Genular: Defining Cellular Identity and Function

Details for: Apex1

Gene ID: 11792

Symbol: Apex1

Ensembl ID: ENSMUSG00000035960

Description: apurinic/apyrimidinic endonuclease 1

Associated with

Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
(R-MMU-73930)
Base excision repair
(R-MMU-73884)
Displacement of dna glycosylase by apex1
(R-MMU-110357)
Pcna-dependent long patch base excision repair
(R-MMU-5651801)
Polb-dependent long patch base excision repair
(R-MMU-110362)
Resolution of abasic sites (ap sites)
(R-MMU-73933)
Resolution of ap sites via the multiple-nucleotide patch replacement pathway
(R-MMU-110373)
Resolution of ap sites via the single-nucleotide replacement pathway
(R-MMU-110381)
3'-5'-dna exonuclease activity
(GO:0008296)
3'-5' exonuclease activity
(GO:0008408)
Base-excision repair
(GO:0006284)
Catalytic activity
(GO:0003824)
Cell redox homeostasis
(GO:0045454)
Cellular response to hydrogen peroxide
(GO:0070301)
Centrosome
(GO:0005813)
Chromatin dna binding
(GO:0031490)
Class ii dna-(apurinic or apyrimidinic site) endonuclease activity
(GO:0052720)
Cytoplasm
(GO:0005737)
Damaged dna binding
(GO:0003684)
Dna-(abasic site) binding
(GO:0140431)
Dna-(apurinic or apyrimidinic site) endonuclease activity
(GO:0003906)
Dna binding
(GO:0003677)
Dna catabolic process
(GO:0006308)
Dna damage response
(GO:0006974)
Dna demethylation
(GO:0080111)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Double-stranded dna 3'-5' dna exonuclease activity
(GO:0008311)
Double-stranded dna exodeoxyribonuclease activity
(GO:0008309)
Double-stranded telomeric dna binding
(GO:0003691)
Endonuclease activity
(GO:0004519)
Endoplasmic reticulum
(GO:0005783)
Exonuclease activity
(GO:0004527)
Hydrolase activity
(GO:0016787)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Negative regulation of smooth muscle cell migration
(GO:0014912)
Nf-kappab binding
(GO:0051059)
Nuclear speck
(GO:0016607)
Nuclease activity
(GO:0004518)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated dna strands
(GO:0090580)
Phosphoric diester hydrolase activity
(GO:0008081)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Regulation of apoptotic process
(GO:0042981)
Regulation of mrna stability
(GO:0043488)
Rna binding
(GO:0003723)
Rna endonuclease activity
(GO:0004521)
Site-specific endodeoxyribonuclease activity, specific for altered base
(GO:0016890)
Telomere maintenance
(GO:0000723)
Telomere maintenance via base-excision repair
(GO:0097698)
Transcription coactivator activity
(GO:0003713)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

DNA-(apurinic or apyrimidinic site) endonuclease

Genular Protein ID: 1947036670

Symbol: APEX1_MOUSE

Name: DNA-(apurinic or apyrimidinic site) endonuclease

UniProtKB Accession Codes:

P28352

Database IDs:

Citations:

PubMed ID: 1939131

Title: cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III.

PubMed ID: 1939131

DOI: 10.1016/s0021-9258(18)54779-7

PubMed ID: 7533013

Title: Genomic structure of the mouse apurinic/apyrimidinic endonuclease gene.

PubMed ID: 7533013

DOI: 10.1007/bf00426079

PubMed ID: 7782087

Title: Cloning, sequence analysis, and chromosomal assignment of the mouse Apex gene.

PubMed ID: 7782087

DOI: 10.1016/0888-7543(95)80083-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1716153

Title: A mouse DNA repair enzyme (APEX nuclease) having exonuclease and apurinic/apyrimidinic endonuclease activities: purification and characterization.

PubMed ID: 1716153

DOI: 10.1016/0167-4838(91)90024-t

PubMed ID: 16617147

Title: Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells.

PubMed ID: 16617147

DOI: 10.1093/nar/gkl177

PubMed ID: 18025127

Title: APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.

PubMed ID: 18025127

DOI: 10.1084/jem.20071289

PubMed ID: 19556307

Title: Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.

PubMed ID: 19556307

DOI: 10.1093/intimm/dxp061

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20473298

Title: The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death.

PubMed ID: 20473298

DOI: 10.1038/ncb2058

Sequence Information:

Length: 317
Mass: 35490
Checksum: CF086691FAC89C4A
Sequence:

MPKRGKKAAA DDGEEPKSEP ETKKSKGAAK KTEKEAAGEG PVLYEDPPDQ KTSPSGKSAT 
LKICSWNVDG LRAWIKKKGL DWVKEEAPDI LCLQETKCSE NKLPAELQEL PGLTHQYWSA 
PSDKEGYSGV GLLSRQCPLK VSYGIGEEEH DQEGRVIVAE FESFVLVTAY VPNAGRGLVR 
LEYRQRWDEA FRKFLKDLAS RKPLVLCGDL NVAHEEIDLR NPKGNKKNAG FTPQERQGFG 
ELLQAVPLAD SFRHLYPNTA YAYTFWTYMM NARSKNVGWR LDYFLLSHSL LPALCDSKIR 
SKALGSDHCP ITLYLAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Apex1

Associated with

Other Information

cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III. PubMed ID: 1939131

Genomic structure of the mouse apurinic/apyrimidinic endonuclease gene. PubMed ID: 7533013

Cloning, sequence analysis, and chromosomal assignment of the mouse Apex gene. PubMed ID: 7782087

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A mouse DNA repair enzyme (APEX nuclease) having exonuclease and apurinic/apyrimidinic endonuclease activities: purification and characterization. PubMed ID: 1716153

Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells. PubMed ID: 16617147

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. PubMed ID: 18025127

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. PubMed ID: 19556307

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death. PubMed ID: 20473298