Details for: Bmal1
Associated with
Other Information
Genular Protein ID: 4089316303
Symbol: BMAL1_MOUSE
Name: Basic helix-loop-helix ARNT-like protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10403839
Title: Characterization of three splice variants and genomic organization of the mouse BMAL1 gene.
PubMed ID: 10403839
PubMed ID: 9704006
Title: Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock.
PubMed ID: 9704006
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9616112
Title: Role of the CLOCK protein in the mammalian circadian mechanism.
PubMed ID: 9616112
PubMed ID: 11779462
Title: Posttranslational mechanisms regulate the mammalian circadian clock.
PubMed ID: 11779462
PubMed ID: 12397359
Title: Dec1 and Dec2 are regulators of the mammalian molecular clock.
PubMed ID: 12397359
DOI: 10.1038/nature01123
PubMed ID: 12897057
Title: BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system.
PubMed ID: 12897057
DOI: 10.1101/gad.1099503
PubMed ID: 14672706
Title: A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.
PubMed ID: 14672706
PubMed ID: 16109848
Title: Circadian clock control by SUMOylation of BMAL1.
PubMed ID: 16109848
PubMed ID: 16628007
Title: Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES.
PubMed ID: 16628007
DOI: 10.4161/cc.5.8.2684
PubMed ID: 16717091
Title: The polycomb group protein EZH2 is required for mammalian circadian clock function.
PubMed ID: 16717091
PubMed ID: 16980631
Title: BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer.
PubMed ID: 16980631
DOI: 10.1128/mcb.00337-06
PubMed ID: 16790549
Title: Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.
PubMed ID: 16790549
PubMed ID: 18075593
Title: CLOCK-mediated acetylation of BMAL1 controls circadian function.
PubMed ID: 18075593
DOI: 10.1038/nature06394
PubMed ID: 18430226
Title: Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK.
PubMed ID: 18430226
PubMed ID: 18662546
Title: SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
PubMed ID: 18662546
PubMed ID: 18662547
Title: The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control.
PubMed ID: 18662547
PubMed ID: 18258755
Title: The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice.
PubMed ID: 18258755
PubMed ID: 18316400
Title: Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators.
PubMed ID: 18316400
DOI: 10.1128/mcb.01931-07
PubMed ID: 18644859
Title: Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex.
PubMed ID: 18644859
DOI: 10.1128/mcb.00583-08
PubMed ID: 19946213
Title: A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation.
PubMed ID: 19946213
PubMed ID: 19141540
Title: Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications.
PubMed ID: 19141540
DOI: 10.1096/fj.08-117697
PubMed ID: 19605937
Title: Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription.
PubMed ID: 19605937
PubMed ID: 19414601
Title: Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription.
PubMed ID: 19414601
DOI: 10.1128/mcb.01864-08
PubMed ID: 19330005
Title: CK2alpha phosphorylates BMAL1 to regulate the mammalian clock.
PubMed ID: 19330005
DOI: 10.1038/nsmb.1578
PubMed ID: 19299583
Title: Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.
PubMed ID: 19299583
PubMed ID: 19286518
Title: Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1.
PubMed ID: 19286518
PubMed ID: 20840750
Title: Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction.
PubMed ID: 20840750
PubMed ID: 20153195
Title: Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2.
PubMed ID: 20153195
PubMed ID: 20430893
Title: CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2.
PubMed ID: 20430893
PubMed ID: 20861012
Title: The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression.
PubMed ID: 20861012
PubMed ID: 20385766
Title: Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver.
PubMed ID: 20385766
DOI: 10.1128/mcb.01141-09
PubMed ID: 21113167
Title: The histone methyltransferase MLL1 permits the oscillation of circadian gene expression.
PubMed ID: 21113167
DOI: 10.1038/nsmb.1961
PubMed ID: 20562852
Title: Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
PubMed ID: 20562852
DOI: 10.1038/nature09253
PubMed ID: 20049328
Title: Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation.
PubMed ID: 20049328
PubMed ID: 20956306
Title: CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function.
PubMed ID: 20956306
PubMed ID: 20093473
Title: Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock.
PubMed ID: 20093473
PubMed ID: 20106950
Title: Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene.
PubMed ID: 20106950
PubMed ID: 22101268
Title: Circadian clock protein BMAL1 regulates cellular senescence in vivo.
PubMed ID: 22101268
PubMed ID: 22045262
Title: Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in beta-cells.
PubMed ID: 22045262
PubMed ID: 21613214
Title: Biochemical analysis of the canonical model for the mammalian circadian clock.
PubMed ID: 21613214
PubMed ID: 21768648
Title: cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene.
PubMed ID: 21768648
PubMed ID: 20658528
Title: Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype.
