Genular: Defining Cellular Identity and Function

Details for: Arf6

Gene ID: 11845

Symbol: Arf6

Ensembl ID: ENSMUSG00000044147

Description: ADP-ribosylation factor 6

Associated with

Clathrin-mediated endocytosis
(R-MMU-8856828)
Membrane trafficking
(R-MMU-199991)
Met receptor recycling
(R-MMU-8875656)
Rab regulation of trafficking
(R-MMU-9007101)
Signaling by met
(R-MMU-6806834)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Tbc/rabgaps
(R-MMU-8854214)
Cell cortex
(GO:0005938)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Cell division
(GO:0051301)
Cell projection
(GO:0042995)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cleavage furrow
(GO:0032154)
Cortical actin cytoskeleton organization
(GO:0030866)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Endocytic recycling
(GO:0032456)
Endocytic vesicle
(GO:0030139)
Endosome
(GO:0005768)
Erythrocyte apoptotic process
(GO:1902217)
Establishment of epithelial cell polarity
(GO:0090162)
Filopodium membrane
(GO:0031527)
Flemming body
(GO:0090543)
Gdp binding
(GO:0019003)
Glutamatergic synapse
(GO:0098978)
Golgi apparatus
(GO:0005794)
G protein activity
(GO:0003925)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Hepatocyte apoptotic process
(GO:0097284)
Hydrolase activity
(GO:0016787)
Intracellular protein transport
(GO:0006886)
Liver development
(GO:0001889)
Maintenance of postsynaptic density structure
(GO:0099562)
Membrane
(GO:0016020)
Myelin sheath
(GO:0043209)
Negative regulation of dendrite development
(GO:2000171)
Negative regulation of protein localization to cell surface
(GO:2000009)
Nervous system development
(GO:0007399)
Nucleotide binding
(GO:0000166)
Plasma membrane
(GO:0005886)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of focal adhesion disassembly
(GO:0120183)
Positive regulation of keratinocyte migration
(GO:0051549)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Positive regulation of protein secretion
(GO:0050714)
Postsynapse
(GO:0098794)
Presynapse
(GO:0098793)
Protein binding
(GO:0005515)
Protein localization to cell surface
(GO:0034394)
Protein localization to endosome
(GO:0036010)
Protein localization to plasma membrane
(GO:0072659)
Protein transport
(GO:0015031)
Recycling endosome
(GO:0055037)
Recycling endosome membrane
(GO:0055038)
Regulation of dendritic spine development
(GO:0060998)
Regulation of filopodium assembly
(GO:0051489)
Regulation of neuron projection development
(GO:0010975)
Regulation of presynapse assembly
(GO:1905606)
Regulation of rac protein signal transduction
(GO:0035020)
Regulation of toll-like receptor 4 signaling pathway
(GO:0034143)
Ruffle
(GO:0001726)
Ruffle assembly
(GO:0097178)
Signaling adaptor activity
(GO:0035591)
Synaptic vesicle endocytosis
(GO:0048488)
Thioesterase binding
(GO:0031996)
Vesicle-mediated transport
(GO:0016192)

Other Information

Proteins

ADP-ribosylation factor 6

Genular Protein ID: 249944244

Symbol: ARF6_MOUSE

Name: ADP-ribosylation factor 6

UniProtKB Accession Codes:

P62331 P26438

Database IDs:

Citations:

PubMed ID: 8947846

Title: Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6).

PubMed ID: 8947846

DOI: 10.1093/oxfordjournals.jbchem.a021484

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11950392

Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.

PubMed ID: 11950392

DOI: 10.1042/bj20020428

PubMed ID: 16325184

Title: The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation.

PubMed ID: 16325184

DOI: 10.1016/j.febslet.2005.11.022

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20080746

Title: FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.

PubMed ID: 20080746

DOI: 10.1073/pnas.0908423107

PubMed ID: 22841714

Title: Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure.

PubMed ID: 22841714

DOI: 10.1016/j.febslet.2012.07.051

PubMed ID: 23572513

Title: Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth.

PubMed ID: 23572513

DOI: 10.1242/jcs.117846

PubMed ID: 27723745

Title: C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons.

PubMed ID: 27723745

DOI: 10.1038/nn.4407

PubMed ID: 29420262

Title: C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.

PubMed ID: 29420262

DOI: 10.1126/science.aan0814

PubMed ID: 22522702

Title: Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis.

PubMed ID: 22522702

DOI: 10.1038/emboj.2012.89

Sequence Information:

Length: 175
Mass: 20082
Checksum: 49E38E59AEA52B98
Sequence:

MGKVLSKIFG NKEMRILMLG LDAAGKTTIL YKLKLGQSVT TIPTVGFNVE TVTYKNVKFN 
VWDVGGQDKI RPLWRHYYTG TQGLIFVVDC ADRDRIDEAR QELHRIINDR EMRDAIILIF 
ANKQDLPDAM KPHEIQEKLG LTRIRDRNWY VQPSCATSGD GLYEGLTWLT SNYKS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Arf6

Associated with

Other Information

Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). PubMed ID: 8947846

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. PubMed ID: 11950392

The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation. PubMed ID: 16325184

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex. PubMed ID: 20080746

Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure. PubMed ID: 22841714

Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth. PubMed ID: 23572513

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons. PubMed ID: 27723745

C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. PubMed ID: 29420262

Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis. PubMed ID: 22522702