Details for: CLCN5

Gene ID: 1184

Symbol: CLCN5

Ensembl ID: ENSG00000171365

Description: chloride voltage-gated channel 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 107.1714
    Cell Significance Index: -16.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.8315
    Cell Significance Index: -17.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.9056
    Cell Significance Index: -17.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.4236
    Cell Significance Index: -11.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.8381
    Cell Significance Index: -14.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3651
    Cell Significance Index: -17.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.3408
    Cell Significance Index: 42.7900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.7501
    Cell Significance Index: 28.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4856
    Cell Significance Index: 294.8300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3840
    Cell Significance Index: 11.0500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0284
    Cell Significance Index: 11.1800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.7271
    Cell Significance Index: 17.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5260
    Cell Significance Index: 11.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5258
    Cell Significance Index: 15.1500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5008
    Cell Significance Index: 3.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4823
    Cell Significance Index: 435.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3768
    Cell Significance Index: 22.6200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3402
    Cell Significance Index: 5.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3371
    Cell Significance Index: 36.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3353
    Cell Significance Index: 54.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2929
    Cell Significance Index: 34.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2900
    Cell Significance Index: 58.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2694
    Cell Significance Index: 197.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2540
    Cell Significance Index: 6.5300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2293
    Cell Significance Index: 1.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2174
    Cell Significance Index: 21.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1901
    Cell Significance Index: 131.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1717
    Cell Significance Index: 3.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1586
    Cell Significance Index: 10.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1562
    Cell Significance Index: 56.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1301
    Cell Significance Index: 2.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1099
    Cell Significance Index: 3.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1008
    Cell Significance Index: 18.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0911
    Cell Significance Index: 3.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0882
    Cell Significance Index: 16.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0868
    Cell Significance Index: 4.8700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0805
    Cell Significance Index: 1.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0726
    Cell Significance Index: 8.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0652
    Cell Significance Index: 8.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0651
    Cell Significance Index: 35.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0572
    Cell Significance Index: 7.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0543
    Cell Significance Index: 0.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0459
    Cell Significance Index: 86.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0385
    Cell Significance Index: 24.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0385
    Cell Significance Index: 17.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0364
    Cell Significance Index: 2.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0229
    Cell Significance Index: 1.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0197
    Cell Significance Index: 0.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0168
    Cell Significance Index: 7.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0063
    Cell Significance Index: 9.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0046
    Cell Significance Index: 0.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0011
    Cell Significance Index: 1.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0032
    Cell Significance Index: -2.0100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0036
    Cell Significance Index: -0.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0067
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0079
    Cell Significance Index: -1.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0103
    Cell Significance Index: -1.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0106
    Cell Significance Index: -5.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0126
    Cell Significance Index: -9.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0373
    Cell Significance Index: -7.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0460
    Cell Significance Index: -2.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0463
    Cell Significance Index: -0.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0493
    Cell Significance Index: -3.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0504
    Cell Significance Index: -5.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0630
    Cell Significance Index: -18.1400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0647
    Cell Significance Index: -0.9300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0716
    Cell Significance Index: -0.8900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0719
    Cell Significance Index: -0.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0865
    Cell Significance Index: -6.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0933
    Cell Significance Index: -11.9600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1138
    Cell Significance Index: -1.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1314
    Cell Significance Index: -1.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1321
    Cell Significance Index: -13.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1324
    Cell Significance Index: -17.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1388
    Cell Significance Index: -3.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1428
    Cell Significance Index: -9.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1519
    Cell Significance Index: -17.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1618
    Cell Significance Index: -11.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1652
    Cell Significance Index: -4.1300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1886
    Cell Significance Index: -1.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1951
    Cell Significance Index: -11.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2004
    Cell Significance Index: -12.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2096
    Cell Significance Index: -2.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2126
    Cell Significance Index: -4.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2127
    Cell Significance Index: -9.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2166
    Cell Significance Index: -11.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2403
    Cell Significance Index: -17.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2543
    Cell Significance Index: -9.6300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2565
    Cell Significance Index: -2.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2567
    Cell Significance Index: -16.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2580
    Cell Significance Index: -13.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2632
    Cell Significance Index: -7.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2736
    Cell Significance Index: -12.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2822
    Cell Significance Index: -3.8500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2883
    Cell Significance Index: -4.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3000
    Cell Significance Index: -9.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3068
    Cell Significance Index: -4.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3108
    Cell Significance Index: -6.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CLCN5 gene is a voltage-gated chloride channel that belongs to the CLC family of chloride channels. It is a transmembrane protein with 12 transmembrane domains, which enables it to regulate the flow of chloride ions across cell membranes. The CLCN5 channel is characterized by its high affinity for chloride ions and its ability to conduct chloride ions in both forward and reverse directions. The channel is also highly regulated by various physiological and pathological stimuli, including changes in pH, temperature, and cellular stress. **Pathways and Functions:** The CLCN5 channel plays a crucial role in regulating ion balance and maintaining cellular homeostasis. It is involved in various cellular processes, including: 1. **Ion transport:** The CLCN5 channel regulates the flow of chloride ions across cell membranes, which is essential for maintaining proper ion balance and cellular homeostasis. 2. **Cell signaling:** The CLCN5 channel is activated by various stimuli, including changes in pH, temperature, and cellular stress, which can trigger signaling pathways that regulate cellular responses. 3. **Endocytosis and exocytosis:** The CLCN5 channel is involved in the regulation of endocytosis and exocytosis, which are critical processes for cellular homeostasis and cellular communication. 4. **Apoptosis and cell survival:** The CLCN5 channel has been implicated in the regulation of apoptosis and cell survival, with alterations in its expression and function contributing to various diseases. **Clinical Significance:** The CLCN5 gene has been implicated in several diseases, including: 1. **X-linked ichthyosis:** A genetic disorder characterized by dry, scaly skin and other dermatological abnormalities. 2. **Spastic paraplegia:** A group of genetic disorders characterized by progressive spasticity and paralysis of the lower limbs. 3. **Neuropathy:** The CLCN5 channel has been implicated in the regulation of neuronal function and has been associated with various forms of neuropathy. 4. **Renal disease:** The CLCN5 channel is highly expressed in the kidney and has been implicated in the regulation of renal function and the pathogenesis of renal disease. In conclusion, the CLCN5 gene is a critical regulator of ion balance and cellular homeostasis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which the CLCN5 channel regulates cellular function and to develop effective therapeutic strategies for the treatment of diseases associated with its dysfunction.

