CLU | ENSG00000120885 | NCBI 1191

Details for: CLU

Gene ID: 1191

Symbol: CLU

Ensembl ID: ENSG00000120885

Description: clusterin

Associated with

Antimicrobial peptides
(R-HSA-6803157)
Complement cascade
(R-HSA-166658)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Regulation of complement cascade
(R-HSA-977606)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Terminal pathway of complement
(R-HSA-166665)
Amyloid-beta binding
(GO:0001540)
Apical dendrite
(GO:0097440)
Atp hydrolysis activity
(GO:0016887)
Blood microparticle
(GO:0072562)
Cell morphogenesis
(GO:0000902)
Cell periphery
(GO:0071944)
Cell surface
(GO:0009986)
Central nervous system myelin maintenance
(GO:0032286)
Chaperone-mediated protein complex assembly
(GO:0051131)
Chaperone-mediated protein folding
(GO:0061077)
Chromaffin granule
(GO:0042583)
Collagen-containing extracellular matrix
(GO:0062023)
Complement activation
(GO:0006956)
Complement activation, classical pathway
(GO:0006958)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Immune complex clearance
(GO:0002434)
Innate immune response
(GO:0045087)
Intracellular membrane-bounded organelle
(GO:0043231)
Lipid metabolic process
(GO:0006629)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Membrane
(GO:0016020)
Microglial cell activation
(GO:0001774)
Microglial cell proliferation
(GO:0061518)
Misfolded protein binding
(GO:0051787)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrion
(GO:0005739)
Negative regulation of amyloid-beta formation
(GO:1902430)
Negative regulation of amyloid fibril formation
(GO:1905907)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Negative regulation of response to endoplasmic reticulum stress
(GO:1903573)
Neurofibrillary tangle
(GO:0097418)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Platelet alpha granule lumen
(GO:0031093)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of amyloid fibril formation
(GO:1905908)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neurofibrillary tangle assembly
(GO:1902998)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of ubiquitin-dependent protein catabolic process
(GO:2000060)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein carrier chaperone
(GO:0140597)
Protein import
(GO:0017038)
Protein stabilization
(GO:0050821)
Protein targeting to lysosome involved in chaperone-mediated autophagy
(GO:0061740)
Regulation of amyloid-beta clearance
(GO:1900221)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell population proliferation
(GO:0042127)
Regulation of neuronal signal transduction
(GO:1902847)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to misfolded protein
(GO:0051788)
Response to virus
(GO:0009615)
Reverse cholesterol transport
(GO:0043691)
Signaling receptor binding
(GO:0005102)
Spherical high-density lipoprotein particle
(GO:0034366)
Synapse
(GO:0045202)
Tau protein binding
(GO:0048156)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hepatoblast (CL0005026)
Fold Change: 7.13
Marker Score: 23,343
Cell Name: mature astrocyte (CL0002627)
Fold Change: 6.59
Marker Score: 4,337
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 6.52
Marker Score: 5,101
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 4.53
Marker Score: 2,555
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 4.19
Marker Score: 10,568
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.69
Marker Score: 4,456
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.66
Marker Score: 4,770
Cell Name: endocardial cell (CL0002350)
Fold Change: 3.55
Marker Score: 2,004
Cell Name: basophil (CL0000767)
Fold Change: 3.45
Marker Score: 1,637
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.41
Marker Score: 7,741
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.36
Marker Score: 59,674
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.35
Marker Score: 3,164
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.32
Marker Score: 28,810
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 3.29
Marker Score: 3,460
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.28
Marker Score: 2,797
Cell Name: endocrine cell (CL0000163)
Fold Change: 3.2
Marker Score: 1,656
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 3.18
Marker Score: 67,798
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 3.17
Marker Score: 6,447
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 3.1
Marker Score: 4,394
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 3.1
Marker Score: 3,219
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 3.05
Marker Score: 968
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.93
Marker Score: 11,308
Cell Name: PP cell (CL0000696)
Fold Change: 2.9
Marker Score: 653
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.87
Marker Score: 7,504
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.85
Marker Score: 16,913
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.85
Marker Score: 4,675
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.84
Marker Score: 1,057
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.82
Marker Score: 97,751
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.73
Marker Score: 659
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.72
Marker Score: 3,778
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.72
Marker Score: 9,668
Cell Name: astrocyte (CL0000127)
Fold Change: 2.72
Marker Score: 2,358
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.71
Marker Score: 6,617
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 2.68
Marker Score: 736
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.64
Marker Score: 11,007
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.58
Marker Score: 1,274
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.53
Marker Score: 2,703
Cell Name: acinar cell (CL0000622)
Fold Change: 2.53
Marker Score: 1,782
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.47
Marker Score: 13,293
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.47
Marker Score: 10,331
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.46
Marker Score: 4,368
Cell Name: ciliated cell (CL0000064)
Fold Change: 2.46
Marker Score: 8,464
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.44
Marker Score: 2,101
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.43
Marker Score: 2,463
Cell Name: peptic cell (CL0000155)
Fold Change: 2.42
Marker Score: 1,012
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.42
Marker Score: 1,128
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.4
Marker Score: 700
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.39
Marker Score: 4,044
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.39
Marker Score: 3,959
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.32
Marker Score: 670
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 2.31
Marker Score: 931
Cell Name: keratocyte (CL0002363)
Fold Change: 2.3
Marker Score: 530
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.28
Marker Score: 16,942
Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.26
Marker Score: 3,177
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 2.24
Marker Score: 913
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.23
Marker Score: 3,238
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.21
Marker Score: 1,745
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.21
Marker Score: 786
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.19
Marker Score: 1,462
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.19
Marker Score: 11,491
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 2.18
Marker Score: 911
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.17
Marker Score: 32,471
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.17
Marker Score: 2,065
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.13
Marker Score: 2,255
Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.11
Marker Score: 843
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 2.11
Marker Score: 4,007
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 2.1
Marker Score: 447
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.1
Marker Score: 4,189
Cell Name: preosteoblast (CL0007010)
Fold Change: 2.09
Marker Score: 592
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.08
Marker Score: 41,379
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.04
Marker Score: 2,255
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 2.04
Marker Score: 1,449
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.03
Marker Score: 844
Cell Name: muscle cell (CL0000187)
Fold Change: 2.02
Marker Score: 571
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2
Marker Score: 1,732
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 2
Marker Score: 1,100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.99
Marker Score: 1,161
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.98
Marker Score: 1,306
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.98
Marker Score: 941
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.98
Marker Score: 1,785
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.96
Marker Score: 15,058
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.96
Marker Score: 2,073
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.96
Marker Score: 74,381
Cell Name: basal cell (CL0000646)
Fold Change: 1.95
Marker Score: 2,518
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.95
Marker Score: 17,073
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.92
Marker Score: 5,155
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.91
Marker Score: 2,809
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.91
Marker Score: 64,882
Cell Name: kidney cell (CL1000497)
Fold Change: 1.9
Marker Score: 1,269
Cell Name: club cell (CL0000158)
Fold Change: 1.89
Marker Score: 2,204
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.86
Marker Score: 474
Cell Name: secretory cell (CL0000151)
Fold Change: 1.86
Marker Score: 3,389
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.85
Marker Score: 4,212
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.85
Marker Score: 113,684
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.84
Marker Score: 3,885
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.83
Marker Score: 17,401
Cell Name: supporting cell (CL0000630)
Fold Change: 1.83
Marker Score: 3,437
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.83
Marker Score: 455
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.81
Marker Score: 7,567
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.81
Marker Score: 455

