Details for: Atf4

Gene ID: 11911

Symbol: Atf4

Ensembl ID: ENSMUSG00000042406

Description: activating transcription factor 4

Associated with

  • Bone mineralization
    (GO:0030282)
  • Camp response element binding protein binding
    (GO:0008140)
  • Cellular response to amino acid starvation
    (GO:0034198)
  • Cellular response to glucose starvation
    (GO:0042149)
  • Cellular response to leucine starvation
    (GO:1990253)
  • Cellular response to oxidative stress
    (GO:0034599)
  • Centrosome
    (GO:0005813)
  • Circadian regulation of gene expression
    (GO:0032922)
  • Circadian rhythm
    (GO:0007623)
  • Cytoplasm
    (GO:0005737)
  • Cytoskeleton
    (GO:0005856)
  • Dendrite membrane
    (GO:0032590)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna binding
    (GO:0003677)
  • Embryonic hemopoiesis
    (GO:0035162)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Gamma-aminobutyric acid signaling pathway
    (GO:0007214)
  • General transcription initiation factor binding
    (GO:0140296)
  • Gluconeogenesis
    (GO:0006094)
  • Hri-mediated signaling
    (GO:0140468)
  • Identical protein binding
    (GO:0042802)
  • Integrated stress response signaling
    (GO:0140467)
  • Intracellular calcium ion homeostasis
    (GO:0006874)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • L-asparagine metabolic process
    (GO:0070982)
  • Lens fiber cell morphogenesis
    (GO:0070309)
  • Leucine zipper domain binding
    (GO:0043522)
  • Membrane
    (GO:0016020)
  • Mrna transcription by rna polymerase ii
    (GO:0042789)
  • Negative regulation of cold-induced thermogenesis
    (GO:0120163)
  • Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
    (GO:1903377)
  • Negative regulation of potassium ion transport
    (GO:0043267)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron projection
    (GO:0043005)
  • Nuclear periphery
    (GO:0034399)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Perk-mediated unfolded protein response
    (GO:0036499)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of biomineral tissue development
    (GO:0070169)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of sodium-dependent phosphate transport
    (GO:2000120)
  • Positive regulation of transcription by rna polymerase i
    (GO:0045943)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular associated smooth muscle cell apoptotic process
    (GO:1905461)
  • Positive regulation of vascular endothelial growth factor production
    (GO:0010575)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of osteoblast differentiation
    (GO:0045667)
  • Regulation of synaptic plasticity
    (GO:0048167)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Response to nutrient levels
    (GO:0031667)
  • Rhythmic process
    (GO:0048511)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription regulator complex
    (GO:0005667)

Other Information

Genular Protein ID: 3020633751

Symbol: ATF4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q06507 Q5U4B2 Q61906

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 78 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8506317

Title: C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements.

PubMed ID: 8506317

DOI: 10.1073/pnas.90.10.4679

PubMed ID: 1631061

Title: Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun.

PubMed ID: 1631061

DOI: 10.1073/pnas.89.13.5789

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10096021

Title: Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.

PubMed ID: 10096021

DOI: 10.1046/j.1365-2443.1998.00230.x

PubMed ID: 10885750

Title: Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor.

PubMed ID: 10885750

DOI: 10.1006/dbio.2000.9699

PubMed ID: 11106749

Title: Regulated translation initiation controls stress-induced gene expression in mammalian cells.

PubMed ID: 11106749

DOI: 10.1016/s1097-2765(00)00108-8

PubMed ID: 11018027

Title: Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.

PubMed ID: 11018027

DOI: 10.1074/jbc.m005594200

PubMed ID: 11806972

Title: Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice.

PubMed ID: 11806972

DOI: 10.1182/blood.v99.3.736

PubMed ID: 12667446

Title: An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.

PubMed ID: 12667446

DOI: 10.1016/s1097-2765(03)00105-9

PubMed ID: 12925279

Title: Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins.

PubMed ID: 12925279

DOI: 10.1016/s0896-6273(03)00501-4

PubMed ID: 15109498

Title: ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome.

PubMed ID: 15109498

DOI: 10.1016/s0092-8674(04)00344-7

PubMed ID: 15277680

Title: Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells.