PubMed ID: 20658528
DOI: 10.1002/jcp.22314
PubMed ID: 22208286
Title: Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells.
PubMed ID: 22208286
PubMed ID: 21966465
Title: Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation.
PubMed ID: 21966465
PubMed ID: 21960634
Title: Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.
PubMed ID: 21960634
PubMed ID: 22894897
Title: The RelB subunit of NFkappaB acts as a negative regulator of circadian gene expression.
PubMed ID: 22894897
DOI: 10.4161/cc.21669
PubMed ID: 22611086
Title: The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway.
PubMed ID: 22611086
DOI: 10.1096/fj.12-205781
PubMed ID: 22981862
Title: Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome.
PubMed ID: 22981862
PubMed ID: 22900038
Title: Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells.
PubMed ID: 22900038
PubMed ID: 23185022
Title: PKCgamma participates in food entrainment by regulating BMAL1.
PubMed ID: 23185022
PubMed ID: 24154698
Title: A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention.
PubMed ID: 24154698
PubMed ID: 23531614
Title: High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice.
PubMed ID: 23531614
PubMed ID: 23576606
Title: Mechanism of the circadian clock in physiology.
PubMed ID: 23576606
PubMed ID: 23955654
Title: The clock gene brain and muscle Arnt-like protein-1 (BMAL1) is involved in hair growth.
PubMed ID: 23955654
PubMed ID: 23291174
Title: The molecular clock regulates circadian transcription of tissue factor gene.
PubMed ID: 23291174
PubMed ID: 23337503
Title: O-GlcNAcylation of BMAL1 regulates circadian rhythms in NIH3T3 fibroblasts.
PubMed ID: 23337503
PubMed ID: 23831463
Title: Effects of NAD(P)H and its derivatives on the DNA-binding activity of NPAS2, a mammalian circadian transcription factor.
PubMed ID: 23831463
PubMed ID: 23395176
Title: O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination.
PubMed ID: 23395176
PubMed ID: 24268780
Title: The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exit.
PubMed ID: 24268780
PubMed ID: 23525013
Title: Brain and muscle Arnt-like 1 is a key regulator of myogenesis.
PubMed ID: 23525013
DOI: 10.1242/jcs.120519
PubMed ID: 24270424
Title: Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.
PubMed ID: 24270424
DOI: 10.1172/jci70317
PubMed ID: 24048828
Title: Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells.
PubMed ID: 24048828
PubMed ID: 23547261
Title: Bmal1 and beta-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced beta-cell failure in mice.
PubMed ID: 23547261
DOI: 10.1128/mcb.01421-12
PubMed ID: 24089055
Title: Metastasis-associated protein 1 is an integral component of the circadian molecular machinery.
PubMed ID: 24089055
DOI: 10.1038/ncomms3545
PubMed ID: 23750248
Title: Global loss of Bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism.
PubMed ID: 23750248
PubMed ID: 23303907
Title: Metabolism and the circadian clock converge.
PubMed ID: 23303907
PubMed ID: 24043798
Title: A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery.
PubMed ID: 24043798
PubMed ID: 23970558
Title: Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes.
PubMed ID: 23970558
PubMed ID: 24481314
Title: BMAL1-dependent regulation of the mTOR signaling pathway delays aging.
PubMed ID: 24481314
PubMed ID: 24529706
Title: SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm.
PubMed ID: 24529706
PubMed ID: 24603368
Title: Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice.
PubMed ID: 24603368
DOI: 10.1038/emm.2013.153
PubMed ID: 24395244
Title: CLOCK:BMAL1 is a pioneer-like transcription factor.
PubMed ID: 24395244
PubMed ID: 24442997
Title: CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity via SIRT1.
PubMed ID: 24442997
DOI: 10.1002/hep.26992
PubMed ID: 24385426
Title: Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression.
PubMed ID: 24385426
PubMed ID: 24378737
Title: Modulation of glucocorticoid receptor induction properties by core circadian clock proteins.
PubMed ID: 24378737
PubMed ID: 24736997
Title: A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.
PubMed ID: 24736997
PubMed ID: 23916625
Title: Molecular architecture of the mammalian circadian clock.
PubMed ID: 23916625
PubMed ID: 26776516
Title: Distinct roles of HDAC3 in the core circadian negative feedback loop are critical for clock function.
PubMed ID: 26776516
PubMed ID: 28985504
Title: CLOCK acetylates ASS1 to drive circadian rhythm of ureagenesis.
PubMed ID: 28985504
PubMed ID: 28903391
Title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.
PubMed ID: 28903391
PubMed ID: 29626158
Title: Deubiquitinating enzyme USP9X regulates cellular clock function by modulating the ubiquitination and degradation of a core circadian protein BMAL1.
