Details for: ADD2

Gene ID: 119

Symbol: ADD2

Ensembl ID: ENSG00000075340

Description: adducin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.32
    Marker Score: 971
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.24
    Marker Score: 44544
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.18
    Marker Score: 9048
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.13
    Marker Score: 31882
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.1
    Marker Score: 16064
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.07
    Marker Score: 76522
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.07
    Marker Score: 7998
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.06
    Marker Score: 19423
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.03
    Marker Score: 124909
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.98
    Marker Score: 75276
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.92
    Marker Score: 3220
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.87
    Marker Score: 17752
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.8
    Marker Score: 15467.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.8
    Marker Score: 8315
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.72
    Marker Score: 3557
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.69
    Marker Score: 980
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.66
    Marker Score: 454
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2520
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.62
    Marker Score: 950
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.58
    Marker Score: 888
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.46
    Marker Score: 4173
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.45
    Marker Score: 559
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.43
    Marker Score: 973
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.36
    Marker Score: 76241
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.31
    Marker Score: 2487.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.27
    Marker Score: 2580
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 851
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.22
    Marker Score: 916
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7677
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4811
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.13
    Marker Score: 1273
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.03
    Marker Score: 495
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16064
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.87
    Marker Score: 1089
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.87
    Marker Score: 1047
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.85
    Marker Score: 511
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.82
    Marker Score: 276
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.81
    Marker Score: 840
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.73
    Marker Score: 390
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.7
    Marker Score: 223
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 458
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.68
    Marker Score: 653
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.68
    Marker Score: 820
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.67
    Marker Score: 214
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.66
    Marker Score: 1344
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.64
    Marker Score: 602.5
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.63
    Marker Score: 312
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.6
    Marker Score: 31964
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.58
    Marker Score: 392
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.56
    Marker Score: 278.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.53
    Marker Score: 251
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.53
    Marker Score: 1661
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 249
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.49
    Marker Score: 216
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.48
    Marker Score: 1987
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.46
    Marker Score: 441
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.44
    Marker Score: 342
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.44
    Marker Score: 141
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.42
    Marker Score: 250
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.42
    Marker Score: 981
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 226
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.4
    Marker Score: 112
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.36
    Marker Score: 12325
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.36
    Marker Score: 189
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.36
    Marker Score: 3620
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.33
    Marker Score: 161
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 88
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.31
    Marker Score: 115
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.31
    Marker Score: 354
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.3
    Marker Score: 371
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.3
    Marker Score: 1219.5
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.3
    Marker Score: 165
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.3
    Marker Score: 194
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.29
    Marker Score: 6286
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.29
    Marker Score: 183
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.27
    Marker Score: 161
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 84
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.27
    Marker Score: 2714

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Other Information

**Key characteristics:** * Gene name: ADD2 * Ensembl ID: ENSG00000075340 * Protein name: ADDB_HUMAN * Protein function: Cytoskeletal protein involved in actin binding, cytoskeleton organization, and cell migration **Pathways and functions:** * **Actin binding:** ADD2 is a key regulator of the actin cytoskeleton, binding to the actin filament and influencing its dynamics and interactions with other cytoskeletal proteins. * **Actin cytoskeleton organization:** ADD2 is involved in the assembly and maintenance of the actin cytoskeleton, ensuring its proper organization and function. * **Actin filament binding:** ADD2 can bind to the barbed-end actin filament, promoting its polymerization and regulating the formation of actin filaments. * **Barbed-end actin filament capping:** ADD2 can cap the barbed-end actin filaments, preventing their further polymerization and preventing the formation of extended, branching actin structures. * **Calmodulin binding:** ADD2 can bind to calmodulin, a protein that regulates actin-cytoskeletal interactions. This binding can modulate the activity of other cytoskeletal proteins and influence cell migration. * **Hemopoiesis:** ADD2 is expressed in hematopoietic cells, where it plays a role in regulating blood cell migration and differentiation. * **Leukocyte migration:** ADD2 is highly expressed in leukocytes, where it is involved in cell adhesion, migration, and rolling. * **Leukocyte tethering or rolling:** ADD2 is crucial for leukocyte tethering or rolling, allowing cells to interact with extracellular matrix components and migrate along extracellular cues. **Clinical significance:** * Mutations in the ADD2 gene have been linked to several human diseases, including autism spectrum disorder (ASD), schizophrenia, and retinal disorders. * Studies have shown that targeting ADD2 signaling can modulate neuronal function and behavior in animal models of these disorders. * Therefore, ADD2 is an important target for developing novel therapeutic strategies for mental health and neurological diseases.

Genular Protein ID: 2158869954

Symbol: ADDB_HUMAN

Name: Beta-adducin

UniProtKB Accession Codes:

P35612 A8K4P2 B4DM17 D6W5G7 D6W5G8 Q13482 Q16412 Q59G82 Q5U5P4 Q6P0P2 Q6PGQ4 Q7Z688 Q7Z689 Q7Z690 Q7Z691

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 23 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1840603

Title: Primary structure and domain organization of human alpha and beta adducin.

PubMed ID: 1840603

DOI: 10.1083/jcb.115.3.665

PubMed ID: 12951058

Title: Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants.

PubMed ID: 12951058

DOI: 10.1016/j.bbrc.2003.08.011

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8566798

Title: Genomic organisation and chromosomal localisation of the gene encoding human beta adducin.

PubMed ID: 8566798

DOI: 10.1016/0378-1119(95)00591-9

PubMed ID: 8810272

Title: Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.

PubMed ID: 8810272

DOI: 10.1074/jbc.271.41.25157

PubMed ID: 18347014

Title: Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1.

PubMed ID: 18347014

DOI: 10.1074/jbc.m707818200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 726
  • Mass: 80854
  • Checksum: B07F7303D929DBA4
  • Sequence:
    • MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS 
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT 
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV 
TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK 
WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE 
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL 
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR 
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE 
NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK 
GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS 
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE 
ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKFR TPSFLKKSKK 
KEKVES

Genular Protein ID: 896790978

Symbol: Q05DK5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05DK5

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 3 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 709
  • Mass: 78833
  • Checksum: 98E0752152DC77B6
  • Sequence:
    • MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS 
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT 
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV 
TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK 
WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE 
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL 
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR 
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE 
NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK 
GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS 
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE 
ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.