Genular: Defining Cellular Identity and Function

Details for: Rhoa

Gene ID: 11848

Symbol: Rhoa

Ensembl ID: ENSMUSG00000007815

Description: ras homolog family member A

Associated with

Axonal growth inhibition (rhoa activation)
(R-MMU-193634)
Axonal growth stimulation
(R-MMU-209563)
Axon guidance
(R-MMU-422475)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
Death receptor signaling
(R-MMU-73887)
Deubiquitination
(R-MMU-5688426)
Developmental biology
(R-MMU-1266738)
Eph-ephrin signaling
(R-MMU-2682334)
Epha-mediated growth cone collapse
(R-MMU-3928663)
Ephb-mediated forward signaling
(R-MMU-3928662)
Erbb2 regulates cell motility
(R-MMU-6785631)
G-protein beta:gamma signalling
(R-MMU-397795)
G alpha (12/13) signalling events
(R-MMU-416482)
G beta:gamma signalling through pi3kgamma
(R-MMU-392451)
Gpcr downstream signalling
(R-MMU-388396)
Gpvi-mediated activation cascade
(R-MMU-114604)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism of proteins
(R-MMU-392499)
Nervous system development
(R-MMU-9675108)
Neutrophil degranulation
(R-MMU-6798695)
Ovarian tumor domain proteases
(R-MMU-5689896)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
P75ntr regulates axonogenesis
(R-MMU-193697)
Pcp/ce pathway
(R-MMU-4086400)
Pi3k/akt activation
(R-MMU-198203)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Post-translational protein modification
(R-MMU-597592)
Ptk6 regulates rho gtpases, ras gtpase and map kinases
(R-MMU-8849471)
Rhoa gtpase cycle
(R-MMU-8980692)
Rhoc gtpase cycle
(R-MMU-9013106)
Rho gtpase cycle
(R-MMU-9012999)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate cit
(R-MMU-5625900)
Rho gtpases activate formins
(R-MMU-5663220)
Rho gtpases activate ktn1
(R-MMU-5625970)
Rho gtpases activate pkns
(R-MMU-5625740)
Rho gtpases activate rhotekin and rhophilins
(R-MMU-5666185)
Rho gtpases activate rocks
(R-MMU-5627117)
Sema4d induced cell migration and growth-cone collapse
(R-MMU-416572)
Sema4d in semaphorin signaling
(R-MMU-400685)
Sema4d mediated inhibition of cell attachment and migration
(R-MMU-416550)
Semaphorin interactions
(R-MMU-373755)
Signaling by erbb2
(R-MMU-1227986)
Signaling by gpcr
(R-MMU-372790)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by ptk6
(R-MMU-8848021)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by robo receptors
(R-MMU-376176)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signaling by vegf
(R-MMU-194138)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Slit2:robo1 increases rhoa activity
(R-MMU-8985586)
Tgf-beta receptor signaling in emt (epithelial to mesenchymal transition)
(R-MMU-2173791)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Alpha-beta t cell lineage commitment
(GO:0002363)
Angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
(GO:0001998)
Aortic valve formation
(GO:0003189)
Cell-matrix adhesion
(GO:0007160)
Cell adhesion
(GO:0007155)
Cell cycle
(GO:0007049)
Cell morphogenesis
(GO:0000902)
Cytoskeleton organization
(GO:0007010)
Gdp binding
(GO:0019003)
G protein activity
(GO:0003925)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Integrin-mediated signaling pathway
(GO:0007229)
Kidney development
(GO:0001822)
Microtubule depolymerization
(GO:0007019)
Myosin binding
(GO:0017022)
Negative regulation of cell-substrate adhesion
(GO:0010812)
Negative regulation of neuron projection development
(GO:0010977)
Neuron migration
(GO:0001764)
Nucleotide binding
(GO:0000166)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Regulation of neuron projection development
(GO:0010975)
Regulation of systemic arterial blood pressure by endothelin
(GO:0003100)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to xenobiotic stimulus
(GO:0009410)
Rho gdp-dissociation inhibitor binding
(GO:0051022)
Rho protein signal transduction
(GO:0007266)
Skeletal muscle tissue development
(GO:0007519)
Small gtpase-mediated signal transduction
(GO:0007264)

Other Information

Proteins

Transforming protein RhoA

Genular Protein ID: 4058745367

Symbol: RHOA_MOUSE

Name: Transforming protein RhoA

UniProtKB Accession Codes:

Q9QUI0 O88336

Database IDs:

Citations:

PubMed ID: 9598304

Title: Transposition of RhoA to the murine Y chromosome.

PubMed ID: 9598304

DOI: 10.1006/geno.1998.5219

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8662891

Title: Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain.

PubMed ID: 8662891

DOI: 10.1074/jbc.271.23.13556

PubMed ID: 9214622

Title: p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.

PubMed ID: 9214622

DOI: 10.1093/emboj/16.11.3044

PubMed ID: 9635436

Title: The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel.

PubMed ID: 9635436

DOI: 10.1016/s0092-8674(00)81212-x

PubMed ID: 9535835

Title: Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7.

PubMed ID: 9535835

DOI: 10.1074/jbc.273.15.8616

PubMed ID: 11058585

Title: Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules.

PubMed ID: 11058585

DOI: 10.1074/jbc.m003839200

PubMed ID: 14697203

Title: Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release.

PubMed ID: 14697203

DOI: 10.1016/s0092-8674(03)01014-6

PubMed ID: 11777936

Title: Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion.

PubMed ID: 11777936

DOI: 10.1083/jcb.200105140

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21543326

Title: Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis.

PubMed ID: 21543326

DOI: 10.1074/jbc.m111.245209

PubMed ID: 20974804

Title: The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.

PubMed ID: 20974804

DOI: 10.1128/mcb.01001-10

PubMed ID: 24352656

Title: Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis.

PubMed ID: 24352656

DOI: 10.1074/jbc.m113.534636

PubMed ID: 29088697

Title: Kctd13 deletion reduces synaptic transmission via increased RhoA.

PubMed ID: 29088697

DOI: 10.1038/nature24470

Sequence Information:

Length: 193
Mass: 21782
Checksum: C4C8BDC31FF858BC
Sequence:

MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQVELALWDT 
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD 
LRNDEHTRRE LAKMKQEPVK PEEGRDMANR IGAFGYMECS AKTKDGVREV FEMATRAALQ 
ARRGKKKSGC LIL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rhoa

Associated with

Other Information

Transposition of RhoA to the murine Y chromosome. PubMed ID: 9598304

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. PubMed ID: 8662891

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. PubMed ID: 9214622

The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel. PubMed ID: 9635436

Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. PubMed ID: 9535835

Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules. PubMed ID: 11058585

Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. PubMed ID: 14697203

Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion. PubMed ID: 11777936

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis. PubMed ID: 21543326

The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. PubMed ID: 20974804

Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis. PubMed ID: 24352656

Kctd13 deletion reduces synaptic transmission via increased RhoA. PubMed ID: 29088697