Details for: CLCNKA

Gene ID: 1187

Symbol: CLCNKA

Ensembl ID: ENSG00000186510

Description: chloride voltage-gated channel Ka

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 10.7104
    Cell Significance Index: 41.0100
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 5.1199
    Cell Significance Index: 17.5800
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 2.2601
    Cell Significance Index: 12.5800
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.1594
    Cell Significance Index: 0.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9666
    Cell Significance Index: 25.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2963
    Cell Significance Index: 15.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2297
    Cell Significance Index: 168.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.1965
    Cell Significance Index: -0.4300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1717
    Cell Significance Index: 2.1700
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.1661
    Cell Significance Index: 1.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1478
    Cell Significance Index: 6.7000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1469
    Cell Significance Index: 2.3300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1315
    Cell Significance Index: 1.0500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.1256
    Cell Significance Index: 2.6200
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1115
    Cell Significance Index: 1.1800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0791
    Cell Significance Index: 0.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0754
    Cell Significance Index: 2.2200
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.0669
    Cell Significance Index: 0.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0624
    Cell Significance Index: 1.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0587
    Cell Significance Index: 4.6500
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.0578
    Cell Significance Index: 0.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0577
    Cell Significance Index: 0.9500
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.0539
    Cell Significance Index: 0.4300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0506
    Cell Significance Index: 0.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0433
    Cell Significance Index: 6.3000
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.0425
    Cell Significance Index: 0.3900
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.0372
    Cell Significance Index: 0.4000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.0135
    Cell Significance Index: 0.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0129
    Cell Significance Index: 1.5000
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.0116
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0106
    Cell Significance Index: 19.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0106
    Cell Significance Index: 1.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0066
    Cell Significance Index: 0.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0043
    Cell Significance Index: 2.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0029
    Cell Significance Index: 0.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0028
    Cell Significance Index: 1.2600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.0022
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0022
    Cell Significance Index: 0.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0008
    Cell Significance Index: 1.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: -0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0003
    Cell Significance Index: -0.1700
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0014
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0020
    Cell Significance Index: -1.1200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0031
    Cell Significance Index: -1.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0035
    Cell Significance Index: -0.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0036
    Cell Significance Index: -0.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0040
    Cell Significance Index: -0.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0052
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0052
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0064
    Cell Significance Index: -1.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0068
    Cell Significance Index: -1.2200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0071
    Cell Significance Index: -0.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0072
    Cell Significance Index: -0.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0076
    Cell Significance Index: -0.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0077
    Cell Significance Index: -1.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0085
    Cell Significance Index: -1.1000
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0101
    Cell Significance Index: -0.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0102
    Cell Significance Index: -0.2600
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0104
    Cell Significance Index: -0.1000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0120
    Cell Significance Index: -0.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0122
    Cell Significance Index: -1.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0125
    Cell Significance Index: -1.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0125
    Cell Significance Index: -0.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0125
    Cell Significance Index: -0.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0141
    Cell Significance Index: -1.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0153
    Cell Significance Index: -0.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0175
    Cell Significance Index: -1.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0203
    Cell Significance Index: -0.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0205
    Cell Significance Index: -1.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0210
    Cell Significance Index: -1.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0223
    Cell Significance Index: -1.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0231
    Cell Significance Index: -1.0900
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0237
    Cell Significance Index: -0.2500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0238
    Cell Significance Index: -0.5800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0250
    Cell Significance Index: -0.3800
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0258
    Cell Significance Index: -0.3000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0263
    Cell Significance Index: -0.3500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0264
    Cell Significance Index: -0.2800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0266
    Cell Significance Index: -0.2100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0270
    Cell Significance Index: -0.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0301
    Cell Significance Index: -1.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0322
    Cell Significance Index: -0.8600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0332
    Cell Significance Index: -0.4900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0339
    Cell Significance Index: -0.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0340
    Cell Significance Index: -0.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0340
    Cell Significance Index: -1.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0341
    Cell Significance Index: -1.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0344
    Cell Significance Index: -0.9900
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: -0.0351
    Cell Significance Index: -0.2600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0354
    Cell Significance Index: -1.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0359
    Cell Significance Index: -0.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0365
    Cell Significance Index: -1.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0368
    Cell Significance Index: -0.7800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0368
    Cell Significance Index: -0.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Voltage-gated chloride channel:** The CLCNKA channel is a voltage-gated chloride channel, meaning it opens and closes in response to changes in the electrical potential across the cell membrane. 2. **High permeability to chloride ions:** The channel has a high permeability to chloride ions, allowing for efficient transport of these ions into and out of cells. 3. **Regulation of chloride transport:** The CLCNKA channel is part of the chloride transport complex, which regulates the movement of chloride ions into and out of cells, maintaining proper fluid balance and ion homeostasis. 4. **Expression in various tissues:** The CLCNKA gene is expressed in a wide range of tissues, including the kidney, heart, nervous system, and gastrointestinal tract. **Pathways and Functions:** 1. **Chloride transport:** The CLCNKA channel is involved in the chloride transport complex, which regulates the movement of chloride ions into and out of cells, maintaining proper fluid balance and ion homeostasis. 2. **Ion balance:** The channel plays a crucial role in maintaining ion balance by regulating the movement of chloride ions into and out of cells, which is essential for maintaining proper fluid balance and nerve function. 3. **Muscle contraction:** The CLCNKA channel is also involved in muscle contraction, as it regulates the movement of chloride ions into and out of muscle cells, which is essential for muscle function. 4. **Renal function:** The CLCNKA channel is expressed in the kidney and plays a crucial role in regulating chloride transport and ion balance in the renal collecting duct. **Clinical Significance:** 1. **Cystic fibrosis:** Mutations in the CLCNKA gene have been associated with cystic fibrosis, a genetic disorder characterized by abnormal chloride transport and ion imbalance. 2. **Respiratory diseases:** The CLCNKA channel is also involved in respiratory diseases, such as chronic obstructive pulmonary disease (COPD), where abnormal chloride transport and ion imbalance contribute to disease progression. 3. **Heart failure:** The CLCNKA channel is expressed in the heart and plays a crucial role in maintaining proper ion balance and fluid balance, making it a potential target for therapeutic interventions in heart failure. 4. **Neurological disorders:** The CLCNKA channel is also involved in neurological disorders, such as epilepsy and anxiety disorders, where abnormal chloride transport and ion imbalance contribute to disease progression. In conclusion, the CLCNKA gene and its encoded chloride voltage-gated channel Ka play a crucial role in regulating ion and water balance in the body, and its dysfunction can contribute to various diseases and disorders. Further research is needed to fully understand the mechanisms of the CLCNKA channel and its clinical significance in human diseases.

