Details for: CLK2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 92.0633
Cell Significance Index: -14.3200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 55.5504
Cell Significance Index: -14.0900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 32.4917
Cell Significance Index: -13.2000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 14.0142
Cell Significance Index: -13.3800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 11.9388
Cell Significance Index: -14.7200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.8744
Cell Significance Index: -11.9000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.7810
Cell Significance Index: -14.9200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.4496
Cell Significance Index: 275.8600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7980
Cell Significance Index: 720.5700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7786
Cell Significance Index: 154.5200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.6683
Cell Significance Index: 77.8800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6273
Cell Significance Index: 17.5300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5324
Cell Significance Index: 86.5900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5072
Cell Significance Index: 26.4200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5055
Cell Significance Index: 54.9800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4516
Cell Significance Index: 20.4700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4337
Cell Significance Index: 86.9900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3680
Cell Significance Index: 22.0900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3603
Cell Significance Index: 10.3800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3423
Cell Significance Index: 4.6700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3406
Cell Significance Index: 7.3800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3110
Cell Significance Index: 8.3200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2483
Cell Significance Index: 17.1700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2137
Cell Significance Index: 38.5300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2123
Cell Significance Index: 76.1400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1751
Cell Significance Index: 21.5300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1673
Cell Significance Index: 12.8400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1609
Cell Significance Index: 22.0900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1549
Cell Significance Index: 7.8300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1393
Cell Significance Index: 96.3200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1355
Cell Significance Index: 7.6100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1330
Cell Significance Index: 6.9100 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.1288
Cell Significance Index: 1.6500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1254
Cell Significance Index: 68.5000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1195
Cell Significance Index: 7.5300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0909
Cell Significance Index: 10.7200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0885
Cell Significance Index: 3.1100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0821
Cell Significance Index: 3.8300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0769
Cell Significance Index: 34.0200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0588
Cell Significance Index: 5.8200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0410
Cell Significance Index: 1.1200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0160
Cell Significance Index: 2.7400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0107
Cell Significance Index: 1.2300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0066
Cell Significance Index: 0.8400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0046
Cell Significance Index: 8.7200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0042
Cell Significance Index: 6.4700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0021
Cell Significance Index: 0.1500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0016
Cell Significance Index: 2.1500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0006
Cell Significance Index: 1.1200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0029
Cell Significance Index: -1.8200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0082
Cell Significance Index: -0.2200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0082
Cell Significance Index: -5.1500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0087
Cell Significance Index: -3.9300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0102
Cell Significance Index: -7.5600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0122
Cell Significance Index: -8.9200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0139
Cell Significance Index: -10.5500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0157
Cell Significance Index: -1.7900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0197
Cell Significance Index: -11.1000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0231
Cell Significance Index: -3.3600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0262
Cell Significance Index: -1.6900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0313
Cell Significance Index: -1.3900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0377
Cell Significance Index: -1.7700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0456
Cell Significance Index: -0.8900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0462
Cell Significance Index: -4.7200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0498
Cell Significance Index: -10.4800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0540
Cell Significance Index: -15.5300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0541
Cell Significance Index: -1.8800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0568
Cell Significance Index: -1.2100 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.0623
Cell Significance Index: -1.0000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0717
Cell Significance Index: -9.2600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0721
Cell Significance Index: -2.7300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1016
Cell Significance Index: -1.7000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1166
Cell Significance Index: -8.6900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1249
Cell Significance Index: -3.2900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1354
Cell Significance Index: -14.1000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1377
Cell Significance Index: -7.2300 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1386
Cell Significance Index: -2.0500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1436
Cell Significance Index: -3.0700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1510
Cell Significance Index: -3.1600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1552
Cell Significance Index: -4.9700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1626
Cell Significance Index: -4.1800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1726
Cell Significance Index: -10.5800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1741
Cell Significance Index: -2.5700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1813
Cell Significance Index: -14.3600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2042
Cell Significance Index: -3.5000 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2241
Cell Significance Index: -2.3200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2243
Cell Significance Index: -3.3800 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2299
Cell Significance Index: -4.2500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2778
Cell Significance Index: -8.1600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2824
Cell Significance Index: -7.2200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2908
Cell Significance Index: -7.2700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2948
Cell Significance Index: -9.3900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3019
Cell Significance Index: -9.8900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3034
Cell Significance Index: -4.3500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3073
Cell Significance Index: -8.8100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3169
Cell Significance Index: -11.1000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3185
Cell Significance Index: -9.3800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3421
Cell Significance Index: -12.5600 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3532
Cell Significance Index: -8.1600 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3670
Cell Significance Index: -7.7900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3737169679
Symbol: CLK2_HUMAN
Name: Dual specificity protein kinase CLK2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7990150
Title: Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.
PubMed ID: 7990150
PubMed ID: 9331372
Title: Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease.
PubMed ID: 9331372
DOI: 10.1101/gr.7.10.1020
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8910305
Title: Activity and autophosphorylation of LAMMER protein kinases.
PubMed ID: 8910305
PubMed ID: 9637771
Title: The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.
PubMed ID: 9637771
PubMed ID: 10480872
Title: The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.
PubMed ID: 10480872
PubMed ID: 12705895
Title: Beacon interacts with cdc2/cdc28-like kinases.
PubMed ID: 12705895
PubMed ID: 14759258
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19168442
Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
PubMed ID: 19168442
PubMed ID: 19282290
Title: Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.
PubMed ID: 19282290
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20682768
Title: Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation.
PubMed ID: 20682768
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 28289210
Title: Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.
PubMed ID: 28289210
Sequence Information:
- Length: 499
- Mass: 60090
- Checksum: E43BBF3BAD6EF991
- Sequence:
MPHPRRYHSS ERGSRGSYRE HYRSRKHKRR RSRSWSSSSD RTRRRRREDS YHVRSRSSYD DRSSDRRVYD RRYCGSYRRN DYSRDRGDAY YDTDYRHSYE YQRENSSYRS QRSSRRKHRR RRRRSRTFSR SSSQHSSRRA KSVEDDAEGH LIYHVGDWLQ ERYEIVSTLG EGTFGRVVQC VDHRRGGARV ALKIIKNVEK YKEAARLEIN VLEKINEKDP DNKNLCVQMF DWFDYHGHMC ISFELLGLST FDFLKDNNYL PYPIHQVRHM AFQLCQAVKF LHDNKLTHTD LKPENILFVN SDYELTYNLE KKRDERSVKS TAVRVVDFGS ATFDHEHHST IVSTRHYRAP EVILELGWSQ PCDVWSIGCI IFEYYVGFTL FQTHDNREHL AMMERILGPI PSRMIRKTRK QKYFYRGRLD WDENTSAGRY VRENCKPLRR YLTSEAEEHH QLFDLIESML EYEPAKRLTL GEALQHPFFA RLRAEPPNKL WDSSRDISR
Genular Protein ID: 82209999
Symbol: B7Z8N6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 271
- Mass: 32314
- Checksum: 376A3C44066C1993
- Sequence:
MFDWFDYHGH MCISFELLGL STFDFLKDNN YLPYPIHQVR HMAFQLCQAV KFLHDNKLTH TDLKPENILF VNSDYELTYN LEKKRDERSV KSTAVRVVDF GSATFDHEHH STIVSTRHYR APEVILELGW SQPCDVWSIG CIIFEYYVGF TLFQTHDNRE HLAMMERILG PIPSRMIRKT RKQKYFYRGR LDWDENTSAG RYVRENCKPL RRYLTSEAEE HHQLFDLIES MLEYEPAKRL TLGEALQHPF FARLRAEPPN KLWDSSRDIS R
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.