Details for: Arc

Gene ID: 11838

Symbol: Arc

Ensembl ID: ENSMUSG00000022602

Description: activity regulated cytoskeletal-associated protein

Associated with

Other Information

Genular Protein ID: 2867934279

Symbol: ARC_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11466419

Title: Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation.

PubMed ID: 11466419

DOI: 10.1523/jneurosci.21-15-05484.2001

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10727859

Title: Activity-regulated, cytoskeleton-associated protein (Arc) is essential for visceral endoderm organization during early embryogenesis.

PubMed ID: 10727859

DOI: 10.1016/s0925-4773(99)00340-8

PubMed ID: 12493697

Title: Developmental association of the synaptic activity-regulated protein arc with the mouse acrosomal organelle and the sperm tail.

PubMed ID: 12493697

DOI: 10.1095/biolreprod.102.004143

PubMed ID: 17088210

Title: Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

PubMed ID: 17088210

DOI: 10.1016/j.neuron.2006.08.024

PubMed ID: 17088213

Title: Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA Receptors.

PubMed ID: 17088213

DOI: 10.1016/j.neuron.2006.08.034

PubMed ID: 19116276

Title: Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons.

PubMed ID: 19116276

DOI: 10.1073/pnas.0806518106

PubMed ID: 20211139

Title: The Angelman syndrome protein Ube3A regulates synapse development by ubiquitinating Arc.

PubMed ID: 20211139

DOI: 10.1016/j.cell.2010.01.026

PubMed ID: 22036569

Title: Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent beta-amyloid generation.

PubMed ID: 22036569

DOI: 10.1016/j.cell.2011.09.036

PubMed ID: 24094104

Title: Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression.

PubMed ID: 24094104

DOI: 10.1016/j.neuron.2013.07.020

PubMed ID: 20228806

Title: Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation.

PubMed ID: 20228806

DOI: 10.1038/nn.2508

PubMed ID: 23791196

Title: Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.

PubMed ID: 23791196

DOI: 10.1016/j.neuron.2013.04.036

PubMed ID: 27524619

Title: Genetic disruption of Arc/Arg3.1 in mice causes alterations in dopamine and neurobehavioral phenotypes related to schizophrenia.

PubMed ID: 27524619

DOI: 10.1016/j.celrep.2016.07.044

PubMed ID: 27038743

Title: Effects of Arc/Arg3.1 gene deletion on rhythmic synchronization of hippocampal CA1 neurons during locomotor activity and sleep.

PubMed ID: 27038743

DOI: 10.1016/j.nlm.2016.03.021

PubMed ID: 28783680

Title: Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation.

PubMed ID: 28783680

DOI: 10.1126/sciimmunol.aaf8665

PubMed ID: 29264923

Title: Palmitoylation and membrane binding of Arc/Arg3.1: a potential role in synaptic depression.

PubMed ID: 29264923

DOI: 10.1021/acs.biochem.7b00959

PubMed ID: 31151856

Title: Arc oligomerization is regulated by CaMKII phosphorylation of the GAG domain: an essential mechanism for plasticity and memory formation.

PubMed ID: 31151856

DOI: 10.1016/j.molcel.2019.05.004

Sequence Information:

  • Length: 396
  • Mass: 45321
  • Checksum: F4D3505FD477D18A
  • Sequence:
  • MELDHMTTGG LHAYPAPRGG PAAKPNVILQ IGKCRAEMLE HVRRTHRHLL TEVSKQVERE 
    LKGLHRSVGK LENNLDGYVP TGDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF 
    YRLERWADRL ESMGGKYPVG SEPARHTVSV GVGGPEPYCQ EADGYDYTVS PYAITPPPAA 
    GELPEQESVE AQQYQSWGPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS 
    QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELEL PQKQGEPLDQ 
    FLWRKRDLYQ TLYVDAEEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ RGMEVQDGLE 
    QAAEPSGTPL PTEDETEALT PALTSESVAS DRTQPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.