Genular Protein ID: 4283081279

Symbol: CLCKA_HUMAN

Name: Chloride channel protein ClC-Ka

UniProtKB Accession Codes:

P51800 B4DPD3 E7EPH6 Q5T5P8 Q5T5Q4 Q7Z6D1 Q86VT1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEBI 8 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 Rhea 4 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8041726

Title: Two highly homologous members of the ClC chloride channel family in both rat and human kidney.

PubMed ID: 8041726

DOI: 10.1073/pnas.91.15.6943

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11734858

Title: Barttin is a Cl- channel beta-subunit crucial for renal Cl-reabsorption and inner ear K+ secretion.

PubMed ID: 11734858

DOI: 10.1038/35107099

PubMed ID: 12111250

Title: Barttin increases surface expression and changes current properties of ClC-K channels.

PubMed ID: 12111250

DOI: 10.1007/s00424-002-0819-8

PubMed ID: 19646679

Title: Molecular basis of DFNB73: mutations of BSND can cause nonsyndromic deafness or Bartter syndrome.

PubMed ID: 19646679

DOI: 10.1016/j.ajhg.2009.07.003

PubMed ID: 18776122

Title: Disease-causing dysfunctions of barttin in Bartter syndrome type IV.

PubMed ID: 18776122

DOI: 10.1681/asn.2008010102

PubMed ID: 20538786

Title: Barttin activates ClC-K channel function by modulating gating.

PubMed ID: 20538786

DOI: 10.1681/asn.2009121274

PubMed ID: 23148261

Title: Dissecting a regulatory calcium-binding site of CLC-K kidney chloride channels.

PubMed ID: 23148261

DOI: 10.1085/jgp.201210878

PubMed ID: 17562318

Title: The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface.

PubMed ID: 17562318

DOI: 10.1016/j.str.2007.04.013

PubMed ID: 15044642

Title: Salt wasting and deafness resulting from mutations in two chloride channels.

PubMed ID: 15044642

DOI: 10.1056/nejmoa032843

PubMed ID: 18310267

Title: Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness.

PubMed ID: 18310267

DOI: 10.1136/jmg.2007.052944

Sequence Information:

  • Length: 687
  • Mass: 75285
  • Checksum: E97C6928470A4460
  • Sequence:
    • MEELVGLREG FSGDPVTLQE LWGPCPHIRR AIQGGLEWLK QKVFRLGEDW YFLMTLGVLM 
ALVSYAMNFA IGCVVRAHQW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPSSGG 
SGIPELKTML AGVILEDYLD IKNFGAKVVG LSCTLATGST LFLGKVGPFV HLSVMIAAYL 
GRVRTTTIGE PENKSKQNEM LVAAAAVGVA TVFAAPFSGV LFSIEVMSSH FSVRDYWRGF 
FAATCGAFIF RLLAVFNSEQ ETITSLYKTS FRVDVPFDLP EIFFFVALGG ICGVLSCAYL 
FCQRTFLSFI KTNRYSSKLL ATSKPVYSAL ATLLLASITY PPGVGHFLAS RLSMKQHLDS 
LFDNHSWALM TQNSSPPWPE ELDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP 
MPAGYFMPIF ILGAAIGRLL GEALAVAFPE GIVTGGVTNP IMPGGYALAG AAAFSGAVTH 
TISTALLAFE LTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTIIVKKLP YLPRILGRNI 
GSHHVRVEHF MNHSITTLAK DTPLEEVVKV VTSTDVTEYP LVESTESQIL VGIVQRAQLV 
QALQAEPPSR APGHQQCLQD ILARGCPTEP VTLTLFSETT LHQAQNLFKL LNLQSLFVTS 
RGRAVGCVSW VEMKKAISNL TNPPAPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.