Details for: CLCNKB

Gene ID: 1188

Symbol: CLCNKB

Ensembl ID: ENSG00000184908

Description: chloride voltage-gated channel Kb

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 15.5707
    Cell Significance Index: 59.6200
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 9.7399
    Cell Significance Index: -1.5200
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 6.8644
    Cell Significance Index: 23.5700
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 2.0984
    Cell Significance Index: 11.6800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6532
    Cell Significance Index: 6.9400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.6291
    Cell Significance Index: 0.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4853
    Cell Significance Index: 6.9500
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.4202
    Cell Significance Index: 1.8600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2802
    Cell Significance Index: 3.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2612
    Cell Significance Index: 7.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2527
    Cell Significance Index: 185.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1766
    Cell Significance Index: 1.4100
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.1722
    Cell Significance Index: 1.6400
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1625
    Cell Significance Index: 1.7200
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.1365
    Cell Significance Index: 1.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1238
    Cell Significance Index: 6.5000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.1081
    Cell Significance Index: 1.1200
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.0902
    Cell Significance Index: 0.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0812
    Cell Significance Index: 6.4300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0797
    Cell Significance Index: 1.2700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0722
    Cell Significance Index: 0.9000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0715
    Cell Significance Index: 0.8500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.0677
    Cell Significance Index: 0.6100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0570
    Cell Significance Index: 1.1600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0479
    Cell Significance Index: 1.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0472
    Cell Significance Index: 2.1400
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.0454
    Cell Significance Index: 0.1300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0375
    Cell Significance Index: 0.5200
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.0344
    Cell Significance Index: 0.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0190
    Cell Significance Index: 2.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0165
    Cell Significance Index: 2.1200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.0121
    Cell Significance Index: 0.1300
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.0076
    Cell Significance Index: 0.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0009
    Cell Significance Index: 0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0009
    Cell Significance Index: 1.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 1.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0002
    Cell Significance Index: 0.2600
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.3800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0010
    Cell Significance Index: -0.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0013
    Cell Significance Index: -0.4600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0014
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0018
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.3800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0025
    Cell Significance Index: -1.4300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0026
    Cell Significance Index: -0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0044
    Cell Significance Index: -0.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0046
    Cell Significance Index: -2.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0046
    Cell Significance Index: -1.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0051
    Cell Significance Index: -0.3900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0055
    Cell Significance Index: -0.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0060
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0062
    Cell Significance Index: -1.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0067
    Cell Significance Index: -0.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0071
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0073
    Cell Significance Index: -1.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0089
    Cell Significance Index: -1.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0090
    Cell Significance Index: -1.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0109
    Cell Significance Index: -1.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0110
    Cell Significance Index: -0.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0113
    Cell Significance Index: -1.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0137
    Cell Significance Index: -0.3500
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: -0.0140
    Cell Significance Index: -0.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0145
    Cell Significance Index: -0.3800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0160
    Cell Significance Index: -0.1800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0165
    Cell Significance Index: -0.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0169
    Cell Significance Index: -0.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0176
    Cell Significance Index: -2.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0182
    Cell Significance Index: -0.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0184
    Cell Significance Index: -1.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0231
    Cell Significance Index: -1.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0233
    Cell Significance Index: -1.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0236
    Cell Significance Index: -1.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0254
    Cell Significance Index: -1.5600
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0260
    Cell Significance Index: -0.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0261
    Cell Significance Index: -0.7100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0279
    Cell Significance Index: -0.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0286
    Cell Significance Index: -0.3900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0288
    Cell Significance Index: -0.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0290
    Cell Significance Index: -0.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0298
    Cell Significance Index: -0.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0307
    Cell Significance Index: -0.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0312
    Cell Significance Index: -0.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0318
    Cell Significance Index: -1.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0318
    Cell Significance Index: -0.4700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0333
    Cell Significance Index: -0.4600
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0363
    Cell Significance Index: -0.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0397
    Cell Significance Index: -0.6700
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0400
    Cell Significance Index: -0.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0404
    Cell Significance Index: -1.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0406
    Cell Significance Index: -1.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0407
    Cell Significance Index: -1.5400
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0411
    Cell Significance Index: -0.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0413
    Cell Significance Index: -1.4400
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0421
    Cell Significance Index: -0.5000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0427
    Cell Significance Index: -0.6000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0429
    Cell Significance Index: -0.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Voltage-gated chloride channel**: CLCNKB is a voltage-gated chloride channel that allows chloride ions to flow into the cell in response to changes in membrane potential. 2. **Ion channel transport**: CLCNKB is involved in the transport of chloride ions across cell membranes, regulating their concentration and maintaining electrolyte balance. 3. **Widespread expression**: CLCNKB is expressed in various tissues, including the kidneys, blood vessels, and immune cells, suggesting its importance in multiple physiological processes. 4. **Cell type specificity**: CLCNKB is specifically expressed in certain cell types, such as distal convoluted tubule epithelial cells, collecting duct intercalated cells, and plasma cells, highlighting its role in specific cellular functions. **Pathways and Functions:** 1. **Chloride channel complex**: CLCNKB is part of the chloride channel complex, which regulates chloride ion transport and maintains electrolyte balance. 2. **Transepithelial chloride transport**: CLCNKB is involved in the transport of chloride ions across epithelial tissues, regulating fluid and electrolyte balance. 3. **Renal absorption**: CLCNKB plays a crucial role in renal sodium ion absorption, regulating sodium ion reabsorption and maintaining electrolyte balance. 4. **Stimuli-sensing channels**: CLCNKB is part of stimuli-sensing channels that respond to changes in membrane potential, regulating cellular responses to environmental stimuli. 5. **Voltage-gated chloride channel activity**: CLCNKB's voltage-gated activity allows it to regulate chloride ion transport in response to changes in membrane potential. **Clinical Significance:** 1. **Renal function disorders**: Mutations in CLCNKB have been associated with renal function disorders, such as Bartter syndrome and pseudohypoaldosteronism type 1. 2. **Electrolyte imbalance**: CLCNKB dysfunction can lead to electrolyte imbalance, resulting in symptoms such as muscle weakness, fatigue, and cardiac arrhythmias. 3. **Immune system disorders**: CLCNKB is expressed in immune cells, suggesting its role in immune system function and disorders, such as autoimmune diseases. 4. **Cancer**: CLCNKB has been implicated in cancer development and progression, particularly in renal and lung cancers. 5. **Therapeutic potential**: CLCNKB's role in maintaining electrolyte balance and renal function makes it a potential target for therapeutic interventions in various diseases. In conclusion, CLCNKB is a critical gene that plays a vital role in maintaining electrolyte balance, renal function, and immune system homeostasis. Its dysfunction can lead to various clinical disorders, highlighting the importance of understanding its functions and mechanisms of action. Further research is needed to fully elucidate the role of CLCNKB in human health and disease.

