Details for: CLK2

Gene ID: 1196

Symbol: CLK2

Ensembl ID: ENSG00000176444

Description: CDC like kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 92.0633
    Cell Significance Index: -14.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.5504
    Cell Significance Index: -14.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.4917
    Cell Significance Index: -13.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.0142
    Cell Significance Index: -13.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.9388
    Cell Significance Index: -14.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.8744
    Cell Significance Index: -11.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7810
    Cell Significance Index: -14.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4496
    Cell Significance Index: 275.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7980
    Cell Significance Index: 720.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7786
    Cell Significance Index: 154.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6683
    Cell Significance Index: 77.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6273
    Cell Significance Index: 17.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5324
    Cell Significance Index: 86.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5072
    Cell Significance Index: 26.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5055
    Cell Significance Index: 54.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4516
    Cell Significance Index: 20.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4337
    Cell Significance Index: 86.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3680
    Cell Significance Index: 22.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3603
    Cell Significance Index: 10.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3423
    Cell Significance Index: 4.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3406
    Cell Significance Index: 7.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3110
    Cell Significance Index: 8.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2483
    Cell Significance Index: 17.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2137
    Cell Significance Index: 38.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2123
    Cell Significance Index: 76.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1751
    Cell Significance Index: 21.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1673
    Cell Significance Index: 12.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1609
    Cell Significance Index: 22.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1549
    Cell Significance Index: 7.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1393
    Cell Significance Index: 96.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1355
    Cell Significance Index: 7.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1330
    Cell Significance Index: 6.9100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1288
    Cell Significance Index: 1.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1254
    Cell Significance Index: 68.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1195
    Cell Significance Index: 7.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0909
    Cell Significance Index: 10.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0885
    Cell Significance Index: 3.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0821
    Cell Significance Index: 3.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0769
    Cell Significance Index: 34.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0588
    Cell Significance Index: 5.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0410
    Cell Significance Index: 1.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0160
    Cell Significance Index: 2.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0107
    Cell Significance Index: 1.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0066
    Cell Significance Index: 0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0046
    Cell Significance Index: 8.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0042
    Cell Significance Index: 6.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0021
    Cell Significance Index: 0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0016
    Cell Significance Index: 2.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0006
    Cell Significance Index: 1.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0029
    Cell Significance Index: -1.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0082
    Cell Significance Index: -5.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0122
    Cell Significance Index: -8.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0139
    Cell Significance Index: -10.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0157
    Cell Significance Index: -1.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0197
    Cell Significance Index: -11.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0231
    Cell Significance Index: -3.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0262
    Cell Significance Index: -1.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0313
    Cell Significance Index: -1.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0377
    Cell Significance Index: -1.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0456
    Cell Significance Index: -0.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0462
    Cell Significance Index: -4.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0498
    Cell Significance Index: -10.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0540
    Cell Significance Index: -15.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0541
    Cell Significance Index: -1.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0568
    Cell Significance Index: -1.2100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0623
    Cell Significance Index: -1.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0717
    Cell Significance Index: -9.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0721
    Cell Significance Index: -2.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1016
    Cell Significance Index: -1.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1166
    Cell Significance Index: -8.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1249
    Cell Significance Index: -3.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1354
    Cell Significance Index: -14.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1377
    Cell Significance Index: -7.2300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1386
    Cell Significance Index: -2.0500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1436
    Cell Significance Index: -3.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1510
    Cell Significance Index: -3.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1552
    Cell Significance Index: -4.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1626
    Cell Significance Index: -4.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1726
    Cell Significance Index: -10.5800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1741
    Cell Significance Index: -2.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1813
    Cell Significance Index: -14.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2042
    Cell Significance Index: -3.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2241
    Cell Significance Index: -2.3200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2243
    Cell Significance Index: -3.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2299
    Cell Significance Index: -4.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2778
    Cell Significance Index: -8.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2824
    Cell Significance Index: -7.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2908
    Cell Significance Index: -7.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2948
    Cell Significance Index: -9.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3019
    Cell Significance Index: -9.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3034
    Cell Significance Index: -4.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3073
    Cell Significance Index: -8.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3169
    Cell Significance Index: -11.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3185
    Cell Significance Index: -9.3800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3421
    Cell Significance Index: -12.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3532
    Cell Significance Index: -8.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3670
    Cell Significance Index: -7.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLK2 is a member of the cyclin-dependent kinase-like (CDKL) family, which is characterized by its dual specificity kinase activity. This means that CLK2 can phosphorylate both serine and threonine residues on target proteins. The kinase is also known for its ability to autophosphorylate, which is essential for its activation. CLK2 has been shown to interact with various proteins, including other kinases, and regulate their activity. **Pathways and Functions:** CLK2 is involved in several key cellular pathways, including: 1. **Negative regulation of gluconeogenesis**: CLK2 phosphorylates and inhibits the activity of key enzymes involved in gluconeogenesis, a metabolic pathway that generates glucose from non-carbohydrate sources. 2. **Regulation of RNA splicing**: CLK2 phosphorylates and activates factors involved in the regulation of RNA splicing, a process that removes introns and joins exons to form a mature mRNA molecule. 3. **Response to ionizing radiation**: CLK2 is activated in response to DNA damage caused by ionizing radiation, where it phosphorylates and activates proteins involved in the repair of DNA damage. 4. **Protein phosphorylation and autophosphorylation**: CLK2 phosphorylates and autophosphorylates its own substrate, which is essential for its activation and regulation. **Clinical Significance:** CLK2 has been implicated in several diseases, including: 1. **Cancer**: CLK2 has been shown to be overexpressed in various types of cancer, including lung, colon, and breast cancer. Its overexpression is associated with poor prognosis and resistance to chemotherapy. 2. **Metabolic disorders**: CLK2 has been shown to play a role in the regulation of gluconeogenesis, which is impaired in diseases such as diabetes and obesity. 3. **Neurological disorders**: CLK2 has been implicated in the regulation of RNA splicing, which is impaired in diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In conclusion, CLK2 is a serine/threonine kinase that plays a crucial role in various cellular processes, including gluconeogenesis, RNA splicing, and response to ionizing radiation. Its involvement in these pathways highlights its potential as a therapeutic target in diseases related to cellular stress and metabolic disorders. Further research is needed to fully understand the mechanisms of CLK2 and its role in human disease.

