Details for: CLK1

Gene ID: 1195

Symbol: CLK1

Ensembl ID: ENSG00000013441

Description: CDC like kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 469.8312
    Cell Significance Index: -73.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 290.1712
    Cell Significance Index: -73.6000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 171.5656
    Cell Significance Index: -81.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 168.6124
    Cell Significance Index: -68.5000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 152.0261
    Cell Significance Index: -78.2000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 120.8604
    Cell Significance Index: -81.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 72.4593
    Cell Significance Index: -69.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 62.5732
    Cell Significance Index: -77.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.5104
    Cell Significance Index: -65.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.3216
    Cell Significance Index: -80.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.6877
    Cell Significance Index: -60.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.9568
    Cell Significance Index: -39.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.6811
    Cell Significance Index: 105.5200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.2315
    Cell Significance Index: 13.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2082
    Cell Significance Index: 142.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2032
    Cell Significance Index: 30.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0892
    Cell Significance Index: 339.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5959
    Cell Significance Index: 43.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5426
    Cell Significance Index: 197.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5414
    Cell Significance Index: 80.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5375
    Cell Significance Index: 305.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2918
    Cell Significance Index: 177.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2475
    Cell Significance Index: 250.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2375
    Cell Significance Index: 56.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1768
    Cell Significance Index: 144.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0801
    Cell Significance Index: 50.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0528
    Cell Significance Index: 189.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9038
    Cell Significance Index: 26.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8856
    Cell Significance Index: 46.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8834
    Cell Significance Index: 1663.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8717
    Cell Significance Index: 94.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8705
    Cell Significance Index: 30.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8663
    Cell Significance Index: 24.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7882
    Cell Significance Index: 348.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7623
    Cell Significance Index: 273.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7331
    Cell Significance Index: 86.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5969
    Cell Significance Index: 15.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5893
    Cell Significance Index: 407.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5361
    Cell Significance Index: 484.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4689
    Cell Significance Index: 35.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4028
    Cell Significance Index: 255.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3742
    Cell Significance Index: 204.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3477
    Cell Significance Index: 18.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3368
    Cell Significance Index: 7.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2579
    Cell Significance Index: 14.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2530
    Cell Significance Index: 15.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2517
    Cell Significance Index: 17.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2164
    Cell Significance Index: 10.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1943
    Cell Significance Index: 33.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1745
    Cell Significance Index: 268.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1629
    Cell Significance Index: 3.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1601
    Cell Significance Index: 9.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1484
    Cell Significance Index: 11.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1453
    Cell Significance Index: 267.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1319
    Cell Significance Index: 2.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1292
    Cell Significance Index: 1.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0936
    Cell Significance Index: 17.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0918
    Cell Significance Index: 124.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0556
    Cell Significance Index: 25.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0519
    Cell Significance Index: 6.7100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0467
    Cell Significance Index: 0.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0417
    Cell Significance Index: -26.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0500
    Cell Significance Index: -37.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0515
    Cell Significance Index: -5.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0615
    Cell Significance Index: -46.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0700
    Cell Significance Index: -51.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0712
    Cell Significance Index: -7.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0909
    Cell Significance Index: -6.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1098
    Cell Significance Index: -61.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2083
    Cell Significance Index: -7.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2222
    Cell Significance Index: -46.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2397
    Cell Significance Index: -34.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2397
    Cell Significance Index: -68.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2428
    Cell Significance Index: -27.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2824
    Cell Significance Index: -7.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2853
    Cell Significance Index: -4.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2896
    Cell Significance Index: -33.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4409
    Cell Significance Index: -50.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5122
    Cell Significance Index: -34.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5672
    Cell Significance Index: -9.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5723
    Cell Significance Index: -14.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5930
    Cell Significance Index: -61.7500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6853
    Cell Significance Index: -7.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7016
    Cell Significance Index: -44.2200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7453
    Cell Significance Index: -5.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7693
    Cell Significance Index: -24.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9203
    Cell Significance Index: -72.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9531
    Cell Significance Index: -17.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9753
    Cell Significance Index: -26.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9825
    Cell Significance Index: -43.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9874
    Cell Significance Index: -60.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0565
    Cell Significance Index: -53.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2090
    Cell Significance Index: -45.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.2530
    Cell Significance Index: -32.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.3721
    Cell Significance Index: -20.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.3771
    Cell Significance Index: -24.3400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.3779
    Cell Significance Index: -23.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.3868
    Cell Significance Index: -33.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.5198
    Cell Significance Index: -32.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5397
    Cell Significance Index: -56.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLK1 is a member of the cyclin-dependent kinase-like (CDK) family, which is characterized by its ability to phosphorylate and regulate the activity of various protein substrates. Unlike traditional CDKs, CLK1 lacks the C-terminal catalytic domain and instead relies on a conserved kinase domain to phosphorylate its substrates. This unique feature allows CLK1 to regulate a distinct set of cellular processes. **Pathways and Functions:** CLK1 is involved in multiple signaling pathways, including: 1. **Cell Cycle Regulation**: CLK1 phosphorylates and regulates the activity of cyclin-dependent kinases (CDKs), which in turn control the progression of the cell cycle. 2. **RNA Splicing**: CLK1 phosphorylates and activates the splicing factor U2AF65, which regulates the alternative splicing of RNA. 3. **Protein Phosphorylation**: CLK1 phosphorylates and regulates the activity of various protein substrates, including transcription factors, kinases, and phosphatases. 4. **Apoptosis**: CLK1 can regulate apoptosis by phosphorylating and activating pro-apoptotic proteins. CLK1 is highly expressed in various cell types, including immune cells, such as T cells, natural killer cells, and dendritic cells. In these cells, CLK1 is involved in regulating T cell receptor signaling, cytokine production, and cell proliferation. **Clinical Significance:** CLK1 has been implicated in various diseases, including: 1. **Cancer**: CLK1 overexpression has been observed in several types of cancer, including breast cancer, prostate cancer, and leukemia. CLK1 may contribute to tumorigenesis by promoting cell proliferation and survival. 2. **Autoimmune Diseases**: CLK1 has been implicated in the regulation of immune responses and may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological Disorders**: CLK1 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to the regulation of neuronal cell survival and function. In conclusion, CLK1 is a multifunctional kinase that plays a critical role in regulating various cellular processes, including cell cycle regulation, RNA splicing, protein phosphorylation, and apoptosis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of CLK1 and its potential therapeutic applications. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms of CLK1 regulation and its role in immune responses. 2. The development of CLK1 inhibitors may provide a novel therapeutic strategy for treating various diseases, including cancer and autoimmune disorders. 3. The study of CLK1 in the context of neurological disorders may lead to the identification of new therapeutic targets for these diseases. By exploring the complex role of CLK1 in immune regulation and beyond, we may uncover new avenues for therapeutic intervention and improve our understanding of the intricate mechanisms that govern human health and disease.

