Details for: CLK2

Gene ID: 1196

Symbol: CLK2

Ensembl ID: ENSG00000176444

Description: CDC like kinase 2

Associated with

Other Information

Genular Protein ID: 3737169679

Symbol: CLK2_HUMAN

Name: Dual specificity protein kinase CLK2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7990150

Title: Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.

PubMed ID: 7990150

DOI: 10.1006/jmbi.1994.1763

PubMed ID: 9331372

Title: Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease.

PubMed ID: 9331372

DOI: 10.1101/gr.7.10.1020

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8910305

Title: Activity and autophosphorylation of LAMMER protein kinases.

PubMed ID: 8910305

DOI: 10.1074/jbc.271.44.27299

PubMed ID: 9637771

Title: The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.

PubMed ID: 9637771

DOI: 10.1006/excr.1998.4083

PubMed ID: 10480872

Title: The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.

PubMed ID: 10480872

DOI: 10.1074/jbc.274.38.26697

PubMed ID: 12705895

Title: Beacon interacts with cdc2/cdc28-like kinases.

PubMed ID: 12705895

DOI: 10.1016/s0006-291x(03)00549-7

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19168442

Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

PubMed ID: 19168442

DOI: 10.1161/circresaha.108.183905

PubMed ID: 19282290

Title: Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.

PubMed ID: 19282290

DOI: 10.1074/jbc.m901026200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20682768

Title: Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation.

PubMed ID: 20682768

DOI: 10.1074/jbc.m110.122044

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28289210

Title: Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.

PubMed ID: 28289210

DOI: 10.1073/pnas.1700082114

Sequence Information:

  • Length: 499
  • Mass: 60090
  • Checksum: E43BBF3BAD6EF991
  • Sequence:
  • MPHPRRYHSS ERGSRGSYRE HYRSRKHKRR RSRSWSSSSD RTRRRRREDS YHVRSRSSYD 
    DRSSDRRVYD RRYCGSYRRN DYSRDRGDAY YDTDYRHSYE YQRENSSYRS QRSSRRKHRR 
    RRRRSRTFSR SSSQHSSRRA KSVEDDAEGH LIYHVGDWLQ ERYEIVSTLG EGTFGRVVQC 
    VDHRRGGARV ALKIIKNVEK YKEAARLEIN VLEKINEKDP DNKNLCVQMF DWFDYHGHMC 
    ISFELLGLST FDFLKDNNYL PYPIHQVRHM AFQLCQAVKF LHDNKLTHTD LKPENILFVN 
    SDYELTYNLE KKRDERSVKS TAVRVVDFGS ATFDHEHHST IVSTRHYRAP EVILELGWSQ 
    PCDVWSIGCI IFEYYVGFTL FQTHDNREHL AMMERILGPI PSRMIRKTRK QKYFYRGRLD 
    WDENTSAGRY VRENCKPLRR YLTSEAEEHH QLFDLIESML EYEPAKRLTL GEALQHPFFA 
    RLRAEPPNKL WDSSRDISR

Genular Protein ID: 82209999

Symbol: B7Z8N6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 271
  • Mass: 32314
  • Checksum: 376A3C44066C1993
  • Sequence:
  • MFDWFDYHGH MCISFELLGL STFDFLKDNN YLPYPIHQVR HMAFQLCQAV KFLHDNKLTH 
    TDLKPENILF VNSDYELTYN LEKKRDERSV KSTAVRVVDF GSATFDHEHH STIVSTRHYR 
    APEVILELGW SQPCDVWSIG CIIFEYYVGF TLFQTHDNRE HLAMMERILG PIPSRMIRKT 
    RKQKYFYRGR LDWDENTSAG RYVRENCKPL RRYLTSEAEE HHQLFDLIES MLEYEPAKRL 
    TLGEALQHPF FARLRAEPPN KLWDSSRDIS R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.