Details for: Arg2

Gene ID: 11847

Symbol: Arg2

Ensembl ID: ENSMUSG00000021125

Description: arginase type II

Associated with

  • Metabolism
    (R-MMU-1430728)
  • Metabolism of amino acids and derivatives
    (R-MMU-71291)
  • Metabolism of proteins
    (R-MMU-392499)
  • Mitochondrial protein degradation
    (R-MMU-9837999)
  • Adaptive immune response
    (GO:0002250)
  • Arginase activity
    (GO:0004053)
  • Arginine catabolic process to ornithine
    (GO:0019547)
  • Arginine metabolic process
    (GO:0006525)
  • Cytoplasm
    (GO:0005737)
  • Hydrolase activity
    (GO:0016787)
  • Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
    (GO:0016813)
  • Immune system process
    (GO:0002376)
  • Innate immune response
    (GO:0045087)
  • Manganese ion binding
    (GO:0030145)
  • Metal ion binding
    (GO:0046872)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of activated cd8-positive, alpha-beta t cell apoptotic process
    (GO:1905403)
  • Negative regulation of cd4-positive, alpha-beta t cell proliferation
    (GO:2000562)
  • Negative regulation of chemokine (c-c motif) ligand 4 production
    (GO:0071644)
  • Negative regulation of chemokine (c-c motif) ligand 5 production
    (GO:0071650)
  • Negative regulation of defense response to bacterium
    (GO:1900425)
  • Negative regulation of interleukin-13 production
    (GO:0032696)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of macrophage inflammatory protein 1 alpha production
    (GO:0071641)
  • Negative regulation of striated muscle contraction
    (GO:0045988)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type 2 immune response
    (GO:0002829)
  • Nitric-oxide synthase binding
    (GO:0050998)
  • Positive regulation of cellular senescence
    (GO:2000774)
  • Regulation of interleukin-1 beta production
    (GO:0032651)
  • Regulation of l-arginine import across plasma membrane
    (GO:1905541)
  • Regulation of reactive oxygen species biosynthetic process
    (GO:1903426)
  • Striated muscle contraction
    (GO:0006941)
  • Urea cycle
    (GO:0000050)
  • Ureteric bud development
    (GO:0001657)

Other Information

Genular Protein ID: 1466594129

Symbol: ARGI2_MOUSE

Name: Arginase-2, mitochondrial

UniProtKB Accession Codes:

O08691

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 13 ChiTaRS 1 DNASU 1 EC 1 EMBL 10 Ensembl 1 GO 27 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9608538

Title: Cloning and characterization of the mouse and rat type II arginase genes.

PubMed ID: 9608538

DOI: 10.1006/mgme.1997.2669

PubMed ID: 9814991

Title: Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells.

PubMed ID: 9814991

DOI: 10.1152/ajpendo.1998.275.5.e740

PubMed ID: 9745037

Title: Structure of the murine arginase II gene.

PubMed ID: 9745037

DOI: 10.1007/s003359900874

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22928666

Title: Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging.

PubMed ID: 22928666

DOI: 10.1111/acel.12001

PubMed ID: 25484082

Title: ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.

PubMed ID: 25484082

DOI: 10.4161/15548627.2014.981789

PubMed ID: 25009204

Title: Repression of arginase-2 expression in dendritic cells by microRNA-155 is critical for promoting T cell proliferation.

PubMed ID: 25009204

DOI: 10.4049/jimmunol.1301913

PubMed ID: 27074721

Title: Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.

PubMed ID: 27074721

DOI: 10.1007/s00726-016-2231-2

PubMed ID: 27745970

Title: L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity.

PubMed ID: 27745970

DOI: 10.1016/j.cell.2016.09.031

PubMed ID: 27214549

Title: Increased mitochondrial arginine metabolism supports bioenergetics in asthma.

PubMed ID: 27214549

DOI: 10.1172/jci82925

Sequence Information:

  • Length: 354
  • Mass: 38878
  • Checksum: B372DF68A19473F2
  • Sequence:
    • MFLRSSASRL LHGQIPCVLT RSVHSVAIVG APFSRGQKKL GVEYGPAAIR EAGLLKRLSR 
LGCHLKDFGD LSFTNVPQDD PYNNLVVYPR SVGLANQELA EVVSRAVSGG YSCVTMGGDH 
SLAIGTIIGH ARHRPDLCVI WVDAHADINT PLTTVSGNIH GQPLSFLIKE LQDKVPQLPG 
FSWIKPCLSP PNIVYIGLRD VEPPEHFILK NYDIQYFSMR EIDRLGIQKV MEQTFDRLIG 
KRQRPIHLSF DIDAFDPKLA PATGTPVVGG LTYREGVYIT EEIHNTGLLS ALDLVEVNPH 
LATSEEEAKA TARLAVDVIA SSFGQTREGG HIVYDHLPTP SSPHESENEE CVRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.