Genular Protein ID: 445881909

Symbol: CLCKB_HUMAN

Name: Chloride channel protein ClC-Kb

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8041726

Title: Two highly homologous members of the ClC chloride channel family in both rat and human kidney.

PubMed ID: 8041726

DOI: 10.1073/pnas.91.15.6943

PubMed ID: 8544406

Title: Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.

PubMed ID: 8544406

DOI: 10.1038/ki.1995.439

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 11734858

Title: Barttin is a Cl- channel beta-subunit crucial for renal Cl-reabsorption and inner ear K+ secretion.

PubMed ID: 11734858

DOI: 10.1038/35107099

PubMed ID: 12111250

Title: Barttin increases surface expression and changes current properties of ClC-K channels.

PubMed ID: 12111250

DOI: 10.1007/s00424-002-0819-8

PubMed ID: 16849430

Title: Barttin modulates trafficking and function of ClC-K channels.

PubMed ID: 16849430

DOI: 10.1073/pnas.0601631103

PubMed ID: 19646679

Title: Molecular basis of DFNB73: mutations of BSND can cause nonsyndromic deafness or Bartter syndrome.

PubMed ID: 19646679

DOI: 10.1016/j.ajhg.2009.07.003

PubMed ID: 18776122

Title: Disease-causing dysfunctions of barttin in Bartter syndrome type IV.

