Details for: Cd5l

Gene ID: 11801

Symbol: Cd5l

Ensembl ID: ENSMUSG00000015854

Description: CD5 antigen-like

Associated with

Other Information

Genular Protein ID: 270949868

Symbol: CD5L_MOUSE

Name: CD5 antigen-like

UniProtKB Accession Codes:

Q9QWK4 O35300 O35301 Q3TXN5 Q505P6 Q91W05

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CPTAC 2 CTD 1 DNASU 1 EMBL 8 Ensembl 1 GO 11 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10651944

Title: Molecular cloning, genomic organization and cell-binding characteristics of mouse Spalpha.

PubMed ID: 10651944

DOI: 10.1046/j.1365-2567.2000.00903.x

PubMed ID: 9892623

Title: Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily.

PubMed ID: 9892623

DOI: 10.1084/jem.189.2.413

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16054063

Title: A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.

PubMed ID: 16054063

DOI: 10.1016/j.cmet.2005.02.002

PubMed ID: 20519120

Title: Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.

PubMed ID: 20519120

DOI: 10.1016/j.cmet.2010.04.013

PubMed ID: 21730133

Title: Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue.

PubMed ID: 21730133

DOI: 10.1073/pnas.1101841108

PubMed ID: 22579686

Title: Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes.

PubMed ID: 22579686

DOI: 10.1016/j.bbrc.2012.05.018

PubMed ID: 23236605

Title: Modification of N-glycosylation modulates the secretion and lipolytic function of apoptosis inhibitor of macrophage (AIM).

PubMed ID: 23236605

DOI: 10.1016/j.febslet.2012.08.017

PubMed ID: 23562157

Title: Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells.

PubMed ID: 23562157

DOI: 10.1016/j.celrep.2013.03.006

PubMed ID: 26607794

Title: Single-cell genomics unveils critical regulators of Th17 cell pathogenicity.

PubMed ID: 26607794

DOI: 10.1016/j.cell.2015.11.009

PubMed ID: 26607793

Title: CD5L/AIM regulates lipid biosynthesis and restrains Th17 cell pathogenicity.

PubMed ID: 26607793

DOI: 10.1016/j.cell.2015.10.068

PubMed ID: 26048980

Title: AIM/CD5L: a key protein in the control of immune homeostasis and inflammatory disease.

PubMed ID: 26048980

DOI: 10.1189/jlb.3ru0215-074r

PubMed ID: 30324136

Title: The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein.

PubMed ID: 30324136

DOI: 10.1126/sciadv.aau1199

Sequence Information:

  • Length: 352
  • Mass: 38863
  • Checksum: 41596AA8012E1AEE
  • Sequence:
    • MAPLFNLMLA ILSIFVGSCF SESPTKVQLV GGAHRCEGRV EVEHNGQWGT VCDDGWDRRD 
VAVVCRELNC GAVIQTPRGA SYQPPASEQR VLIQGVDCNG TEDTLAQCEL NYDVFDCSHE 
EDAGAQCENP DSDLLFIPED VRLVDGPGHC QGRVEVLHQS QWSTVCKAGW NLQVSKVVCR 
QLGCGRALLT YGSCNKNTQG KGPIWMGKMS CSGQEANLRS CLLSRLENNC THGEDTWMEC 
EDPFELKLVG GDTPCSGRLE VLHKGSWGSV CDDNWGEKED QVVCKQLGCG KSLHPSPKTR 
KIYGPGAGRI WLDDVNCSGK EQSLEFCRHR LWGYHDCTHK EDVEVICTDF DV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.