Genular Protein ID: 1701848938

Symbol: CLK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49759 B4DFW7 Q0P694 Q8N5V8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 3 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 37 PDBsum 37 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 Rhea 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1704889

Title: Molecular cloning of a novel human cdc2/CDC28-like protein kinase.

PubMed ID: 1704889

DOI: 10.1016/s0021-9258(19)67807-5

PubMed ID: 7990150

Title: Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.

PubMed ID: 7990150

DOI: 10.1006/jmbi.1994.1763

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10480872

Title: The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.

PubMed ID: 10480872

DOI: 10.1074/jbc.274.38.26697

PubMed ID: 12705895

Title: Beacon interacts with cdc2/cdc28-like kinases.

PubMed ID: 12705895

DOI: 10.1016/s0006-291x(03)00549-7

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19168442

Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

PubMed ID: 19168442

DOI: 10.1161/circresaha.108.183905

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 484
  • Mass: 57291
  • Checksum: F34B5B44988BD118
  • Sequence:
    • MRHSKRTYCP DWDDKDWDYG KWRSSSSHKR RKRSHSSAQE NKRCKYNHSK MCDSHYLESR 
SINEKDYHSR RYIDEYRNDY TQGCEPGHRQ RDHESRYQNH SSKSSGRSGR SSYKSKHRIH 
HSTSHRRSHG KSHRRKRTRS VEDDEEGHLI CQSGDVLSAR YEIVDTLGEG AFGKVVECID 
HKAGGRHVAV KIVKNVDRYC EAARSEIQVL EHLNTTDPNS TFRCVQMLEW FEHHGHICIV 
FELLGLSTYD FIKENGFLPF RLDHIRKMAY QICKSVNFLH SNKLTHTDLK PENILFVQSD 
YTEAYNPKIK RDERTLINPD IKVVDFGSAT YDDEHHSTLV STRHYRAPEV ILALGWSQPC 
DVWSIGCILI EYYLGFTVFP THDSKEHLAM MERILGPLPK HMIQKTRKRK YFHHDRLDWD 
EHSSAGRYVS RRCKPLKEFM LSQDVEHERL FDLIQKMLEY DPAKRITLRE ALKHPFFDLL 
KKSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.