PubMed ID: 29626158
DOI: 10.1042/bcj20180005
PubMed ID: 29937374
Title: Autophagy regulates the liver clock and glucose metabolism by degrading CRY1.
PubMed ID: 29937374
PubMed ID: 29996098
Title: The circadian clock controls immune checkpoint pathway in sepsis.
PubMed ID: 29996098
PubMed ID: 29138967
Title: Mice lacking EGR1 have impaired clock gene (BMAL1) oscillation, locomotor activity, and body temperature.
PubMed ID: 29138967
PubMed ID: 30096135
Title: Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock.
PubMed ID: 30096135
PubMed ID: 31294688
Title: Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters.
PubMed ID: 31294688
DOI: 10.7554/elife.43235
PubMed ID: 22653727
Title: Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
PubMed ID: 22653727
Sequence Information:
- Length: 632
- Mass: 69452
- Checksum: 9669C3712A95C2DE
- Sequence:
MADQRMDISS TISDFMSPGP TDLLSGSLGT SGVDCNRKRK GSATDYQLDD FAFEESMDTD KDDPHGRLEY AEHQGRIKNA REAHSQIEKR RRDKMNSFID ELASLVPTCN AMSRKLDKLT VLRMAVQHMK TLRGATNPYT EANYKPTFLS DDELKHLILR AADGFLFVVG CDRGKILFVS ESVFKILNYS QNDLIGQSLF DYLHPKDIAK VKEQLSSSDT APRERLIDAK TGLPVKTDIT PGPSRLCSGA RRSFFCRMKC NRPSVKVEDK DFASTCSKKK DRKSFCTIHS TGYLKSWPPT KMGLDEDNEP DNEGCNLSCL VAIGRLHSHM VPQPANGEIR VKSMEYVSRH AIDGKFVFVD QRATAILAYL PQELLGTSCY EYFHQDDIGH LAECHRQVLQ TREKITTNCY KFKIKDGSFI TLRSRWFSFM NPWTKEVEYI VSTNTVVLAN VLEGGDPTFP QLTAPPHSMD SMLPSGEGGP KRTHPTVPGI PGGTRAGAGK IGRMIAEEIM EIHRIRGSSP SSCGSSPLNI TSTPPPDASS PGGKKILNGG TPDIPSTGLL PGQAQETPGY PYSDSSSILG ENPHIGIDMI DNDQGSSSPS NDEAAMAVIM SLLEADAGLG GPVDFSDLPW PL
Genular Protein ID: 665097796
Symbol: Q3UHZ2_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10349636
Title: High-efficiency full-length cDNA cloning.
PubMed ID: 10349636
PubMed ID: 11042159
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
PubMed ID: 11042159
DOI: 10.1101/gr.145100
PubMed ID: 11076861
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
PubMed ID: 11076861
DOI: 10.1101/gr.152600
PubMed ID: 11217851
Title: Functional annotation of a full-length mouse cDNA collection.
PubMed ID: 11217851
DOI: 10.1038/35055500
PubMed ID: 12466851
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
PubMed ID: 12466851
DOI: 10.1038/nature01266
PubMed ID: 16141073
Title: Antisense Transcription in the Mammalian Transcriptome.
PubMed ID: 16141073
Sequence Information:
- Length: 626
- Mass: 68685
- Checksum: 837330EF65406CE4
- Sequence:
MADQRMDISS TISDFMSPGP TDLLSGSLGT SGVDCNRKRK GSATDYQESM DTDKDDPHGR LEYAEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP TCNAMSRKLD KLTVLRMAVQ HMKTLRGATN PYTEANYKPT FLSDDELKHL ILRAADGFLF VVGCDRGKIL FVSESVFKIL NYSQNDLIGQ SLFDYLHPKD IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC SGARRSFFCR MKCNRPSVKV EDKDFASTCS KKKADRKSFC TIHSTGYLKS WPPTKMGLDE DNEPDNEGCN LSCLVAIGRL HSHMVPQPAN GEIRVKSMEY VSRHAIDGKF VFVDQRATAI LAYLPQELLG TSCYEYFHQD DIGHLAECHR QVLQTREKIT TNCYKFKIKD GSFITLRSRW FSFMNPWTKE VEYIVSTNTV VLANVLEGGD PTFPQLTAPP HSMDSMLPSG EGGPKRTHPT VPGIPGGTRA GAGKIGRMIA EEIMEIHRIR GSSPSSCGSS PLNITSTPPP DASSPGGKKI LNGGTPDIPS TGLLPGQAQE TPGYPYSDSS SILGENPHIG IDMIDNDQGS SSPSNDEAAM AVIMSLLEAD AGLGGPVDFS DLPWPL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.