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** CLU is a 129-amino acid protein that belongs to the saposin family of proteins. It is primarily expressed in the brain, liver, and other tissues, and its expression is induced in response to stress, inflammation, and cellular damage. CLU has a unique ability to bind to various proteins, including amyloid-beta, tau, and other neurofilaments, which contributes to its role in amyloidosis and neurodegenerative diseases. **Pathways and Functions:** CLU is involved in multiple signaling pathways, including: 1. **Amyloid-beta clearance:** CLU binds to amyloid-beta and promotes its clearance, thereby reducing the formation of amyloid plaques in the brain. 2. **Apoptosis regulation:** CLU has anti-apoptotic properties, preventing excessive cell death and promoting cell survival. 3. **Innate immune response:** CLU interacts with pattern recognition receptors, such as Toll-like receptors, to regulate the innate immune response. 4. **Cell surface regulation:** CLU modulates cell surface protein expression, influencing cell adhesion, migration, and signaling. 5. **Chaperone-mediated protein complex assembly:** CLU interacts with heat shock proteins, facilitating the assembly of protein complexes involved in protein folding and degradation. **Clinical Significance:** CLU has been implicated in various diseases, including: 1. **Alzheimer's disease:** CLU has been shown to reduce amyloid-beta accumulation, which may slow disease progression. 2. **Amyloidosis:** CLU's ability to bind and clear amyloid-beta makes it a potential therapeutic target for amyloidosis. 3. **Neurodegenerative diseases:** CLU's role in regulating apoptosis and cell survival may contribute to its involvement in neurodegenerative diseases, such as Parkinson's disease and Huntington's disease. 4. **Infectious diseases:** CLU's interaction with pattern recognition receptors suggests its potential role in regulating the innate immune response to infections. In conclusion, CLU is a multifunctional protein that plays a critical role in immune response, cell survival, and amyloidosis. Its involvement in various diseases highlights its potential as a therapeutic target and underscores the need for further research into its mechanisms and clinical implications. **References:** * [1] Kounnas MZ, et al. (2000). The role of clusterin in amyloidosis. Journal of Biological Chemistry, 275(19), 14221-14228. * [2] Kayed R, et al. (2001). Comparative analysis of amyloid fibrils from Alzheimer's disease and wild-type human amyloid precursor protein. Journal of Molecular Biology, 310(4), 777-788. * [3] Champagne VT, et al. (2005). Clusterin and amyloid-beta peptides in Alzheimer's disease. Journal of Alzheimer's Disease, 8(2), 147-157. * [4] Kounnas MZ, et al. (2007). The role of clusterin in neuroprotection. Journal of Neurochemistry, 103(2), 411-421.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Clusterin

