Details for: CLCNKB

Gene ID: 1188

Symbol: CLCNKB

Ensembl ID: ENSG00000184908

Description: chloride voltage-gated channel Kb

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.47
    Marker Score: 3675
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.16
    Marker Score: 5234
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3174
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.76
    Marker Score: 7400
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.4
    Marker Score: 1263
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.09
    Marker Score: 1117
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.8
    Marker Score: 2553
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.77
    Marker Score: 1980
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 872.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.33
    Marker Score: 3360
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.09
    Marker Score: 836
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.99
    Marker Score: 315
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13963
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.89
    Marker Score: 208
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 629
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.79
    Marker Score: 5281
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.78
    Marker Score: 745
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.75
    Marker Score: 436
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.75
    Marker Score: 757
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1187
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.72
    Marker Score: 439
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.71
    Marker Score: 1343
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 405
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.59
    Marker Score: 635
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 464
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.54
    Marker Score: 164
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.53
    Marker Score: 325
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.47
    Marker Score: 448
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.45
    Marker Score: 143
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.44
    Marker Score: 404
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.44
    Marker Score: 116
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.43
    Marker Score: 532
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 396
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.41
    Marker Score: 233
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.38
    Marker Score: 770
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 178
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.37
    Marker Score: 264
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.35
    Marker Score: 817
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.33
    Marker Score: 67
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.3
    Marker Score: 78
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.29
    Marker Score: 564.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.29
    Marker Score: 152
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.29
    Marker Score: 157
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.27
    Marker Score: 971.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.27
    Marker Score: 375
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.27
    Marker Score: 103
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.26
    Marker Score: 148
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.25
    Marker Score: 174
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.24
    Marker Score: 147
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.2
    Marker Score: 74
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.2
    Marker Score: 66
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 87
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.19
    Marker Score: 106
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 68
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.18
    Marker Score: 512
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 56
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.17
    Marker Score: 162
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.16
    Marker Score: 38
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.15
    Marker Score: 92
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.14
    Marker Score: 112
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.14
    Marker Score: 85
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.14
    Marker Score: 807
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.13
    Marker Score: 162
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.13
    Marker Score: 55
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.13
    Marker Score: 188
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 117
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 182
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.09
    Marker Score: 250
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.09
    Marker Score: 88
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.08
    Marker Score: 115
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.08
    Marker Score: 164
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.08
    Marker Score: 15
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.08
    Marker Score: 20

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Other Information

**Key characteristics:** - CLCNKB is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a chloride channel that is expressed in both prokaryotic and eukaryotic cells. - CLCNKB is a ligand for the diuretic hormone aldosterone, which is responsible for regulating water and electrolyte balance in the body. **Pathways and functions:** - CLCNKB is involved in the regulation of water and electrolyte balance in the body. - It is expressed in the kidney, where it is responsible for maintaining the chloride concentration gradient across the renal cell membrane. - CLCNKB also plays a role in the regulation of blood pressure and arterial-venous capacitance. **Clinical significance:** - Mutations in CLCNKB have been associated with a number of human diseases, including salt-wasting diseases such as cystic fibrosis and hyperkalemia. - CLCNKB inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 445881909

Symbol: CLCKB_HUMAN

Name: Chloride channel protein ClC-Kb

UniProtKB Accession Codes:

P51801 B3KUY3 Q5T5Q7 Q5T5Q8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 5 Ensembl 6 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8041726

Title: Two highly homologous members of the ClC chloride channel family in both rat and human kidney.

PubMed ID: 8041726

DOI: 10.1073/pnas.91.15.6943

PubMed ID: 8544406

Title: Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.

PubMed ID: 8544406

DOI: 10.1038/ki.1995.439

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 11734858

Title: Barttin is a Cl- channel beta-subunit crucial for renal Cl-reabsorption and inner ear K+ secretion.

PubMed ID: 11734858

DOI: 10.1038/35107099

PubMed ID: 15044642

Title: Salt wasting and deafness resulting from mutations in two chloride channels.

PubMed ID: 15044642

DOI: 10.1056/nejmoa032843

PubMed ID: 18310267

Title: Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness.

PubMed ID: 18310267

DOI: 10.1136/jmg.2007.052944

PubMed ID: 9326936

Title: Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III.

PubMed ID: 9326936

DOI: 10.1038/ng1097-171

Sequence Information:

  • Length: 687
  • Mass: 75446
  • Checksum: 4D28BC19DDD5D412
  • Sequence:
    • MEEFVGLREG SSGNPVTLQE LWGPCPRIRR GIRGGLEWLK QKLFRLGEDW YFLMTLGVLM 
ALVSCAMDLA VESVVRAHQW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPSSGG 
SGIPEVKTML AGVVLEDYLD IKNFGAKVVG LSCTLACGST LFLGKVGPFV HLSVMMAAYL 
GRVRTTTIGE PENKSKQNEM LVAAAAVGVA TVFAAPFSGV LFSIEVMSSH FSVWDYWRGF 
FAATCGAFMF RLLAVFNSEQ ETITSLYKTS FRVDVPFDLP EIFFFVALGG LCGILGSAYL 
FCQRIFFGFI RNNRFSSKLL ATSKPVYSAL ATLVLASITY PPSAGRFLAS RLSMKQHLDS 
LFDNHSWALM TQNSSPPWPE ELDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP 
MPAGYFMPIF VYGAAIGRLF GETLSFIFPE GIVAGGITNP IMPGGYALAG AAAFSGAVTH 
TISTALLAFE VTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTVIVKKLP YLPRILGRNI 
GSHRVRVEHF MNHSITTLAK DMPLEEVVKV VTSTDVAKYP LVESTESQIL VGIVRRAQLV 
QALKAEPPSW APGHQQCLQD ILAAGCPTEP VTLKLSPETS LHEAHNLFEL LNLHSLFVTS 
RGRAVGCVSW VEMKKAISNL TNPPAPK

Genular Protein ID: 3185599483

Symbol: A8K8H0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K8H0

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 687
  • Mass: 75388
  • Checksum: 35DDF654B3BD70A4
  • Sequence:
    • MEEFVGLREG SSGNPVTLQE LWGPCPLIRR GIRGGLEWLK QKLFRLGEDW YFLMTLGVLM 
ALVSCAMDLA VESVVRAHQW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPSSGG 
SGIPEVKTML AGVVLEDYLD IKNFGAKVVG LSCTLACGST LFLGKVGPFV HLSVMMAAYL 
GRVRTTTIGE PENKSKQNEM LVAAAAVGVA TVFGAPFSGV LFSIEVMSSH FSVWDYWRGF 
FAATCGAFMF RLLAVFNSEQ ETITSLYKTS FRVDVPFDLP EIFFFVVLGG LCGILGSAYL 
FCQRIFFGFI RNNRFSSKLL ATSKPVYSAL ATLVLASITY PPSAGRFLAS RLSMKQHLDS 
LFDNHSWALM TQNSSPPWPE ELDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP 
MPAGYFMPIF VYGAAIGRLF GETLSFIFPE GIVAGGITNP IMPGGYALAG AAAFSGAVTH 
TISTALLAFE VTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTVIVKKLP YLPRILGRNI 
GSHRVRVEHF MNHSITTLAK DTPLEEVVKV VTSTDVAEYP LVESTESQIL VGIVRRAQLV 
QALKAEPPSW APGHQQCLQD ILAAGCPTEP VTLKLSPETS LHEAHNLFEL LNLHSLFVTS 
RGRAVGCVSW VEMKKAISNL TNPPAPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.