Genular: Defining Cellular Identity and Function

Details for: Atp2a2

Gene ID: 11938

Symbol: Atp2a2

Ensembl ID: ENSMUSG00000029467

Description: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

Associated with

Cardiac conduction
(R-MMU-5576891)
Hemostasis
(R-MMU-109582)
Ion channel transport
(R-MMU-983712)
Ion homeostasis
(R-MMU-5578775)
Ion transport by p-type atpases
(R-MMU-936837)
Muscle contraction
(R-MMU-397014)
Platelet calcium homeostasis
(R-MMU-418360)
Platelet homeostasis
(R-MMU-418346)
Reduction of cytosolic ca++ levels
(R-MMU-418359)
Transport of small molecules
(R-MMU-382551)
Apical ectoplasmic specialization
(GO:0061831)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Autophagosome assembly
(GO:0000045)
Autophagosome membrane docking
(GO:0016240)
Calcium ion-transporting atpase complex
(GO:0090534)
Calcium ion binding
(GO:0005509)
Calcium ion import into sarcoplasmic reticulum
(GO:1990036)
Calcium ion transmembrane transport
(GO:0070588)
Calcium ion transport
(GO:0006816)
Calcium ion transport from cytosol to endoplasmic reticulum
(GO:1903515)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Cellular response to oxidative stress
(GO:0034599)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum calcium ion homeostasis
(GO:0032469)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Er-nucleus signaling pathway
(GO:0006984)
Extrinsic component of cytoplasmic side of plasma membrane
(GO:0031234)
Intercalated disc
(GO:0014704)
Intracellular calcium ion homeostasis
(GO:0006874)
Lncrna binding
(GO:0106222)
Longitudinal sarcoplasmic reticulum
(GO:0014801)
Lutropin-choriogonadotropic hormone receptor binding
(GO:0031775)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrion-endoplasmic reticulum membrane tethering
(GO:1990456)
Monoatomic ion transport
(GO:0006811)
Negative regulation of heart contraction
(GO:0045822)
Negative regulation of receptor binding
(GO:1900121)
Neuron cellular homeostasis
(GO:0070050)
Nucleotide binding
(GO:0000166)
Organelle localization by membrane tethering
(GO:0140056)
Organelle organization
(GO:0006996)
P-type calcium transporter activity
(GO:0005388)
P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
(GO:0086039)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane bounded cell projection
(GO:0120025)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of endoplasmic reticulum calcium ion concentration
(GO:0032470)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of calcium ion-dependent exocytosis of neurotransmitter
(GO:1903233)
Regulation of cardiac muscle cell action potential involved in regulation of contraction
(GO:0098909)
Regulation of cardiac muscle cell membrane potential
(GO:0086036)
Regulation of cardiac muscle contraction by calcium ion signaling
(GO:0010882)
Regulation of muscle contraction
(GO:0006937)
Regulation of the force of heart contraction
(GO:0002026)
Relaxation of cardiac muscle
(GO:0055119)
Response to peptide hormone
(GO:0043434)
Ribbon synapse
(GO:0097470)
S100 protein binding
(GO:0044548)
Sarcoplasmic reticulum
(GO:0016529)
Sarcoplasmic reticulum calcium ion transport
(GO:0070296)
Sarcoplasmic reticulum membrane
(GO:0033017)
T-tubule organization
(GO:0033292)
Transition between fast and slow fiber
(GO:0014883)
Transmembrane transporter binding
(GO:0044325)
Transporter activity
(GO:0005215)

Other Information

Proteins

Calcium pump 2
Q5DTI2_MOUSE

Genular Protein ID: 1838602464

Symbol: AT2A2_MOUSE

Name: Calcium pump 2

UniProtKB Accession Codes:

O55143 Q9R2A9 Q9WUT5

Database IDs:

Citations:

PubMed ID: 10656932

Title: Structure and organization of the mouse Atp2a2 gene encoding the sarco(endo)plasmic reticulum Ca(2+)-ATPase 2 (SERCA2) isoforms.

PubMed ID: 10656932

DOI: 10.1007/s003350010030

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14749390

Title: TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis.

PubMed ID: 14749390

DOI: 10.1128/mcb.24.4.1758-1768.2004

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18403730

Title: S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products.

PubMed ID: 18403730

DOI: 10.1161/circresaha.107.167544

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22355118

Title: Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout.

PubMed ID: 22355118

DOI: 10.1073/pnas.1120172109

PubMed ID: 22971924

Title: Tuning the structural coupling between the transmembrane and cytoplasmic domains of phospholamban to control sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) function.

PubMed ID: 22971924

DOI: 10.1007/s10974-012-9319-4

PubMed ID: 23395171

Title: Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation.

PubMed ID: 23395171

DOI: 10.1016/j.cmet.2013.01.002

PubMed ID: 28890335

Title: The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

PubMed ID: 28890335

DOI: 10.1016/j.molcel.2017.08.005

PubMed ID: 32116663

Title: Role of TG2-mediated SERCA2 serotonylation on hypoxic pulmonary vein remodeling.

PubMed ID: 32116663

DOI: 10.3389/fphar.2019.01611

PubMed ID: 32973183

Title: MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme.

PubMed ID: 32973183

DOI: 10.1038/s41467-020-18607-1

PubMed ID: 35036403

Title: TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics.

PubMed ID: 35036403

DOI: 10.3389/fcell.2021.747667

PubMed ID: 35412553

Title: FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics.