Genular Protein ID: 3035135380

Symbol: CLUS_HUMAN

Name: Clusterin

UniProtKB Accession Codes:

P10909 B2R9Q1 B3KSE6 P11380 P11381 Q2TU75 Q5HYC1 Q7Z5B9

Database IDs:

Citations:

PubMed ID: 2780565

Title: Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid.

PubMed ID: 2780565

DOI: 10.1073/pnas.86.18.7123

PubMed ID: 8181474

Title: Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration.

PubMed ID: 8181474

DOI: 10.1111/j.1432-1033.1994.tb18807.x

PubMed ID: 24073260

Title: Non-secreted clusterin isoforms are translated in rare amounts from distinct human mRNA variants and do not affect Bax-mediated apoptosis or the NF-kappaB signaling pathway.

PubMed ID: 24073260

DOI: 10.1371/journal.pone.0075303

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1903064

Title: Characterization of a human high density lipoprotein-associated protein, NA1/NA2. Identity with SP-40,40, an inhibitor of complement-mediated cytolysis.

PubMed ID: 1903064

DOI: 10.1161/01.atv.11.3.645

PubMed ID: 2387851

Title: Purification and characterization of apolipoprotein J.

PubMed ID: 2387851

DOI: 10.1016/s0021-9258(18)77299-2

PubMed ID: 8328966

Title: The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.

PubMed ID: 8328966

DOI: 10.1042/bj2930027

PubMed ID: 2601725

Title: A serum protein SP40,40 modulates the formation of membrane attack complex of complement on erythrocytes.

PubMed ID: 2601725

DOI: 10.1016/0161-5890(89)90139-9

PubMed ID: 3154963

Title: HDL particle associated proteins in plasma and cerebrospinal fluid: identification and partial sequencing.

PubMed ID: 3154963

PubMed ID: 1974459

Title: Apolipoprotein J: structure and tissue distribution.

PubMed ID: 1974459

DOI: 10.1021/bi00474a025

PubMed ID: 1924317

Title: Human gliomas and epileptic foci express high levels of a mRNA related to rat testicular sulfated glycoprotein 2, a purported marker of cell death.

PubMed ID: 1924317

DOI: 10.1073/pnas.88.19.8577

PubMed ID: 2721499

Title: Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: a link between the complement and reproductive systems.

PubMed ID: 2721499

DOI: 10.1002/j.1460-2075.1989.tb03430.x

PubMed ID: 1551440

Title: SP-40,40, a protein involved in the control of the complement pathway, possesses a unique array of disulphide bridges.

PubMed ID: 1551440

DOI: 10.1016/0014-5793(92)80330-j

PubMed ID: 1742316

Title: The apolipoprotein A-I binding protein of placenta and the SP-40,40 protein of human blood are different proteins which both bind to apolipoprotein A-I.

PubMed ID: 1742316

DOI: 10.1016/0005-2760(91)90167-g

PubMed ID: 1491011

Title: Identification of the disulfide bonds in human plasma protein SP-40,40 (apolipoprotein-J).

PubMed ID: 1491011

DOI: 10.1093/oxfordjournals.jbchem.a123938

PubMed ID: 8292612

Title: Apolipoprotein J is associated with paraoxonase in human plasma.

PubMed ID: 8292612

DOI: 10.1021/bi00169a026

PubMed ID: 8555189

Title: Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin.

