Details for: CLCNKA

Gene ID: 1187

Symbol: CLCNKA

Ensembl ID: ENSG00000186510

Description: chloride voltage-gated channel Ka

Associated with

Other Information

Genular Protein ID: 4283081279

Symbol: CLCKA_HUMAN

Name: Chloride channel protein ClC-Ka

UniProtKB Accession Codes:

P51800 B4DPD3 E7EPH6 Q5T5P8 Q5T5Q4 Q7Z6D1 Q86VT1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEBI 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 7 EPD 1 Ensembl 3 EvolutionaryTrace 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8041726

Title: Two highly homologous members of the ClC chloride channel family in both rat and human kidney.

PubMed ID: 8041726

DOI: 10.1073/pnas.91.15.6943

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11734858

Title: Barttin is a Cl- channel beta-subunit crucial for renal Cl-reabsorption and inner ear K+ secretion.

PubMed ID: 11734858

DOI: 10.1038/35107099

PubMed ID: 18310267

Title: Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness.

PubMed ID: 18310267

DOI: 10.1136/jmg.2007.052944

PubMed ID: 23148261

Title: Dissecting a regulatory calcium-binding site of CLC-K kidney chloride channels.

PubMed ID: 23148261

DOI: 10.1085/jgp.201210878

PubMed ID: 17562318

Title: The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface.

PubMed ID: 17562318

DOI: 10.1016/j.str.2007.04.013

PubMed ID: 15044642

Title: Salt wasting and deafness resulting from mutations in two chloride channels.

PubMed ID: 15044642

DOI: 10.1056/nejmoa032843

Sequence Information:

  • Length: 687
  • Mass: 75285
  • Checksum: E97C6928470A4460
  • Sequence:
    • MEELVGLREG FSGDPVTLQE LWGPCPHIRR AIQGGLEWLK QKVFRLGEDW YFLMTLGVLM 
ALVSYAMNFA IGCVVRAHQW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPSSGG 
SGIPELKTML AGVILEDYLD IKNFGAKVVG LSCTLATGST LFLGKVGPFV HLSVMIAAYL 
GRVRTTTIGE PENKSKQNEM LVAAAAVGVA TVFAAPFSGV LFSIEVMSSH FSVRDYWRGF 
FAATCGAFIF RLLAVFNSEQ ETITSLYKTS FRVDVPFDLP EIFFFVALGG ICGVLSCAYL 
FCQRTFLSFI KTNRYSSKLL ATSKPVYSAL ATLLLASITY PPGVGHFLAS RLSMKQHLDS 
LFDNHSWALM TQNSSPPWPE ELDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP 
MPAGYFMPIF ILGAAIGRLL GEALAVAFPE GIVTGGVTNP IMPGGYALAG AAAFSGAVTH 
TISTALLAFE LTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTIIVKKLP YLPRILGRNI 
GSHHVRVEHF MNHSITTLAK DTPLEEVVKV VTSTDVTEYP LVESTESQIL VGIVQRAQLV 
QALQAEPPSR APGHQQCLQD ILARGCPTEP VTLTLFSETT LHQAQNLFKL LNLQSLFVTS 
RGRAVGCVSW VEMKKAISNL TNPPAPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.