Genular: Defining Cellular Identity and Function

Details for: Atp6v1b2

Gene ID: 11966

Symbol: Atp6v1b2

Ensembl ID: ENSMUSG00000006273

Description: ATPase, H+ transporting, lysosomal V1 subunit B2

Associated with

Amino acids regulate mtorc1
(R-MMU-9639288)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to starvation
(R-MMU-9711097)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Insulin receptor recycling
(R-MMU-77387)
Ion channel transport
(R-MMU-983712)
Iron uptake and transport
(R-MMU-917937)
Ros and rns production in phagocytes
(R-MMU-1222556)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Transferrin endocytosis and recycling
(R-MMU-917977)
Transport of small molecules
(R-MMU-382551)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Atp metabolic process
(GO:0046034)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Extrinsic component of synaptic vesicle membrane
(GO:0098850)
Intracellular membrane-bounded organelle
(GO:0043231)
Membrane
(GO:0016020)
Microvillus
(GO:0005902)
Monoatomic ion transport
(GO:0006811)
Myelin sheath
(GO:0043209)
Nucleotide binding
(GO:0000166)
Plasma membrane
(GO:0005886)
Proton-transporting atpase activity, rotational mechanism
(GO:0046961)
Proton-transporting v-type atpase, v1 domain
(GO:0033180)
Proton transmembrane transport
(GO:1902600)
Ruffle
(GO:0001726)
Synapse
(GO:0045202)
Synaptic vesicle lumen acidification
(GO:0097401)
Vacuolar acidification
(GO:0007035)
Vacuolar proton-transporting v-type atpase, v1 domain
(GO:0000221)

Other Information

Proteins

V-type proton ATPase subunit B, brain isoform

Genular Protein ID: 955182094

Symbol: VATB2_MOUSE

Name: V-type proton ATPase subunit B, brain isoform

UniProtKB Accession Codes:

P62814 O09045 P50517 Q3TG74 Q3TL62 Q3TVK6 Q3TWR0 Q3U791 Q3U7C8 Q3U9Z0 Q3UAW7

Database IDs:

Citations:

PubMed ID: 8741845

Title: Resorption-cycle-dependent polarization of mRNAs for different subunits of V-ATPase in bone-resorbing osteoclasts.

PubMed ID: 8741845

DOI: 10.1091/mbc.7.1.129

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15013950

Title: Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis.

PubMed ID: 15013950

DOI: 10.1152/ajpcell.00464.2003

PubMed ID: 16174750

Title: The B1-subunit of the H(+) ATPase is required for maximal urinary acidification.

PubMed ID: 16174750

DOI: 10.1073/pnas.0506769102

PubMed ID: 17898041

Title: Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice.

PubMed ID: 17898041

DOI: 10.1152/ajprenal.00160.2007

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24913193

Title: De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome.

PubMed ID: 24913193

DOI: 10.1038/cr.2014.77

PubMed ID: 29993276

Title: H+-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney.

PubMed ID: 29993276

DOI: 10.1152/ajprenal.00539.2017

Sequence Information:

Length: 511
Mass: 56551
Checksum: E116BF9A36EEF36B
Sequence:

MALRAMRGIV NGAAPELPVP TGGPMAGARE QALAVSRNYL SQPRLTYKTV SGVNGPLVIL 
DHVKFPRYAE IVHLTLPDGT KRSGQVLEVS GSKAVVQVFE GTSGIDAKKT SCEFTGDILR 
TPVSEDMLGR VFNGSGKPID RGPVVLAEDF LDIMGQPINP QCRIYPEEMI QTGISAIDGM 
NSIARGQKIP IFSAAGLPHN EIAAQICRQA GLVKKSKDVV DYSEENFAIV FAAMGVNMET 
ARFFKSDFEE NGSMDNVCLF LNLANDPTIE RIITPRLALT TAEFLAYQCE KHVLVILTDM 
SSYAEALREV SAAREEVPGR RGFPGYMYTD LATIYERAGR VEGRNGSITQ IPILTMPNDD 
ITHPIPDLTG YITEGQIYVD RQLHNRQIYP PINVLPSLSR LMKSAIGEGM TRKDHADVSN 
QLYACYAIGK DVQAMKAVVG EEALTSDDLL YLEFLQKFEK NFITQGPYEN RTVYETLDIG 
WQLLRIFPKE MLKRIPQSTL SEFYPRDSAK H

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Atp6v1b2

Associated with

Other Information

Resorption-cycle-dependent polarization of mRNAs for different subunits of V-ATPase in bone-resorbing osteoclasts. PubMed ID: 8741845

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis. PubMed ID: 15013950

The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. PubMed ID: 16174750

Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice. PubMed ID: 17898041

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome. PubMed ID: 24913193

H+-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney. PubMed ID: 29993276