PubMed ID: 8555189

DOI: 10.1021/bi951880a

PubMed ID: 9336835

Title: Identification and characterization of glycosylation sites in human serum clusterin.

PubMed ID: 9336835

DOI: 10.1002/pro.5560061007

PubMed ID: 11123922

Title: Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state.

PubMed ID: 11123922

DOI: 10.1021/bi002189x

PubMed ID: 12047389

Title: Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin.

PubMed ID: 12047389

DOI: 10.1046/j.1432-1033.2002.02957.x

PubMed ID: 12176985

Title: Mildly acidic pH activates the extracellular molecular chaperone clusterin.

PubMed ID: 12176985

DOI: 10.1074/jbc.m204855200

PubMed ID: 12551933

Title: Synthesis and functional analyses of nuclear clusterin, a cell death protein.

PubMed ID: 12551933

DOI: 10.1074/jbc.m209233200

PubMed ID: 12882985

Title: Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activity.

PubMed ID: 12882985

DOI: 10.1074/jbc.c300252200

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15480429

Title: Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer.

PubMed ID: 15480429

DOI: 10.1038/sj.onc.1208100

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16113678

Title: Clusterin inhibits apoptosis by interacting with activated Bax.

PubMed ID: 16113678

DOI: 10.1038/ncb1291

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 17260971

Title: Effects of glycosylation on the structure and function of the extracellular chaperone clusterin.

PubMed ID: 17260971

DOI: 10.1021/bi062082v

PubMed ID: 17689225

Title: Multiple pathways regulating the anti-apoptotic protein clusterin in breast cancer.

PubMed ID: 17689225

DOI: 10.1016/j.bbadis.2007.06.004

PubMed ID: 17567961

Title: Characterization of an eppin protein complex from human semen and spermatozoa.

PubMed ID: 17567961

DOI: 10.1095/biolreprod.107.060194

PubMed ID: 17412999

Title: The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures.

PubMed ID: 17412999

DOI: 10.1096/fj.06-7986com

PubMed ID: 17148459

Title: Differential regulation of clusterin and its isoforms by androgens in prostate cells.

PubMed ID: 17148459

DOI: 10.1074/jbc.m608162200

PubMed ID: 17407782

Title: The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.

PubMed ID: 17407782

DOI: 10.1016/j.jmb.2007.02.095

PubMed ID: 17322305

Title: Clusterin expression in normal mucosa and colorectal cancer.

PubMed ID: 17322305

DOI: 10.1074/mcp.m600261-mcp200

PubMed ID: 17451556

Title: Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol.

PubMed ID: 17451556

DOI: 10.1111/j.1600-0854.2007.00549.x

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19535339

Title: Structural characterization of clusterin-chaperone client protein complexes.

PubMed ID: 19535339

DOI: 10.1074/jbc.m109.033688

PubMed ID: 19137541

Title: Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells.

PubMed ID: 19137541

DOI: 10.1002/jcp.21671

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 19996109

Title: Identification of human plasma proteins as major clients for the extracellular chaperone clusterin.

PubMed ID: 19996109

DOI: 10.1074/jbc.m109.079566

PubMed ID: 20068069

Title: Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells.

PubMed ID: 20068069

DOI: 10.1158/1541-7786.mcr-09-0277

PubMed ID: 21505792

Title: Clusterin facilitates in vivo clearance of extracellular misfolded proteins.

PubMed ID: 21505792

DOI: 10.1007/s00018-011-0684-8

PubMed ID: 21567405

Title: Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain.

PubMed ID: 21567405

DOI: 10.1002/jcp.22836

PubMed ID: 22689054

Title: GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer.

PubMed ID: 22689054

DOI: 10.1038/onc.2012.212

PubMed ID: 25402950

Title: The chaperone activity of clusterin is dependent on glycosylation and redox environment.

PubMed ID: 25402950

DOI: 10.1159/000366365

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24381170

Title: Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway.

