Genular: Defining Cellular Identity and Function

Details for: Atp6v1a

Gene ID: 11964

Symbol: Atp6v1a

Ensembl ID: ENSMUSG00000052459

Description: ATPase, H+ transporting, lysosomal V1 subunit A

Associated with

Amino acids regulate mtorc1
(R-MMU-9639288)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to starvation
(R-MMU-9711097)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Insulin receptor recycling
(R-MMU-77387)
Ion channel transport
(R-MMU-983712)
Iron uptake and transport
(R-MMU-917937)
Ros and rns production in phagocytes
(R-MMU-1222556)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Transferrin endocytosis and recycling
(R-MMU-917977)
Transport of small molecules
(R-MMU-382551)
Apical plasma membrane
(GO:0016324)
Atpase complex
(GO:1904949)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Atp metabolic process
(GO:0046034)
Cellular response to increased oxygen levels
(GO:0036295)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Extrinsic component of synaptic vesicle membrane
(GO:0098850)
Intracellular iron ion homeostasis
(GO:0006879)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Microvillus
(GO:0005902)
Mitochondrion
(GO:0005739)
Monoatomic ion transport
(GO:0006811)
Myelin sheath
(GO:0043209)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Plasma membrane
(GO:0005886)
Proton-transporting atpase activity, rotational mechanism
(GO:0046961)
Proton-transporting atp synthase activity, rotational mechanism
(GO:0046933)
Proton-transporting v-type atpase, v1 domain
(GO:0033180)
Proton-transporting v-type atpase complex
(GO:0033176)
Proton transmembrane transport
(GO:1902600)
Secretory granule
(GO:0030141)
Synaptic vesicle lumen acidification
(GO:0097401)
Transmembrane transporter complex
(GO:1902495)
Vacuolar proton-transporting v-type atpase, v1 domain
(GO:0000221)

Other Information

Proteins

V-type proton ATPase catalytic subunit A

Genular Protein ID: 4115250739

Symbol: VATA_MOUSE

Name: V-type proton ATPase catalytic subunit A

UniProtKB Accession Codes:

P50516 Q3TKS0 Q3U5W3 Q3U777 Q3UDZ9 Q3US31 Q8CHX2

Database IDs:

Citations:

PubMed ID: 8741845

Title: Resorption-cycle-dependent polarization of mRNAs for different subunits of V-ATPase in bone-resorbing osteoclasts.

PubMed ID: 8741845

DOI: 10.1091/mbc.7.1.129

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11495928

Title: Molecular cloning and characterization of Atp6n1b: a novel fourth murine vacuolar H+-ATPase a-subunit gene.

PubMed ID: 11495928

DOI: 10.1074/jbc.m107267200

PubMed ID: 17114649

Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

PubMed ID: 17114649

DOI: 10.1074/mcp.m600046-mcp200

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23863464

Title: AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney.

PubMed ID: 23863464

DOI: 10.1152/ajprenal.00303.2013

PubMed ID: 31786107

Title: Heat shock factor 4 regulates lysosome activity by modulating the alphaB-crystallin-ATP6V1A-mTOR complex in ocular lens.

PubMed ID: 31786107

DOI: 10.1016/j.bbagen.2019.129496

Sequence Information:

Length: 617
Mass: 68326
Checksum: D46AC76D9C7580A7
Sequence:

MDFSKLPKIR DEDKESTFGY VHGVSGPVVT ACDMAGAAMY ELVRVGHSEL VGEIIRLEGD 
MATIQVYEET SGVSVGDPVL RTGKPLSVEL GPGIMGAIFD GIQRPLSDIS SQTQSIYIPR 
GVNVSALSRD IKWEFIPSKN LRVGSHITGG DIYGIVNENS LIKHKIMLPP RNRGSVTYIA 
PPGNYDASDV VLELEFEGVK EKFSMVQVWP VRQVRPVTEK LPANHPLLTG QRVLDALFPC 
VQGGTTAIPG AFGCGKTVIS QSLSKYSNSD VIIYVGCGER GNEMSEVLRD FPELTMEVDG 
KVESIMKRTA LVANTSNMPV AAREASIYTG ITLSEYFRDM GYHVSMMADS TSRWAEALRE 
ISGRLAEMPA DSGYPAYLGA RLASFYERAG RVKCLGNPER EGSVSIVGAV SPPGGDFSDP 
VTSATLGIVQ VFWGLDKKLA QRKHFPSVNW LISYSKYMRA LDEYYDKHFT EFVPLRTKAK 
EILQEEEDLA EIVQLVGKAS LAETDKITLE VAKLIKDDFL QQNGYTPYDR FCPFYKTVGM 
LSNMISFYDM ARRAVETTAQ SDNKITWSII REHMGEILYK LSSMKFKDPV KDGEAKIKAD 
YAQLLEDMQN AFRSLED

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Atp6v1a

Associated with

Other Information

Resorption-cycle-dependent polarization of mRNAs for different subunits of V-ATPase in bone-resorbing osteoclasts. PubMed ID: 8741845

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning and characterization of Atp6n1b: a novel fourth murine vacuolar H+-ATPase a-subunit gene. PubMed ID: 11495928

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. PubMed ID: 17114649

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. PubMed ID: 23863464

Heat shock factor 4 regulates lysosome activity by modulating the alphaB-crystallin-ATP6V1A-mTOR complex in ocular lens. PubMed ID: 31786107