Details for: CLCNKB
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 15.5707
Cell Significance Index: 59.6200 - Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 9.7399
Cell Significance Index: -1.5200 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 6.8644
Cell Significance Index: 23.5700 - Cell Name: salivary gland glandular cell (CL1001596)
Fold Change: 2.0984
Cell Significance Index: 11.6800 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.6532
Cell Significance Index: 6.9400 - Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.6291
Cell Significance Index: 0.4500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.4853
Cell Significance Index: 6.9500 - Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 0.4202
Cell Significance Index: 1.8600 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.2802
Cell Significance Index: 3.5400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2612
Cell Significance Index: 7.0000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2527
Cell Significance Index: 185.3100 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.1766
Cell Significance Index: 1.4100 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.1722
Cell Significance Index: 1.6400 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.1625
Cell Significance Index: 1.7200 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.1365
Cell Significance Index: 1.0900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1238
Cell Significance Index: 6.5000 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.1081
Cell Significance Index: 1.1200 - Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.0902
Cell Significance Index: 0.7900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.0812
Cell Significance Index: 6.4300 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.0797
Cell Significance Index: 1.2700 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.0722
Cell Significance Index: 0.9000 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.0715
Cell Significance Index: 0.8500 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.0677
Cell Significance Index: 0.6100 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.0570
Cell Significance Index: 1.1600 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 0.0479
Cell Significance Index: 1.0000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0472
Cell Significance Index: 2.1400 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.0454
Cell Significance Index: 0.1300 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.0375
Cell Significance Index: 0.5200 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.0344
Cell Significance Index: 0.2900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0190
Cell Significance Index: 2.2200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0165
Cell Significance Index: 2.1200 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.0121
Cell Significance Index: 0.1300 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.0076
Cell Significance Index: 0.0800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0009
Cell Significance Index: 0.0400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0009
Cell Significance Index: 1.6000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0005
Cell Significance Index: 1.0300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0002
Cell Significance Index: 0.2600 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0003
Cell Significance Index: -0.3800 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0007
Cell Significance Index: -0.0100 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0010
Cell Significance Index: -0.5600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0013
Cell Significance Index: -0.4600 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0014
Cell Significance Index: -0.0600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0018
Cell Significance Index: -1.3900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0019
Cell Significance Index: -1.3800 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0023
Cell Significance Index: -0.0300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0025
Cell Significance Index: -1.4300 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0026
Cell Significance Index: -0.0200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0028
Cell Significance Index: -1.7700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0044
Cell Significance Index: -0.5000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0046
Cell Significance Index: -2.1100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0046
Cell Significance Index: -1.3100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0051
Cell Significance Index: -0.3900 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0055
Cell Significance Index: -0.0900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0060
Cell Significance Index: -1.2000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0062
Cell Significance Index: -1.0600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0067
Cell Significance Index: -0.6800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0071
Cell Significance Index: -1.4200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0073
Cell Significance Index: -1.5300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0089
Cell Significance Index: -1.2900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0090
Cell Significance Index: -1.2300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0109
Cell Significance Index: -1.9700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0110
Cell Significance Index: -0.5700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0113
Cell Significance Index: -1.4600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0137
Cell Significance Index: -0.3500 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: -0.0140
Cell Significance Index: -0.1300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0145
Cell Significance Index: -0.3800 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.0160
Cell Significance Index: -0.1800 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: -0.0165
Cell Significance Index: -0.1500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0169
Cell Significance Index: -0.3700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0176
Cell Significance Index: -2.1600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0182
Cell Significance Index: -0.9200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0184
Cell Significance Index: -1.3700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0231
Cell Significance Index: -1.4900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0233
Cell Significance Index: -1.3100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0236
Cell Significance Index: -1.5900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0254
Cell Significance Index: -1.5600 - Cell Name: osteoclast (CL0000092)
Fold Change: -0.0260
Cell Significance Index: -0.2700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0261
Cell Significance Index: -0.7100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0279
Cell Significance Index: -0.4700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0286
Cell Significance Index: -0.3900 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.0288
Cell Significance Index: -0.1800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0290
Cell Significance Index: -0.8600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0298
Cell Significance Index: -0.5100 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0307
Cell Significance Index: -0.7700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0312
Cell Significance Index: -0.4600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0318
Cell Significance Index: -1.5000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0318
Cell Significance Index: -0.4700 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0333
Cell Significance Index: -0.4600 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: -0.0363
Cell Significance Index: -0.3600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0397
Cell Significance Index: -0.6700 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: -0.0400
Cell Significance Index: -0.4300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0404
Cell Significance Index: -1.2900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0406
Cell Significance Index: -1.4900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0407
Cell Significance Index: -1.5400 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: -0.0411
Cell Significance Index: -0.4400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0413
Cell Significance Index: -1.4400 - Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
Fold Change: -0.0421
Cell Significance Index: -0.5000 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: -0.0427
Cell Significance Index: -0.6000 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.0429
Cell Significance Index: -0.5100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 445881909
Symbol: CLCKB_HUMAN
Name: Chloride channel protein ClC-Kb
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8041726
Title: Two highly homologous members of the ClC chloride channel family in both rat and human kidney.
