Genular: Defining Cellular Identity and Function

Details for: Birc2

Gene ID: 11797

Symbol: Birc2

Ensembl ID: ENSMUSG00000057367

Description: baculoviral IAP repeat-containing 2

Associated with

Apoptosis
(R-MMU-109581)
Apoptotic cleavage of cellular proteins
(R-MMU-111465)
Apoptotic execution phase
(R-MMU-75153)
Cytokine signaling in immune system
(R-MMU-1280215)
Death receptor signaling
(R-MMU-73887)
Deubiquitination
(R-MMU-5688426)
Ikk complex recruitment mediated by rip1
(R-MMU-937041)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism of proteins
(R-MMU-392499)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Nod1/2 signaling pathway
(R-MMU-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-MMU-168643)
Post-translational protein modification
(R-MMU-597592)
Programmed cell death
(R-MMU-5357801)
Regulated necrosis
(R-MMU-5218859)
Regulation of necroptotic cell death
(R-MMU-5675482)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Ripk1-mediated regulated necrosis
(R-MMU-5213460)
Signal transduction
(R-MMU-162582)
Tnfr1-induced nf-kappa-b signaling pathway
(R-MMU-5357956)
Tnfr1-induced proapoptotic signaling
(R-MMU-5357786)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-MMU-5676594)
Tnf signaling
(R-MMU-75893)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Ub-specific processing proteases
(R-MMU-5689880)
Apoptotic process
(GO:0006915)
Cd40 receptor complex
(GO:0035631)
Cellular response to tumor necrosis factor
(GO:0071356)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Fbxo family protein binding
(GO:0098770)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Necroptotic process
(GO:0070266)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of necroptotic process
(GO:0060546)
Negative regulation of ripoptosome assembly involved in necroptotic process
(GO:1902443)
Nucleus
(GO:0005634)
Placenta development
(GO:0001890)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of protein k48-linked ubiquitination
(GO:1902524)
Positive regulation of protein k63-linked ubiquitination
(GO:1902523)
Positive regulation of protein monoubiquitination
(GO:1902527)
Positive regulation of protein polyubiquitination
(GO:1902916)
Positive regulation of protein ubiquitination
(GO:0031398)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein polyubiquitination
(GO:0000209)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell cycle
(GO:0051726)
Regulation of necroptotic process
(GO:0060544)
Regulation of non-canonical nf-kappab signal transduction
(GO:1901222)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Response to hypoxia
(GO:0001666)
Transcription coactivator activity
(GO:0003713)
Transferase activity
(GO:0016740)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase activity
(GO:0061630)
Xy body
(GO:0001741)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Baculoviral IAP repeat-containing protein 2

Genular Protein ID: 3253194401

Symbol: BIRC2_MOUSE

Name: Baculoviral IAP repeat-containing protein 2

UniProtKB Accession Codes:

Q62210 A6H6S7 O08864

Database IDs:

Citations:

PubMed ID: 8548810

Title: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.

PubMed ID: 8548810

DOI: 10.1016/0092-8674(95)90149-3

PubMed ID: 9441758

Title: Genomic characterization of the mouse inhibitor of apoptosis protein 1 and 2 genes.

PubMed ID: 9441758

DOI: 10.1006/geno.1997.5059

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18621737

Title: c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.

PubMed ID: 18621737

DOI: 10.1074/jbc.c800128200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

Length: 612
Mass: 69676
Checksum: E08969D93C6C610D
Sequence:

MDKTVSQRLG QGTLHQKLKR IMEKSTILSN WTKESEEKMK FDFSCELYRM STYSAFPRGV 
PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKQGDSPV EKHRQFYPSC SFVQTLLSAS 
LQSPSKNMSP VKSRFAHSSP LERGGIHSNL CSSPLNSRAV EDFSSRMDPC SYAMSTEEAR 
FLTYSMWPLS FLSPAELARA GFYYIGPGDR VACFACGGKL SNWEPKDDAM SEHRRHFPHC 
PFLENTSETQ RFSISNLSMQ THSARLRTFL YWPPSVPVQP EQLASAGFYY VDRNDDVKCF 
CCDGGLRCWE PGDDPWIEHA KWFPRCEFLI RMKGQEFVDE IQARYPHLLE QLLSTSDTPG 
EENADPTETV VHFGPGESSE DVVMMSTPVV KAALEMGFSR SLVRQTVQRQ ILATGENYRT 
VNDIVSVLLN AEDERREEEK ERQTEEMASG DLSLIRKNRM ALFQQLTHVL PILDNLLEAS 
VITKQEHDII RQKTQIPLQA RELIDTVLVK GNAAANIFKN SLKEIDSTLY ENLFVEKNMK 
YIPTEDVSGL SLEEQLRRLQ EERTCKVCMD REVSIVFIPC GHLVVCQECA PSLRKCPICR 
GTIKGTVRTF LS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Birc2

Associated with

Other Information

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. PubMed ID: 8548810

Genomic characterization of the mouse inhibitor of apoptosis protein 1 and 2 genes. PubMed ID: 9441758

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation. PubMed ID: 18621737

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079