Details for: ADD1

Gene ID: 118

Symbol: ADD1

Ensembl ID: ENSG00000087274

Description: adducin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.83
    Marker Score: 8073
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.68
    Marker Score: 57298
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.51
    Marker Score: 4838
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.48
    Marker Score: 1480
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.47
    Marker Score: 2355
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.46
    Marker Score: 733
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.26
    Marker Score: 2606
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.21
    Marker Score: 2759
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.2
    Marker Score: 74195
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.08
    Marker Score: 9637
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.08
    Marker Score: 41356
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.06
    Marker Score: 76082
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.04
    Marker Score: 77612
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.03
    Marker Score: 1188
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.01
    Marker Score: 1738
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.99
    Marker Score: 8292
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.96
    Marker Score: 29374
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.96
    Marker Score: 8131
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.95
    Marker Score: 4672
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.94
    Marker Score: 14849
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.92
    Marker Score: 2070
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.89
    Marker Score: 7324
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.89
    Marker Score: 115938
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.87
    Marker Score: 17595
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.86
    Marker Score: 2250
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.86
    Marker Score: 18806
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.84
    Marker Score: 4046
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.84
    Marker Score: 794
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.83
    Marker Score: 766
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.8
    Marker Score: 4581
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.79
    Marker Score: 18439
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.77
    Marker Score: 9276
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.77
    Marker Score: 16799
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.75
    Marker Score: 2358
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.75
    Marker Score: 2571
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.74
    Marker Score: 2532
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.74
    Marker Score: 14952
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.71
    Marker Score: 1480
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7
    Marker Score: 17127
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.7
    Marker Score: 6904
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.69
    Marker Score: 1115
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.69
    Marker Score: 2383
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.68
    Marker Score: 622
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.68
    Marker Score: 1857
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.67
    Marker Score: 1040.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.66
    Marker Score: 821
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.63
    Marker Score: 10628
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.61
    Marker Score: 1389
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.61
    Marker Score: 397
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.6
    Marker Score: 6714.5
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.6
    Marker Score: 663
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.6
    Marker Score: 834.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.59
    Marker Score: 366
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.59
    Marker Score: 5631
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.59
    Marker Score: 5870
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.58
    Marker Score: 1420
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.58
    Marker Score: 952
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.58
    Marker Score: 639
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.57
    Marker Score: 1663
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.56
    Marker Score: 1533
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.54
    Marker Score: 1415
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.54
    Marker Score: 1562
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.53
    Marker Score: 865
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.52
    Marker Score: 6351
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.52
    Marker Score: 363
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.52
    Marker Score: 1633
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.51
    Marker Score: 1950
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.5
    Marker Score: 26699
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.5
    Marker Score: 1619
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.49
    Marker Score: 873
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.48
    Marker Score: 2285
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.48
    Marker Score: 717
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.47
    Marker Score: 12930
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.47
    Marker Score: 732
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.47
    Marker Score: 2084
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.47
    Marker Score: 521
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.47
    Marker Score: 4003
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.46
    Marker Score: 3439
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.46
    Marker Score: 2023
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.46
    Marker Score: 371
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.46
    Marker Score: 849
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.45
    Marker Score: 423
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.45
    Marker Score: 1452
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.44
    Marker Score: 897
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.44
    Marker Score: 1297
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.42
    Marker Score: 783
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.42
    Marker Score: 3343
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.42
    Marker Score: 947
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.41
    Marker Score: 2822
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.41
    Marker Score: 386
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.41
    Marker Score: 22564
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.4
    Marker Score: 1734
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.4
    Marker Score: 487
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.4
    Marker Score: 722
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.39
    Marker Score: 949
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.39
    Marker Score: 1461
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.39
    Marker Score: 4770
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.38
    Marker Score: 500
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.37
    Marker Score: 1535
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.37
    Marker Score: 313