Genular Protein ID: 878290816

Symbol: CLCN5_HUMAN

Name: Chloride channel protein 5

UniProtKB Accession Codes:

P51795 A1L475 B3KPN6 Q5JQD5 Q7RTN8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 9 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8575751

Title: Cloning and characterization of CLCN5, the human kidney chloride channel gene implicated in Dent disease (an X-linked hereditary nephrolithiasis).

PubMed ID: 8575751

DOI: 10.1006/geno.1995.9960

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7874126

Title: Isolation and partial characterization of a chloride channel gene which is expressed in kidney and is a candidate for Dent's disease (an X-linked hereditary nephrolithiasis).

PubMed ID: 7874126

PubMed ID: 12886045

Title: Four additional CLCN5 exons encode a widely expressed novel long CLC-5 isoform but fail to explain Dent's phenotype in patients without mutations in the short variant.

PubMed ID: 12886045

DOI: 10.1159/000071883

PubMed ID: 10198195

Title: Expression of CLCN voltage-gated chloride channel genes in human blood vessels.

PubMed ID: 10198195

DOI: 10.1006/jmcc.1998.0901

PubMed ID: 15489223

Title: Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells.

PubMed ID: 15489223

DOI: 10.1074/jbc.m411491200

PubMed ID: 20466723

Title: The late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression.

PubMed ID: 20466723

DOI: 10.1074/jbc.m110.125971

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17195847

Title: Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5.

PubMed ID: 17195847

DOI: 10.1038/nsmb1188

PubMed ID: 8559248

Title: A common molecular basis for three inherited kidney stone diseases.

PubMed ID: 8559248

DOI: 10.1038/379445a0

PubMed ID: 9187673

Title: A second family with XLRH displays the mutation S244L in the CLCN5 gene.

PubMed ID: 9187673

DOI: 10.1007/s004390050448

PubMed ID: 9259268

Title: Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders.

PubMed ID: 9259268

DOI: 10.1093/hmg/6.8.1233

PubMed ID: 9062355

Title: Idiopathic low molecular weight proteinuria associated with hypercalciuric nephrocalcinosis in Japanese children is due to mutations of the renal chloride channel (CLCN5).

PubMed ID: 9062355

DOI: 10.1172/jci119262

PubMed ID: 9602200

Title: X-linked recessive nephrolithiasis: presentation and diagnosis in children.

PubMed ID: 9602200

DOI: 10.1016/s0022-3476(98)70318-x

PubMed ID: 9853249

Title: Functional characterization of renal chloride channel, CLCN5, mutations associated with Dent'sJapan disease.

