Details for: CLCN3

Gene ID: 1182

Symbol: CLCN3

Ensembl ID: ENSG00000109572

Description: chloride voltage-gated channel 3

Associated with

Other Information

Genular Protein ID: 1603048291

Symbol: CLCN3_HUMAN

Name: H(+)/Cl(-) exchange transporter 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7665160

Title: Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein.

PubMed ID: 7665160

DOI: 10.1006/geno.1995.1015

PubMed ID: 9678416

Title: Ion transporters and receptors in cDNA libraries from lens and cornea epithelia.

PubMed ID: 9678416

DOI: 10.1080/02713689808951247

PubMed ID: 11274166

Title: Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase.

PubMed ID: 11274166

DOI: 10.1074/jbc.m009376200

PubMed ID: 11967229

Title: ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC.

PubMed ID: 11967229

DOI: 10.1096/fj.01-0845fje

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10198195

Title: Expression of CLCN voltage-gated chloride channel genes in human blood vessels.

PubMed ID: 10198195

DOI: 10.1006/jmcc.1998.0901

PubMed ID: 12471024

Title: The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins.

PubMed ID: 12471024

DOI: 10.1074/jbc.m211050200

PubMed ID: 29845874

Title: CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease.

PubMed ID: 29845874

DOI: 10.1152/physrev.00047.2017

PubMed ID: 34186028

Title: Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders.

PubMed ID: 34186028

DOI: 10.1016/j.ajhg.2021.06.003

Sequence Information:

  • Length: 818
  • Mass: 90966
  • Checksum: 30FF0A6A2D6EF3B8
  • Sequence:
  • MESEQLFHRG YYRNSYNSIT SASSDEELLD GAGVIMDFQT SEDDNLLDGD TAVGTHYTMT 
    NGGSINSSTH LLDLLDEPIP GVGTYDDFHT IDWVREKCKD RERHRRINSK KKESAWEMTK 
    SLYDAWSGWL VVTLTGLASG ALAGLIDIAA DWMTDLKEGI CLSALWYNHE QCCWGSNETT 
    FEERDKCPQW KTWAELIIGQ AEGPGSYIMN YIMYIFWALS FAFLAVSLVK VFAPYACGSG 
    IPEIKTILSG FIIRGYLGKW TLMIKTITLV LAVASGLSLG KEGPLVHVAC CCGNIFSYLF 
    PKYSTNEAKK REVLSAASAA GVSVAFGAPI GGVLFSLEEV SYYFPLKTLW RSFFAALVAA 
    FVLRSINPFG NSRLVLFYVE YHTPWYLFEL FPFILLGVFG GLWGAFFIRA NIAWCRRRKS 
    TKFGKYPVLE VIIVAAITAV IAFPNPYTRL NTSELIKELF TDCGPLESSS LCDYRNDMNA 
    SKIVDDIPDR PAGIGVYSAI WQLCLALIFK IIMTVFTFGI KVPSGLFIPS MAIGAIAGRI 
    VGIAVEQLAY YHHDWFIFKE WCEVGADCIT PGLYAMVGAA ACLGGVTRMT VSLVVIVFEL 
    TGGLEYIVPL MAAVMTSKWV GDAFGREGIY EAHIRLNGYP FLDAKEEFTH TTLAADVMRP 
    RRNDPPLAVL TQDNMTVDDI ENMINETSYN GFPVIMSKES QRLVGFALRR DLTIAIESAR 
    KKQEGIVGSS RVCFAQHTPS LPAESPRPLK LRSILDMSPF TVTDHTPMEI VVDIFRKLGL 
    RQCLVTHNGR LLGIITKKDI LRHMAQTANQ DPASIMFN

Genular Protein ID: 2768621752

Symbol: B3KXK0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 725
  • Mass: 80529
  • Checksum: 3BB035171445CF06
  • Sequence:
  • MDASSDPYLP YDGGGDNIPL RELHKRGTHY TMTNGGSINS STHLLDLLDE PIPGVGTYDD 
    FHTIDWVREK CKDRERHRRI NSKKKESAWE MTKSLYDAWS GWLVVTLTGL ASGALAGLID 
    IAADWMTDLK EGICLSALWY NHEQCCWGSN ETTFEERDKC PQWKTWAELI IGQAEGPGSY 
    IMNYIMYIFW ALSFAFLAVS LVKVFAPYAC GSGIPEIKTI LSGFIIRGYL GKWTLMIKTI 
    TLVLAVASGL SLGKEGPLVH VACCCGNIFS YLFPKYSTNE AKKREVLSAA SAAGVSVAFG 
    APIGGVLFSL EEVSYYFPLK TLWRSFFAAL VAAFVLRSIN PFGNSRLVLF YVEYHTPWYL 
    FELFPFILLG VFGGLWGAFF IRANIAWCRR RKSTKFGKYP VLEVIIVAAI TAVIAFPNPY 
    TRLNTSELIK ELFTDCGPLE SSSLCDYRND MNASKIVDDI PDRPAGIGVY SAIWQLCLAL 
    IFKIIMTVFT FGIKVPSGLF IPSMAIGAIA GRIVGIAVEQ LAYYHHDWFI FKEWCEVGAD 
    CITPGLYAMV GAAACLGGVT RMTVSLVVIV FELTGGLEYI VPLMAAVMTS KWVGDAFGRE 
    GIYEAHIRLN GYPFLDAKEE FTHTTLAADV MRPRRNDPPL AVLTQDNMTV DDIENMINET 
    SYNGFPVIMS KESQRLVGFA LRRDLTIAIE SARKKQEGIV GSSRVCFAQH TPSLPAESPR 
    PLKLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.