Genular: Defining Cellular Identity and Function

Details for: Ar

Gene ID: 11835

Symbol: Ar

Ensembl ID: ENSMUSG00000046532

Description: androgen receptor

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-MMU-5625886)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Deubiquitination
(R-MMU-5688426)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-MMU-3371497)
Metabolism of proteins
(R-MMU-392499)
Nuclear receptor transcription pathway
(R-MMU-383280)
Post-translational protein modification
(R-MMU-597592)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate pkns
(R-MMU-5625740)
Rna polymerase ii transcription
(R-MMU-73857)
Runx2 regulates bone development
(R-MMU-8941326)
Runx2 regulates osteoblast differentiation
(R-MMU-8940973)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Transcriptional regulation by runx2
(R-MMU-8878166)
Ub-specific processing proteases
(R-MMU-5689880)
Androgen binding
(GO:0005497)
Androgen receptor signaling pathway
(GO:0030521)
Atpase binding
(GO:0051117)
Beta-catenin binding
(GO:0008013)
Chromatin binding
(GO:0003682)
Copulation
(GO:0007620)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
Epithelial cell morphogenesis
(GO:0003382)
Estrogen response element binding
(GO:0034056)
Fertilization
(GO:0009566)
Intracellular estrogen receptor signaling pathway
(GO:0030520)
Intracellular receptor signaling pathway
(GO:0030522)
Intracellular steroid hormone receptor signaling pathway
(GO:0030518)
In utero embryonic development
(GO:0001701)
Leydig cell differentiation
(GO:0033327)
Lipid binding
(GO:0008289)
Male courtship behavior
(GO:0008049)
Male gonad development
(GO:0008584)
Male somatic sex determination
(GO:0019102)
Mapk cascade
(GO:0000165)
Metal ion binding
(GO:0046872)
Molecular adaptor activity
(GO:0060090)
Multicellular organism growth
(GO:0035264)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of integrin biosynthetic process
(GO:0045720)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear androgen receptor binding
(GO:0050681)
Nuclear receptor activity
(GO:0004879)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of insulin-like growth factor receptor signaling pathway
(GO:0043568)
Positive regulation of integrin biosynthetic process
(GO:0045726)
Positive regulation of intracellular estrogen receptor signaling pathway
(GO:0033148)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Pou domain binding
(GO:0070974)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of systemic arterial blood pressure
(GO:0003073)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Reproductive behavior
(GO:0019098)
Ribonucleotide binding
(GO:0032553)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii general transcription initiation factor binding
(GO:0001091)
Sequence-specific dna binding
(GO:0043565)
Signaling receptor binding
(GO:0005102)
Single fertilization
(GO:0007338)
Skeletal muscle hypertrophy
(GO:0014734)
Spermatogenesis
(GO:0007283)
Steroid binding
(GO:0005496)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Androgen receptor

Genular Protein ID: 3486421433

Symbol: ANDR_MOUSE

Name: Androgen receptor

UniProtKB Accession Codes:

P19091

Database IDs:

Citations:

PubMed ID: 2403358

Title: Molecular cloning of androgen receptors from divergent species with a polymerase chain reaction technique: complete cDNA sequence of the mouse androgen receptor and isolation of androgen receptor cDNA probes from dog, guinea pig and clawed frog.

PubMed ID: 2403358

DOI: 10.1016/0006-291x(90)91202-4

PubMed ID: 2178222

Title: Structure and size distribution of the androgen receptor mRNA in wild-type and Tfm/Y mutant mice.

PubMed ID: 2178222

DOI: 10.1210/mend-4-10-1600

PubMed ID: 1883336

Title: The mouse androgen receptor. Functional analysis of the protein and characterization of the gene.

PubMed ID: 1883336

DOI: 10.1042/bj2780269

PubMed ID: 1681426

Title: A frameshift mutation destabilizes androgen receptor messenger RNA in the Tfm mouse.

PubMed ID: 1681426

DOI: 10.1210/mend-5-4-573

PubMed ID: 12058073

Title: Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription.

PubMed ID: 12058073

DOI: 10.1091/mbc.01-10-0484

PubMed ID: 15199138

Title: Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4.

PubMed ID: 15199138

DOI: 10.1128/mcb.24.13.5821-5834.2004

PubMed ID: 15882980

Title: A zinc finger protein TZF is a novel corepressor of androgen receptor.

