Genular: Defining Cellular Identity and Function

Details for: Neurog3

Gene ID: 11925

Symbol: Neurog3

Ensembl ID: ENSMUSG00000044312

Description: neurogenin 3

Associated with

Axon development
(GO:0061564)
Cell differentiation
(GO:0030154)
Chromatin dna binding
(GO:0031490)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
E-box binding
(GO:0070888)
Epithelial cell differentiation
(GO:0030855)
Forebrain development
(GO:0030900)
Intracellular anatomical structure
(GO:0005622)
Multicellular organism development
(GO:0007275)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of dendrite morphogenesis
(GO:0048814)
Regulation of dna-templated transcription
(GO:0006355)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sensory organ development
(GO:0007423)
Transdifferentiation
(GO:0060290)

Other Information

Proteins

Neurogenin-3

Genular Protein ID: 3807090378

Symbol: NGN3_MOUSE

Name: Neurogenin-3

UniProtKB Accession Codes:

P70661

Database IDs:

Citations:

PubMed ID: 9108377

Title: Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors.

PubMed ID: 9108377

DOI: 10.1242/dev.124.8.1611

PubMed ID: 9000438

Title: Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS.

PubMed ID: 9000438

DOI: 10.1006/mcne.1996.0060

PubMed ID: 10677506

Title: Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.

PubMed ID: 10677506

DOI: 10.1073/pnas.97.4.1607

PubMed ID: 18560595

Title: Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network.

PubMed ID: 18560595

DOI: 10.1371/journal.pone.0002430

PubMed ID: 19759004

Title: Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.

PubMed ID: 19759004

DOI: 10.1074/jbc.m109.048694

Sequence Information:

Length: 214
Mass: 23267
Checksum: 1AB31183291FB98B
Sequence:

MAPHPLDALT IQVSPETQQP FPGASDHEVL SSNSTPPSPT LIPRDCSEAE VGDCRGTSRK 
LRARRGGRNR PKSELALSKQ RRSRRKKAND RERNRMHNLN SALDALRGVL PTFPDDAKLT 
KIETLRFAHN YIWALTQTLR IADHSFYGPE PPVPCGELGS PGGGSNGDWG SIYSPVSQAG 
NLSPTASLEE FPGLQVPSSP SYLLPGALVF SDFL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Neurog3

Associated with

Other Information

Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors. PubMed ID: 9108377

Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. PubMed ID: 9000438

Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. PubMed ID: 10677506