Genular Protein ID: 3737169679

Symbol: CLK2_HUMAN

Name: Dual specificity protein kinase CLK2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7990150

Title: Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.

PubMed ID: 7990150

DOI: 10.1006/jmbi.1994.1763

PubMed ID: 9331372

Title: Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease.

PubMed ID: 9331372

DOI: 10.1101/gr.7.10.1020

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8910305

Title: Activity and autophosphorylation of LAMMER protein kinases.

PubMed ID: 8910305

DOI: 10.1074/jbc.271.44.27299

PubMed ID: 9637771

Title: The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.

PubMed ID: 9637771

DOI: 10.1006/excr.1998.4083

PubMed ID: 10480872

Title: The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.

PubMed ID: 10480872

DOI: 10.1074/jbc.274.38.26697

PubMed ID: 12705895

Title: Beacon interacts with cdc2/cdc28-like kinases.

PubMed ID: 12705895

DOI: 10.1016/s0006-291x(03)00549-7

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19168442

Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

PubMed ID: 19168442

DOI: 10.1161/circresaha.108.183905

PubMed ID: 19282290

Title: Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.

PubMed ID: 19282290

DOI: 10.1074/jbc.m901026200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20682768

Title: Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation.

PubMed ID: 20682768

DOI: 10.1074/jbc.m110.122044

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28289210

Title: Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.

PubMed ID: 28289210

DOI: 10.1073/pnas.1700082114

Sequence Information:

  • Length: 499
  • Mass: 60090
  • Checksum: E43BBF3BAD6EF991
  • Sequence:
  • MPHPRRYHSS ERGSRGSYRE HYRSRKHKRR RSRSWSSSSD RTRRRRREDS YHVRSRSSYD 
    DRSSDRRVYD RRYCGSYRRN DYSRDRGDAY YDTDYRHSYE YQRENSSYRS QRSSRRKHRR 
    RRRRSRTFSR SSSQHSSRRA KSVEDDAEGH LIYHVGDWLQ ERYEIVSTLG EGTFGRVVQC 
    VDHRRGGARV ALKIIKNVEK YKEAARLEIN VLEKINEKDP DNKNLCVQMF DWFDYHGHMC 
    ISFELLGLST FDFLKDNNYL PYPIHQVRHM AFQLCQAVKF LHDNKLTHTD LKPENILFVN 
    SDYELTYNLE KKRDERSVKS TAVRVVDFGS ATFDHEHHST IVSTRHYRAP EVILELGWSQ 
    PCDVWSIGCI IFEYYVGFTL FQTHDNREHL AMMERILGPI PSRMIRKTRK QKYFYRGRLD 
    WDENTSAGRY VRENCKPLRR YLTSEAEEHH QLFDLIESML EYEPAKRLTL GEALQHPFFA 
    RLRAEPPNKL WDSSRDISR

Genular Protein ID: 82209999

Symbol: B7Z8N6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 271
  • Mass: 32314
  • Checksum: 376A3C44066C1993
  • Sequence:
  • MFDWFDYHGH MCISFELLGL STFDFLKDNN YLPYPIHQVR HMAFQLCQAV KFLHDNKLTH 
    TDLKPENILF VNSDYELTYN LEKKRDERSV KSTAVRVVDF GSATFDHEHH STIVSTRHYR 
    APEVILELGW SQPCDVWSIG CIIFEYYVGF TLFQTHDNRE HLAMMERILG PIPSRMIRKT 
    RKQKYFYRGR LDWDENTSAG RYVRENCKPL RRYLTSEAEE HHQLFDLIES MLEYEPAKRL 
    TLGEALQHPF FARLRAEPPN KLWDSSRDIS R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.