PubMed ID: 15882980

DOI: 10.1016/j.bbrc.2005.04.024

PubMed ID: 15988012

Title: GAC63, a GRIP1-dependent nuclear receptor coactivator.

PubMed ID: 15988012

DOI: 10.1128/mcb.25.14.5965-5972.2005

PubMed ID: 16446156

Title: Opposite effects of alternative TZF spliced variants on androgen receptor.

PubMed ID: 16446156

DOI: 10.1016/j.bbrc.2005.12.213

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 23487765

Title: ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways.

PubMed ID: 23487765

DOI: 10.1073/pnas.1218318110

PubMed ID: 28751364

Title: Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.

PubMed ID: 28751364

DOI: 10.1073/pnas.1704955114

PubMed ID: 17911242

Title: A surface on the androgen receptor that allosterically regulates coactivator binding.

PubMed ID: 17911242

DOI: 10.1073/pnas.0708036104

Sequence Information:

Length: 899
Mass: 98194
Checksum: FD9EE07C07F7A568
Sequence:

MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REAIQNPGPR HPEAANIAPP GACLQQRQET 
SPRRRRRQQH TEDGSPQAHI RGPTGYLALE EEQQPSQQQA ASEGHPESSC LPEPGAATAP 
GKGLPQQPPA PPDQDDSAAP STLSLLGPTF PGLSSCSADI KDILNEAGTM QLLQQQQQQQ 
QHQQQHQQHQ QQQEVISEGS SARAREATGA PSSSKDSYLG GNSTISDSAK ELCKAVSVSM 
GLGVEALEHL SPGEQLRGDC MYASLLGGPP AVRPTPCAPL PECKGLPLDE GPGKSTEETA 
EYSSFKGGYA KGLEGESLGC SGSSEAGSSG TLEIPSSLSL YKSGALDEAA AYQNRDYYNF 
PLALSGPPHP PPPTHPHARI KLENPLDYGS AWAAAAAQCR YGDLGSLHGG SVAGPSTGSP 
PATTSSSWHT LFTAEEGQLY GPGGGGGSSS PSDAGPVAPY GYTRPPQGLT SQESDYSASE 
VWYPGGVVNR VPYPSPNCVK SEMGPWMENY SGPYGDMRLD STRDHVLPID YYFPPQKTCL 
ICGDEASGCH YGALTCGSCK VFFKRAAEGK QKYLCASRND CTIDKFRRKN CPSCRLRKCY 
EAGMTLGARK LKKLGNLKLQ EEGENSNAGS PTEDPSQKMT VSHIEGYECQ PIFLNVLEAI 
EPGVVCAGHD NNQPDSFAAL LSSLNELGER QLVHVVKWAK ALPGFRNLHV DDQMAVIQYS 
WMGLMVFAMG WRSFTNVNSR MLYFAPDLVF NEYRMHKSRM YSQCVRMRHL SQEFGWLQIT 
PQEFLCMKAL LLFSIIPVDG LKNQKFFDEL RMNYIKELDR IIACKRKNPT SCSRRFYQLT 
KLLDSVQPIA RELHQFTFDL LIKSHMVSVD FPEMMAEIIS VQVPKILSGK VKPIYFHTQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ar

Associated with

Other Information

Molecular cloning of androgen receptors from divergent species with a polymerase chain reaction technique: complete cDNA sequence of the mouse androgen receptor and isolation of androgen receptor cDNA probes from dog, guinea pig and clawed frog. PubMed ID: 2403358

Structure and size distribution of the androgen receptor mRNA in wild-type and Tfm/Y mutant mice. PubMed ID: 2178222

The mouse androgen receptor. Functional analysis of the protein and characterization of the gene. PubMed ID: 1883336

A frameshift mutation destabilizes androgen receptor messenger RNA in the Tfm mouse. PubMed ID: 1681426

Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. PubMed ID: 12058073

Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. PubMed ID: 15199138

A zinc finger protein TZF is a novel corepressor of androgen receptor. PubMed ID: 15882980

GAC63, a GRIP1-dependent nuclear receptor coactivator. PubMed ID: 15988012

Opposite effects of alternative TZF spliced variants on androgen receptor. PubMed ID: 16446156

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. PubMed ID: 22170608

ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways. PubMed ID: 23487765

Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. PubMed ID: 28751364

A surface on the androgen receptor that allosterically regulates coactivator binding. PubMed ID: 17911242