PubMed ID: 35412553

DOI: 10.1084/jem.20212491

Sequence Information:

Length: 1044
Mass: 114858
Checksum: 06A753982116C421
Sequence:

MENAHTKTVE EVLGHFGVNE STGLSLEQVK KLKERWGSNE LPAEEGKTLL ELVIEQFEDL 
LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILVA NAIVGVWQER NAENAIEALK 
EYEPEMGKVY RQDRKSVQRI KAKDIVPGDI VEIAVGDKVP ADIRLTSIKS TTLRVDQSIL 
TGESVSVIKH TDPVPDPRAV NQDKKNMLFS GTNIAAGKAM GVVVATGVNT EIGKIRDEMV 
ATEQERTPLQ QKLDEFGEQL SKVISLICIA VWIINIGHFN DPVHGGSWIR GAIYYFKIAV 
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 
MSVCRMFILD KVEGDTCSLN EFSITGSTYA PIGEVQKDDK PVKCHQYDGL VELATICALC 
NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTELK GLSKIERANA CNSVIKQLMK 
KEFTLEFSRD RKSMSVYCTP NKPSRTSMSK MFVKGAPEGV IDRCTHIRVG STKVPMTPGV 
KQKIMSVIRE WGSGSDTLRC LALATHDNPL KREEMHLEDS ANFIKYETNL TFVGCVGMLD 
PPRIEVASSV KLCRQAGIRV IMITGDNKGT AVAICRRIGI FGQDEDVTSK AFTGREFDEL 
SPSAQRDACL NARCFARVEP SHKSKIVEFL QSFDEITAMT GDGVNDAPAL KKSEIGIAMG 
SGTAVAKTAS EMVLADDNFS TIVAAVEEGR AIYNNMKQFI RYLISSNVGE VVCIFLTAAL 
GFPEALIPVQ LLWVNLVTDG LPATALGFNP PDLDIMNKPP RNPKEPLISG WLFFRYLAIG 
CYVGAATVGA AAWWFIAADG GPRVSFYQLS HFLQCKEDNP DFDGVDCAIF ESPYPMTMAL 
SVLVTIEMCN ALNSLSENQS LLRMPPWENI WLVGSICLSM SLHFLILYVE PLPLIFQITP 
LNLTQWLMVL KISLPVILMD ETLKFVARNY LEQPGKECVQ PATKSSCSLS ACTDGISWPF 
VLLIMPLVVW VYSTDTNFSD MFWS

Genular Protein ID: 2013988472

Symbol: Q5DTI2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5DTI2

Database IDs:

Sequence Information:

Length: 1061
Mass: 116600
Checksum: 36926C3C74B87480
Sequence:

ARRPRGREAR PAGAPAAMEN AHTKTVEEVL GHFGVNESTG LSLEQVKKLK ERWGSNELPA 
EEGKTLLELV IEQFEDLLVR ILLLAACISF VLAWFEEGEE TITAFVEPFV ILLILVANAI 
VGVWQERNAE NAIEALKEYE PEMGKVYRQD RKSVQRIKAK DIVPGDIVEI AVGDKVPADI 
RLTSIKSTTL RVDQSILTGE SVSVIKHTDP VPDPRAVNQD KKNMLFSGTN IAAGKAMGVV 
VATGVNTEIG KIRDEMVATE QERTPLQQKL DEFGEQLSKV ISLICIAVWI INIGHFNDPV 
HGGSWIRGAI YYFKIAVALA VAAIPEGLPA VITTCLALGT RRMAKKNAIV RSLPSVETLG 
CTSVICSDKT GTLTTNQMSV CRMFILDKVE GDTCSLNEFS ITGSTYAPIG EVQKDDKPVK 
CHQYDGLVEL ATICALCNDS ALDYNEAKGV YEKVGEATET ALTCLVEKMN VFDTELKGLS 
KIERANACNS VIKQLMKKEF TLEFSRDRKS MSVYCTPNKP SRTSMSKMFV KGAPEGVIDR 
CTHIRVGSTK VPMTPGVKQK IMSVIREWGS GSDTLRCLAL ATHDNPLKRE EMHLEDSANF 
IKYETNLTFV GCVGMLDPPR IEVASSVKLC RQAGIRVIMI TGDNKGTAVA ICRRIGIFGQ 
DEDVTSKAFT GREFDELSPS AQRDACLNAR CFARVEPSHK SKIVEFLQSF DEITAMTGDG 
VNDAPALKKS EIGIAMGSGT AVAKTASEMV LADDNFSTIV AAVEEGRAIY NNMKQFIRYL 
ISSNVGEVVC IFLTAALGFP EALIPVQLLW VNLVTDGLPA TALGFNPPDL DIMNKPPRNP 
KEPLISGWLF FRYLAIGCYV GAATVGAAAW WFIAADGGPR VSFYQLSHFL QCKEDNPDFD 
GVDCAIFESP YPMTMALSVL VTIEMCNALN SLSENQSLLR MPPWENIWLV GSICLSMSLH 
FLILYVEPLP LIFQITPLNL TQWLMVLKIS LPVILMDETL KFVARNYLEQ PGKECVQPAT 
KSSCSLSACT DGISWPFVLL IMPLVVWVYS TDTNFSDMFW S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Atp2a2

Associated with

Other Information

Structure and organization of the mouse Atp2a2 gene encoding the sarco(endo)plasmic reticulum Ca(2+)-ATPase 2 (SERCA2) isoforms. PubMed ID: 10656932

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. PubMed ID: 14749390

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. PubMed ID: 18403730

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout. PubMed ID: 22355118

Tuning the structural coupling between the transmembrane and cytoplasmic domains of phospholamban to control sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) function. PubMed ID: 22971924

Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. PubMed ID: 23395171

The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. PubMed ID: 28890335

Role of TG2-mediated SERCA2 serotonylation on hypoxic pulmonary vein remodeling. PubMed ID: 32116663

MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. PubMed ID: 32973183

TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics. PubMed ID: 35036403

FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics. PubMed ID: 35412553