PubMed ID: 9853249

DOI: 10.1046/j.1523-1755.1998.00203.x

PubMed ID: 11136179

Title: Identification of two novel mutations in the CLCN5 gene in Japanese patients with familial idiopathic low molecular weight proteinuria (Japanese Dent's disease).

PubMed ID: 11136179

DOI: 10.1016/s0272-6386(01)80067-6

PubMed ID: 15086899

Title: Evidence for genetic heterogeneity in Dent's disease.

PubMed ID: 15086899

DOI: 10.1111/j.1523-1755.2004.00571.x

PubMed ID: 16247550

Title: Dent's disease and prevalence of renal stones in dialysis patients in Northeastern Italy.

PubMed ID: 16247550

DOI: 10.1007/s10038-005-0317-x

PubMed ID: 16822791

Title: Phenotypic and genetic heterogeneity in Dent's disease -- the results of an Italian collaborative study.

PubMed ID: 16822791

DOI: 10.1093/ndt/gfl274

PubMed ID: 16416111

Title: Family history may be misleading in the diagnosis of Dent's disease.

PubMed ID: 16416111

DOI: 10.1007/s00240-005-0005-5

PubMed ID: 17262170

Title: A missense mutation in the chloride/proton ClC-5 antiporter gene results in increased expression of an alternative mRNA form that lacks exons 10 and 11. Identification of seven new CLCN5 mutations in patients with Dent's disease.

PubMed ID: 17262170

DOI: 10.1007/s10038-007-0112-y

PubMed ID: 18025833

Title: Functional characterization of a novel missense CLCN5 mutation causing alterations in proximal tubular endocytic machinery in Dent's disease.

PubMed ID: 18025833

DOI: 10.1159/000111253

PubMed ID: 19019917

Title: Characterization of Dent's disease mutations of CLC-5 reveals a correlation between functional and cell biological consequences and protein structure.

PubMed ID: 19019917

DOI: 10.1152/ajprenal.90526.2008

PubMed ID: 19657328

Title: Novel CLCN5 mutations in patients with Dent's disease result in altered ion currents or impaired exchanger processing.

PubMed ID: 19657328

DOI: 10.1038/ki.2009.305

PubMed ID: 21305656

Title: Heterogeneity in the processing of CLCN5 mutants related to Dent disease.

PubMed ID: 21305656

DOI: 10.1002/humu.21467

Sequence Information:

  • Length: 816
  • Mass: 90785
  • Checksum: C9C63CC222959F35
  • Sequence:
    • MAMWQGAMDN RGFQQGSFSS FQNSSSDEDL MDIPATAMDF SMRDDVPPLD REVGEDKSYN 
GGGIGSSNRI MDFLEEPIPG VGTYDDFNTI DWVREKSRDR DRHREITNKS KESTWALIHS 
VSDAFSGWLL MLLIGLLSGS LAGLIDISAH WMTDLKEGIC TGGFWFNHEH CCWNSEHVTF 
EERDKCPEWN SWSQLIISTD EGAFAYIVNY FMYVLWALLF AFLAVSLVKV FAPYACGSGI 
PEIKTILSGF IIRGYLGKWT LVIKTITLVL AVSSGLSLGK EGPLVHVACC CGNILCHCFN 
KYRKNEAKRR EVLSAAAAAG VSVAFGAPIG GVLFSLEEVS YYFPLKTLWR SFFAALVAAF 
TLRSINPFGN SRLVLFYVEF HTPWHLFELV PFILLGIFGG LWGALFIRTN IAWCRKRKTT 
QLGKYPVIEV LVVTAITAIL AFPNEYTRMS TSELISELFN DCGLLDSSKL CDYENRFNTS 
KGGELPDRPA GVGVYSAMWQ LALTLILKIV ITIFTFGMKI PSGLFIPSMA VGAIAGRLLG 
VGMEQLAYYH QEWTVFNSWC SQGADCITPG LYAMVGAAAC LGGVTRMTVS LVVIMFELTG 
GLEYIVPLMA AAMTSKWVAD ALGREGIYDA HIRLNGYPFL EAKEEFAHKT LAMDVMKPRR 
NDPLLTVLTQ DSMTVEDVET IISETTYSGF PVVVSRESQR LVGFVLRRDL IISIENARKK 
QDGVVSTSII YFTEHSPPLP PYTPPTLKLR NILDLSPFTV TDLTPMEIVV DIFRKLGLRQ 
CLVTHNGRLL GIITKKDVLK HIAQMANQDP DSILFN

