Genular: Defining Cellular Identity and Function

Details for: Apoe

Gene ID: 11816

Symbol: Apoe

Ensembl ID: ENSMUSG00000002985

Description: apolipoprotein E

Associated with

Binding and uptake of ligands by scavenger receptors
(R-MMU-2173782)
Chylomicron assembly
(R-MMU-8963888)
Chylomicron clearance
(R-MMU-8964026)
Chylomicron remodeling
(R-MMU-8963901)
Hdl remodeling
(R-MMU-8964058)
Metabolism
(R-MMU-1430728)
Metabolism of fat-soluble vitamins
(R-MMU-6806667)
Metabolism of proteins
(R-MMU-392499)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Plasma lipoprotein assembly
(R-MMU-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plasma lipoprotein clearance
(R-MMU-8964043)
Plasma lipoprotein remodeling
(R-MMU-8963899)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Retinoid metabolism and transport
(R-MMU-975634)
Scavenging by class a receptors
(R-MMU-3000480)
Sensory perception
(R-MMU-9709957)
Transport of small molecules
(R-MMU-382551)
Vesicle-mediated transport
(R-MMU-5653656)
Visual phototransduction
(R-MMU-2187338)
Amyloid-beta binding
(GO:0001540)
Antioxidant activity
(GO:0016209)
Axon regeneration
(GO:0031103)
Cgmp-mediated signaling
(GO:0019934)
Cholesterol catabolic process
(GO:0006707)
Cholesterol efflux
(GO:0033344)
Cholesterol metabolic process
(GO:0008203)
Cholesterol transfer activity
(GO:0120020)
Chylomicron remnant clearance
(GO:0034382)
Enzyme binding
(GO:0019899)
Gene expression
(GO:0010467)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heparan sulfate proteoglycan binding
(GO:0043395)
Heparin binding
(GO:0008201)
High-density lipoprotein particle assembly
(GO:0034380)
High-density lipoprotein particle clearance
(GO:0034384)
High-density lipoprotein particle remodeling
(GO:0034375)
Hydroxyapatite binding
(GO:0046848)
Identical protein binding
(GO:0042802)
Intracellular calcium ion homeostasis
(GO:0006874)
Lipid binding
(GO:0008289)
Lipid metabolic process
(GO:0006629)
Lipid transport
(GO:0006869)
Lipid transporter activity
(GO:0005319)
Lipid transport involved in lipid storage
(GO:0010877)
Lipoprotein metabolic process
(GO:0042157)
Lipoprotein particle binding
(GO:0071813)
Locomotory exploration behavior
(GO:0035641)
Long-chain fatty acid transport
(GO:0015909)
Long-term memory
(GO:0007616)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Low-density lipoprotein particle remodeling
(GO:0034374)
Melanosome organization
(GO:0032438)
Metal chelating activity
(GO:0046911)
Negative regulation of blood coagulation
(GO:0030195)
Negative regulation of endothelial cell migration
(GO:0010596)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of platelet activation
(GO:0010544)
Neuron projection development
(GO:0031175)
Nitric oxide mediated signal transduction
(GO:0007263)
Phosphatidylcholine-sterol o-acyltransferase activator activity
(GO:0060228)
Phospholipid binding
(GO:0005543)
Phospholipid efflux
(GO:0033700)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of low-density lipoprotein particle receptor catabolic process
(GO:0032805)
Positive regulation of neuron projection development
(GO:0010976)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein homodimerization activity
(GO:0042803)
Protein import
(GO:0017038)
Protein localization
(GO:0008104)
Receptor-mediated endocytosis
(GO:0006898)
Regulation of cdc42 protein signal transduction
(GO:0032489)
Regulation of gene expression
(GO:0010468)
Response to dietary excess
(GO:0002021)
Response to oxidative stress
(GO:0006979)
Signaling receptor binding
(GO:0005102)
Tau protein binding
(GO:0048156)
Triglyceride metabolic process
(GO:0006641)
Very-low-density lipoprotein particle clearance
(GO:0034447)
Very-low-density lipoprotein particle receptor binding
(GO:0070326)
Very-low-density lipoprotein particle remodeling
(GO:0034372)
Virion assembly
(GO:0019068)

Other Information

Proteins

Apolipoprotein E

Genular Protein ID: 3649156902

Symbol: APOE_MOUSE

Name: Apolipoprotein E

UniProtKB Accession Codes:

P08226

Database IDs:

Citations:

PubMed ID: 2550421

Title: Structure and expression of mouse apolipoprotein E gene.

PubMed ID: 2550421

DOI: 10.1093/oxfordjournals.jbchem.a122828

PubMed ID: 3865219

Title: Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit.

PubMed ID: 3865219

DOI: 10.1073/pnas.82.23.8085

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1870200

Title: Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes.

PubMed ID: 1870200

DOI: 10.1128/jvi.65.9.4759-4768.1991

PubMed ID: 16876491

Title: Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications.

PubMed ID: 16876491

DOI: 10.1016/j.bbapap.2006.06.001

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 1423598

Title: Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.

PubMed ID: 1423598

DOI: 10.1016/0092-8674(92)90362-g

PubMed ID: 12569158

Title: Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis.

PubMed ID: 12569158

DOI: 10.1172/jci15555

PubMed ID: 20037584

Title: CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

PubMed ID: 20037584

DOI: 10.1038/ni.1836

PubMed ID: 23676495

Title: Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans.

PubMed ID: 23676495

DOI: 10.1172/jci67398

PubMed ID: 23812099

Title: CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.

PubMed ID: 23812099

DOI: 10.1038/ni.2639

PubMed ID: 26387950

Title: Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells.

PubMed ID: 26387950

DOI: 10.1016/j.celrep.2015.08.057

PubMed ID: 29516132

Title: Cell-specific production, secretion, and function of apolipoprotein E.

PubMed ID: 29516132

DOI: 10.1007/s00109-018-1632-y

Sequence Information:

Length: 311
Mass: 35867
Checksum: 3B36FA897CC34170
Sequence:

MKALWAVLLV TLLTGCLAEG EPEVTDQLEW QSNQPWEQAL NRFWDYLRWV QTLSDQVQEE 
LQSSQVTQEL TALMEDTMTE VKAYKKELEE QLGPVAEETR ARLGKEVQAA QARLGADMED 
LRNRLGQYRN EVHTMLGQST EEIRARLSTH LRKMRKRLMR DAEDLQKRLA VYKAGAREGA 
ERGVSAIRER LGPLVEQGRQ RTANLGAGAA QPLRDRAQAF GDRIRGRLEE VGNQARDRLE 
EVREHMEEVR SKMEEQTQQI RLQAEIFQAR LKGWFEPIVE DMHRQWANLM EKIQASVATN 
PIITPVAQEN Q

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Apoe

Associated with

Other Information

Structure and expression of mouse apolipoprotein E gene. PubMed ID: 2550421

Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit. PubMed ID: 3865219

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes. PubMed ID: 1870200

Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications. PubMed ID: 16876491

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. PubMed ID: 1423598

Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis. PubMed ID: 12569158

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. PubMed ID: 20037584

Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. PubMed ID: 23676495

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. PubMed ID: 23812099

Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells. PubMed ID: 26387950

Cell-specific production, secretion, and function of apolipoprotein E. PubMed ID: 29516132