Details for: CLIC2

Gene ID: 1193

Symbol: CLIC2

Ensembl ID: ENSG00000155962

Description: chloride intracellular channel 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.0825
    Cell Significance Index: -9.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.2500
    Cell Significance Index: -8.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 25.3854
    Cell Significance Index: -11.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 22.7845
    Cell Significance Index: -11.7200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 8.4378
    Cell Significance Index: 89.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.0553
    Cell Significance Index: -5.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8053
    Cell Significance Index: -11.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.4036
    Cell Significance Index: 42.4800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.8992
    Cell Significance Index: 13.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.3565
    Cell Significance Index: 15.4100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.0951
    Cell Significance Index: 15.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0525
    Cell Significance Index: 30.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.0116
    Cell Significance Index: 32.4000
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.3907
    Cell Significance Index: 2.2400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.3597
    Cell Significance Index: 6.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3182
    Cell Significance Index: 6.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2709
    Cell Significance Index: 54.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2370
    Cell Significance Index: 32.5500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.2328
    Cell Significance Index: 2.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2112
    Cell Significance Index: 34.3500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2105
    Cell Significance Index: 3.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1972
    Cell Significance Index: 2.6900
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.1690
    Cell Significance Index: 0.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1204
    Cell Significance Index: 4.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1159
    Cell Significance Index: 6.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1028
    Cell Significance Index: 5.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0816
    Cell Significance Index: 3.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0793
    Cell Significance Index: 28.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0653
    Cell Significance Index: 12.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0628
    Cell Significance Index: 12.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0505
    Cell Significance Index: 7.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0294
    Cell Significance Index: 22.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0146
    Cell Significance Index: 0.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0145
    Cell Significance Index: 2.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0083
    Cell Significance Index: 15.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0010
    Cell Significance Index: 1.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0014
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0034
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0041
    Cell Significance Index: -2.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0045
    Cell Significance Index: -0.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0052
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0062
    Cell Significance Index: -3.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0074
    Cell Significance Index: -4.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0135
    Cell Significance Index: -2.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0143
    Cell Significance Index: -10.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0164
    Cell Significance Index: -7.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0166
    Cell Significance Index: -9.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0178
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0334
    Cell Significance Index: -5.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0398
    Cell Significance Index: -11.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0499
    Cell Significance Index: -3.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0503
    Cell Significance Index: -5.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0508
    Cell Significance Index: -6.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0542
    Cell Significance Index: -1.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0547
    Cell Significance Index: -5.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0585
    Cell Significance Index: -6.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0600
    Cell Significance Index: -3.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0638
    Cell Significance Index: -8.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0692
    Cell Significance Index: -7.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0770
    Cell Significance Index: -7.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0810
    Cell Significance Index: -10.4600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0889
    Cell Significance Index: -1.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0891
    Cell Significance Index: -10.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0920
    Cell Significance Index: -6.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0989
    Cell Significance Index: -11.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0993
    Cell Significance Index: -5.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1005
    Cell Significance Index: -10.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1154
    Cell Significance Index: -2.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1171
    Cell Significance Index: -8.2800
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.1230
    Cell Significance Index: -0.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1318
    Cell Significance Index: -9.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1393
    Cell Significance Index: -11.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1451
    Cell Significance Index: -4.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1628
    Cell Significance Index: -7.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1689
    Cell Significance Index: -7.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1721
    Cell Significance Index: -11.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1747
    Cell Significance Index: -9.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1758
    Cell Significance Index: -9.1300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1762
    Cell Significance Index: -2.5300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1950
    Cell Significance Index: -2.6700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2011
    Cell Significance Index: -6.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2129
    Cell Significance Index: -6.7800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2139
    Cell Significance Index: -9.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2202
    Cell Significance Index: -3.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2346
    Cell Significance Index: -7.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2426
    Cell Significance Index: -8.5000
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.2529
    Cell Significance Index: -2.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2657
    Cell Significance Index: -6.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2743
    Cell Significance Index: -10.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2766
    Cell Significance Index: -5.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2906
    Cell Significance Index: -10.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2934
    Cell Significance Index: -6.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3134
    Cell Significance Index: -10.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3300
    Cell Significance Index: -7.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3335
    Cell Significance Index: -8.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3347
    Cell Significance Index: -8.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLIC2 is a member of the Chloride Intracellular Channel (CLIC) family, which comprises proteins that share a conserved structure and function. CLIC2 is characterized by its ability to form pores in cellular membranes, allowing chloride ions to flow through and regulate various cellular processes. The protein is expressed in numerous cell types, including immune cells, epithelial cells, and muscle cells, underscoring its broad functional significance. **Pathways and Functions:** CLIC2 is involved in multiple signaling pathways, including: 1. **Cardiac Conduction:** CLIC2 regulates the release of sequestered calcium ions from the sarcoplasmic reticulum, influencing cardiac muscle contraction and electrical activity. 2. **Cellular Oxidant Detoxification:** CLIC2 participates in the regulation of glutathione peroxidase activity, which protects cells against oxidative stress. 3. **Ion Homeostasis:** CLIC2 maintains ion balance by regulating chloride ion transport across cellular membranes. 4. **Signal Transduction:** CLIC2 modulates the activity of various signaling pathways, including those involved in cellular responses to stimuli. **Clinical Significance:** CLIC2 has been implicated in various diseases and disorders, including: 1. **Cardiovascular Diseases:** CLIC2 dysfunction has been linked to cardiac arrhythmias, heart failure, and sudden cardiac death. 2. **Immunological Disorders:** CLIC2 has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, where it plays a role in the regulation of immune cell function. 3. **Muscular Disorders:** CLIC2 mutations have been identified in patients with muscular dystrophy and myasthenia gravis. 4. **Cancer:** CLIC2 has been implicated in cancer progression and metastasis, where it regulates cell migration, invasion, and survival. In conclusion, CLIC2 is a multifunctional protein that plays a critical role in various cellular processes, including ion homeostasis, cellular oxidant detoxification, and signal transduction. Its dysregulation has been implicated in various diseases and disorders, highlighting the need for further research into the mechanisms underlying CLIC2 function and its clinical significance.