PubMed ID: 18776122

DOI: 10.1681/asn.2008010102

PubMed ID: 15044642

Title: Salt wasting and deafness resulting from mutations in two chloride channels.

PubMed ID: 15044642

DOI: 10.1056/nejmoa032843

PubMed ID: 18310267

Title: Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness.

PubMed ID: 18310267

DOI: 10.1136/jmg.2007.052944

PubMed ID: 9326936

Title: Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III.

PubMed ID: 9326936

DOI: 10.1038/ng1097-171

PubMed ID: 10906158

Title: Mutations in the chloride channel gene CLCNKB as a cause of classic Bartter syndrome.

PubMed ID: 10906158

DOI: 10.1681/asn.v1181449

Sequence Information:

  • Length: 687
  • Mass: 75446
  • Checksum: 4D28BC19DDD5D412
  • Sequence:
  • MEEFVGLREG SSGNPVTLQE LWGPCPRIRR GIRGGLEWLK QKLFRLGEDW YFLMTLGVLM 
    ALVSCAMDLA VESVVRAHQW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPSSGG 
    SGIPEVKTML AGVVLEDYLD IKNFGAKVVG LSCTLACGST LFLGKVGPFV HLSVMMAAYL 
    GRVRTTTIGE PENKSKQNEM LVAAAAVGVA TVFAAPFSGV LFSIEVMSSH FSVWDYWRGF 
    FAATCGAFMF RLLAVFNSEQ ETITSLYKTS FRVDVPFDLP EIFFFVALGG LCGILGSAYL 
    FCQRIFFGFI RNNRFSSKLL ATSKPVYSAL ATLVLASITY PPSAGRFLAS RLSMKQHLDS 
    LFDNHSWALM TQNSSPPWPE ELDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP 
    MPAGYFMPIF VYGAAIGRLF GETLSFIFPE GIVAGGITNP IMPGGYALAG AAAFSGAVTH 
    TISTALLAFE VTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTVIVKKLP YLPRILGRNI 
    GSHRVRVEHF MNHSITTLAK DMPLEEVVKV VTSTDVAKYP LVESTESQIL VGIVRRAQLV 
    QALKAEPPSW APGHQQCLQD ILAAGCPTEP VTLKLSPETS LHEAHNLFEL LNLHSLFVTS 
    RGRAVGCVSW VEMKKAISNL TNPPAPK

Genular Protein ID: 3185599483

Symbol: A8K8H0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 687
  • Mass: 75388
  • Checksum: 35DDF654B3BD70A4
  • Sequence:
  • MEEFVGLREG SSGNPVTLQE LWGPCPLIRR GIRGGLEWLK QKLFRLGEDW YFLMTLGVLM 
    ALVSCAMDLA VESVVRAHQW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPSSGG 
    SGIPEVKTML AGVVLEDYLD IKNFGAKVVG LSCTLACGST LFLGKVGPFV HLSVMMAAYL 
    GRVRTTTIGE PENKSKQNEM LVAAAAVGVA TVFGAPFSGV LFSIEVMSSH FSVWDYWRGF 
    FAATCGAFMF RLLAVFNSEQ ETITSLYKTS FRVDVPFDLP EIFFFVVLGG LCGILGSAYL 
    FCQRIFFGFI RNNRFSSKLL ATSKPVYSAL ATLVLASITY PPSAGRFLAS RLSMKQHLDS 
    LFDNHSWALM TQNSSPPWPE ELDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP 
    MPAGYFMPIF VYGAAIGRLF GETLSFIFPE GIVAGGITNP IMPGGYALAG AAAFSGAVTH 
    TISTALLAFE VTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTVIVKKLP YLPRILGRNI 
    GSHRVRVEHF MNHSITTLAK DTPLEEVVKV VTSTDVAEYP LVESTESQIL VGIVRRAQLV 
    QALKAEPPSW APGHQQCLQD ILAAGCPTEP VTLKLSPETS LHEAHNLFEL LNLHSLFVTS 
    RGRAVGCVSW VEMKKAISNL TNPPAPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.