PubMed ID: 15277680

DOI: 10.1073/pnas.0400541101

PubMed ID: 15775988

Title: TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.

PubMed ID: 15775988

DOI: 10.1038/sj.emboj.7600596

PubMed ID: 15911876

Title: FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice.

PubMed ID: 15911876

DOI: 10.1083/jcb.200412139

PubMed ID: 16751105

Title: SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.

PubMed ID: 16751105

DOI: 10.1016/j.cell.2006.05.012

PubMed ID: 17369260

Title: TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway.

PubMed ID: 17369260

DOI: 10.1074/jbc.m611723200

PubMed ID: 19232401

Title: FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes.

PubMed ID: 19232401

DOI: 10.1016/j.gep.2009.02.002

PubMed ID: 21159964

Title: Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA.

PubMed ID: 21159964

DOI: 10.1523/jneurosci.1598-10.2010

PubMed ID: 21768648

Title: cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene.

PubMed ID: 21768648

DOI: 10.1074/jbc.m111.258970

PubMed ID: 22974638

Title: ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.

PubMed ID: 22974638

DOI: 10.1016/j.bbamcr.2012.08.020

PubMed ID: 22298775

Title: FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis.

PubMed ID: 22298775

DOI: 10.1074/jbc.m111.282897

PubMed ID: 22572884

Title: Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain.

PubMed ID: 22572884

DOI: 10.1124/mol.112.079079

PubMed ID: 23663782

Title: The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

PubMed ID: 23663782

DOI: 10.1016/j.cell.2013.04.023

PubMed ID: 23624402

Title: ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

PubMed ID: 23624402

DOI: 10.1038/ncb2738

PubMed ID: 24809345

Title: Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

PubMed ID: 24809345

DOI: 10.1371/journal.pgen.1004348

PubMed ID: 31444471

Title: Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders.

PubMed ID: 31444471

DOI: 10.1038/s41380-019-0485-2

Sequence Information:

  • Length: 349
  • Mass: 38355
  • Checksum: 0C3F895755B1C7B9
  • Sequence:
    • MTEMSFLNSE VLAGDLMSPF DQSGLGAEES LGLLDDYLEV AKHLKPHGFS SDKAGSSEWP 
AMDDGLASAS DTGKEDAFSG TDWMLEKMDL KEFDFDALFR MDDLETMPDE LLTTLDDTCD 
LFAPLVQETN KEPPQTVNPI GHLPESLIKV DQVAPFTFLQ PFPCSPGVLS STPEHSFSLE 
LGSEVDISEG DRKPDSAAYI TLIPPCVKEE DTPSDNDSGI CMSPESYLGS PQHSPSTSRA 
PPDNLPSPGG SRGSPRPKPY DPPGVSLTAK VKTEKLDKKL KKMEQNKTAA TRYRQKKRAE 
QEALTGECKE LEKKNEALKE KADSLAKEIQ YLKDLIEEVR KARGKKRVP

Genular Protein ID: 3387840920

Symbol: Q8CF69_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CF69

Database IDs:

AGR 1 ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 InterPro 2 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 Pfam 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 350
  • Mass: 38716
  • Checksum: 6394500297E6C3CE
  • Sequence:
    • MTEMSFLNSE VLAGDLMSPF DQSGLGAEES LGLLDDYLEV AKHLKPHGFS SDKAGSSEWP 
GLWMMAWPVP QTPGKEDAFS GTDWMLEKMD LKEFDFDALF RMDDLETMPD ELLTTLDDTC 
DLFAPLVQET NKEPPQTVNP IGHLPESLIK VDQVAPFTFL QPFPCSPGVL SSTPEHSFSL 
ELGSEVDISE GDRKPDSAAY ITLIPPCVKE EDTPSDNDSG ICMSPESYLG SPQHSPSTSR 
APPDNLPSPG GSRGSPRPKP YDPPGVSLTA KVKTEKLDKK LKKMEQNKTA ATRYRQKKRA 
EQEALTGECK ELEKKNEALK EKADSLAKEI QYLKDLIEEV RKARGKKRVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.