Details for: CLIC1

Gene ID: 1192

Symbol: CLIC1

Ensembl ID: ENSG00000213719

Description: chloride intracellular channel 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.32
    Marker Score: 3752
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.87
    Marker Score: 2956
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 4.4
    Marker Score: 18282
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.31
    Marker Score: 12577
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 4.18
    Marker Score: 1225
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.18
    Marker Score: 233529
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.14
    Marker Score: 11429
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 4.04
    Marker Score: 3434
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.02
    Marker Score: 12672.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.93
    Marker Score: 9980
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.9
    Marker Score: 45386
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.74
    Marker Score: 5408
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.71
    Marker Score: 3307
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.7
    Marker Score: 4112
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.66
    Marker Score: 2759
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.6
    Marker Score: 4349.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.59
    Marker Score: 8769
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.55
    Marker Score: 22678
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.51
    Marker Score: 5167
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.48
    Marker Score: 3367
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.47
    Marker Score: 1793.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.46
    Marker Score: 1551
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.42
    Marker Score: 2288
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.39
    Marker Score: 3882
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.39
    Marker Score: 25211
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.35
    Marker Score: 113878
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.31
    Marker Score: 3116
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.31
    Marker Score: 9292
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.27
    Marker Score: 28404
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.26
    Marker Score: 2567
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.21
    Marker Score: 2823
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.2
    Marker Score: 6227
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.13
    Marker Score: 9821
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 3.1
    Marker Score: 1890
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.09
    Marker Score: 11906
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 3.07
    Marker Score: 3693
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 3.06
    Marker Score: 2033
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.05
    Marker Score: 13090
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.05
    Marker Score: 4320
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.03
    Marker Score: 23691
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.02
    Marker Score: 2192
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.01
    Marker Score: 40497
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3
    Marker Score: 103977.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.98
    Marker Score: 7430
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.98
    Marker Score: 2653
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.96
    Marker Score: 7227
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.96
    Marker Score: 29959
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.95
    Marker Score: 1000.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.94
    Marker Score: 6679
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.93
    Marker Score: 2932
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.92
    Marker Score: 18681
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.91
    Marker Score: 2205
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.9
    Marker Score: 1654
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.9
    Marker Score: 1250
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.89
    Marker Score: 1696
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.87
    Marker Score: 2562
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.86
    Marker Score: 2247
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.85
    Marker Score: 13692
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.84
    Marker Score: 4951
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.84
    Marker Score: 1611
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.83
    Marker Score: 2384
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.81
    Marker Score: 2301
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.79
    Marker Score: 71395
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.79
    Marker Score: 11399
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.78
    Marker Score: 2667
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.78
    Marker Score: 1599
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.78
    Marker Score: 2816
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.77
    Marker Score: 2003
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.76
    Marker Score: 7164.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.76
    Marker Score: 7398
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.76
    Marker Score: 2966
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.74
    Marker Score: 23616
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.73
    Marker Score: 2911
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.72
    Marker Score: 13382
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.72
    Marker Score: 5110
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.71
    Marker Score: 990
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.71
    Marker Score: 11688
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.71
    Marker Score: 2308
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.7
    Marker Score: 1388
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.68
    Marker Score: 824
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.67
    Marker Score: 1091
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.67
    Marker Score: 878
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.66
    Marker Score: 1670
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.65
    Marker Score: 2750
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.65
    Marker Score: 1477
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.64
    Marker Score: 5282
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.64
    Marker Score: 1317
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.63
    Marker Score: 1250
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.63
    Marker Score: 907
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.62
    Marker Score: 5130
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.62
    Marker Score: 1523
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.61
    Marker Score: 7736
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.6
    Marker Score: 6566
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.6
    Marker Score: 2430
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.6
    Marker Score: 1467
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.59
    Marker Score: 1007
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.59
    Marker Score: 1561
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.59
    Marker Score: 919
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.58
    Marker Score: 617
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.58
    Marker Score: 4369

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Other Information

**Key characteristics:** - CLIC1 is a transmembrane protein with a predicted molecular weight of approximately 120 kDa. - It is a member of the chloride intracellular channel (CIC) family of proteins. - CLIC1 is expressed in high levels in certain cell types, including monocyte and dendritic cells. **Pathways and functions:** - CLIC1 is involved in the regulation of cell adhesion and migration through its interaction with cadherins. - It is also involved in the regulation of chloride transport, both by promoting chloride efflux and by regulating the activity of chloride intracellular channels. - CLIC1 is involved in the regulation of mitochondrial membrane potential and signal transduction. **Clinical significance:** - Mutations in CLIC1 have been linked to a number of human diseases, including cancer, cardiovascular disease, and kidney disease. - CLIC1 inhibitors are being investigated as potential treatments for these diseases. **Additional information:** - CLIC1 is a relatively novel protein, with no known paralogs in humans. - It is expressed in a variety of cell types, including monocyte, dendritic, and endothelial cells. - It is a key regulator of cell adhesion, migration, and signaling.

Genular Protein ID: 1564106755

Symbol: CLIC1_HUMAN

Name: Chloride intracellular channel protein 1

UniProtKB Accession Codes:

O00299 Q15089 Q502X1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 5 CPTC 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 11 EPD 1 Ensembl 35 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 17 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SFLD 2 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9139710

Title: Molecular cloning and expression of a chloride ion channel of cell nuclei.

PubMed ID: 9139710

DOI: 10.1074/jbc.272.19.12575

PubMed ID: 10191309

Title: A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.

PubMed ID: 10191309

DOI: 10.1523/jneurosci.19-08-02919.1999

PubMed ID: 10384126

Title: Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region.

PubMed ID: 10384126

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10834939

Title: Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells.

PubMed ID: 10834939

DOI: 10.1096/fasebj.14.9.1171

PubMed ID: 11195932

Title: The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle.

PubMed ID: 11195932

DOI: 10.1111/j.1469-7793.2000.00541.x

PubMed ID: 10793131

Title: Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli.

PubMed ID: 10793131

DOI: 10.1091/mbc.11.5.1509

PubMed ID: 11940526

Title: CLIC1 inserts from the aqueous phase into phospholipid membranes, where it functions as an anion channel.

PubMed ID: 11940526

DOI: 10.1152/ajpcell.00402.2001

PubMed ID: 11978800

Title: Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1.

PubMed ID: 11978800

DOI: 10.1074/jbc.m203666200

PubMed ID: 12163479

Title: AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.

PubMed ID: 12163479

DOI: 10.1074/jbc.m112277200

PubMed ID: 12681486

Title: Interaction of sedlin with chloride intracellular channel proteins.

PubMed ID: 12681486

DOI: 10.1016/s0014-5793(03)00228-x

PubMed ID: 18850721

Title: Formation of an unfolding intermediate state of soluble chloride intracellular channel protein CLIC1 at acidic pH.

PubMed ID: 18850721

DOI: 10.1021/bi801147r

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11551966

Title: Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.

PubMed ID: 11551966

DOI: 10.1074/jbc.m107804200

PubMed ID: 14613939

Title: The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition.

PubMed ID: 14613939

DOI: 10.1074/jbc.m308444200

Sequence Information:

  • Length: 241
  • Mass: 26923
  • Checksum: 163EEB7481826A0A
  • Sequence:
    • MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP 
GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN 
SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL 
LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL 
K

Genular Protein ID: 150614609

Symbol: Q53FB0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53FB0

Database IDs:

ARBA 18 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SFLD 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 241
  • Mass: 27015
  • Checksum: 82A16A931FFB8D8B
  • Sequence:
    • MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP 
GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN 
SNPALNDNLE KGLLKYLKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL 
LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.