Genular: Defining Cellular Identity and Function

Details for: Asah1

Gene ID: 11886

Symbol: Asah1

Ensembl ID: ENSMUSG00000031591

Description: N-acylsphingosine amidohydrolase 1

Associated with

Glycosphingolipid catabolism
(R-MMU-9840310)
Glycosphingolipid metabolism
(R-MMU-1660662)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Neutrophil degranulation
(R-MMU-6798695)
Sphingolipid metabolism
(R-MMU-428157)
Cellular response to tumor necrosis factor
(GO:0071356)
Ceramidase activity
(GO:0102121)
Ceramide biosynthetic process
(GO:0046513)
Ceramide catabolic process
(GO:0046514)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fatty acid amide hydrolase activity
(GO:0017064)
Fatty acid metabolic process
(GO:0006631)
Hydrolase activity
(GO:0016787)
Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
(GO:0016811)
Keratinocyte differentiation
(GO:0030216)
Lipid metabolic process
(GO:0006629)
Lung development
(GO:0030324)
Lysosome
(GO:0005764)
N-acylsphingosine amidohydrolase activity
(GO:0017040)
Nuclear receptor binding
(GO:0016922)
Nucleus
(GO:0005634)
Regulation of programmed necrotic cell death
(GO:0062098)
Regulation of steroid biosynthetic process
(GO:0050810)
Response to organic substance
(GO:0010033)
Sphingolipid metabolic process
(GO:0006665)
Sphingosine biosynthetic process
(GO:0046512)
Transcription corepressor activity
(GO:0003714)

Other Information

Proteins

Acylsphingosine deacylase

Genular Protein ID: 48956980

Symbol: ASAH1_MOUSE

Name: Acylsphingosine deacylase

UniProtKB Accession Codes:

Q9WV54

Database IDs:

Citations:

PubMed ID: 9653654

Title: Cloning and characterization of the full-length cDNA and genomic sequences encoding murine acid ceramidase.

PubMed ID: 9653654

DOI: 10.1006/geno.1998.5334

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10974027

Title: Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death.

PubMed ID: 10974027

DOI: 10.1084/jem.192.5.601

PubMed ID: 11829492

Title: Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes.

PubMed ID: 11829492

DOI: 10.1006/geno.2002.6686

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23770692

Title: Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs.

PubMed ID: 23770692

DOI: 10.1038/nm.3214

Sequence Information:

Length: 394
Mass: 44670
Checksum: DA7BFBFDC45C9F65
Sequence:

MRGQSLLTWV LAAAVTCAQA QDVPPWTEDC RKSTYPPSGP TYRGPVPWHT INLDLPPYKR 
WHELLAQKAP ALRILVNSIT SLVNTFVPSG KLMKMVDQKL PGMIGSLPDP FGEEMRGIAD 
VTGIPLGEII SFNIFYELFT MCTSIITEDE KGHLLHGRNM DFGIFLGWNI NNNTWVVTEE 
LKPLTVNLDF QRNNKTVFKA TSFVGYVGML TGFKPGLFSL SLNERFSING GYLGILEWMF 
GRKDAQWVGF ITRSVLENTT SYEEAKNTLT KTKIMAPVYF ILGGKKSGEG CVITRERKES 
LDVYELDPKH GRWYVVQTNY DRWKNTLFID DRRTPAKKCL NHTTQKNLSF ATIYDVLSTK 
PVLNKLTVFT TLMDVTKGQF ESHLRDCPDP CIGW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Asah1

Associated with

Other Information

Cloning and characterization of the full-length cDNA and genomic sequences encoding murine acid ceramidase. PubMed ID: 9653654

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. PubMed ID: 10974027

Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. PubMed ID: 11829492

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. PubMed ID: 23770692