Genular Protein ID: 3277760979

Symbol: V9GYG7_HUMAN

Name: N/A

UniProtKB Accession Codes:

V9GYG7

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 HGNC 1 HOGENOM 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 2 Proteomes 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 64
  • Mass: 7019
  • Checksum: 98DCE3A561E465BD
  • Sequence:
    • MAMWQGAMDN RGFQQGSFSS FQNSSSDEDL MDIPATAMDF SMRDDVPPLD REVGGIIIGD 
DNLS

Genular Protein ID: 1094726847

Symbol: A8K4H5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K4H5

Database IDs:

ARBA 18 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 2 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 3 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 1 RuleBase 1 SMART 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 746
  • Mass: 83090
  • Checksum: 5528DC0F687D85DD
  • Sequence:
    • MDFLEEPIPG VGTYDDFNTI DWVREKSRDR DRHREITNKS KESTWALIHS VSDAFSGWLL 
MLLIGLLSGS LAGLIDISAH WMTDLKEGIC TGGFWFNHEH CCWNSEHVTF EERDKCPEWN 
SWSQLIISTD EGAFAYIVNY FMYVLWALLF AFLAVSLVKV FAPYACGSGI PEIKTILSVF 
IIRGYLGKWT LVIKTITLVL AVSSGLSLGK EGPLVHVACC CGNILCHCFN KYGKNEAKRR 
EVLSAAAAAG VSVAFGAPIG GVLFSLEEVS YYFPLKTLWR SFFAALVAAF TLRSINPFGN 
SRLVLFYVEF HTPWHLFELV PFILLGIFGG LWGALFIRTN IAWCRKRKTT QLGKYPVIEV 
LVVTAITAIL AFPNEYTRMS TSELISELFN DCGLLDSSKL CDYENRFNTS KGGELPDRPA 
GVGVYSAMWQ LALTLILKIV ITIFTFGMKI PSGLFIPSMA VGAIAGRLLG VGMEQLAYYH 
QEWTVFNSWC SQGADCITPG LYAMVGAAAC LGGVTRMTVS LVVIMFELTG GLEYIVPLMA 
AAMTSKWVAD ALGREGIYDA HIRLNGYPFL EAKEEFAHKT LAMDVMKPRR NDPLLTVLTQ 
DSMTVEDVET IISETTYSGF PVVVSRESQR LVGFVLRRDL IISIENARKK QDGVVSTSII 
YFTEHSPPLP PYTPPTLKLR NILDLSPFTV TDLTPMEIVV DIFRKLGLRQ CLVTHNGRLL 
GIITKKDVLK HIAQMANQDP DSILFN

Genular Protein ID: 3393837069

Symbol: B3KRR2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KRR2

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 3 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 RuleBase 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 648
  • Mass: 71767
  • Checksum: 87B51D0207FFF2F6
  • Sequence:
    • MNIVAGTLSM SPLKRDKCPE WNSWSQLIIS TDEGAFAYIV NYFMYVLWAL LFAFLAVSLV 
KVFAPYACGS GIPEIKTILS GFIIRGYLGK WTLVIKTITL VLAVSSGLSL GKEGPLVHVA 
CCCGNILCHC FNKYRKNEAK RREVLSAAAA AGVSVAFGAP IGGVLFSLEE VSYYFPLKTL 
WRSFFAALVA AFTLRSINPF GNSRLVLFYV EFHTPWHLFE LVPFILLGIF GGLWGALFIR 
TNIAWCRKRK TTQLGKYPVI EVLVVTAITA ILAFPNEYTR MSTSELISEL FNDYGLLDSS 
KLCDYENRFN TSKGGELPDR PAGVGVYSAM WQLALTLILK IVITIFTFGM KIPSGLFIPS 
MAVGAIAGRL LGVGMEQLAY YHQEWTVFNS WCSQGADCIT PGLYAMVGAA ACLGGVTRMT 
VSLVVIMFEL TGGLEYIVPL MAAAMTSKWV ADALGREGIY DAHIRLNGYP FLEAKEEFAH 
KTLAMDVMKP RRNDPLLTVL TQDSMTVEDV ETIISETTYS GFPVVVSRES QRLVGFVLRR 
DLIISIENAR KKQDGVVSTS IIYFTEHSPP LPPYTPPTLK LRNILDLSPF TVTDLTPMEI 
VVDIFRKLGL RQCLVTHNGR LLGIITKKDV LKHIAQMANQ DPDSILFN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.