Details for: Arx

Gene ID: 11878

Symbol: Arx

Ensembl ID: ENSMUSG00000035277

Description: aristaless related homeobox

Associated with

  • Axon guidance
    (GO:0007411)
  • Cell differentiation
    (GO:0030154)
  • Cell proliferation in forebrain
    (GO:0021846)
  • Cerebral cortex gabaergic interneuron migration
    (GO:0021853)
  • Cerebral cortex tangential migration
    (GO:0021800)
  • Chromatin binding
    (GO:0003682)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Embryonic olfactory bulb interneuron precursor migration
    (GO:0021831)
  • Epithelial cell fate commitment
    (GO:0072148)
  • Forebrain development
    (GO:0030900)
  • Globus pallidus development
    (GO:0021759)
  • Interneuron migration
    (GO:1904936)
  • Lipid digestion
    (GO:0044241)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nervous system development
    (GO:0007399)
  • Neuron migration
    (GO:0001764)
  • Nucleus
    (GO:0005634)
  • Olfactory bulb development
    (GO:0021772)
  • Organ growth
    (GO:0035265)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of organ growth
    (GO:0046622)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of epithelial cell proliferation
    (GO:0050678)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Other Information

Genular Protein ID: 1227001654

Symbol: ARX_MOUSE

Name: Homeobox protein ARX

UniProtKB Accession Codes:

O35085 A2A4G9 Q9QYT4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 4 Ensembl 2 GO 27 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9256348

Title: Expression of a novel aristaless related homeobox gene 'Arx' in the vertebrate telencephalon, diencephalon and floor plate.

PubMed ID: 9256348

DOI: 10.1016/s0925-4773(97)00062-2

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 12379852

Title: Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans.

PubMed ID: 12379852

DOI: 10.1038/ng1009

PubMed ID: 31691806

Title: Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.

PubMed ID: 31691806

DOI: 10.1093/hmg/ddz254

Sequence Information:

  • Length: 564
  • Mass: 58490
  • Checksum: 74FEBBD3BA92B39C
  • Sequence:
    • MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL PAPLASRADQ 
EKAMQGSPKS SSAPFEAELH LPPKLRRLYG PGGGRLLQGA AAAAAAAAAA AAAATATGTA 
GPRGEVPPPP PPAARPGERQ DSAGAVAAAA AAAAWDTLKI SQAPQVSISR SKSYRENGAP 
FVPPPPALDE LSGPGGVAHP EERLSAASGP GSAPAAGGGT GAEDDEEELL EDEEDEEEEE 
ELLEDDDEEL LEDDARALLK EPRRCSVATT GTVAAAAAAA AAAVATEGGE LSPKEELLLH 
PEDAEGKDGE DSVCLSAGSD SEEGLLKRKQ RRYRTTFTSY QLEELERAFQ KTHYPDVFTR 
EELAMRLDLT EARVQVWFQN RRAKWRKREK AGAQTHPPGL PFPGPLSATH PLSPYLDASP 
FPPHHPALDS AWTAAAAAAA AAFPSLPPPP GSASLPPSGA PLGLSTFLGA AVFRHPAFIS 
PAFGRLFSTM APLTSASTAA ALLRQPTPAV EGAVASGALA DPATAAADRR ASSIAALRLK 
AKEHAAQLTQ LNILPGTSTG KEVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.