Details for: CLIC1

Gene ID: 1192

Symbol: CLIC1

Ensembl ID: ENSG00000213719

Description: chloride intracellular channel 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 648.8788
    Cell Significance Index: -100.9300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 294.8919
    Cell Significance Index: -121.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 281.3005
    Cell Significance Index: -71.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 278.7890
    Cell Significance Index: -113.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 253.1546
    Cell Significance Index: -119.5200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 233.2299
    Cell Significance Index: -119.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 178.1759
    Cell Significance Index: -119.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 121.3101
    Cell Significance Index: -115.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 88.7096
    Cell Significance Index: -109.3800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 36.7609
    Cell Significance Index: 916.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.7097
    Cell Significance Index: -113.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.7300
    Cell Significance Index: -82.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.1676
    Cell Significance Index: -41.9500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 9.6244
    Cell Significance Index: 177.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.7940
    Cell Significance Index: 228.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.9774
    Cell Significance Index: 280.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.8047
    Cell Significance Index: 374.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.7513
    Cell Significance Index: 124.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.7165
    Cell Significance Index: 351.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.4391
    Cell Significance Index: 50.4300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.3828
    Cell Significance Index: 77.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.6805
    Cell Significance Index: 475.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.5631
    Cell Significance Index: 82.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.1405
    Cell Significance Index: 370.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1025
    Cell Significance Index: 1694.3300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 3.0152
    Cell Significance Index: 21.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.9624
    Cell Significance Index: 534.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9138
    Cell Significance Index: 79.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.8315
    Cell Significance Index: 348.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7572
    Cell Significance Index: 378.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.5093
    Cell Significance Index: 71.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5049
    Cell Significance Index: 130.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.2171
    Cell Significance Index: 980.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.0748
    Cell Significance Index: 265.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.0269
    Cell Significance Index: 18.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.8033
    Cell Significance Index: 93.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7598
    Cell Significance Index: 82.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.5989
    Cell Significance Index: 9.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4194
    Cell Significance Index: 30.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3075
    Cell Significance Index: 92.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3052
    Cell Significance Index: 27.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8317
    Cell Significance Index: 28.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8285
    Cell Significance Index: 164.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4443
    Cell Significance Index: 20.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2278
    Cell Significance Index: 38.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1947
    Cell Significance Index: 37.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1686
    Cell Significance Index: 127.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1581
    Cell Significance Index: 115.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0734
    Cell Significance Index: 1.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0616
    Cell Significance Index: 6.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0370
    Cell Significance Index: 0.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0208
    Cell Significance Index: 2.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: -0.0187
    Cell Significance Index: 0.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0394
    Cell Significance Index: -1.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0465
    Cell Significance Index: -87.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0580
    Cell Significance Index: -42.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0672
    Cell Significance Index: -123.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0804
    Cell Significance Index: -123.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0910
    Cell Significance Index: -123.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1075
    Cell Significance Index: -67.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1304
    Cell Significance Index: -5.3400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1357
    Cell Significance Index: -0.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1555
    Cell Significance Index: -87.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1698
    Cell Significance Index: -107.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2635
    Cell Significance Index: -119.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3016
    Cell Significance Index: -63.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3116
    Cell Significance Index: -7.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3289
    Cell Significance Index: -117.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3507
    Cell Significance Index: -2.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3611
    Cell Significance Index: -5.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4157
    Cell Significance Index: -119.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4682
    Cell Significance Index: -53.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.5970
    Cell Significance Index: -119.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6419
    Cell Significance Index: -74.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7121
    Cell Significance Index: -103.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7334
    Cell Significance Index: -23.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7955
    Cell Significance Index: -90.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8844
    Cell Significance Index: -9.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8905
    Cell Significance Index: -70.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0992
    Cell Significance Index: -114.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.1701
    Cell Significance Index: -32.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2357
    Cell Significance Index: -16.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4613
    Cell Significance Index: -39.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5287
    Cell Significance Index: -85.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.5556
    Cell Significance Index: -119.3800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.6548
    Cell Significance Index: -17.9900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.7382
    Cell Significance Index: -10.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.9363
    Cell Significance Index: -122.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.9501
    Cell Significance Index: -119.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.9728
    Cell Significance Index: -69.3200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -2.1818
    Cell Significance Index: -20.0400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -2.2646
    Cell Significance Index: -19.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.2771
    Cell Significance Index: -67.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -2.3200
    Cell Significance Index: -121.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.4035
    Cell Significance Index: -60.0800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -2.4777
    Cell Significance Index: -11.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.5050
    Cell Significance Index: -72.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.5929
    Cell Significance Index: -21.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.6447
    Cell Significance Index: -97.0900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -2.6974
    Cell Significance Index: -34.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLIC1 is a chloride channel protein that belongs to the ClC family of proteins. It is a small, multifunctional protein that plays a critical role in regulating chloride ion movement across cellular membranes. CLIC1 is highly expressed in immune cells and has been shown to be involved in various cellular processes, including: * Cell differentiation and proliferation * Cell survival and apoptosis * Signal transduction and regulation of cellular responses * Regulation of mitochondrial membrane potential and function **Pathways and Functions:** CLIC1 has been implicated in multiple signaling pathways, including: * **Blood microparticle formation and regulation**: CLIC1 is involved in the regulation of blood microparticle formation and function, which is critical for maintaining cardiovascular health. * **Brush border function**: CLIC1 plays a role in regulating the function of the brush border, a complex structure involved in nutrient absorption and secretion in the small intestine. * **Cadherin binding and regulation**: CLIC1 interacts with cadherins, which are cell adhesion molecules involved in maintaining tissue structure and function. * **Chloride channel activity and regulation**: CLIC1 is a chloride channel protein that regulates chloride ion movement across cellular membranes. * **Signal transduction and regulation of cellular responses**: CLIC1 is involved in regulating various signaling pathways, including those related to cell differentiation, proliferation, and survival. **Clinical Significance:** Dysregulation of CLIC1 has been linked to various diseases, including: * **Cancer**: CLIC1 has been implicated in cancer progression and metastasis, particularly in breast, lung, and colon cancers. * **Autoimmune disorders**: CLIC1 has been linked to autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. * **Cardiovascular diseases**: CLIC1 has been implicated in cardiovascular diseases, including atherosclerosis and heart failure. * **Neurological disorders**: CLIC1 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, CLIC1 is a multifaceted gene involved in immune response, cellular homeostasis, and disease pathogenesis. Its dysregulation has been linked to various diseases, highlighting the importance of understanding the mechanisms of CLIC1 regulation and its role in maintaining cellular homeostasis. Further research is needed to elucidate the functions of CLIC1 and its implications in human disease.

