Genular: Defining Cellular Identity and Function

Details for: Rhob

Gene ID: 11852

Symbol: Rhob

Ensembl ID: ENSMUSG00000054364

Description: ras homolog family member B

Associated with

Axon guidance
(R-MMU-422475)
Developmental biology
(R-MMU-1266738)
G alpha (12/13) signalling events
(R-MMU-416482)
Gpcr downstream signalling
(R-MMU-388396)
Gpvi-mediated activation cascade
(R-MMU-114604)
Hemostasis
(R-MMU-109582)
Nervous system development
(R-MMU-9675108)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Rhob gtpase cycle
(R-MMU-9013026)
Rho gtpase cycle
(R-MMU-9012999)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate cit
(R-MMU-5625900)
Rho gtpases activate formins
(R-MMU-5663220)
Rho gtpases activate pkns
(R-MMU-5625740)
Rho gtpases activate rocks
(R-MMU-5627117)
Sema4d induced cell migration and growth-cone collapse
(R-MMU-416572)
Sema4d in semaphorin signaling
(R-MMU-400685)
Semaphorin interactions
(R-MMU-373755)
Signaling by gpcr
(R-MMU-372790)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Actin filament organization
(GO:0007015)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
Cell adhesion
(GO:0007155)
Cell differentiation
(GO:0030154)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to ionizing radiation
(GO:0071479)
Cleavage furrow
(GO:0032154)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Endosome to lysosome transport
(GO:0008333)
Endothelial tube morphogenesis
(GO:0061154)
Gdp binding
(GO:0019003)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Intracellular protein transport
(GO:0006886)
Late endosome
(GO:0005770)
Membrane
(GO:0016020)
Mitotic cytokinesis
(GO:0000281)
Multicellular organism development
(GO:0007275)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell migration
(GO:0030336)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of endothelial cell migration
(GO:0010595)
Protein binding
(GO:0005515)
Protein transport
(GO:0015031)
Regulation of cell migration
(GO:0030334)
Regulation of modification of postsynaptic structure
(GO:0099159)
Schaffer collateral - ca1 synapse
(GO:0098685)
Signal transduction
(GO:0007165)
Small gtpase-mediated signal transduction
(GO:0007264)
Synapse
(GO:0045202)

Other Information

Proteins

Rho-related GTP-binding protein RhoB

Genular Protein ID: 2177461481

Symbol: RHOB_MOUSE

Name: Rho-related GTP-binding protein RhoB

UniProtKB Accession Codes:

P62746 P01121 Q9CUV7

Database IDs:

Citations:

PubMed ID: 8831676

Title: Cloning of the RhoB gene from the mouse genome and characterization of its promoter region.

PubMed ID: 8831676

DOI: 10.1006/bbrc.1996.1415

PubMed ID: 15543229

Title: RhoB mRNA is stabilized by HuR after UV light.

PubMed ID: 15543229

DOI: 10.1038/sj.onc.1208224

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11564874

Title: RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells.

PubMed ID: 11564874

DOI: 10.1128/mcb.21.20.6906-6912.2001

PubMed ID: 11353846

Title: RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage.

PubMed ID: 11353846

DOI: 10.1073/pnas.111137198

PubMed ID: 14597666

Title: RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development.

PubMed ID: 14597666

DOI: 10.1101/gad.1134603

PubMed ID: 7559652

Title: The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments.

PubMed ID: 7559652

DOI: 10.1074/jbc.270.42.25172

PubMed ID: 8662891

Title: Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain.

PubMed ID: 8662891

DOI: 10.1074/jbc.271.23.13556

PubMed ID: 13679852

Title: Mitogen-responsive expression of RhoB is regulated by RNA stability.

PubMed ID: 13679852

DOI: 10.1038/sj.onc.1206638

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 196
Mass: 22123
Checksum: CCE6FD53AE00CD83
Sequence:

MAAIRKKLVV VGDGACGKTC LLIVFSKDEF PEVYVPTVFE NYVADIEVDG KQVELALWDT 
AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWV PEVKHFCPNV PIILVANKKD 
LRSDEHVRTE LARMKQEPVR TDDGRAMAVR IQAYDYLECS AKTKEGVREV FETATRAALQ 
KRYGSQNGCI NCCKVL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rhob

Associated with

Other Information

Cloning of the RhoB gene from the mouse genome and characterization of its promoter region. PubMed ID: 8831676

RhoB mRNA is stabilized by HuR after UV light. PubMed ID: 15543229

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells. PubMed ID: 11564874

RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage. PubMed ID: 11353846

RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. PubMed ID: 14597666

The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments. PubMed ID: 7559652

Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. PubMed ID: 8662891

Mitogen-responsive expression of RhoB is regulated by RNA stability. PubMed ID: 13679852

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079