Genular Protein ID: 415942671

Symbol: CLIC2_HUMAN

Name: Chloride intracellular channel protein 2

UniProtKB Accession Codes:

O15247 A8K9S0 O15174 Q5JT80 Q8TCE3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 13 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 5 SFLD 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9339381

Title: Genomic structure of a novel chloride channel gene, CLIC2, in Xq28.

PubMed ID: 9339381

DOI: 10.1006/geno.1997.4922

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12681486

Title: Interaction of sedlin with chloride intracellular channel proteins.

PubMed ID: 12681486

DOI: 10.1016/s0014-5793(03)00228-x

PubMed ID: 15147738

Title: CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels.

PubMed ID: 15147738

DOI: 10.1016/j.biocel.2004.01.026

PubMed ID: 15916532

Title: A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP.

PubMed ID: 15916532

DOI: 10.1042/bj20042113

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814392

Title: An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.

PubMed ID: 22814392

DOI: 10.1093/hmg/dds292

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25581026

Title: Members of the chloride intracellular ion channel protein family demonstrate glutaredoxin-like enzymatic activity.

PubMed ID: 25581026

DOI: 10.1371/journal.pone.0115699

PubMed ID: 17945253

Title: Structure of the Janus protein human CLIC2.

PubMed ID: 17945253

DOI: 10.1016/j.jmb.2007.09.041

PubMed ID: 18186468

Title: The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications.

PubMed ID: 18186468

DOI: 10.1002/prot.21922

Sequence Information:

  • Length: 247
  • Mass: 28356
  • Checksum: 9DB896034DD103E8
  • Sequence:
    • MSGLRPGTQV DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT TVDMTRKPEE 
LKDLAPGTNP PFLVYNKELK TDFIKIEEFL EQTLAPPRYP HLSPKYKESF DVGCNLFAKF 
SAYIKNTQKE ANKNFEKSLL KEFKRLDDYL NTPLLDEIDP DSAEEPPVSR RLFLDGDQLT 
LADCSLLPKL NIIKVAAKKY RDFDIPAEFS GVWRYLHNAY AREEFTHTCP EDKEIENTYA 
NVAKQKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.