Details for: CLIC2

Gene ID: 1193

Symbol: CLIC2

Ensembl ID: ENSG00000155962

Description: chloride intracellular channel 2

Associated with

Other Information

Genular Protein ID: 415942671

Symbol: CLIC2_HUMAN

Name: Chloride intracellular channel protein 2

UniProtKB Accession Codes:

O15247 A8K9S0 O15174 Q5JT80 Q8TCE3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SFLD 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9339381

Title: Genomic structure of a novel chloride channel gene, CLIC2, in Xq28.

PubMed ID: 9339381

DOI: 10.1006/geno.1997.4922

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12681486

Title: Interaction of sedlin with chloride intracellular channel proteins.

PubMed ID: 12681486

DOI: 10.1016/s0014-5793(03)00228-x

PubMed ID: 15147738

Title: CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels.

PubMed ID: 15147738

DOI: 10.1016/j.biocel.2004.01.026

PubMed ID: 15916532

Title: A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP.

PubMed ID: 15916532

DOI: 10.1042/bj20042113

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814392

Title: An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.

PubMed ID: 22814392

DOI: 10.1093/hmg/dds292

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17945253

Title: Structure of the Janus protein human CLIC2.

PubMed ID: 17945253

DOI: 10.1016/j.jmb.2007.09.041

PubMed ID: 18186468

Title: The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications.

PubMed ID: 18186468

DOI: 10.1002/prot.21922

Sequence Information:

  • Length: 247
  • Mass: 28356
  • Checksum: 9DB896034DD103E8
  • Sequence:
    • MSGLRPGTQV DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT TVDMTRKPEE 
LKDLAPGTNP PFLVYNKELK TDFIKIEEFL EQTLAPPRYP HLSPKYKESF DVGCNLFAKF 
SAYIKNTQKE ANKNFEKSLL KEFKRLDDYL NTPLLDEIDP DSAEEPPVSR RLFLDGDQLT 
LADCSLLPKL NIIKVAAKKY RDFDIPAEFS GVWRYLHNAY AREEFTHTCP EDKEIENTYA 
NVAKQKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.