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Other Information

**Key characteristics:** * Type: Protein * Ensembl ID: ENSG00000087274 * Protein length: 117 amino acids * Domain: Cadherin-like domain * Subcellular location: Cytoplasm **Pathways and functions:** * **Actin binding:** ADD1 binds to the actin cytoskeleton, influencing cell migration, cell cycle regulation, and cell signaling. * **Apoptotic cleavage of cellular proteins:** It is involved in apoptosis, where it acts as a death receptor for caspases and triggers the activation of caspases that lead to cell death. * **Apoptotic execution phase:** ADD1 is also involved in the apoptotic execution phase, where caspases cleave specific proteins involved in cell death. * **Cadherin binding:** It interacts with cadherins, which are cell adhesion molecules, and modulates cell-cell interactions. * **Calmodulin binding:** ADD1 can bind to calmodulin, which is a calcium-binding protein, and regulate its activity. * **Caspase-mediated cleavage of cytoskeletal proteins:** ADD1 is a substrate for caspases, which are enzymes that cleave specific proteins involved in cell death. * **Cellular responses to stimuli:** ADD1 is involved in various cellular responses to stimuli, such as growth, differentiation, and migration. * **Cellular responses to stress:** It also plays a role in cellular responses to stress, such as heat shock and ischemia. * **Ire1alpha activates chaperones:** ADD1 interacts with Ire1alpha, a protein that activates chaperones, which are proteins that bind to misfolded or damaged proteins and facilitate their folding and trafficking to the lysosome for degradation. **Clinical significance:** * Mutations in the ADD1 gene have been linked to various eye diseases, including retinitis pigmentosa and age-related macular degeneration. * Studies have shown that targeting ADD1 can inhibit cell death and promote the survival of retinal rod cells in animal models of retinal diseases. * Therefore, ADD1 is a potential therapeutic target for eye diseases characterized by retinal cell loss.

Genular Protein ID: 3457601786

Symbol: ADDA_HUMAN

Name: Alpha-adducin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1840603

Title: Primary structure and domain organization of human alpha and beta adducin.

PubMed ID: 1840603

DOI: 10.1083/jcb.115.3.665

PubMed ID: 1284592

Title: Cloning and mapping of the alpha-adducin gene close to D4S95 and assessment of its relationship to Huntington disease.

PubMed ID: 1284592

DOI: 10.1093/hmg/1.9.669

PubMed ID: 7774961

Title: Genomic organization of the human alpha-adducin gene and its alternately spliced isoforms.

PubMed ID: 7774961

DOI: 10.1016/0888-7543(95)80113-z

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1345173

Title: Cloning of the alpha-adducin gene from the Huntington's disease candidate region of chromosome 4 by exon amplification.

PubMed ID: 1345173

DOI: 10.1038/ng1192-223

PubMed ID: 8810272

Title: Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.

PubMed ID: 8810272

DOI: 10.1074/jbc.271.41.25157

PubMed ID: 10209029

Title: Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.

PubMed ID: 10209029

DOI: 10.1083/jcb.145.2.347

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9674650

Title: Human alpha-adducin gene, blood pressure, and sodium metabolism.

PubMed ID: 9674650

DOI: 10.1161/01.hyp.32.1.138

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

Sequence Information:

  • Length: 737
  • Mass: 80955
  • Checksum: DF13AB30B12F20B6
  • Sequence:
  • MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM 
    ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS 
    LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF 
    LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI 
    HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR 
    NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV 
    GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS 
    FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KWTKEDGHRT 
    STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT 
    ASKAIIEKEY QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS 
    PPDQPAVPHP PPSTPIKLEE DLVPEPTTGD DSDAATFKPT LPDLSPDEPS EALGFPMLEK 
    EEEAHRPPSP TEAPTEASPE PAPDPAPVAE EAAPSAVEEG AAADPGSDGS PGKSPSKKKK 
    KFRTPSFLKK SKKKSDS

Genular Protein ID: 1858454274

Symbol: A0A804HL01_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 799
  • Mass: 87700
  • Checksum: 30E40C295B5F2E83
  • Sequence:
  • MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM 
    ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS 
    LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF 
    LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI 
    HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR 
    NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV 
    GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS 
    FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KVWTNITHDH 
    VKPLLQSLSS GVCVPSCITN CLWTKEDGHR TSTSAVPNLF VPLNTNPKEV QEMRNKIREQ 
    NLQDIKTAGP QSQVLCGVVM DRSLVQDAPL SDCTETIEGL ELTEQTFSPA KSLSFRKGEL 
    VTASKAIIEK EYQPHVIVST TGPNPFTTLT DRELEEYRRE VERKQKGSEE NLDEAREQKE 
    KSPPDQPAVP HPPPSTPIKL EEDLVPEPTT GDDSDAATFK PTLPDLSPDE PSEALGFPML 
    EKEEEAHRPP SPTEAPTEAS PEPAPDPAPV AEEAAPSAVE EGAAADPGSD GSPGKSPSKK 
    KKKFRTPSFL KKSKKKSDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.