSLFIPPQT PPETPSPDET SAPCPNIHIN STIPGIHILK 
IMWKWIGELQ LSIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.