Details for: CLK1

Gene ID: 1195

Symbol: CLK1

Ensembl ID: ENSG00000013441

Description: CDC like kinase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.17
    Marker Score: 107789
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.87
    Marker Score: 2250
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.74
    Marker Score: 7557
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.63
    Marker Score: 1993
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.42
    Marker Score: 10144
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.42
    Marker Score: 2059
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.36
    Marker Score: 2516
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.3
    Marker Score: 6441
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.25
    Marker Score: 3926
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.18
    Marker Score: 22098
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.17
    Marker Score: 1155.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.15
    Marker Score: 1540
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.14
    Marker Score: 512
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.1
    Marker Score: 3235
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.01
    Marker Score: 4408
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.01
    Marker Score: 586
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2
    Marker Score: 19856
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.98
    Marker Score: 1000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.97
    Marker Score: 25978
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.95
    Marker Score: 1140
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.95
    Marker Score: 679
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.94
    Marker Score: 2340
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.94
    Marker Score: 391
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.92
    Marker Score: 779
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.92
    Marker Score: 1204
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.92
    Marker Score: 1852
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.91
    Marker Score: 780
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.91
    Marker Score: 3333
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.91
    Marker Score: 5571
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.9
    Marker Score: 856
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9
    Marker Score: 2001
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.89
    Marker Score: 598
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.89
    Marker Score: 3770
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.88
    Marker Score: 844
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.88
    Marker Score: 6960
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.87
    Marker Score: 806
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.86
    Marker Score: 2505
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.86
    Marker Score: 8024
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.86
    Marker Score: 1754
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.86
    Marker Score: 798
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.85
    Marker Score: 3873
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.85
    Marker Score: 2243
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.85
    Marker Score: 2013
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.84
    Marker Score: 571
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.84
    Marker Score: 766
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.82
    Marker Score: 630
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.82
    Marker Score: 2142
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.82
    Marker Score: 2343
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.81
    Marker Score: 397
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.8
    Marker Score: 820
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.8
    Marker Score: 445
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.79
    Marker Score: 2641
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.79
    Marker Score: 1605
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.79
    Marker Score: 412
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.79
    Marker Score: 440
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.79
    Marker Score: 15673
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.79
    Marker Score: 4275
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.78
    Marker Score: 1026
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.78
    Marker Score: 1514
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.78
    Marker Score: 407
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.77
    Marker Score: 1490
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.77
    Marker Score: 3597
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.76
    Marker Score: 7345
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.76
    Marker Score: 438
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.76
    Marker Score: 663
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.76
    Marker Score: 2987
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.76
    Marker Score: 465
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.75
    Marker Score: 1273
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.75
    Marker Score: 914
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.75
    Marker Score: 372
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.74
    Marker Score: 495.5
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 1.74
    Marker Score: 484
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.74
    Marker Score: 2034
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 1.73
    Marker Score: 505
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.73
    Marker Score: 1150
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.73
    Marker Score: 991
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 1.73
    Marker Score: 487
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.72
    Marker Score: 1733
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.72
    Marker Score: 884
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.72
    Marker Score: 90904
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 1.72
    Marker Score: 488
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.71
    Marker Score: 1484
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.71
    Marker Score: 853
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.71
    Marker Score: 1823.5
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 1.7
    Marker Score: 512
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.7
    Marker Score: 8349
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.7
    Marker Score: 536
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.69
    Marker Score: 3026
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.69
    Marker Score: 475.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.69
    Marker Score: 421
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.69
    Marker Score: 463
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.69
    Marker Score: 444
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.68
    Marker Score: 1936
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.68
    Marker Score: 481.5
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.68
    Marker Score: 441
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.68
    Marker Score: 421
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 1.66
    Marker Score: 771
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.66
    Marker Score: 374
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 1.66
    Marker Score: 648
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.66
    Marker Score: 1526

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Other Information

**Key characteristics:** * The CLK1 gene is located on chromosome 19p13.2. * It is a large gene, encoding a protein of 1,673 amino acids. * The protein is a transmembrane protein that is expressed in a variety of cell types. * It is a key regulator of cell cycle progression and growth. **Pathways and functions:** * The CLK1 protein is a key regulator of cell cycle progression. It is involved in the regulation of cell cycle entry into the G1 phase, and it is also involved in the regulation of cell cycle exit from the G1 phase. * The CLK1 protein is also involved in cell growth. It is expressed in cells that are actively dividing, and it is required for the initiation of cell cycle entry. * The CLK1 protein is also involved in the regulation of differentiation. It is expressed in cells that are differentiating into a specific cell type. * The CLK1 protein is a key regulator of inflammation. It is expressed in cells that are activated in inflammation, and it is required for the production of inflammatory cytokines. **Clinical significance:** * Mutations in the CLK1 gene have been linked to a number of human diseases, including breast cancer, lung cancer, and colorectal cancer. * The CLK1 gene is a potential target for cancer therapy. Antibodies against the CLK1 protein have been shown to be effective in inhibiting tumor growth in animal models of cancer.

Genular Protein ID: 1701848938

Symbol: CLK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49759 B4DFW7 Q0P694 Q8N5V8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 3 EMBL 8 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 41 PDBsum 37 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 Rhea 12 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1704889

Title: Molecular cloning of a novel human cdc2/CDC28-like protein kinase.

PubMed ID: 1704889

DOI: 10.1016/s0021-9258(19)67807-5

PubMed ID: 7990150

Title: Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.

PubMed ID: 7990150

DOI: 10.1006/jmbi.1994.1763

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10480872

Title: The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.

PubMed ID: 10480872

DOI: 10.1074/jbc.274.38.26697

PubMed ID: 12705895

Title: Beacon interacts with cdc2/cdc28-like kinases.

PubMed ID: 12705895

DOI: 10.1016/s0006-291x(03)00549-7

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19168442

Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

PubMed ID: 19168442

DOI: 10.1161/circresaha.108.183905

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 484
  • Mass: 57291
  • Checksum: F34B5B44988BD118
  • Sequence:
    • MRHSKRTYCP DWDDKDWDYG KWRSSSSHKR RKRSHSSAQE NKRCKYNHSK MCDSHYLESR 
SINEKDYHSR RYIDEYRNDY TQGCEPGHRQ RDHESRYQNH SSKSSGRSGR SSYKSKHRIH 
HSTSHRRSHG KSHRRKRTRS VEDDEEGHLI CQSGDVLSAR YEIVDTLGEG AFGKVVECID 
HKAGGRHVAV KIVKNVDRYC EAARSEIQVL EHLNTTDPNS TFRCVQMLEW FEHHGHICIV 
FELLGLSTYD FIKENGFLPF RLDHIRKMAY QICKSVNFLH SNKLTHTDLK PENILFVQSD 
YTEAYNPKIK RDERTLINPD IKVVDFGSAT YDDEHHSTLV STRHYRAPEV ILALGWSQPC 
DVWSIGCILI EYYLGFTVFP THDSKEHLAM MERILGPLPK HMIQKTRKRK YFHHDRLDWD 
EHSSAGRYVS RRCKPLKEFM LSQDVEHERL FDLIQKMLEY DPAKRITLRE ALKHPFFDLL 
KKSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.