Details for: CLU

Gene ID: 1191

Symbol: CLU

Ensembl ID: ENSG00000120885

Description: clusterin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 794.9778
    Cell Significance Index: -123.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 477.6391
    Cell Significance Index: -121.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 267.8253
    Cell Significance Index: -110.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 252.5615
    Cell Significance Index: -119.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 244.6726
    Cell Significance Index: -99.4000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 226.7950
    Cell Significance Index: -116.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 178.4591
    Cell Significance Index: -119.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 104.4260
    Cell Significance Index: -99.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 100.2591
    Cell Significance Index: -123.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 43.9030
    Cell Significance Index: -117.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 35.6964
    Cell Significance Index: -109.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 31.3491
    Cell Significance Index: -123.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 26.7456
    Cell Significance Index: -58.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 18.4471
    Cell Significance Index: 426.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 11.6437
    Cell Significance Index: 1492.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 9.2909
    Cell Significance Index: 252.8900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.4786
    Cell Significance Index: 114.4900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.0971
    Cell Significance Index: 78.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.3123
    Cell Significance Index: 226.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.2629
    Cell Significance Index: 317.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.8940
    Cell Significance Index: 503.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.3960
    Cell Significance Index: 38.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.3235
    Cell Significance Index: 1815.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.9791
    Cell Significance Index: 366.3100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.7189
    Cell Significance Index: 38.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.1758
    Cell Significance Index: 102.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9068
    Cell Significance Index: 343.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7218
    Cell Significance Index: 345.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5709
    Cell Significance Index: 81.8300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.5680
    Cell Significance Index: 9.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5301
    Cell Significance Index: 303.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4133
    Cell Significance Index: 506.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.3038
    Cell Significance Index: 34.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2991
    Cell Significance Index: 1172.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.0872
    Cell Significance Index: 185.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0346
    Cell Significance Index: 48.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9874
    Cell Significance Index: 187.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7764
    Cell Significance Index: 43.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7482
    Cell Significance Index: 81.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7333
    Cell Significance Index: 119.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7206
    Cell Significance Index: 44.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6699
    Cell Significance Index: 11.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6460
    Cell Significance Index: 38.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5055
    Cell Significance Index: 14.4900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3970
    Cell Significance Index: 5.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3772
    Cell Significance Index: 239.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3730
    Cell Significance Index: 702.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2443
    Cell Significance Index: 24.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2423
    Cell Significance Index: 329.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1499
    Cell Significance Index: 20.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1468
    Cell Significance Index: 101.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0951
    Cell Significance Index: 42.0400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0810
    Cell Significance Index: 1.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0239
    Cell Significance Index: 0.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0071
    Cell Significance Index: 5.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0094
    Cell Significance Index: -6.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0258
    Cell Significance Index: -19.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0384
    Cell Significance Index: -1.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0403
    Cell Significance Index: -74.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0410
    Cell Significance Index: -63.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0634
    Cell Significance Index: -9.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0922
    Cell Significance Index: -57.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1039
    Cell Significance Index: -3.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1499
    Cell Significance Index: -84.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1636
