Associated with
Other Information
Genular Protein ID: 3035135380
Symbol: CLUS_HUMAN
Name: Clusterin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2780565
Title: Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid.
PubMed ID: 2780565
PubMed ID: 8181474
Title: Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration.
PubMed ID: 8181474
PubMed ID: 24073260
Title: Non-secreted clusterin isoforms are translated in rare amounts from distinct human mRNA variants and do not affect Bax-mediated apoptosis or the NF-kappaB signaling pathway.
PubMed ID: 24073260
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1903064
Title: Characterization of a human high density lipoprotein-associated protein, NA1/NA2. Identity with SP-40,40, an inhibitor of complement-mediated cytolysis.
PubMed ID: 1903064
PubMed ID: 2387851
Title: Purification and characterization of apolipoprotein J.
PubMed ID: 2387851
PubMed ID: 8328966
Title: The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.
PubMed ID: 8328966
DOI: 10.1042/bj2930027
PubMed ID: 2601725
Title: A serum protein SP40,40 modulates the formation of membrane attack complex of complement on erythrocytes.
PubMed ID: 2601725
PubMed ID: 3154963
Title: HDL particle associated proteins in plasma and cerebrospinal fluid: identification and partial sequencing.
PubMed ID: 3154963
PubMed ID: 1974459
Title: Apolipoprotein J: structure and tissue distribution.
PubMed ID: 1974459
DOI: 10.1021/bi00474a025
PubMed ID: 1924317
Title: Human gliomas and epileptic foci express high levels of a mRNA related to rat testicular sulfated glycoprotein 2, a purported marker of cell death.
PubMed ID: 1924317
PubMed ID: 2721499
Title: Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: a link between the complement and reproductive systems.
PubMed ID: 2721499
PubMed ID: 1551440
Title: SP-40,40, a protein involved in the control of the complement pathway, possesses a unique array of disulphide bridges.
PubMed ID: 1551440
PubMed ID: 1742316
Title: The apolipoprotein A-I binding protein of placenta and the SP-40,40 protein of human blood are different proteins which both bind to apolipoprotein A-I.
PubMed ID: 1742316
PubMed ID: 1491011
Title: Identification of the disulfide bonds in human plasma protein SP-40,40 (apolipoprotein-J).
PubMed ID: 1491011
PubMed ID: 8292612
Title: Apolipoprotein J is associated with paraoxonase in human plasma.
PubMed ID: 8292612
DOI: 10.1021/bi00169a026
PubMed ID: 8555189
Title: Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin.
PubMed ID: 8555189
DOI: 10.1021/bi951880a
PubMed ID: 9336835
Title: Identification and characterization of glycosylation sites in human serum clusterin.
PubMed ID: 9336835
PubMed ID: 11123922
Title: Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state.
PubMed ID: 11123922
DOI: 10.1021/bi002189x
PubMed ID: 12047389
Title: Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin.
PubMed ID: 12047389
PubMed ID: 12176985
Title: Mildly acidic pH activates the extracellular molecular chaperone clusterin.
PubMed ID: 12176985
PubMed ID: 12551933
Title: Synthesis and functional analyses of nuclear clusterin, a cell death protein.
PubMed ID: 12551933
PubMed ID: 12882985
Title: Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activity.
PubMed ID: 12882985
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 15480429
Title: Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer.
PubMed ID: 15480429
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 16113678
Title: Clusterin inhibits apoptosis by interacting with activated Bax.
PubMed ID: 16113678
DOI: 10.1038/ncb1291
PubMed ID: 16548883
Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.
PubMed ID: 16548883
PubMed ID: 16740002
Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.
PubMed ID: 16740002
DOI: 10.1021/pr050492k
PubMed ID: 16263699
Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.
PubMed ID: 16263699
PubMed ID: 17260971
Title: Effects of glycosylation on the structure and function of the extracellular chaperone clusterin.
PubMed ID: 17260971
DOI: 10.1021/bi062082v
PubMed ID: 17689225
Title: Multiple pathways regulating the anti-apoptotic protein clusterin in breast cancer.
PubMed ID: 17689225
PubMed ID: 17567961
Title: Characterization of an eppin protein complex from human semen and spermatozoa.
PubMed ID: 17567961
PubMed ID: 17412999
Title: The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures.
PubMed ID: 17412999
PubMed ID: 17148459
Title: Differential regulation of clusterin and its isoforms by androgens in prostate cells.
PubMed ID: 17148459
PubMed ID: 17407782
Title: The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.
PubMed ID: 17407782
PubMed ID: 17322305
Title: Clusterin expression in normal mucosa and colorectal cancer.
PubMed ID: 17322305
PubMed ID: 17451556
Title: Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol.
PubMed ID: 17451556
PubMed ID: 18780401
Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.
PubMed ID: 18780401
PubMed ID: 19535339
Title: Structural characterization of clusterin-chaperone client protein complexes.
PubMed ID: 19535339
PubMed ID: 19137541
Title: Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells.
PubMed ID: 19137541
DOI: 10.1002/jcp.21671
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19139490
Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.
PubMed ID: 19139490
PubMed ID: 19838169
Title: Enrichment of glycopeptides for glycan structure and attachment site identification.
PubMed ID: 19838169
DOI: 10.1038/nmeth.1392
PubMed ID: 19996109
Title: Identification of human plasma proteins as major clients for the extracellular chaperone clusterin.
PubMed ID: 19996109
PubMed ID: 20068069
Title: Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells.
PubMed ID: 20068069
PubMed ID: 21505792
Title: Clusterin facilitates in vivo clearance of extracellular misfolded proteins.
PubMed ID: 21505792
PubMed ID: 21567405
Title: Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain.
PubMed ID: 21567405
DOI: 10.1002/jcp.22836
PubMed ID: 22689054
Title: GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer.
PubMed ID: 22689054
DOI: 10.1038/onc.2012.212
PubMed ID: 25402950
Title: The chaperone activity of clusterin is dependent on glycosylation and redox environment.
PubMed ID: 25402950
DOI: 10.1159/000366365
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24381170
Title: Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway.
PubMed ID: 24381170
Sequence Information:
- Length: 449
- Mass: 52495
- Checksum: 9583DE4CCECC169F
- Sequence:
MMKTLLLFVG LLLTWESGQV LGDQTVSDNE LQEMSNQGSK YVNKEIQNAV NGVKQIKTLI EKTNEERKTL LSNLEEAKKK KEDALNETRE SETKLKELPG VCNETMMALW EECKPCLKQT CMKFYARVCR SGSGLVGRQL EEFLNQSSPF YFWMNGDRID SLLENDRQQT HMLDVMQDHF SRASSIIDEL FQDRFFTREP QDTYHYLPFS LPHRRPHFFF PKSRIVRSLM PFSPYEPLNF HAMFQPFLEM IHEAQQAMDI HFHSPAFQHP PTEFIREGDD DRTVCREIRH NSTGCLRMKD QCDKCREILS VDCSTNNPSQ AKLRRELDES LQVAERLTRK YNELLKSYQW KMLNTSSLLE QLNEQFNWVS RLANLTQGED QYYLRVTTVA SHTSDSDVPS GVTEVVVKLF DSDPITVTVP VEVSRKNPKF METVAEKALQ EYRKKHREE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.