Genular: Defining Cellular Identity and Function

Details for: Arg1

Gene ID: 11846

Symbol: Arg1

Ensembl ID: ENSMUSG00000019987

Description: arginase, liver

Associated with

Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Neutrophil degranulation
(R-MMU-6798695)
Adaptive immune response
(GO:0002250)
Arginase activity
(GO:0004053)
Arginine catabolic process to ornithine
(GO:0019547)
Arginine metabolic process
(GO:0006525)
Collagen biosynthetic process
(GO:0032964)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to protozoan
(GO:0042832)
Extracellular space
(GO:0005615)
Hydrolase activity
(GO:0016787)
Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
(GO:0016813)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Manganese ion binding
(GO:0030145)
Metal ion binding
(GO:0046872)
Mitochondrial outer membrane
(GO:0005741)
Negative regulation of activated t cell proliferation
(GO:0046007)
Negative regulation of t-helper 2 cell cytokine production
(GO:2000552)
Negative regulation of t cell proliferation
(GO:0042130)
Negative regulation of type ii interferon-mediated signaling pathway
(GO:0060336)
Neuronal cell body
(GO:0043025)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of neutrophil mediated killing of fungus
(GO:0070965)
Regulation of l-arginine import across plasma membrane
(GO:1905541)
Urea cycle
(GO:0000050)

Other Information

Proteins

Arginase-1

Genular Protein ID: 3240066123

Symbol: ARGI1_MOUSE

Name: Arginase-1

UniProtKB Accession Codes:

Q61176 Q3TB74 Q3UEL0 Q4FK78 Q80VI4

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7537672

Title: Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines.

PubMed ID: 7537672

DOI: 10.1002/eji.1830250436

PubMed ID: 12193690

Title: Shaping gene expression in activated and resting primary macrophages by IL-10.

PubMed ID: 12193690

DOI: 10.4049/jimmunol.169.5.2253

PubMed ID: 15313928

Title: Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses.

PubMed ID: 15313928

DOI: 10.1158/0008-5472.can-04-0465

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19414774

Title: Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I.

PubMed ID: 19414774

DOI: 10.4049/jimmunol.0803926

PubMed ID: 19360123

Title: Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis.

PubMed ID: 19360123

DOI: 10.1371/journal.ppat.1000371

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20483789

Title: Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis.

PubMed ID: 20483789

DOI: 10.4049/jimmunol.0902009

PubMed ID: 23248265

Title: The key role of IL-6-arginase cascade for inducing dendritic cell-dependent CD4(+) T cell dysfunction in tumor-bearing mice.

PubMed ID: 23248265

DOI: 10.4049/jimmunol.1103797

PubMed ID: 23552798

Title: Local arginase 1 activity is required for cutaneous wound healing.

PubMed ID: 23552798

DOI: 10.1038/jid.2013.164

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23637937

Title: Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.

PubMed ID: 23637937

DOI: 10.1371/journal.pone.0061961

PubMed ID: 27043409

Title: Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.

PubMed ID: 27043409

DOI: 10.1038/ni.3421

Sequence Information:

Length: 323
Mass: 34808
Checksum: 6D0231978AC1B977
Sequence:

MSSKPKSLEI IGAPFSKGQP RGGVEKGPAA LRKAGLLEKL KETEYDVRDH GDLAFVDVPN 
DSSFQIVKNP RSVGKANEEL AGVVAEVQKN GRVSVVLGGD HSLAVGSISG HARVHPDLCV 
IWVDAHTDIN TPLTTSSGNL HGQPVSFLLK ELKGKFPDVP GFSWVTPCIS AKDIVYIGLR 
DVDPGEHYII KTLGIKYFSM TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPAF 
TPATGTPVLG GLSYREGLYI TEEIYKTGLL SGLDIMEVNP TLGKTAEEVK STVNTAVALT 
LACFGTQREG NHKPGTDYLK PPK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Arg1

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. PubMed ID: 7537672

Shaping gene expression in activated and resting primary macrophages by IL-10. PubMed ID: 12193690

Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. PubMed ID: 15313928

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I. PubMed ID: 19414774

Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PubMed ID: 19360123

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. PubMed ID: 20483789

The key role of IL-6-arginase cascade for inducing dendritic cell-dependent CD4(+) T cell dysfunction in tumor-bearing mice. PubMed ID: 23248265

Local arginase 1 activity is required for cutaneous wound healing. PubMed ID: 23552798

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PubMed ID: 23637937

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. PubMed ID: 27043409