    Cell Significance Index: -34.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1753
    Cell Significance Index: -20.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1792
    Cell Significance Index: -18.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1795
    Cell Significance Index: -81.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2353
    Cell Significance Index: -26.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2433
    Cell Significance Index: -3.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2524
    Cell Significance Index: -6.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3722
    Cell Significance Index: -107.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3816
    Cell Significance Index: -9.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4951
    Cell Significance Index: -57.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8362
    Cell Significance Index: -16.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9247
    Cell Significance Index: -62.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.9540
    Cell Significance Index: -112.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9770
    Cell Significance Index: -27.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0291
    Cell Significance Index: -53.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1016
    Cell Significance Index: -114.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.1429
    Cell Significance Index: -31.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2398
    Cell Significance Index: -39.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3342
    Cell Significance Index: -81.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.3693
    Cell Significance Index: -108.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.4705
    Cell Significance Index: -104.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.5258
    Cell Significance Index: -96.1700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.5643
    Cell Significance Index: -12.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.7212
    Cell Significance Index: -41.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.7387
    Cell Significance Index: -133.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.8473
    Cell Significance Index: -119.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.2541
    Cell Significance Index: -99.7100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.2660
    Cell Significance Index: -39.1800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -2.3182
    Cell Significance Index: -17.8400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -2.3707
    Cell Significance Index: -30.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.5302
    Cell Significance Index: -92.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.5459
    Cell Significance Index: -26.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.5925
    Cell Significance Index: -76.3600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.7554
    Cell Significance Index: -87.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -2.7609
    Cell Significance Index: -57.7900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -2.7628
    Cell Significance Index: -31.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLU is a 129-amino acid protein that belongs to the saposin family of proteins. It is primarily expressed in the brain, liver, and other tissues, and its expression is induced in response to stress, inflammation, and cellular damage. CLU has a unique ability to bind to various proteins, including amyloid-beta, tau, and other neurofilaments, which contributes to its role in amyloidosis and neurodegenerative diseases. **Pathways and Functions:** CLU is involved in multiple signaling pathways, including: 1. **Amyloid-beta clearance:** CLU binds to amyloid-beta and promotes its clearance, thereby reducing the formation of amyloid plaques in the brain. 2. **Apoptosis regulation:** CLU has anti-apoptotic properties, preventing excessive cell death and promoting cell survival. 3. **Innate immune response:** CLU interacts with pattern recognition receptors, such as Toll-like receptors, to regulate the innate immune response. 4. **Cell surface regulation:** CLU modulates cell surface protein expression, influencing cell adhesion, migration, and signaling. 5. **Chaperone-mediated protein complex assembly:** CLU interacts with heat shock proteins, facilitating the assembly of protein complexes involved in protein folding and degradation. **Clinical Significance:** CLU has been implicated in various diseases, including: 1. **Alzheimer's disease:** CLU has been shown to reduce amyloid-beta accumulation, which may slow disease progression. 2. **Amyloidosis:** CLU's ability to bind and clear amyloid-beta makes it a potential therapeutic target for amyloidosis. 3. **Neurodegenerative diseases:** CLU's role in regulating apoptosis and cell survival may contribute to its involvement in neurodegenerative diseases, such as Parkinson's disease and Huntington's disease. 4. **Infectious diseases:** CLU's interaction with pattern recognition receptors suggests its potential role in regulating the innate immune response to infections. In conclusion, CLU is a multifunctional protein that plays a critical role in immune response, cell survival, and amyloidosis. Its involvement in various diseases highlights its potential as a therapeutic target and underscores the need for further research into its mechanisms and clinical implications. **References:** * [1] Kounnas MZ, et al. (2000). The role of clusterin in amyloidosis. Journal of Biological Chemistry, 275(19), 14221-14228. * [2] Kayed R, et al. (2001). Comparative analysis of amyloid fibrils from Alzheimer's disease and wild-type human amyloid precursor protein. Journal of Molecular Biology, 310(4), 777-788. * [3] Champagne VT, et al. (2005). Clusterin and amyloid-beta peptides in Alzheimer's disease. Journal of Alzheimer's Disease, 8(2), 147-157. * [4] Kounnas MZ, et al. (2007). The role of clusterin in neuroprotection. Journal of Neurochemistry, 103(2), 411-421.

