Details for: CLCNKA

Gene ID: 1187

Symbol: CLCNKA

Ensembl ID: ENSG00000186510

Description: chloride voltage-gated channel Ka

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.5
    Marker Score: 2656
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.15
    Marker Score: 5772
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.77
    Marker Score: 2936
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.59
    Marker Score: 839
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.29
    Marker Score: 20160
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.26
    Marker Score: 1186
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.22
    Marker Score: 1236
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.13
    Marker Score: 1038
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7304
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.04
    Marker Score: 1465
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.98
    Marker Score: 1186
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.93
    Marker Score: 2346
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.89
    Marker Score: 687
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 492
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.79
    Marker Score: 186
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1195
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.7
    Marker Score: 221
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.65
    Marker Score: 719.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.64
    Marker Score: 305
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1202
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 483
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.59
    Marker Score: 187
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.53
    Marker Score: 281
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.47
    Marker Score: 143
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.46
    Marker Score: 283
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.46
    Marker Score: 497
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.42
    Marker Score: 858
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.42
    Marker Score: 471
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.41
    Marker Score: 393
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.41
    Marker Score: 109
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.4
    Marker Score: 771
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.35
    Marker Score: 2980
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.33
    Marker Score: 412
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.26
    Marker Score: 624
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.26
    Marker Score: 82
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 138
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.22
    Marker Score: 158
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.21
    Marker Score: 886
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 93
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.2
    Marker Score: 709
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 52
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.15
    Marker Score: 31
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.15
    Marker Score: 146
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.14
    Marker Score: 89
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.14
    Marker Score: 484
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.13
    Marker Score: 84
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.13
    Marker Score: 48.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 183
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1
    Marker Score: 212
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.1
    Marker Score: 39
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.09
    Marker Score: 180
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 84
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.08
    Marker Score: 49
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.07
    Marker Score: 14
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.07
    Marker Score: 102
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.07
    Marker Score: 140
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.06
    Marker Score: 368
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.06
    Marker Score: 123
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.06
    Marker Score: 61
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.06
    Marker Score: 164
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 49
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.05
    Marker Score: 19

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Other Information

**Key characteristics:** * CLCNKA is a transmembrane protein with a predicted molecular weight of approximately 500 kDa. * It is a chloride channel, which means that it allows the flow of chloride ions across the cell membrane. * CLCNKA is a member of the chloride channel superfamily, which is characterized by the presence of a single transmembrane domain and a conserved pore-forming sequence. * It is expressed in a variety of cell types, including epithelial cells in the kidney, heart, and blood vessels. * CLCNKA is a key regulator of chloride transport in the body. **Pathways and functions:** * CLCNKA is involved in maintaining the resting membrane potential of cells. * It is expressed in epithelial cells in the kidney, where it is responsible for regulating water and electrolyte balance. * CLCNKA is also expressed in cardiac muscle, where it is involved in maintaining the resting membrane potential of cardiac cells. * It is a key regulator of chloride transport in the body, and its dysfunction can lead to a number of diseases, including kidney disease and heart failure. **Clinical significance:** * Mutations in the CLCNKA gene have been linked to a number of human diseases, including kidney disease, heart failure, and glaucoma. * Clinically, CLCNKA inhibitors are being developed as potential treatments for these diseases. * Understanding the role of CLCNKA in health and disease has important implications for the development of new treatments for a variety of diseases.

Genular Protein ID: 4283081279

Symbol: CLCKA_HUMAN

Name: Chloride channel protein ClC-Ka

UniProtKB Accession Codes:

P51800 B4DPD3 E7EPH6 Q5T5P8 Q5T5Q4 Q7Z6D1 Q86VT1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEBI 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 7 EPD 1 Ensembl 3 EvolutionaryTrace 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8041726

Title: Two highly homologous members of the ClC chloride channel family in both rat and human kidney.

PubMed ID: 8041726

DOI: 10.1073/pnas.91.15.6943

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11734858

Title: Barttin is a Cl- channel beta-subunit crucial for renal Cl-reabsorption and inner ear K+ secretion.

PubMed ID: 11734858

DOI: 10.1038/35107099

PubMed ID: 18310267

Title: Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness.

PubMed ID: 18310267

DOI: 10.1136/jmg.2007.052944

PubMed ID: 23148261

Title: Dissecting a regulatory calcium-binding site of CLC-K kidney chloride channels.

PubMed ID: 23148261

DOI: 10.1085/jgp.201210878

PubMed ID: 17562318

Title: The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface.

PubMed ID: 17562318

DOI: 10.1016/j.str.2007.04.013

PubMed ID: 15044642

Title: Salt wasting and deafness resulting from mutations in two chloride channels.

PubMed ID: 15044642

DOI: 10.1056/nejmoa032843

Sequence Information:

  • Length: 687
  • Mass: 75285
  • Checksum: E97C6928470A4460
  • Sequence:
    • MEELVGLREG FSGDPVTLQE LWGPCPHIRR AIQGGLEWLK QKVFRLGEDW YFLMTLGVLM 
ALVSYAMNFA IGCVVRAHQW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPSSGG 
SGIPELKTML AGVILEDYLD IKNFGAKVVG LSCTLATGST LFLGKVGPFV HLSVMIAAYL 
GRVRTTTIGE PENKSKQNEM LVAAAAVGVA TVFAAPFSGV LFSIEVMSSH FSVRDYWRGF 
FAATCGAFIF RLLAVFNSEQ ETITSLYKTS FRVDVPFDLP EIFFFVALGG ICGVLSCAYL 
FCQRTFLSFI KTNRYSSKLL ATSKPVYSAL ATLLLASITY PPGVGHFLAS RLSMKQHLDS 
LFDNHSWALM TQNSSPPWPE ELDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP 
MPAGYFMPIF ILGAAIGRLL GEALAVAFPE GIVTGGVTNP IMPGGYALAG AAAFSGAVTH 
TISTALLAFE LTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTIIVKKLP YLPRILGRNI 
GSHHVRVEHF MNHSITTLAK DTPLEEVVKV VTSTDVTEYP LVESTESQIL VGIVQRAQLV 
QALQAEPPSR APGHQQCLQD ILARGCPTEP VTLTLFSETT LHQAQNLFKL LNLQSLFVTS 
RGRAVGCVSW VEMKKAISNL TNPPAPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.