Genular Protein ID: 1564106755

Symbol: CLIC1_HUMAN

Name: Chloride intracellular channel protein 1

UniProtKB Accession Codes:

O00299 Q15089 Q502X1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 5 CPTC 1 CTD 1 ChEBI 13 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 11 Ensembl 35 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 Rhea 8 SFLD 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9139710

Title: Molecular cloning and expression of a chloride ion channel of cell nuclei.

PubMed ID: 9139710

DOI: 10.1074/jbc.272.19.12575

PubMed ID: 10191309

Title: A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.

PubMed ID: 10191309

DOI: 10.1523/jneurosci.19-08-02919.1999

PubMed ID: 10384126

Title: Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region.

PubMed ID: 10384126

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10834939

Title: Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells.

PubMed ID: 10834939

DOI: 10.1096/fasebj.14.9.1171

PubMed ID: 11195932

Title: The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle.

PubMed ID: 11195932

DOI: 10.1111/j.1469-7793.2000.00541.x

PubMed ID: 10793131

Title: Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli.

PubMed ID: 10793131

DOI: 10.1091/mbc.11.5.1509

PubMed ID: 10874038

Title: CLIC-1 functions as a chloride channel when expressed and purified from bacteria.

PubMed ID: 10874038

DOI: 10.1074/jbc.m004301200

PubMed ID: 11940526

Title: CLIC1 inserts from the aqueous phase into phospholipid membranes, where it functions as an anion channel.

PubMed ID: 11940526

DOI: 10.1152/ajpcell.00402.2001

PubMed ID: 11978800

Title: Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1.

PubMed ID: 11978800

DOI: 10.1074/jbc.m203666200

PubMed ID: 12163479

Title: AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.

PubMed ID: 12163479

DOI: 10.1074/jbc.m112277200

PubMed ID: 12681486

Title: Interaction of sedlin with chloride intracellular channel proteins.

PubMed ID: 12681486

DOI: 10.1016/s0014-5793(03)00228-x

PubMed ID: 16339885

Title: Redox regulation of CLIC1 by cysteine residues associated with the putative channel pore.

PubMed ID: 16339885

DOI: 10.1529/biophysj.105.072678

PubMed ID: 18850721

Title: Formation of an unfolding intermediate state of soluble chloride intracellular channel protein CLIC1 at acidic pH.

PubMed ID: 18850721

DOI: 10.1021/bi801147r

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25581026

Title: Members of the chloride intracellular ion channel protein family demonstrate glutaredoxin-like enzymatic activity.

PubMed ID: 25581026

DOI: 10.1371/journal.pone.0115699

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 37759794

Title: In Vitro Enzymatic Studies Reveal pH and Temperature Sensitive Properties of the CLIC Proteins.

PubMed ID: 37759794

DOI: 10.3390/biom13091394

PubMed ID: 11551966

Title: Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.

PubMed ID: 11551966

DOI: 10.1074/jbc.m107804200

PubMed ID: 14613939

Title: The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition.

PubMed ID: 14613939

DOI: 10.1074/jbc.m308444200

Sequence Information:

  • Length: 241
  • Mass: 26923
  • Checksum: 163EEB7481826A0A
  • Sequence:
    • MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP 
GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN 
SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL 
LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL 
K

Genular Protein ID: 150614609

Symbol: Q53FB0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53FB0

Database IDs:

ARBA 25 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 10 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 5 Gene3D 2 InterPro 7 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 Pfam 2 RefSeq 1 Rhea 8 RuleBase 1 SFLD 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 241
  • Mass: 27015
  • Checksum: 82A16A931FFB8D8B
  • Sequence:
    • MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP 
GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN 
SNPALNDNLE KGLLKYLKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL 
LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.