PubMed ID: 8041726
PubMed ID: 8544406
Title: Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.
PubMed ID: 8544406
DOI: 10.1038/ki.1995.439
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 11734858
Title: Barttin is a Cl- channel beta-subunit crucial for renal Cl-reabsorption and inner ear K+ secretion.
PubMed ID: 11734858
DOI: 10.1038/35107099
PubMed ID: 12111250
Title: Barttin increases surface expression and changes current properties of ClC-K channels.
PubMed ID: 12111250
PubMed ID: 16849430
Title: Barttin modulates trafficking and function of ClC-K channels.
PubMed ID: 16849430
PubMed ID: 19646679
Title: Molecular basis of DFNB73: mutations of BSND can cause nonsyndromic deafness or Bartter syndrome.
PubMed ID: 19646679
PubMed ID: 18776122
Title: Disease-causing dysfunctions of barttin in Bartter syndrome type IV.
PubMed ID: 18776122
PubMed ID: 15044642
Title: Salt wasting and deafness resulting from mutations in two chloride channels.
PubMed ID: 15044642
DOI: 10.1056/nejmoa032843
PubMed ID: 18310267
Title: Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness.
PubMed ID: 18310267
PubMed ID: 9326936
Title: Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III.
PubMed ID: 9326936
DOI: 10.1038/ng1097-171
PubMed ID: 10906158
Title: Mutations in the chloride channel gene CLCNKB as a cause of classic Bartter syndrome.
PubMed ID: 10906158
DOI: 10.1681/asn.v1181449
Sequence Information:
- Length: 687
- Mass: 75446
- Checksum: 4D28BC19DDD5D412
- Sequence:
MEEFVGLREG SSGNPVTLQE LWGPCPRIRR GIRGGLEWLK QKLFRLGEDW YFLMTLGVLM ALVSCAMDLA VESVVRAHQW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPSSGG SGIPEVKTML AGVVLEDYLD IKNFGAKVVG LSCTLACGST LFLGKVGPFV HLSVMMAAYL GRVRTTTIGE PENKSKQNEM LVAAAAVGVA TVFAAPFSGV LFSIEVMSSH FSVWDYWRGF FAATCGAFMF RLLAVFNSEQ ETITSLYKTS FRVDVPFDLP EIFFFVALGG LCGILGSAYL FCQRIFFGFI RNNRFSSKLL ATSKPVYSAL ATLVLASITY PPSAGRFLAS RLSMKQHLDS LFDNHSWALM TQNSSPPWPE ELDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP MPAGYFMPIF VYGAAIGRLF GETLSFIFPE GIVAGGITNP IMPGGYALAG AAAFSGAVTH TISTALLAFE VTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTVIVKKLP YLPRILGRNI GSHRVRVEHF MNHSITTLAK DMPLEEVVKV VTSTDVAKYP LVESTESQIL VGIVRRAQLV QALKAEPPSW APGHQQCLQD ILAAGCPTEP VTLKLSPETS LHEAHNLFEL LNLHSLFVTS RGRAVGCVSW VEMKKAISNL TNPPAPK
Genular Protein ID: 3185599483
Symbol: A8K8H0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 687
- Mass: 75388
- Checksum: 35DDF654B3BD70A4
- Sequence:
MEEFVGLREG SSGNPVTLQE LWGPCPLIRR GIRGGLEWLK QKLFRLGEDW YFLMTLGVLM ALVSCAMDLA VESVVRAHQW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPSSGG SGIPEVKTML AGVVLEDYLD IKNFGAKVVG LSCTLACGST LFLGKVGPFV HLSVMMAAYL GRVRTTTIGE PENKSKQNEM LVAAAAVGVA TVFGAPFSGV LFSIEVMSSH FSVWDYWRGF FAATCGAFMF RLLAVFNSEQ ETITSLYKTS FRVDVPFDLP EIFFFVVLGG LCGILGSAYL FCQRIFFGFI RNNRFSSKLL ATSKPVYSAL ATLVLASITY PPSAGRFLAS RLSMKQHLDS LFDNHSWALM TQNSSPPWPE ELDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP MPAGYFMPIF VYGAAIGRLF GETLSFIFPE GIVAGGITNP IMPGGYALAG AAAFSGAVTH TISTALLAFE VTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTVIVKKLP YLPRILGRNI GSHRVRVEHF MNHSITTLAK DTPLEEVVKV VTSTDVAEYP LVESTESQIL VGIVRRAQLV QALKAEPPSW APGHQQCLQD ILAAGCPTEP VTLKLSPETS LHEAHNLFEL LNLHSLFVTS RGRAVGCVSW VEMKKAISNL TNPPAPK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.