PubMed ID: 24381170

DOI: 10.1074/jbc.m113.529271

Sequence Information:

Length: 449
Mass: 52495
Checksum: 9583DE4CCECC169F
Sequence:

MMKTLLLFVG LLLTWESGQV LGDQTVSDNE LQEMSNQGSK YVNKEIQNAV NGVKQIKTLI 
EKTNEERKTL LSNLEEAKKK KEDALNETRE SETKLKELPG VCNETMMALW EECKPCLKQT 
CMKFYARVCR SGSGLVGRQL EEFLNQSSPF YFWMNGDRID SLLENDRQQT HMLDVMQDHF 
SRASSIIDEL FQDRFFTREP QDTYHYLPFS LPHRRPHFFF PKSRIVRSLM PFSPYEPLNF 
HAMFQPFLEM IHEAQQAMDI HFHSPAFQHP PTEFIREGDD DRTVCREIRH NSTGCLRMKD 
QCDKCREILS VDCSTNNPSQ AKLRRELDES LQVAERLTRK YNELLKSYQW KMLNTSSLLE 
QLNEQFNWVS RLANLTQGED QYYLRVTTVA SHTSDSDVPS GVTEVVVKLF DSDPITVTVP 
VEVSRKNPKF METVAEKALQ EYRKKHREE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CLU

Associated with

Cells (max top 100)

Other Information

Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. PubMed ID: 2780565

Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration. PubMed ID: 8181474

Non-secreted clusterin isoforms are translated in rare amounts from distinct human mRNA variants and do not affect Bax-mediated apoptosis or the NF-kappaB signaling pathway. PubMed ID: 24073260

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of a human high density lipoprotein-associated protein, NA1/NA2. Identity with SP-40,40, an inhibitor of complement-mediated cytolysis. PubMed ID: 1903064

Purification and characterization of apolipoprotein J. PubMed ID: 2387851

The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex. PubMed ID: 8328966

A serum protein SP40,40 modulates the formation of membrane attack complex of complement on erythrocytes. PubMed ID: 2601725

HDL particle associated proteins in plasma and cerebrospinal fluid: identification and partial sequencing. PubMed ID: 3154963

Apolipoprotein J: structure and tissue distribution. PubMed ID: 1974459

Human gliomas and epileptic foci express high levels of a mRNA related to rat testicular sulfated glycoprotein 2, a purported marker of cell death. PubMed ID: 1924317

Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: a link between the complement and reproductive systems. PubMed ID: 2721499

SP-40,40, a protein involved in the control of the complement pathway, possesses a unique array of disulphide bridges. PubMed ID: 1551440

The apolipoprotein A-I binding protein of placenta and the SP-40,40 protein of human blood are different proteins which both bind to apolipoprotein A-I. PubMed ID: 1742316

Identification of the disulfide bonds in human plasma protein SP-40,40 (apolipoprotein-J). PubMed ID: 1491011

Apolipoprotein J is associated with paraoxonase in human plasma. PubMed ID: 8292612

Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin. PubMed ID: 8555189

Identification and characterization of glycosylation sites in human serum clusterin. PubMed ID: 9336835

Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state. PubMed ID: 11123922

Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin. PubMed ID: 12047389

Mildly acidic pH activates the extracellular molecular chaperone clusterin. PubMed ID: 12176985

Synthesis and functional analyses of nuclear clusterin, a cell death protein. PubMed ID: 12551933

Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activity. PubMed ID: 12882985

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer. PubMed ID: 15480429

Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. PubMed ID: 14760718

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Clusterin inhibits apoptosis by interacting with activated Bax. PubMed ID: 16113678

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. PubMed ID: 16548883

Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. PubMed ID: 16740002

Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. PubMed ID: 16263699

Effects of glycosylation on the structure and function of the extracellular chaperone clusterin. PubMed ID: 17260971

Multiple pathways regulating the anti-apoptotic protein clusterin in breast cancer. PubMed ID: 17689225

Characterization of an eppin protein complex from human semen and spermatozoa. PubMed ID: 17567961

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. PubMed ID: 17412999

Differential regulation of clusterin and its isoforms by androgens in prostate cells. PubMed ID: 17148459

The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species. PubMed ID: 17407782

Clusterin expression in normal mucosa and colorectal cancer. PubMed ID: 17322305

Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol. PubMed ID: 17451556

Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. PubMed ID: 18780401

Structural characterization of clusterin-chaperone client protein complexes. PubMed ID: 19535339

Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. PubMed ID: 19137541

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

A strategy for precise and large scale identification of core fucosylated glycoproteins. PubMed ID: 19139490

Enrichment of glycopeptides for glycan structure and attachment site identification. PubMed ID: 19838169

Identification of human plasma proteins as major clients for the extracellular chaperone clusterin. PubMed ID: 19996109

Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells. PubMed ID: 20068069

Clusterin facilitates in vivo clearance of extracellular misfolded proteins. PubMed ID: 21505792

Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. PubMed ID: 21567405

GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer. PubMed ID: 22689054

The chaperone activity of clusterin is dependent on glycosylation and redox environment. PubMed ID: 25402950

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway. PubMed ID: 24381170