Genular: Defining Cellular Identity and Function

Details for: Atp2a1

Gene ID: 11937

Symbol: Atp2a1

Ensembl ID: ENSMUSG00000030730

Description: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

Associated with

Cardiac conduction
(R-MMU-5576891)
Hemostasis
(R-MMU-109582)
Ion channel transport
(R-MMU-983712)
Ion homeostasis
(R-MMU-5578775)
Ion transport by p-type atpases
(R-MMU-936837)
Muscle contraction
(R-MMU-397014)
Platelet calcium homeostasis
(R-MMU-418360)
Platelet homeostasis
(R-MMU-418346)
Reduction of cytosolic ca++ levels
(R-MMU-418359)
Transport of small molecules
(R-MMU-382551)
Apoptotic mitochondrial changes
(GO:0008637)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Calcium-dependent atpase activity
(GO:0030899)
Calcium ion binding
(GO:0005509)
Calcium ion import
(GO:0070509)
Calcium ion transmembrane transport
(GO:0070588)
Calcium ion transport
(GO:0006816)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
H zone
(GO:0031673)
I band
(GO:0031674)
Intracellular calcium ion homeostasis
(GO:0006874)
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
(GO:0070059)
Maintenance of mitochondrion location
(GO:0051659)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Monoatomic ion transport
(GO:0006811)
Negative regulation of endoplasmic reticulum calcium ion concentration
(GO:0032471)
Negative regulation of striated muscle contraction
(GO:0045988)
Nucleotide-sugar transmembrane transporter activity
(GO:0005338)
Nucleotide binding
(GO:0000166)
P-type calcium transporter activity
(GO:0005388)
Positive regulation of endoplasmic reticulum calcium ion concentration
(GO:0032470)
Positive regulation of fast-twitch skeletal muscle fiber contraction
(GO:0031448)
Positive regulation of mitochondrial calcium ion concentration
(GO:0051561)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of muscle contraction
(GO:0006937)
Regulation of striated muscle contraction
(GO:0006942)
Relaxation of skeletal muscle
(GO:0090076)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to peptide hormone
(GO:0043434)
Sarcoplasmic reticulum
(GO:0016529)
Sarcoplasmic reticulum calcium ion transport
(GO:0070296)
Sarcoplasmic reticulum membrane
(GO:0033017)
Transporter activity
(GO:0005215)

Other Information

Proteins

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Genular Protein ID: 3318200377

Symbol: AT2A1_MOUSE

Name: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

UniProtKB Accession Codes:

Q8R429

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21697544

Title: Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice.

PubMed ID: 21697544

DOI: 10.1152/ajpcell.00409.2010

PubMed ID: 22961106

Title: Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.

PubMed ID: 22961106

DOI: 10.1038/nm.2897

PubMed ID: 25640239

Title: A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.

PubMed ID: 25640239

DOI: 10.1016/j.cell.2015.01.009

PubMed ID: 26816378

Title: Muscle physiology. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle.

PubMed ID: 26816378

DOI: 10.1126/science.aad4076

Sequence Information:

Length: 994
Mass: 109425
Checksum: 884FBDD286B4916B
Sequence:

MEAAHSKSTE ECLSYFGVSE TTGLTPDQVK RHLEKYGPNE LPAEEGKSLW ELVVEQFEDL 
LVRILLLAAC ISFVLAWFEE GEETVTAFVE PFVILLILIA NAIVGVWQER NAENAIEALK 
EYEPEMGKVY RADRKSVQRI KARDIVPGDI VEVAVGDKVP ADIRILSIKS TTLRVDQSIL 
TGESVSVIKH TDPVPDPRAV NQDKKNMLFS GTNIAAGKAV GIVATTGVST EIGKIRDQMA 
ATEQDKTPLQ QKLDEFGEQL SKVISLICVA VWLINIGHFN DPVHGGSWFR GAIYYFKIAV 
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 
MSVCKMFIID KVDGDVCSLN EFSITGSTYA PEGEVLKNDK PVRAGQYDGL VELATICALC 
NDSSLDFNET KGVYEKVGEA TETALTTLVE KMNVFNTEVR SLSKVERANA CNSVIRQLMK 
KEFTLEFSRD RKSMSVYCSP AKSSRAAVGN KMFVKGAPEG VIDRCNYVRV GTTRVPLTGP 
VKEKIMSVIK EWGTGRDTLR CLALATRDTP PKREEMVLDD SAKFMEYEMD LTFVGVVGML 
DPPRKEVTGS IQLCRDAGIR VIMITGDNKG TAIAICRRIG IFSENEEVTD RAYTGREFDD 
LPLAEQREAC RRACCFARVE PSHKSKIVEY LQSYDEITAM TGDGVNDAPA LKKAEIGIAM 
GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAA 
LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMDRP PRSPKEPLIS GWLFFRYMAI 
GGYVGAATVG AAAWWFLYAE DGPHVSYHQL THFMQCTEHN PEFDGLDCEV FEAPEPMTMA 
LSVLVTIEMC NALNSLSENQ SLLRMPPWVN IWLLGSICLS MSLHFLILYV DPLPMIFKLR 
ALDFTQWLMV LKISLPVIGL DELLKFIARN YLEG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Atp2a1

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice. PubMed ID: 21697544

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. PubMed ID: 22961106

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance. PubMed ID: 25640239