Genular: Defining Cellular Identity and Function

Details for: Xiap

Gene ID: 11798

Symbol: Xiap

Ensembl ID: ENSMUSG00000025860

Description: X-linked inhibitor of apoptosis

Associated with

Activation of caspases through apoptosome-mediated cleavage
(R-MMU-111459)
Apoptosis
(R-MMU-109581)
Apoptotic factor-mediated response
(R-MMU-111471)
Cytochrome c-mediated apoptotic response
(R-MMU-111461)
Deactivation of the beta-catenin transactivating complex
(R-MMU-3769402)
Death receptor signaling
(R-MMU-73887)
Formation of apoptosome
(R-MMU-111458)
Intracellular signaling by second messengers
(R-MMU-9006925)
Intrinsic pathway for apoptosis
(R-MMU-109606)
Pip3 activates akt signaling
(R-MMU-1257604)
Programmed cell death
(R-MMU-5357801)
Pten regulation
(R-MMU-6807070)
Regulated necrosis
(R-MMU-5218859)
Regulation of necroptotic cell death
(R-MMU-5675482)
Regulation of pten localization
(R-MMU-8948747)
Regulation of pten stability and activity
(R-MMU-8948751)
Regulation of the apoptosome activity
(R-MMU-9627069)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Ripk1-mediated regulated necrosis
(R-MMU-5213460)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Smac(diablo)-mediated dissociation of iap:caspase complexes
(R-MMU-111464)
Smac (diablo) binds to iaps
(R-MMU-111463)
Smac, xiap-regulated apoptotic response
(R-MMU-111469)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Tnfr1-induced nf-kappa-b signaling pathway
(R-MMU-5357956)
Tnfr1-induced proapoptotic signaling
(R-MMU-5357786)
Tnf signaling
(R-MMU-75893)
Apoptotic process
(GO:0006915)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Cytoplasm
(GO:0005737)
Endopeptidase regulator activity
(GO:0061135)
Identical protein binding
(GO:0042802)
Inhibition of cysteine-type endopeptidase activity involved in apoptotic process
(GO:1990001)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Negative regulation of neuron apoptotic process
(GO:0043524)
Neuron apoptotic process
(GO:0051402)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of protein ubiquitination
(GO:0031398)
Protease binding
(GO:0002020)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein serine/threonine kinase binding
(GO:0120283)
Regulation of apoptosis involved in tissue homeostasis
(GO:0060785)
Regulation of cell cycle
(GO:0051726)
Scaffold protein binding
(GO:0097110)
Transferase activity
(GO:0016740)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

E3 ubiquitin-protein ligase XIAP

Genular Protein ID: 3374627194

Symbol: XIAP_MOUSE

Name: E3 ubiquitin-protein ligase XIAP

UniProtKB Accession Codes:

Q60989 A2BGY6 O08865

Database IDs:

Citations:

PubMed ID: 8643514

Title: Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

PubMed ID: 8643514

DOI: 10.1073/pnas.93.10.4974

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18761086

Title: XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2.

PubMed ID: 18761086

DOI: 10.1016/j.cellsig.2008.08.004

PubMed ID: 19473982

Title: X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization.

PubMed ID: 19473982

DOI: 10.1074/jbc.c109.009522

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23788729

Title: Sept4/ARTS regulates stem cell apoptosis and skin regeneration.

PubMed ID: 23788729

DOI: 10.1126/science.1233029

PubMed ID: 29452636

Title: Disruption of XIAP-RIP2 association blocks NOD2-mediated inflammatory signaling.

PubMed ID: 29452636

DOI: 10.1016/j.molcel.2018.01.016

PubMed ID: 30389919

Title: ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.

PubMed ID: 30389919

DOI: 10.1038/s41467-018-06941-4

Sequence Information:

Length: 496
Mass: 56079
Checksum: EE5D242D3C3DF12E
Sequence:

MTFNSFEGTR TFVLADTNKD EEFVEEFNRL KTFANFPSSS PVSASTLARA GFLYTGEGDT 
VQCFSCHAAI DRWQYGDSAV GRHRRISPNC RFINGFYFEN GAAQSTNPGI QNGQYKSENC 
VGNRNPFAPD RPPETHADYL LRTGQVVDIS DTIYPRNPAM CSEEARLKSF QNWPDYAHLT 
PRELASAGLY YTGADDQVQC FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNVNVRSE 
SGVSSDRNFP NSTNSPRNPA MAEYEARIVT FGTWTSSVNK EQLARAGFYA LGEGDKVKCF 
HCGGGLTDWK PSEDPWEQHA KWYPGCKYLL DEKGQEYINN IHLTHSLEES LGRTAEKTPS 
LTKKIDDTIF QNPMVQEAIR MGFSFKDIKK TMEEKIQTSG SSYLSLEVLI ADLVSAQKDN 
TEDESSQTSL QKDISTEEQL RRLQEEKLCK ICMDRNIAIV FVPCGHLVTC KQCAEAVDKC 
PMCYTVITFK QKIFMS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Xiap

Associated with

Other Information

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. PubMed ID: 8643514

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. PubMed ID: 18761086

X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization. PubMed ID: 19473982

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Sept4/ARTS regulates stem cell apoptosis and skin regeneration. PubMed ID: 23788729

Disruption of XIAP-RIP2 association blocks NOD2-mediated inflammatory signaling. PubMed ID: 29452636

ARTS mediates apoptosis and regeneration of the intestinal stem cell niche. PubMed ID: 30389919