Details for: CLIC2

Gene ID: 1193

Symbol: CLIC2

Ensembl ID: ENSG00000155962

Description: chloride intracellular channel 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.2
    Marker Score: 2200
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.19
    Marker Score: 1330
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.98
    Marker Score: 1977.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.63
    Marker Score: 1276
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1157
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168922
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.35
    Marker Score: 8789
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 846
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.2
    Marker Score: 1445
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.16
    Marker Score: 693
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.15
    Marker Score: 2293
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.15
    Marker Score: 445
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4793
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.09
    Marker Score: 261
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.07
    Marker Score: 1807
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.03
    Marker Score: 35072.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48026
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.98
    Marker Score: 1228
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.93
    Marker Score: 1342
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5105
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.88
    Marker Score: 1415.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.87
    Marker Score: 2215
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.85
    Marker Score: 180
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.81
    Marker Score: 923
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 612
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.78
    Marker Score: 1139
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.78
    Marker Score: 5192.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.77
    Marker Score: 235
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.75
    Marker Score: 336
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.71
    Marker Score: 641
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.69
    Marker Score: 596
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.69
    Marker Score: 692
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.68
    Marker Score: 1792
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.68
    Marker Score: 478
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.63
    Marker Score: 355
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.63
    Marker Score: 3301
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.62
    Marker Score: 672
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.62
    Marker Score: 1603
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.62
    Marker Score: 426
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 383
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.59
    Marker Score: 137
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.58
    Marker Score: 133
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.57
    Marker Score: 247
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.56
    Marker Score: 14217
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.55
    Marker Score: 229
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.55
    Marker Score: 134
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.55
    Marker Score: 491
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.55
    Marker Score: 287
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.54
    Marker Score: 633
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.53
    Marker Score: 821
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.53
    Marker Score: 2292
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.52
    Marker Score: 3171
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.52
    Marker Score: 529
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.52
    Marker Score: 31943.5
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.51
    Marker Score: 135
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5
    Marker Score: 946
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5
    Marker Score: 228.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.5
    Marker Score: 309
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.49
    Marker Score: 356
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.49
    Marker Score: 446
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.48
    Marker Score: 4541
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.47
    Marker Score: 117
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.46
    Marker Score: 264
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.46
    Marker Score: 229
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.46
    Marker Score: 3927
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.44
    Marker Score: 712
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.44
    Marker Score: 219
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 438
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.42
    Marker Score: 5640.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.41
    Marker Score: 628
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.4
    Marker Score: 166
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.38
    Marker Score: 264
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.38
    Marker Score: 781
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.38
    Marker Score: 89
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.38
    Marker Score: 138
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.37
    Marker Score: 182
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.37
    Marker Score: 99
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.36
    Marker Score: 124
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.35
    Marker Score: 3325
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.35
    Marker Score: 223
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.35
    Marker Score: 391
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.35
    Marker Score: 335
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.34
    Marker Score: 110
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.34
    Marker Score: 193

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Other Information

**Key characteristics:** * CLIC2 is a transmembrane protein that belongs to the chloride intracellular channel family. * It is a member of the chloride channel superfamily, which is responsible for maintaining the resting membrane potential of cells by controlling the movement of chloride ions across the cell membrane. * CLIC2 is a non-selective cation channel that allows chloride ions to flow down their concentration gradient. * It is localized to the sarcolemma of cardiac muscle cells, where it is involved in regulating cardiac conduction. **Pathways and functions:** * CLIC2 is involved in cardiac conduction by regulating the opening and closing of ion channels in the cardiac membrane. * It allows chloride ions to flow into the cell, which can depolarize the membrane and trigger cardiac contraction. * CLIC2 also plays a role in cellular oxidant detoxification by facilitating the efflux of hydrogen peroxide across the cell membrane. * It is involved in the regulation of calcium signaling by controlling the release of calcium ions from the sarcoplasmic reticulum. **Clinical significance:** * Mutations in CLIC2 have been linked to several human diseases, including hyperkalemia, heart failure, and stroke. * In hyperkalemia, CLIC2 mutations can lead to the accumulation of chloride ions in the cell, which can cause cardiac arrhythmias and other complications. * In heart failure, CLIC2 mutations can lead to the impaired regulation of calcium signaling, which can result in cardiac remodeling and failure. **Additional information:** * CLIC2 is a highly conserved protein that is found in mammals and birds. * It is expressed in both the adult and embryonic heart. * It is a key regulator of cardiac muscle contraction. * It is a potential target for therapeutic interventions in heart disease.

Genular Protein ID: 415942671

Symbol: CLIC2_HUMAN

Name: Chloride intracellular channel protein 2

UniProtKB Accession Codes:

O15247 A8K9S0 O15174 Q5JT80 Q8TCE3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SFLD 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9339381

Title: Genomic structure of a novel chloride channel gene, CLIC2, in Xq28.

PubMed ID: 9339381

DOI: 10.1006/geno.1997.4922

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12681486

Title: Interaction of sedlin with chloride intracellular channel proteins.

PubMed ID: 12681486

DOI: 10.1016/s0014-5793(03)00228-x

PubMed ID: 15147738

Title: CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels.

PubMed ID: 15147738

DOI: 10.1016/j.biocel.2004.01.026

PubMed ID: 15916532

Title: A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP.

PubMed ID: 15916532

DOI: 10.1042/bj20042113

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814392

Title: An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.

PubMed ID: 22814392

DOI: 10.1093/hmg/dds292

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17945253

Title: Structure of the Janus protein human CLIC2.

PubMed ID: 17945253

DOI: 10.1016/j.jmb.2007.09.041

PubMed ID: 18186468

Title: The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications.

PubMed ID: 18186468

DOI: 10.1002/prot.21922

Sequence Information:

  • Length: 247
  • Mass: 28356
  • Checksum: 9DB896034DD103E8
  • Sequence:
    • MSGLRPGTQV DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT TVDMTRKPEE 
LKDLAPGTNP PFLVYNKELK TDFIKIEEFL EQTLAPPRYP HLSPKYKESF DVGCNLFAKF 
SAYIKNTQKE ANKNFEKSLL KEFKRLDDYL NTPLLDEIDP DSAEEPPVSR RLFLDGDQLT 
LADCSLLPKL NIIKVAAKKY RDFDIPAEFS GVWRYLHNAY AREEFTHTCP EDKEIENTYA 
NVAKQKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.