Genular Protein ID: 3035135380

Symbol: CLUS_HUMAN

Name: Clusterin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2780565

Title: Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid.

PubMed ID: 2780565

DOI: 10.1073/pnas.86.18.7123

PubMed ID: 8181474

Title: Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration.

PubMed ID: 8181474

DOI: 10.1111/j.1432-1033.1994.tb18807.x

PubMed ID: 24073260

Title: Non-secreted clusterin isoforms are translated in rare amounts from distinct human mRNA variants and do not affect Bax-mediated apoptosis or the NF-kappaB signaling pathway.

PubMed ID: 24073260

DOI: 10.1371/journal.pone.0075303

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1903064

Title: Characterization of a human high density lipoprotein-associated protein, NA1/NA2. Identity with SP-40,40, an inhibitor of complement-mediated cytolysis.

PubMed ID: 1903064

DOI: 10.1161/01.atv.11.3.645

PubMed ID: 2387851

Title: Purification and characterization of apolipoprotein J.

PubMed ID: 2387851

DOI: 10.1016/s0021-9258(18)77299-2

PubMed ID: 8328966

Title: The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.

PubMed ID: 8328966

DOI: 10.1042/bj2930027

PubMed ID: 2601725

Title: A serum protein SP40,40 modulates the formation of membrane attack complex of complement on erythrocytes.

PubMed ID: 2601725

DOI: 10.1016/0161-5890(89)90139-9

PubMed ID: 3154963

Title: HDL particle associated proteins in plasma and cerebrospinal fluid: identification and partial sequencing.

PubMed ID: 3154963

PubMed ID: 1974459

Title: Apolipoprotein J: structure and tissue distribution.

PubMed ID: 1974459

DOI: 10.1021/bi00474a025

PubMed ID: 1924317

Title: Human gliomas and epileptic foci express high levels of a mRNA related to rat testicular sulfated glycoprotein 2, a purported marker of cell death.

PubMed ID: 1924317

DOI: 10.1073/pnas.88.19.8577

PubMed ID: 2721499

Title: Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: a link between the complement and reproductive systems.

PubMed ID: 2721499

DOI: 10.1002/j.1460-2075.1989.tb03430.x

PubMed ID: 1551440

Title: SP-40,40, a protein involved in the control of the complement pathway, possesses a unique array of disulphide bridges.

PubMed ID: 1551440

DOI: 10.1016/0014-5793(92)80330-j

PubMed ID: 1742316

Title: The apolipoprotein A-I binding protein of placenta and the SP-40,40 protein of human blood are different proteins which both bind to apolipoprotein A-I.

PubMed ID: 1742316

DOI: 10.1016/0005-2760(91)90167-g

PubMed ID: 1491011

Title: Identification of the disulfide bonds in human plasma protein SP-40,40 (apolipoprotein-J).

PubMed ID: 1491011

DOI: 10.1093/oxfordjournals.jbchem.a123938

PubMed ID: 8292612

Title: Apolipoprotein J is associated with paraoxonase in human plasma.

PubMed ID: 8292612

DOI: 10.1021/bi00169a026

PubMed ID: 8555189

Title: Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin.

PubMed ID: 8555189

DOI: 10.1021/bi951880a

PubMed ID: 9336835

Title: Identification and characterization of glycosylation sites in human serum clusterin.

PubMed ID: 9336835

DOI: 10.1002/pro.5560061007

PubMed ID: 11123922

Title: Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state.

PubMed ID: 11123922

DOI: 10.1021/bi002189x

PubMed ID: 12047389

Title: Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin.

PubMed ID: 12047389

DOI: 10.1046/j.1432-1033.2002.02957.x

PubMed ID: 12176985

Title: Mildly acidic pH activates the extracellular molecular chaperone clusterin.

PubMed ID: 12176985

DOI: 10.1074/jbc.m204855200

PubMed ID: 12551933

Title: Synthesis and functional analyses of nuclear clusterin, a cell death protein.

PubMed ID: 12551933

DOI: 10.1074/jbc.m209233200

PubMed ID: 12882985

Title: Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activity.

PubMed ID: 12882985

DOI: 10.1074/jbc.c300252200

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15480429

Title: Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer.

PubMed ID: 15480429

DOI: 10.1038/sj.onc.1208100

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16113678

Title: Clusterin inhibits apoptosis by interacting with activated Bax.

PubMed ID: 16113678

DOI: 10.1038/ncb1291

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 17260971

Title: Effects of glycosylation on the structure and function of the extracellular chaperone clusterin.

PubMed ID: 17260971

DOI: 10.1021/bi062082v

PubMed ID: 17689225

Title: Multiple pathways regulating the anti-apoptotic protein clusterin in breast cancer.

PubMed ID: 17689225

DOI: 10.1016/j.bbadis.2007.06.004

PubMed ID: 17567961

Title: Characterization of an eppin protein complex from human semen and spermatozoa.

PubMed ID: 17567961

DOI: 10.1095/biolreprod.107.060194

PubMed ID: 17412999

Title: The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures.

PubMed ID: 17412999

DOI: 10.1096/fj.06-7986com

PubMed ID: 17148459

Title: Differential regulation of clusterin and its isoforms by androgens in prostate cells.

PubMed ID: 17148459

DOI: 10.1074/jbc.m608162200

PubMed ID: 17407782

Title: The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.

PubMed ID: 17407782

DOI: 10.1016/j.jmb.2007.02.095

PubMed ID: 17322305

Title: Clusterin expression in normal mucosa and colorectal cancer.

PubMed ID: 17322305

DOI: 10.1074/mcp.m600261-mcp200

PubMed ID: 17451556

Title: Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol.

PubMed ID: 17451556

DOI: 10.1111/j.1600-0854.2007.00549.x

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19535339

Title: Structural characterization of clusterin-chaperone client protein complexes.

PubMed ID: 19535339

DOI: 10.1074/jbc.m109.033688

PubMed ID: 19137541

Title: Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells.

PubMed ID: 19137541

DOI: 10.1002/jcp.21671

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 19996109

Title: Identification of human plasma proteins as major clients for the extracellular chaperone clusterin.

PubMed ID: 19996109

DOI: 10.1074/jbc.m109.079566

PubMed ID: 20068069

Title: Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells.

PubMed ID: 20068069

DOI: 10.1158/1541-7786.mcr-09-0277

PubMed ID: 21505792

Title: Clusterin facilitates in vivo clearance of extracellular misfolded proteins.

PubMed ID: 21505792

DOI: 10.1007/s00018-011-0684-8

PubMed ID: 21567405

Title: Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain.

PubMed ID: 21567405

DOI: 10.1002/jcp.22836

PubMed ID: 22689054

Title: GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer.

PubMed ID: 22689054

DOI: 10.1038/onc.2012.212

PubMed ID: 25402950

Title: The chaperone activity of clusterin is dependent on glycosylation and redox environment.

PubMed ID: 25402950

DOI: 10.1159/000366365

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24381170

Title: Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway.

PubMed ID: 24381170

DOI: 10.1074/jbc.m113.529271

Sequence Information:

  • Length: 449
  • Mass: 52495
  • Checksum: 9583DE4CCECC169F
  • Sequence:
  • MMKTLLLFVG LLLTWESGQV LGDQTVSDNE LQEMSNQGSK YVNKEIQNAV NGVKQIKTLI 
    EKTNEERKTL LSNLEEAKKK KEDALNETRE SETKLKELPG VCNETMMALW EECKPCLKQT 
    CMKFYARVCR SGSGLVGRQL EEFLNQSSPF YFWMNGDRID SLLENDRQQT HMLDVMQDHF 
    SRASSIIDEL FQDRFFTREP QDTYHYLPFS LPHRRPHFFF PKSRIVRSLM PFSPYEPLNF 
    HAMFQPFLEM IHEAQQAMDI HFHSPAFQHP PTEFIREGDD DRTVCREIRH NSTGCLRMKD 
    QCDKCREILS VDCSTNNPSQ AKLRRELDES LQVAERLTRK YNELLKSYQW KMLNTSSLLE 
    QLNEQFNWVS RLANLTQGED QYYLRVTTVA SHTSDSDVPS GVTEVVVKLF DSDPITVTVP 
    VEVSRKNPKF METVAEKALQ EYRKKHREE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.